• Science of Emotion and Sensibility
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• v.13 no.4
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• pp.777-788
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• 2010

Early diagnosis of autism and intervention of medical treatment are very significant to develop specific social communication skill for children with autistic spectrum disorders (ASDs). But they have difficulties in medical treatment because of lack of a public welfare institution and special medical system. In particular, few children can access such treatment and the existing single-therapist clinics are inefficient with regard to cost and time. Therefore, new methods should be studied for developing various products, services, and systems for autistic children. This study discusses the potential use of an interactive design as assistive technology for such children. We utilize the experience gained in the collaborative design of the interactive therapy system (ITS). The key methods include a collaborative design with rapid interactive prototyping, heuristic evaluation, user-centered process, VR technology, tangible interface, and scenario-based contents. We applied these methods to the ITS and proved the efficiency of interactive design as an assistive technology through clinical experimentation.

• Journal of Acupuncture Research
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• v.32 no.4
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• pp.167-175
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• 2015

Objectives : This study was performed to confirm the effectiveness of East-West collaborative hospital treatment on the prognosis of Bell's palsy. Methods : We screened patients who visited the Facial Palsy Center in Kyung Hee University Korean Medicine Hospital at Gangdong between June 2006 and June 2014 by inclusion/exclusion criteria. We reviewed the medical records of 270 patients, including demographics and results of electromyography. We tried to compare the recovery rate of Bell's palsy in the medical records with that of the previous study by calculating the odds ratio after 2, 3 and 6 months from the onset. Results : The odds ratio between our data and that from the previous study after 6 months from the onset was 4.899. Additionally, the odds ratios after 2 and 3 months from the onset were 1.471 and 2.054, respectively. All the odds ratios showed statistical significance. Conclusions : East-West collaborative hospital treatment showed significant effectiveness on the prognosis of Bell's palsy.

• Journal of Acupuncture Research
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• v.17 no.4
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• pp.180-187
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• 2000

By process of treatment for a case which diagnosed as glossopharyngeal neuralgia and admitted from the 4th, August, 2000 to the 1st, September, 2000, the results are as follows. Method & Resuits : This patient was diagnosed as Flaring up of Heart-fire(心火上炎), medicated Gamichengsimyeonja-eum(JiaWeiQingXinLianZi-Yin) and acupunture therapy was taken on proximal acupoints of right throat and parotid and distal acupoints inciuding Yuji(L10, 魚際), Taixi(K6,太谿), Zhaohai(K3, 照海), Hegu(LI4, 合谷) and Taichong(Liv3, 太衝). And negative therapy was taken on some pressure points of Jianzhongshu(SI15, 肩中兪) Jianjing(G21, 肩井) and Futu(LI18, 扶突). As a result, the patient's paroxysmal megalgia was improved. Conclusion : I consider that idiopathic pain diseases including glossopharyngeal neuralgia can improved by Oriental-Western collaborative medical treatment and continuous research must be accumulated subsequently.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.5
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• pp.2093-2098
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• 2015

In patients with multiple myeloma (MM), once-weekly intravenous injection or twice-weekly subcutaneous injection (SC) of bortezomib has been proven to offer non-inferior efficacy to standard twice-weekly intravenous administration, with an improved safety profile. However, whether once-weekly SC bortezomib can further reduce the incidence rate of peripheral neuropathy (PN) and not compromise the efficacy remains to be investigated. 25 patients of MM treated with once-weekly SC bortezomib were reviewed in this study. The median treatment cycles were 4 (range, 2-9 cycles). Complete response (CR) rate was 52%, ${\geq}$very good partial response (VGPR) rate was 72%, and ${\geq}$partial response (PR) rate was 84%. 1-year and 2-year PFS rate was 63.0% and 34.3%, respectively, and 2-year OS rate was 100%. Any grade of PN was reported in 9 patients (36.0%), with 7 patients (28.0%) had grade 1 PN, and 2 patients (8.0%) had grade 2 PN. No patients reported grade 3/4 PN in this cohort. In conclusion, once-weekly subcutaneous administration of bortezomib offers excellent efficacy with a further improved safety profile, especially with regard to PN. It needs to be validated in future prospective randomized trials.

• The Journal of Internal Korean Medicine
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• v.41 no.4
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• pp.658-667
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• 2020

Objectives: The purpose of this study was to analyze trends in Korean-Western Collaborative Medicine studies by disease group. Methods: Articles published until May 2020 were searched in domestic databases (NDSL, RISS, KISS, DBPIA, and KoreanTK) using the keywords '한양방', '양한방', '협진', '협의진료', '의한의', '의·한의', and '통합의학'. The articles were analyzed according to the publication year, journal type, research methodology, and disease group using the major and intermediate classifications of the Korean Standard Classification of Diseases (KCD-7). Results: In total, 112 articles were selected. The most frequent major disease groups were disease codes G, C (D), I, and M, in that order. The medium disease groups numbered 41 and most commonly involved collaborative studies on cerebrovascular diseases. Among the three top KCD-7 major group diseases, publications on Group C (D) were increasing significantly, publications on Group G were slightly increasing, but, publications on Group I decreased in the 2010s compared to the 2000s. Conclusions: In this study, we analyzed the frequent disease groups treated with domestic Korean-Western medicine in collaborative studies using the major and medium classifications of KCD-7. Well-designed clinical trials and economic evaluation research are needed, and this study can provide directions for future collaborative studies using Korean-Western medicine.

• Asian-Australasian Journal of Animal Sciences
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• v.30 no.2
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• pp.236-245
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• 2017

Objective: The study was to investigate the effects of alanyl-glutamine (Ala-Gln) and glutamine (Gln) supplementation on the intestinal mucosa barrier in piglets. Methods: A total of 180 barrows with initial weight $10.01{\pm}0.03kg$ were randomly allocated to three treatments, and each treatment consisted of three pens and twenty pigs per pen. The piglets of three groups were fed with control diet [0.62% alanine (Ala)], Ala-Gln diet (0.5% Ala-Gln), Gln diet (0.34% Gln and 0.21% Ala), respectively. Results: The results showed that in comparison with control diet, dietary Ala-Gln supplementation increased the height of villi in duodenum and jejunum (p<0.05), Gln supplementation increased the villi height of jejunum (p<0.05), Ala-Gln supplementation up-regulated the mRNA expressions of epidermal growth factor receptor and insulin-like growth factor 1 receptor in jejunal mucosa (p<0.05), raised the mRNA expressions of Claudin-1, Occludin, zonula occludens protein-1 (ZO-1) and the protein levels of Occludin, ZO-1 in jejunal mucosa (p<0.05), Ala-Gln supplementation enlarged the number of goblet cells in duodenal and ileal epithelium (p<0.05), Gln increased the number of goblet cells in duodenal epithelium (p<0.05) and Ala-Gln supplementation improved the concentrations of secretory immunoglobulin A and immunoglobulin G in the jejunal mucosa (p<0.05). Conclusion: These results demonstrated that dietary Ala-Gln supplementation could maintain the integrity of small intestine and promote the functions of intestinal mucosa barriers in piglets.

• Asian-Australasian Journal of Animal Sciences
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• v.28 no.12
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• pp.1784-1793
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• 2015

This study was carried out to investigate the effects of tributyrin (TB) on the growth performance, pro-inflammatory cytokines, intestinal morphology, energy status, disaccharidase activity, and antioxidative capacity of broilers challenged with lipopolysaccharide (LPS). A total of 160 one-day-old Cobb broilers were allocated to 1 of 4 treatments, with 4 replicated pens per treatment and 10 birds per pen. The experiment consisted of a $2{\times}2$ factorial arrangements of treatments with TB supplementation (0 or 500 mg/kg) and LPS challenge (0 or $500{\mu}g/kg$ body weight [BW]). On days 22, 24, and 26 of the trial, broilers received an intraperitoneal administration of $500{\mu}g/kg$ BW LPS or saline. Dietary TB showed no effect on growth performance. However, LPS challenge decreased the average daily gain of broilers from day 22 to day 26 of the trial. Dietary TB supplementation inhibited the increase of interleukin-$1{\beta}$ (in the jejunum and ileum), interleukin-6 (in the duodenum and jejunum), and prostaglandin $E_2$ (in the duodenum) of LPS-challenged broilers. Similar inhibitory effects of TB in the activities of total nitric oxide synthase (in the ileum) and inducible nitric oxide synthase (in the jejunum) were also observed in birds challenged with LPS. Additionally, TB supplementation mitigated the decrease of ileal adenosine triphosphate, adenosine diphosphate and total adenine nucleotide and the reduction of jejunal catalase activity induced by LPS. Taken together, these results suggest that the TB supplementation was able to reduce the release of pro-inflammatory cytokines and improve the energy status and anti-oxidative capacity in the small intestine of LPS-challenged broilers.

• Journal of Society of Preventive Korean Medicine
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• v.14 no.1
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• pp.25-35
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• 2010

Objectives : This study was aimed to investigate attitude of western medicine(WM), Korean medicine (KM), and nursing school students toward the east-west collaborative medical practices(EWCMP). Methods : The participants were 185 WM students, 123 KM students, and 230 nursing students belonging to two universities (P and D) in Busan metropolitan city, Korea. Data were collected with self-administered questionnaires and analyzed with descriptive statistics, $X^2$ test, t-test and ANOVA with SPSS win 14.0. Results : Of 538 participants, overall 87.1% has heard EWCMP. Preferred type of EWCMP was significantly different by participants' backgrounds. WM students preferred (western) medical treatment with minor supportive Korean medical care(85.5%). However, KM students emphasized EWCMP with the same weight in both medical and Korean medical treatment(59.0%), and nursing students were in between two schools. Intention to recommend EWCMP for the consumer was 67.4%, and also showed very different between WM students and others, 37.3% of WM students, 89.4% of KM students, and 83.9% of nursing students. WM students showed more negative opinion on the EWCMP than KM and nursing students, Conclusions : The attitude of WM, KM, and nursing school students toward EWCMP was very similar to that of WM doctors, KM doctors, and nurses, respectively. WM students showed big difference in the overall attitude toward EWCMP from that of KM and nursing students. It is recommended to introduce the joint curriculum or exchange programs between WM and KM schools.

• Journal of Korean Medicine Rehabilitation
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• v.29 no.1
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• pp.41-61
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• 2019

Objectives The purpose of this survey was to investigate the using experiences and attitudes of general public toward the East-West collaborative medical practices (EWCMP). Methods We selected objects in general public and structured questionnaires were administrated to both 295 offline participants and 795 online participants. The data was collected from 15 to 28 February 2016 and analyzed statistically by frequency, ${\chi}^2$ cross-over analysis with SPSS software. Results The total number of participants was 1,090 and 66.1% of them has heard but only 19.5% has ever used EWCMP. For participants who has used EWCMP, the decision to use it was made by themselves (53.2%), 44.0% of them was satisfied with EWCMP, 89.4% of them showed revisiting intention to EWCMP hospital, and 72.2% of them showed the intention to introduce EWCMP to others. And 52.3% of them were optimistic about the prospects of EWCMP, especially in the field of disease treatment (49.9%) and rehabilitation (20.6%). On the reasons for lack of development of EWCMP, 31.9% of them listed prejudices existing on both sides firstly (31.9%). Preferred type of EWCMP was to use both western and Korean medical treatment at the same weight (53.9%). To promote EWCMP, it is required to confirm the concept of collaborative medical practice to the medical professions and government authorities (29.5%). Conclusions Considering low proportion of utilization and positive attitude toward the EWCMP among general populations, it is need to introduce or advertise EWCMP to them.

• Journal of the Korea Convergence Society
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• v.10 no.9
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• pp.31-36
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• 2019

Music therapy, a field that convergence music and treatment, which play a fundamental role in personality formation, possesses diverse and complex treatment methods. Music therapists in charge of music therapy may experience the same phenomenon as countertransference in consultation with clients. In addition, experiencing psychological burnout, there are many difficulties in reaching the final goal of music therapy. In this paper, we provide a collaborative filtering-based music therapy consultation data recommendation model for smooth music therapy consultation with clients who visited for music therapy. The proposed model grasps the similarity between the conventional consultation data and the new consultant data through the euclidean distance algorithm. This is to recommend similar consultation materials. Since music therapists can provide optimal consultation materials for consultants who need music therapy, smooth consultation is expected.