• Maxillofacial Plastic and Reconstructive Surgery
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• v.34 no.6
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• pp.377-383
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• 2012

Purpose: The aim of this study was to evaluate the effect of 4-hexylresorcinol and hydroxyapatite combination graft on bone regeneration in the rabbit calvarial defect model. Methods: Ten New Zealand white rabbits were used for this study. Bilateral round shaped defects (diameter: 8.0 mm) were created on the parietal bone. 4-hexylresorcinol and hydroxyapatite combination graft material was grafted into the right parietal bone defect area (experimental). The left bone defect area was not filled with anything (control). The animals were sacrificed at 4 weeks and 8 weeks after grafting. A micro-computerized tomography of each specimen was taken, and the specimens were stained for histological analysis. Results: The average value of bone mineral density (BMD) and Bone volume (BV) was higher in the experimental group than in the control group at 4 weeks and 8 weeks after surgery. However, the difference was not statistically significant (P>0.05) at 8 weeks after grafting. The BMD and BV in the experimental group at 4 weeks after surgery was significantly higher than those in the control group (P<0.05). Conclusion: 4-hexylresorcinol and hydroxyapatite combination graft material showed higher initial bone formation than the control, however, there was no difference at 8weeks after operation.

• Food Science of Animal Resources
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• v.44 no.3
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• pp.586-606
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• 2024

The study was performed to determine the effect of faba bean protein isolate (FBPI) alone or in combination with microbial transglutaminase (MTG) on the rheological properties of pork myofibrillar protein gel (MPG), and physiochemical and textural properties of reduced-salt, low-fat pork model sausages (LFMSs). The cooking yields of MPGs with MTG or FBPI alone decreased and increased, respectively. However, the combination of FBPI and MTG was similar to the control (CTL) without FBPI or MTG. Gel strength values of MPG added with both FBPI and MTG were higher than treatments with FBPI or MTG alone. The hydrophobicity values of CTL were lower than those of MPG with FBPI alone, whereas the addition of MTG decreased the hydrophobicity of MPGs. The incorporation of FBPI alone or in combination with MTG decreased sulfhydryl groups (p<0.05). Shear stress values of MPGs with MTG tended to be higher than those of non-MTG treatments at all shear rates, and the addition of FBPI into MPGs increased shear stress values. Reduced-salt (1.0%) LFMSs with FBPI alone or combined with MTG had both lower cooking loss and expressible moisture values than those of CTL and similar values to the reference sample (REF, 1.5% salt). Textural properties of reduced-salt LFMSs with FBPI or MTG were similar to those of REF. These results demonstrated that the combination of FBPI and MTG could improve the water binding capacity and textural properties of pork MPGs and LFMSs and might be suitable for application in the development of healthier meat products.

• The Pure and Applied Mathematics
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• v.20 no.1
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• pp.59-70
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• 2013

The purpose of this study was to develop a zero-inflated Rasch (ZI-Rasch) model, a combination of the Rasch model and the ZIP model. The ZI-Rasch model was considered in this study as an appropriate alternative to the Rasch model for zero-inflated data. To investigate the relative appropriateness of the ZI-Rasch model, several analyses were conducted using PROC NLMIXED procedures in SAS under various simulation conditions. Sets of criteria for model evaluations (-2LL, AIC, AICC, and BIC) and parameter estimations (RMSE, and $r$) from the ZI-Rasch model were compared with those from the Rasch model. In the data-model fit indices, regardless of the simulation conditions, the ZI-Rasch model produced better fit statistics than did the Rasch model, even when the response data were generated from the Rasch model. In terms of item parameter ${\lambda}$ estimations, the ZI-Rasch model produced estimates similar to those of the Rasch model.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• v.1
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• pp.535-540
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• 2006

The relationship between the observable noise model and the satellite elevation angle can be modeled quite well by an exponential function.[Jin, 1996] Noise size and dependence on the elevation angle are, however, different for each observation and receiver type. Therefore, the coefficient determination of this model is an issue, and various methods including PR-CP, single difference, and time difference have been suggested. The limitations of them are difficulty to model the carrier phase noise and to eliminate bias. To overcome these disadvantages for using Jin's model, we suggest zero baseline double difference (DD) and noise sorting algorithm. Data DD technique in zero baseline is useful to eliminate all the troublesome GPS biases, and the remaining error is the sum of GPS measurement noises from two satellites. These DD residuals for hours should be sorted by the combination of satellite elevation angles, and then variance value of the residual for each combination can be estimated. Using these values, we construct an over-determined linear equation whose solution is a set of noise variance for each satellite elevation angle. With 24hr Trimble 4000ssi data, we easily worked out the coefficients of the noise model not only for pseudorange but also for carrier phase. We estimated the standard deviation of the measurement DD using our model, and plotted 1 and 3 sigma lines for every epoch to verify the representation of the residual error. 63.3% of pseudorange residual and 65.9% of phase error did not exceed the 1 sigma lines. Additionally, 99.2% and 99.5% of them lied within 3sigma line. These figures prove that the Gaussian property of measurement noise, and that the suggested model by our algorithm corresponds to the observable noise information.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.9
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• pp.5243-5248
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• 2013

Background: Triptolide, extracted from the herb Tripteryglum wilfordii Hook.f that has long been used as a natural medicine in China, has attracted much interest for its anti-cancer effects against some kinds of tumours in recent years. Artesunate, extracted from the Chinese herb Artemisia annua, has proven to be effective and safe as an anti-malarial drug that possesses anticancer potential. The present study attempted to clarify if triptolide enhances artesunate-induced cytotoxicity in pancreatic cancer cell lines in vitro and in vivo. Methods: In vitro, to test synergic actions, cell viability and apoptosis were analyzed after treatment of pancreatic cancer cell lines with the two agents singly or in combination. The molecular mechanisms of apoptotic effects were also explored using qRT-PCR and Western blotting. In vivo, a tumor xenograft model was established in nude mice, for assessment of inhibitory effects of triptolide and artesunate. Results: We could show that the combination of triptolide and artesunate could inhibit pancreatic cancer cell line growth, and induce apoptosis, accompanied by expression of HSP 20 and HSP 27, indicating important roles in the synergic effects. Moreover, tumor growth was decreased with triptolide and artesunate synergy. Conclusion: Our result indicated that triptolide and artesunate in combination at low concentrations can exert synergistic anti-tumor effects in pancreatic cancer cells with potential clinical applications.

• Transactions of the Korean Society of Automotive Engineers
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• v.25 no.2
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• pp.242-249
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• 2017

In this study, the relationship between the shape of a passenger airbag and the possibility of injury is analyzed using the Taguchi method. The optimal shape combination is proposed for a design guideline that can reduce the possibility of injury to the dummy. The airbag FE model for analysis is obtained using a CAD system that can change the shape through several independent variables. The widths of the left / right, top / bottom, and back / forth direction of the airbag shape are set as the design factors, and the effect of the combination injury probability according to the shape is analyzed. The minimum geometric combinations are obtained using the orthogonal array method. The signal to noise ratio is calculated and the optimal shape combination is obtained through sensitivity analysis. The obtained optimal shape combination is compared with the possibility of injury of the initial airbag shape to confirm improved airbag performance.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.8 no.1
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• pp.88-98
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• 1996

The present study is concerned with the flow friction and heat transfer characteristics of the combination of various regenerator materials, using the different Darcy number and porosity, which is filled uniformly and partially in a tube under oscillating flow condition. The poros medium is adopted as Brinkmann-Forschheimer extended Darcy model. Numerical results are obtained or the flow and temperature fields and described the effect of the combination of various regenerator materials and Womersley number on the pressure drop, the heat transfer and the regenerator efficiency. The results obtained indicate that not only heat transfer between the tube wall and oscillating flow but also the pressure drop at both ends of the regenerator are increased, while the regenerator efficiency is decreased in the increase of womersley number. It is also found that the friction factor is increased as Reynolds number is increased. The comparison between the combination of the various regenerator materials and the homogeneous regenerator material shows that the regenerator efficiency can be enhanced with the proper combination of various regenerator materials even though the averaged porosity of the regenerator is same.

• Applied Chemistry for Engineering
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• v.25 no.3
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• pp.330-336
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• 2014

Purification of indole contained in model coal tar absorption oil was examined by extraction-distillation-crystallization combination. The absorption oil consists of nine components such as four kinds of nitrogen heterocyclic compounds (9.2% quinoline, 2.4% iso-quinoline, 4.7% indole, 2.4% quinaldine), three kinds of bicyclic aromatic compounds (14.2% 1-methylnaphthalene, 31.8% 2-methylnaphthalene, 23.5% dimethylnaphthalene), 5.5% biphenyl and 3.3% phenyl ether. 99.5% indole was recovered by combination of formamide extraction-distillation-solute crystallization using n-hexane. Furthermore, the recovery process of indole contained in coal tar absorption oil was studied by using the experimental results obtained by each operation of this work.

• The Journal of the Korea institute of electronic communication sciences
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• v.16 no.2
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• pp.355-362
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• 2021

Since coaxial magnetic gears use non-contact power transmission, friction, wear, noise, and heat generated in the power transmission process of existing mechanical gears can be minimized. Currently, research for application to various industries is being actively conducted, but among the characteristics of coaxial magnetic gears, the problem of rapidly decreasing torque density at a high gear ratio was discussed. This paper proposes a direction for multiple gear combination using low gear ratio coaxial magnetic gears with high torque density. In order to confirm the effectiveness of the method, the torque density was compared with a single high gear ratio model, and the combination and design direction of multiple coaxial magnetic gears were shown.

• The Korean Journal of Physiology and Pharmacology
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• v.27 no.3
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• pp.221-230
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• 2023

Diabetic kidney disease is one of the most serious complications of diabetes. Although diabetic kidney disease can be effectively controlled through strict blood glucose management and corresponding symptomatic treatment, these therapies cannot reduce its incidence in diabetic patients. The sodium-glucose cotransporter 2 (SGLT2) inhibitors and the traditional Chinese herb "Gegen" have been widely used in diabetes-related therapy. However, it remains unclear whether the combined use of these two kinds of medicines contributes to an increased curative effect on diabetic kidney disease. In this study, we examined this issue by evaluating the efficacy of the combination of puerarin, an active ingredient of Gegen, and canagliflozin, an SGLT2 inhibitor for a 12-week intervention using a mouse model of diabetes. The results indicated that the combination of puerarin and canagliflozin was superior to canagliflozin alone in improving the metabolic and renal function parameters of diabetic mice. Our findings suggested that the renoprotective effect of combined puerarin and canagliflozin in diabetic mice was achieved by reducing renal lipid accumulation. This study provides a new strategy for the clinical prevention and treatment of diabetic kidney disease. The puerarin and SGLT2 inhibitor combination therapy at the initial stage of diabetes may effectively delay the occurrence of diabetic kidney injury, and significantly alleviate the burden of renal lipotoxicity.