• 복식문화연구
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• 제16권5호
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• pp.863-877
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• 2008

The purpose of this study is to investigate the effect of dot pattern size(0.8, 1.8, 2.5, 5, 8), color combination (BG/R, Y/B), value tone(lt/dk, p/g), area-ratio on image information. Sets of stimulus and response scales(7 point semantic) were used as experimental materials. The stimuli were 20 color pictures manipulated with the combination of dot pattern size, color combination, value tone and area-ratio using computer simulation. The subjects were 240 female undergraduates living in Gyeongsangnam-do. Image factor of the stimulus was composed of 4 different components, visibility, chastity.feminity, cuteness and attractiveness. In the visibility, color combination, value tone, area-ratio, dot pattern size showed independent effect. In the chastity feminity, color combination, value tone, showed independent effect. In the cuteness, value tone, area-ratio, dot pattern size showed independent effect. Significant interaction effects of color and area-ratio combination on visibility and cuteness were found. Interaction efforts of color and value tone combination, value tone and area-ratio was significant on cuteness. For visibility image, BG/R combination of color and yellow background/blue dots were effective. For cuteness image, pale/grayish tone and background/dots area-ratio were effective.

• 디자인학연구
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• 제17권2호
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• pp.209-220
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• 2004

본 연구는 웹 디자인에서 배색(color combination)과 레이아웃(layout)에 의한 감성 효과를 알아보기 위하여 수행되었다. 본 연구에서는 여덟 가지 배색 샘플(sample)과 네 가지 기본 레이아웃(layout)을 선정하여, 그 조합으로 웹 페이지를 디자인하여 배색과 레이아웃 타입에 따른 감성 효과를 알아보았다. 배색과 레이아웃에 의한 감성 효과는 '밝고 소프트하고 화려한' 배색과 레이아웃 타입에서 '밝다, 환하다, 간단하다, 따뜻하다, 간결하다, 소프트하다' 가 주 감성 효과로 나타났다. 그리고 '어둡고 딱딱하며 간단한' 배색과 레이아웃 타입에서는 '차갑다, 칙칙하다, 어둡다, 딱딱하다, 도회적이다'의 감성 효과가 나타났다. 또, 배색에 의한 감성 효과는 배색의 감성을 포함하고 있는 감성 어휘들이 우선적으로 나타난 것으로 보아 배색에서부터 오는 감성 효과가 크다고 해석되었다. 또한 레이아웃에 의한 감성 효과는 레이아웃 A와 B에서 C와 D타입으로 갈수록 즉, 레이아웃이 복잡해질수록 '화려하고 도회적인' 인상을 받는 것으로 나타났다. 배색에 의한 감성 효과가 레이아웃에 의한 감성효과보다 크게 나타났으나 배색은 레이아웃에 의해 이루어지므로 레이아웃에 의한 감성 효과도 중요한 것으로 해석되었다.

• 생물정신의학
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• 제4권2호
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• pp.251-258
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• 1997

The dysfunction of either or both noradrenaline and serotonin system are important in the pathophysiology of depression. Previous reports have suggested that there may be an important interaction between these two systems. Recently, some investigators have suggested that the combination of tricyclic antidepressants(TCAs) and selective serotonin reuptake inhibitors(SSRIs) would produce a rapid synergistic effect on down-regulation of either or both of these two systems and that this combination may produce a more rapid and absolute antidepressant effect. We compared the treatment efficacy, treatment associated side effects, treatment satisfaction, and the quality of life between the combination therapy of dothiepin-sertraline as well as the therapy of dothiepin alone in the treatment of major depressive disorder and dysthymic disorder. In our study, the combination therapy of dothiepin and sertraline produced a more rapid and absolute antidepressant effect than dothiepin alone. And the patients with combination therapy experienced relatively high treatment satisfaction than the patients with dothiepin therapy. The patients' quality of life improved more rapidly in the combination therapy, especially, in the health perception, social behavior, and life satisfaction, than dothiepin alone. These results support the hypothesis that the combination of TCA and SSRI may produce a rapid synergistic effect on either or both norepinephrine and serotonin system, and more rapid antidepressant effect and high treatment satisfaction.

• Journal of Microbiology
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• 제45권5호
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• pp.473-477
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• 2007

The in vitro antibacterial activity against antibiotic-resistant Propionibacterium acnes of kaempferol isolated from the Impatiens balsamina alone and in combination with erythromycin or clindamycin antibiotics was investigated. The antibiotic combination effect against antibiotic-resistant P. acnes was studied by checkerboard test. Kaempferol and quercetin demonstrated antibacterial activities against P. acnes. Minimum inhibitory concentrations (MICs) for both compounds were ${\leq}32\;{\mu}g/ml\;and\;{\leq}64{\mu}g/ml$ for clindamycin-sensitive and -resistant P. acnes, respectively. The four combination formulations (kaempferol and either erythromycin or clindamycin; quercetin and either erythromycin or clindamycin) exhibited a synergic inhibition of P. acnes growth. The combination of kaempferol with quercetin showed an indifferent effect. The combination of clindamycin with kaempferol or quercetin showed a greater synergic effect than that of erythromycin with kaempferol or quercetin. Thus, these combinations demonstrated the potential to treat acne.

• 정보화정책
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• 제27권3호
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• pp.82-111
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• 2020

최근 빅데이터 활용의 영향요인으로 개인정보 규제요인과 가명정보 결합이 핵심 정책수단으로 등장하고 있다. 본 연구는 개인정보 규제요인과 빅데이터 활용의 관계에서 제3의 변수로서 가명정보 결합의 매개효과 및 조절효과를 실증분석하였다. 분석결과, 첫째, 개인정보 규제요인 중 개인정보 정의, 개인정보 동의, 법령위반 처벌강도 요인이, 그리고 가명정보 결합요인 중 결합 비식별성, 결합 가명정보 표준화, 결합 책임성이 빅데이터의 활용에 정(+)의 유의한 관계를 보였다. 둘째, 가명정보 결합 요인 중 결합 비식별성, 결합 가명정보 표준화, 결합 책임성이 개인정보 규제요인과 빅데이터 활용과의 관계에서 정(+)의 매개효과를 보였다. 셋째, 개인정보 규제요인과 빅데이터 활용과의 관계에서 가명정보 결합기관 유형인 자유형, 중개형, 지정형의 순서에 따라 조절효과가 다를 것이라는 가설은 기각되었다. 이상의 분석결과를 기반으로 개인정보 보호와 빅데이터 활용이 조화를 이루는 '착한규제'의 정책대안을 제시하였다.

• 한국의류학회지
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• 제27권3_4호
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• pp.395-406
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• 2003

The Purpose of this study is to find out the effect of clothing style and color, tone combination on impressions formation. The experimental materials developed for this study are a set of stimuli and response scale(The 7-point semantic). The stimuli are 36pictures manipulated with clothing style, color and tone variation by computer drawing. The subjects are 216 female undergraduate students and 216 female of middle age(40~50) in Chin-ji city. The resulte of this study are as follows : Impression factor of the stimulus was consisted of the 5 different demensions(attractiveness, elegance, activity, revealation, tenderness). Among there, attractiveness and elegance factors proved to be more important. In the attractiveness and tenderness, clothing style, color, tone combinations and perceiver's age had the significant effect. In the elegance and revealation, color and perceiver's age had the significant effect but in the activity, only color did not have the significant effect. Significant interaction effects of clothing style and color, style and tone combination, and color and perceiver's age on attractiveness and revealation were found. Interaction effect of color and tone combination was significant on the elegance and revealation, and that of color and perceiver's age was significant on tenderness.

• 혜화의학회지
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• 제8권1호
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• pp.837-851
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• 1999

In order to inverstigate interactive effects of Samultang(SMT) and SMT composition and the principle of prescription, I examined the effects of SMT and combination of three components of SMT, In C57BL/6 mouse with oral administration of SMT and cyclophosphamide(CTX) treatment, white blood cells, platelet were counted. Also, those were anti-anemia effect for rat which have hemolytic anemia induced by phenylhydrazine. The results were summerized as follows : 1. In vivo analysis of the effect of the SMT by orally administrated C57BL/6 mice with the SMT and was treated with cyclophosphamide (CTX). When the number of white blood cell. platelet was counted, there was ameliorative effects of leucopenia or thrombocytopenia as a protection to CTX. 2. It was acknowledged that SMT and its composition increased RBC count and hemlytic significantly in rat which have hemolytic anemia. 3. Among SMT composition Angelicae gigantis Radix and Cnidii Rhizoma solution and among the combination group Rehmanniae Radix and Cnidii Rhizoma combination and SMT solution showed significant effects for hemoglobin and weight of spleen in mouse which have hemolytic anemia. Thus it was acknowledged that Rehmanniae Radix and Cnidii Rhizoma combination had effect to improve hemoglobin and weight of spleen. From above these results it was acknowledged that SMT has effects that ameliorative effects of leucopenia or thrombocytopenia as a protection to CTX and anti-anemic effect for the rat which have hemolytic anemia induced by phenylhydrazine and these effects depend upon its combination of SMT composition. Especially it was acknowleged, though there are the slight difference according to combination, that Paeoniae Radix Alba combination had improving effect for physical change. So it is though that Paeoniae Radix Alba is main material for this kind of disease and continuous study is needed.

• Asian-Australasian Journal of Animal Sciences
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• 제17권9호
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• pp.1192-1196
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• 2004

In order to detect the molecular mechanism of heterosis in pigs, the mRNA differential display technique was performed to investigate the differences in gene expression of pig's Longissimus dorsi between the high-parent heterosis cross combination Landrace${\times}$Large White and the mid-parent heterosis cross combination Large White${\times}$Meishan. Three pig purebreds, Large White, Meishan, and Landrace and four types of reciprocal $F_1$ hybrids were analyzed using nine 3'-end anchored primers in combination with ten 5'-end arbitrary primers and nearly 7,000 reproducible bands were examined. The patterns of gene expression of each cross combination were analyzed and eight common patterns (fifteen kinds) were found. When the results from the two cross combinations were put together and compared, eight different typical expression patterns were observed, these indicated that the patterns of gene expression of these two cross combinations had obvious differences. Gene expression correlation and cluster analyses of the two cross combinations indicated that the gene expression of the mid-parent heterosis cross combination was correlated with maternal effect, but in the high-parent heterosis cross combination, paternal effect acted in the gene expression of the hybrids or the gene expression of the hybrids was biased towards one parent.

• Asian Pacific Journal of Cancer Prevention
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• 제15권17호
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• pp.7129-7135
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• 2014

Background: In this study, we aimed to evaluate the growth inhibitory effect of the combination of ethaselen (BBSKE) and low fixed dose of selenite against A549 human non-small cell lung cancer cells in vitro. Materials and Methods: Growth inhibitory effects against A549 cells were determined by SRB assay. Combination index (CI) values were calculated based on Chou-Talalay median-effect analyses. Dose reduction index (DRI) values were applied to calculate dose reduction of selenite. Contents of free thiols and GSH were determined by DTNB assay and intracellular ROS levels by DCFH-DA fluorescence labeling. Results: Compared with BBSKE or selenite single treatment, the combined application of ethaselen and a low fixed dose of selenite shortened the onset time of sodium selenite, reduced $IC_{50}$ values, and increased the maximum inhibition rates, suggesting a possible molecular mechanism of the synergism. Obvious synergistic effects were observed after different times of combination treatment, especially after 24 h. Compared with selenite single treatment, dosage of selenite could be remarkably reduced in combination therapy to gain the same inhibitory effect on cell proliferation. Compared with BBSKE single treatment, the content of free thiols and GSH were significantly reduced and ROS levels greatly elevated in the combination group. For the combination treatment, cell viability increased as greater concentrations of GSH were added. Conclusions: All these results indicate that the combination treatment of BBSKE and selenite showed synergism to inhibit A549 cell proliferation in vitro, and also reduced the selenite dosage to mitigate its toxicity which is very meaningful for combination chemotherapy of lung cancer. The synergism was probably caused by the accelerated exhaustion of intracellular reductive substances, such as free thiols and GSH, which ultimately leads to enhanced oxidative stress and apoptosis.

• 대한약침학회지
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• 제23권1호
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• pp.18-24
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• 2020

Objectives: Pain is considered as a cause of sickness and the most prevalent symptom which makes people visit a physician. Nowadays, combination therapy is becoming useful to relieve chronic and postsurgical pain. The aim of this study was to study the promethazine (as an antihistamine) interactions with antinociceptive effect of diclofenac (as a non-steroidal anti-inflammatory drugs). Methods: In initial part of the study, we investigate the analgesic effect of diclofenac. Using writhing test, we demonstrate that diclofenac significantly reduces writhe response induced by acetic acid in a dose-dependent manner. In this study, we evaluate the combination effect of promethazine on diclofenac analgesic effect. Results: We observed that diclofenac inhibited pain in the dose dependent manner which means that by increasing dose of diclofenac a significant decrease in pain was observed. This experimental setup allowed calculation of the dose that caused 50% antinociception (ED50) for diclofenac. The ED50 for diclofenac in this study was determined to be 9.1 mg/kg according our previous study. Additionally, promethazine was showed a dose-dependent inhibition of writhes. The combination of different doses of promethazine (2, 4, 6 mg / kg) with diclofenac ED50 (9.1 mg / kg) was injected to mice. Promethazine 4 and 6 mg / kg in combination with diclofenac had significantly led to increase analgesic effect of diclofenac. Conclusion: In conclusion, these results add important information to the existing knowledge on combination of diclofenac and antihistamine in pain therapies to be used in clinical practice and maybe helpful in designing the future guidelines.