• Herbal Formula Science
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• v.12 no.2
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• pp.119-137
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• 2004

In order to evaluate the anti-tumor and synergic effect of Soonkiwhajungtang with doxorubicin, the inhibitory concentration(IC), $IC_{50}\;and\;IC_{90}$ of single use of doxorubicin and Soonkiwhajungtang with their concomitant treatment against Colon-26(Murine Rectum Carcinoma) was observed using MTT(Microculture Tetrazolium test) assay. In addition, their anti-tumor effects were also observed in the xenograft nude mice models agianst to Colon-26 cell lines. Soonkiwhajungtang has only mimic direct anti-tumor effect against to Colon-26 cell lines but they were decreased general depressed signs induced by implantation of tumor cell lines and increased the total WBC and lymphocyte numbers. So, it is considered or expected that Soonkiwhajungtang extracts were reduced the critical toxicity of doxorubicin and shows favorable synergic effect with doxorubidn and Soonkiwhajungtang extracts.

• Herbal Formula Science
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• v.12 no.1
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• pp.131-148
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• 2004

In order to evaluate the anti-tumor and synergic effect of Bojungikkeehapdaechilkitang with doxorubicin, the inhibitory concentration(IC), $IC_{50}\;and\;IC_{90}$ of single use of doxorubicin and Bojungikkeehapdaechilkitang with their concomitant treatment against 3LL(Lewis lung carcinoma) was observed using MTT(Microculture Tetrazolium test) assay. In addition, their anti-tumor effects were also observed in the xenograft nude mice models agianst to 3LL cell lines. Bojungikkeehapdaechilkitang has only mimic direct anti-tumor effect against to 3LL cell lines but they were decreased general depressed signs induced by implantation of tumor cell lines and increased the total WBC and lymphocyte numbers. So, it is considered or expected that Bojungikkeehapdaechilkitang extracts were reduced the critical toxicity of doxorubicin and shows favorable synergic effect with doxorubicin and Bojungikkeehapdaechilkitang extracts.

• Journal of Oriental Neuropsychiatry
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• v.16 no.1
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• pp.171-183
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• 2005

Objective : The Korean famous medicinal prescription of Subi-jeon was investigated for their antidepressant effects by tail suspension test, hot plate test, reserpine-induced hypothermia test. In addition, the monoamine oxidase activity was determined in vivo. Methods : The methanol extract reduced dose-dependently the duration of immobility in the tail suspension test, by 31.4 and 34%(p<0.05) at doses of 500mg/kg and 1g/kg, respectively, compared with control group. In comparison with this, the effect of the water extract was very weak. Results : 1. In the hot plate test, the methanol extract potently increased the jump latency time(p<0.05) compared to the control group, exhibiting the inhibition rate of 197% and 256% at doses of 500mg/kg and 1g/kg(per os), respectively, which is more effective than the water extract. 2. Both extracts suppressed the fall of body temperature induced by reserpine(reserpine-induced hypothermia) in a dose-dependent manner, showing the less effect at lower doses and better effect at higher doses compared to the water extract. 3. Both extracts inhibited the brain monoamine oxidase activity in an in vivo assay compared to the control group, the activity of water extract was better than that of the methanol extract. Conclusion : The prescription of Subi-jeon can be useful for the prevention and treatment of depression.

• The Journal of Pediatrics of Korean Medicine
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• v.24 no.3
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• pp.33-42
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• 2010

Objectives: The purpose of this study is to investigate the frequency of side effects, and the range of the side effects from Korean herb medicine on children. Methods: The study has been carried out from 212 children who took Korean herb medicine in Department of Pediatrics, $\bigcirc\;\bigcirc$ Oriental Medical Hospital from September 2009 to February 2010. The study was completed through patients chart review and telephone survey. Results: 1. There were 6 side effect cases on male, and 3 side effect cases on female out of 212 children. The incidence of side effect was 4.2%. 2. The most common side effect was abdominal pain. The most common related organ was digestive organ. 3. The side effect occurred within one to three days after taking Korean herb medicine, and the symptoms were mostly disappeared after taking the Korean herb medicine into divided dose or less dose. Conclusions: The symptom of side effects on children was not as severe as other adverse drug reactions often seen in Western medication. The most common symptom was abdominal pain. Further studies are needed.

• Journal of Veterinary Clinics
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• v.19 no.2
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• pp.225-227
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• 2002

Various commercial shampoos were frequently prescribed for dermatologicstherapy in small animal practice. Skin surface sebum affected by the shampoos, however, was not evaluated routinely. In order to evaluate the skin surface sebum for the exact prescription of shampoos methods to measure skin surface sebum of shampoos are needed. This study was undertaken to evaluate the skin surface sebum effect of shampoo on canine skin using sebometry. Five healthy dogs were applied with 3 commercial shampoos: Sebocalm, Sebolytics, and Benzoyl peroxide. Sebocalm had a great effect on skin surface seoum and normal saline also affected the skin sebum. Sebolytics and benzoyl peroxide had a moderate effect of skin sebum. The lowest effect was shown in detergent. Therefore, Sebumeter was considered a good and convenient apparatus for skin sebum measurement in order to evaluate the effect of shampoos on skin sebum. None of the products tested had any negative effect on the skin barrier function.

• Korean Journal of Pharmacognosy
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• v.42 no.2
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• pp.182-186
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• 2011

Houttuynia cordata Thunb.[H.cordata]belonging to Saururaceae, is a wild medicinal herb of perennial plants, and grows well in a place with a lot of shade and moisture. The medical action of H.cordata is reported to have an antitumer effect, toxicity-suppressive effect, antifungal effect, diuretic effect, and antioxidative action, but its effect hasn't been reported on cardiovascular diseases, such as ateriosclerosis and hypertension yet. This study intended to confirm the effect of the water extract of H.cordata on the migration and proliferation of rat aortic smooth muscle cells. Such results show that the water extract of H.cordata suppresses the migration and proliferation of rat aortic smooth muscle cells. It is believed that a useful clue will be offered later to the prevention of cardiovascular diseases such as ateriosclerosis and hypertension, and the development of their medicines on the basis of the fact.

• The Journal of Asian Finance, Economics and Business
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• v.7 no.8
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• pp.95-102
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• 2020

The purpose of this study is to test both the alignment theory and entertainment theory on family firms listed on the Pakistan Stock Exchange. To achieve these goals, we collected secondary data from 164 non-financial family firms in various sectors during 2014-18. These family firms are classified into two categories: family control firms and family owned firms. We take the audit fee and the audit quality as dependent variables while family control firms, family-owned firms, and family CEOs as independent variables. In addition, the study uses leverage, profit and export as control variables. To test the effect of the explanatory variables on the output variables, we use two econometric models, Ordinary Least Square and the Probit regression model. In addition, Huber Sandwich test is used to check the non-normality and heteroscedasticity of panel data. Contrary to the alignment effect, the study supports the entrenchment effect and advocates that family-controlled firms as well as family-owned firms are not conscientious regarding the selection of external auditors during their contracts with audit firms. They are less likely to pay high audit fees for good quality audit in Pakistan. Furthermore, the study shows a statistically significant and positive relationship between audit quality and audit fees.

• Biomolecules & Therapeutics
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• v.4 no.2
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• pp.162-166
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• 1996

This study was done to investigate whether cholic acid derivatives have anti-stress activity and what is a cause of this anti-stress effect. Seven cholic acid derivatives (cholic acid, taurocholic acid, ursodeoxycholic acid, tauroursodeoxychoic acid, chenodeoxy cholic acid, dehydrocholic acid, hyodeoxycholic acid) were used, silymarin and valproic acid were used as positive controls. Stress was induced by restraint immobilization technique plus water immersion (24hrs) and adrenal weight, spleen weight, adrenal ascorbic acid, serum cholesterol, lactate dehydrogenase (LDH), alkaline phosphatase (ALP), adrenal cholesterol, glucose and corticosterone levels were measured as stress indicators. Most cholic acid derivatives markedly decreased the adrenal weight, and TUDCA and DHCA increased the spleen weight. The restraint stress induced increments in serum LDH, ALP and cholesterol were attenuated by most cholic acid derivatives. Cholic acid, taurocholic acid and tauroursodeoxycholic acid only increased the content of adrenal ascorbate. While valproic acid showed an inhibitory effect against stress, silymarin did not. Our findings suggest that most cholic acid derivatives have anti-stress effect and that their anti-stress effect is, in part, related to choleretic activity.

• Journal of the Korean Society for Aviation and Aeronautics
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• v.30 no.3
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• pp.38-53
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• 2022

Recently, the acquisition and production of information using digital tools and the creation of new knowledge are emphasized as important educational elements. Therefore, in this study, the effect of learning achievement according to the digital literacy level of college students was analyzed. For the analysis, a questionnaire is conducted with college students majoring in aviation services attending universities in Seoul Capital Area and Chungcheong area. To verify the hypothesis of the study, demographic characteristics are identified based on the questionnaire, reliability and validity of measurement items are verified, and structural equation model analysis is performed to verify the hypothesis. The analysis results are as follows. First, among the sub-factors of digital literacy competency of college students majoring in aviation service, 'technology use' is found to have a positive effect on 'cognitive flow' and 'emotional flow' of learning flow except 'behavioral flow'. Second, among the sub-factors of digital literacy competency, 'self-learning' is found to have a positive effect on 'cognitive flow', 'emotional flow', and 'behavioral flow' in learning flow. Third, the sub-factors of learning flow, 'cognitive flow', 'emotional flow', and 'behavioral flow' have a positive effect on 'learning satisfaction'. Fourth, 'learning satisfaction' is found to have a positive effect on 'learning outcomes'. Based on the research results, practical support measures and strategies for educational success are presented.

• Journal of Korean Library and Information Science Society
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• v.50 no.4
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• pp.561-580
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• 2019

The purpose of this study is to examine the effect of bibliotherapy on college students' competency. For this purpose, data were collected from the students who participated in bibliotherapy class. As a result, it was found that bibliotherapy strengthened college students' competency. Specifically, it was found that bibliotherapy has a positive effect on enhancing self-identity and interpersonal relationships in college students. In addition, it has a positive effect on problem solving, and motivation for achievement. These results may be a rationale for the need of bibliotherapy course to strengthen students' competency at college.