Browse > Article

The Effect of a Hydroxyapatite and 4-hexylresorcinol Combination Graft on Bone Regeneration in the Rabbit Calvarial Defect Model  

Kim, Min Keun (Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University)
Park, Yong Tae (Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University)
Kim, Seong-Gon (Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University)
Park, Young-Wook (Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University)
Lee, Suk-Keun (Department of Oral Pathology, College of Dentistry, Gangneung-Wonju National University)
Choi, Weon-Sik (Gangneung Center, Korea Basic Science Institute)
Publication Information
Maxillofacial Plastic and Reconstructive Surgery / v.34, no.6, 2012 , pp. 377-383 More about this Journal
Abstract
Purpose: The aim of this study was to evaluate the effect of 4-hexylresorcinol and hydroxyapatite combination graft on bone regeneration in the rabbit calvarial defect model. Methods: Ten New Zealand white rabbits were used for this study. Bilateral round shaped defects (diameter: 8.0 mm) were created on the parietal bone. 4-hexylresorcinol and hydroxyapatite combination graft material was grafted into the right parietal bone defect area (experimental). The left bone defect area was not filled with anything (control). The animals were sacrificed at 4 weeks and 8 weeks after grafting. A micro-computerized tomography of each specimen was taken, and the specimens were stained for histological analysis. Results: The average value of bone mineral density (BMD) and Bone volume (BV) was higher in the experimental group than in the control group at 4 weeks and 8 weeks after surgery. However, the difference was not statistically significant (P>0.05) at 8 weeks after grafting. The BMD and BV in the experimental group at 4 weeks after surgery was significantly higher than those in the control group (P<0.05). Conclusion: 4-hexylresorcinol and hydroxyapatite combination graft material showed higher initial bone formation than the control, however, there was no difference at 8weeks after operation.
Keywords
4-hexylresorcinol; Hydroxyapatite; Bone regeneration;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Laurie SW, Kaban LB, Mulliken JB, Murray JE. Donor-site morbidity after harvesting rib and iliac bone. Plast Reconstr Surg 1984;73:933-8.   DOI   ScienceOn
2 Younger EM, Chapman MW. Morbidity at bone graft donor sites. J Orthop Trauma 1989;3:192-5.   DOI
3 Dumas JE, Davis T, Holt GE, et al. Synthesis, characterization, and remodeling of weight-bearing allograft bone/polyurethane composites in the rabbit. Acta Biomater 2010;6: 2394-406.   DOI   ScienceOn
4 Hagen A, Gorenoi V, Schonermark MP. Bone graft substitutes for the treatment of traumatic fractures of the extremities. GMS Health Technol Assess 2012;8:Doc04. [Epub]
5 Hing KA, Best SM, Tanner KE, Bonfield W, Revell PA. Quantification of bone ingrowth within bone-derived porous hydroxyapatite implants of varying density. J Mater Sci Mater Med 1999;10:663-70.   DOI   ScienceOn
6 Liu DM. Fabrication and characterization of porous hydroxyapatite granules. Biomaterials 1996;17:1955-7.   DOI   ScienceOn
7 Frame JW. Hydroxyapatite as a biomaterial for alveolar ridge augmentation. Int J Oral Maxillofac Surg 1987;16:642-55.   DOI   ScienceOn
8 Abd El-Fattah H, Helmy Y, El-Kholy B, Marie M. In vivo animal histomorphometric study for evaluating biocompatibility and osteointegration of nano-hydroxyapatite as biomaterials in tissue engineering. J Egypt Natl Canc Inst 2010;22:241-50.
9 National Toxicology Program. NTP Toxicology and Carcinogenesis Studies of 4-Hexylresorcinol (CAS No. 136-77-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies). Natl Toxicol Program Tech Rep Ser 1988;330:1-166.
10 Iyidogan NF, Bayindirli A. Effect of L-cysteine, kojic acid and 4-hexylresorcinol combination on inhibition of enzymatic browning in Amasya apple juice. J Food Eng 2004;62:299-304.   DOI   ScienceOn
11 Martinez-Alvarez O, Lopez-Caballero ME, Montero P, Gomez- Guillena MC. Spraying of 4-hexylresorcinol based formulations to prevent enzymatic browning in Norway lobsters (Nephropsnorvegicus) during chilled storage. Food Chem 2007;100: 147-55.   DOI   ScienceOn
12 Kim SG, Lee SW, Park YW, Jeong JH, Choi JY. 4-hexylresorcinol inhibits NF-${\kappa}B$ phosphorylation and has a synergistic effect with cisplatin in KB cells. Oncol Rep 2011; 26:1527-32.
13 Kim SG, Jeong JH, Park YW, et al. 4-Hexylresorcinol inhibits transglutaminase-2 activity and has synergistic effects along with cisplatin in KB cells. Oncol Rep 2011;25:1597-602.
14 Misch CE, Dietsh F. Bone-grafting materials in implant dentistry. Implant Dent 1993;2:158-67.   DOI   ScienceOn
15 Peres JA, Lamano T. Strategies for stimulation of new bone formation: a critical review. Braz Dent J 2011;22:443-8.   DOI
16 Kim SG, Hahn BD, Park DS, et al. Aerosol deposition of hydroxyapatite and 4-hexylresorcinol coatings on titanium alloys for dental implants. J Oral Maxillofac Surg 2011;69: e354-63.   DOI   ScienceOn