• International Journal of Oral Biology
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• 제44권2호
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• pp.37-42
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• 2019

Oral squamous cell carcinoma (OSCC) is the most common oral malignancy and an increasing global public health problem. OSCC frequently invades the jaw bone. OSCC-induced bone invasion has a significant impact on tumor stage, treatment selection, patient outcome, and quality of life. A number of studies have shown that osteoclast-mediated bone resorption is a major step in the progression of bone invasion by OSCC; however, the molecular mechanisms involved in OSCC bone invasion are not yet clear. In this review, we present the clinical types of OSCC bone invasion and summarize the role of key molecules, including proteases, cytokines, and growth factors, in the sequential process of bone invasion. A better understanding of bone invasion will facilitate the discovery of molecular targets for early detection and treatment of OSCC bone invasion.

• International Journal of Computer Science & Network Security
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• 제22권6호
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• pp.139-144
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• 2022

Technological advancements taken the health care industry by a storm by embedding sensors in human body to measure their vitals. These smart solutions provide better and flexible health care to patients, and also easy monitoring for the medical practitioners. However, these innovative solutions provide their own set of challenges. The major challenge faced by embedding sensors in body is the issue of lack of infinite energy source. This work presents a meta-heuristic based routing model using modified PSO, and adopts an energy harvesting scheme to improve the network lifetime. The routing process is governed by modifying the fitness function of PSO to include charge, temperature and other vital factors required for node selection. A reactive routing model is adopted to ensure reliable packet delivery. Experiments have been performed and comparisons indicate that the proposed Energy Harvesting and Modified PSO (EHMP) model demonstrates low overhead, higher network lifetime and better network stability.

• International Journal of Computer Science & Network Security
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• 제22권3호
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• pp.285-291
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• 2022

WSN is the major component for information transfer in IoT environments. Source Location Privacy (SLP) has attracted attention in WSN environments. Effective SLP can avoid adversaries to backtrack and capture source nodes. This work presents a Two-Level Randomized Sector-based Routing (TLRSR) model to ensure SLP in wireless environments. Sector creation is the initial process, where the nodes in the network are grouped into defined sectors. The first level routing process identifies sector-based route to the destination node, which is performed by Ant Colony Optimization (ACO). The second level performs route extraction, which identifies the actual nodes for transmission. The route extraction is randomized and is performed using Simulated Annealing. This process is distributed between the nodes, hence ensures even charge depletion across the network. Randomized node selection process ensures SLP and also avoids depletion of certain specific nodes, resulting in increased network lifetime. Experiments and comparisons indicate faster route detection and optimal paths by the TLRSR model.

• Biomolecules & Therapeutics
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• 제29권6호
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• pp.582-595
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• 2021

Researchers have endeavored to identify the etiology of inflammatory bowel diseases, including Crohn's disease and ulcerative colitis. Though the pathogenesis of inflammatory bowel diseases remains unknown, dysregulation of the immune system in the host gastrointestinal tract is believed to be the major causative factor. Omics is a powerful methodological tool that can reveal biochemical information stored in clinical samples. Lipidomics is a subset of omics that explores the lipid classes associated with inflammation. One objective of the present systematic review was to facilitate the identification of biochemical targets for use in future lipidomic studies on inflammatory bowel diseases. The use of high-resolution mass spectrometry to observe alterations in global lipidomics might help elucidate the immunoregulatory mechanisms involved in inflammatory bowel diseases and discover novel biomarkers for them. Assessment of the characteristics of previous clinical trials on inflammatory bowel diseases could help researchers design and establish patient selection and analytical method criteria for future studies on these conditions. In this study, we curated literature exclusively from four databases and extracted lipidomics-related data from literature, considering criteria. This paper suggests that the lipidomics approach toward research in inflammatory bowel diseases can clarify their pathogenesis and identify clinically valuable biomarkers to predict and monitor their progression.

• Annals of Clinical Neurophysiology
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• 제8권2호
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• pp.107-124
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• 2006

The basal ganglia are a group of nuclei located in the deep portion of the brain. Along with the cerebellum, the basal ganglia have a major role in controlling human voluntary movements, and their dysfunction is apparently responsible for various involuntary movements. Although the exact mechanism of how the basal ganglia control movements has yet to be clarified, the model of focused selection (through the direct pathway) and tonic inhibition (via the indirect pathway) is proposed to be a principal functional model of the basal ganglia. Parkinson's disease (PD) is classically characterized by bradykinesia, rigidity and tremor-at-rest. All features seem to be associated with dopamine depletion resulting from the degeneration of the nigrostriatal pathway, which produces reduced activity of the direct pathway and a concurrent enhancement of excitatory output from STN. This change may result in increased tonic background inhibition and reduced focused selection via the direct pathway, causing difficulties in performing voluntary movements selectively. However, it has not been possible to define a single underlying pathophysiologic mechanism that explains all parkinsonian symptoms. Here the data that give separate understanding to each of the three classic features are discussed.

• 한국식생활문화학회지
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• 제38권3호
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• pp.154-162
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• 2023

This study investigated the awareness and consumption behavior of 118 vegetarians and omnivores toward plant-based dairy alternatives. The preference and choice attribute questionnaires were compared. Significant differences were obtained between the two groups when considering the purchase experience, preference, and selection attributes of plant-based dairy alternatives. Vegetarians had more experience purchasing plant-based dairy alternative products. In both groups, environmental and animal protection were the major factors that influenced the highest response rate for purchasing plant-based dairy alternatives. The preference score of vegetarians for plant-based dairy alternative products was high, indicating that vegetarianism had a significant effect on their preference for plant-based dairy alternative products. Analysis of selection attributes revealed that price, product weight, appearance, and manufacturer were considered important by vegetarians, whereas nutritional components and labeling, manufacturing environment, composition of ingredients, and taste and texture were considered more important by the omnivores. Results of this study can be used as basic data for the future development of the fast-growing industry producing plant-based dairy alternative products.

• 의학교육논단
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• 제26권1호
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• pp.5-18
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• 2024

The author recommends the creation of a nationwide career guidance program at the national level through the establishment of a long-term cohort, involving collaboration among medical schools nationwide. This cohort would be constructed for the purpose of analyzing correlations from admission to medical school to post-graduate education, facilitating the development of a career guidance program. This will aid in career development through students' self-analysis and competency building. Each medical school should operate a systematic career guidance program. Career guidance for post-graduate major selection should be included in the regular curriculum. Schools are advised to operate student counseling rooms for various career guidance services. For example, medical schools can operate 1:1 career counseling, academic counseling, career guidance surveys, psychological tests, and counseling. It is advisable to establish a mentor-professor system, connect mentor professors, and build a network of experts related to majors to provide immediate support according to students' needs. Professional mentor training should be provided to mentor professors. To provide opportunities for students to experience their career paths in advance, early clinical exposure, long-term integrated clinical practice, community-based clinical practice, participation in student research programs, career fairs, and student internship programs are recommended. In South Korea, it is necessary to systematically operate the internship system and make improvements to facilitate optical career choices. Additionally, considering the significant influence of social factors on students' career choices in South Korea, efforts should be made to identify and address the issues related to these social factors.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제10권11호
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• pp.5476-5496
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• 2016

Energy efficiency of resource-constrained wireless sensor networks is critical in applications such as real-time monitoring/surveillance. To improve the energy efficiency and reduce the energy consumption, the time series data can be compressed before transmission. However, most of the compression algorithms for time series data were developed only for single variate scenarios, while in practice there are often multiple sensor nodes in one application and the collected data is actually multivariate time series. In this paper, we propose to compress the time series data by the Lasso (least absolute shrinkage and selection operator) approximation. We show that, our approach can be naturally extended for compressing the multivariate time series data. Our extension is novel since it constructs an optimal projection of the original multivariates where the best energy efficiency can be realized. The two algorithms are named by ULasso (Univariate Lasso) and MLasso (Multivariate Lasso), for which we also provide practical guidance for parameter selection. Finally, empirically evaluation is implemented with several publicly available real-world data sets from different application domains. We quantify the algorithm performance by measuring the approximation error, compression ratio, and computation complexity. The results show that ULasso and MLasso are superior to or at least equivalent to compression performance of LTC and PLAMlis. Particularly, MLasso can significantly reduce the smooth multivariate time series data, without breaking the major trends and important changes of the sensor network system.

• 대한한의학회지
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• 제37권3호
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• pp.112-122
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• 2016

Objectives: This study aimed to assess the validity of 'Korean Diagnosis Related Groups-Korean Medicine (KDRG-KM)' which was developed by Health Insurance Review & Assessment Service (HIRA) in 2013 Methods: Among inpatient EDI claim data issued by hospitals and clinics in 2012, the data which included Korean medicine procedures were selected and analyzed. We selected control targets in the Korean medicine hospitals which had longer Episodes-Costliness index (ECI) and Lengthiness index (LI) than average of total Korean medicine hospitals, and compared the results of selection between the major diagnosis-based patient classification system and the KDRG-KM system. Finally, the explanation power (R2) and coefficient of variation (CV) of the KDRG-KM system using practice expenses were calculated. Results: The numbers of control target in Korean medicine hospitals changed from 36 to 32 when patient grouping adjustment method was changed from major diagnosis to KDRG-KM. For expenses of all outpatient claim data on Korean medicine, explanation power of KDRG-KM system was 66.48% after excluding outliers. CVs of expenses of patient groups in Korean medicine hospitals were gathered from under 70% to under 90%, and those in long-term care hospitals mostly belonged under 70%. Conclusions: The validity of KDRG-KM system was assured in terms of explanation power. By adapting KDRG-KM system, fairness of control targets selection for costliness management in Korean medicine hospitals can be enhanced.

• 한국물환경학회지
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• 제25권6호
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• pp.855-862
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• 2009

This paper pointed out major problems of land use regulation policy surrounding Paldang Lake as follows: (1) inefficient management system, (2) inconsistent administrative management, (3) illogical selection of regulated area, (4) contradictory present system, and (5) controversial discharge control. Several regulation laws for the land-use surrounding Paldang Lake caused confusion of application and inefficiency of management. Amendment of regulation laws made it possible that the regulated area was developed, which resulted in the deterioration of water quality. In addition, successive regulations without scientific implementation overexpanded regulated area and focus on the discharge concentration of contaminated sources stimulated development of small size sources. To overcome these problems, we suggested reestablishment of regulated area, differentiation of regulation amendments, and flexibility in the application of regulation. It is necessary to arrange regulated area based on the efficient land use management and scientific implementation and then to mitigate land use regulation under the sustainable development. For the flexible application of regulation, it is required to amend the rule in response to the change of environmental condition and development of environmental techniques.