• Journal of Distribution Science
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• v.16 no.2
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• pp.19-24
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• 2018

Purpose - Drone delivery is expected to revolutionize the supply chain industry. This paper aims to introduce a collaborative parcel delivery problem by truck and drone (hereinafter called "TDRP") and propose a novel heuristic method to solve the problem. Research design, data, and methodology - To show the effectiveness of collaborative delivery by truck and drone, we generate a toy problem composed of 9 customers and the speed of drone is assumed to be two times faster than truck. We compared the delivery completion times by 'truck only' case and 'truck and drone' case by solving the optimization problem respectively. Results - We provide literature reviews for truck and drone routing problem for collaborative delivery and propose a novel and original heuristic method to solve the problem with numerical example. By numerical example, collaborative delivery is expected to reduce delivery completion time by 12~33% than 'truck only' case. Conclusions - In this paper, we introduce the TDRP in order for collaborative delivery to be effective and propose a novel and original heuristic method to solve the problem. The results of research will be help to develop effective heuristic solution and optimize the parcel delivery by using drone.

• Journal of Ginseng Research
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• v.41 no.3
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• pp.373-378
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• 2017

Ocotillol-type saponins are one kind of tetracyclic triterpenoids, sharing a tetrahydrofuran ring. Natural ocotillol-type saponins have been discovered in Panax quinquefolius L., Panax japonicus, Hana mina, and Vietnamese ginseng. In recent years, the semisynthesis of 20(S/R)-ocotillol-type saponins has been reported. The biological activities of ocotillol-type saponins include neuroprotective effect, antimyocardial ischemia, antiinflammatory, antibacterial, and antitumor activities. Owing to their chemical structure, pharmacological actions, and the stereoselective activity on antimyocardial ischemia, ocotillol-type saponins are subjected to extensive consideration. In this review, we sum up the discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins.

• Journal of Ginseng Research
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• v.44 no.1
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• pp.14-23
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• 2020

Ginseng has been used as a popular herbal medicine in East Asia for at least two millennia. However, 20(R)-ginseng saponins, one class of important rare ginsenosides, are rare in natural products. 20(R)-ginseng saponins are generally prepared by chemical epimerization and microbial transformation from 20(S)-isomers. The C20 configuration of 20(R)-ginseng saponins are usually determined by ¹³C NMR and X-ray single-crystal diffraction. 20(R)-ginseng saponins have antitumor, antioxidative, antifatigue, neuroprotective, and osteoclastogenesis inhibitory effects, among others. Owing to the chemical structure and pharmacological and stereoselective properties, 20(R)-ginseng saponins have attracted a great deal of attention in recent years. In this study, the discovery, identification, chemical epimerization, microbial transformation, pharmacological activities, and metabolism of 20(R)-ginseng saponins are summarized.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.12 no.3
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• pp.1330-1347
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• 2018

Mobile Ad hoc Network (MANET) is a collection of nodes or communication devices that wish to communicate without any fixed infrastructure and predetermined organization of available links. The effort has been made by proposing a scheme to overcome the critical security issue in MANET. The insufficiency of security considerations in the design of Ad hoc On-Demand Distance Vector protocol makes it vulnerable to the threats of collaborative black hole attacks, where hacker nodes attack the data packets and drop them instead of forwarding. To secure mobile ad hoc networks from collaborative black hole attacks, we implement our scheme and considered sensor's energy as a key feature with a better packet delivery ratio, less delay time and high throughput. The proposed scheme has offered an improved solution to diminish collaborative black hole attacks with high performance and benchmark results as compared to the existing schemes EDRIAODV and DRIAODV respectively. This paper has shown that throughput and packet delivery ratio increase while the end to end delay decreases as compared to existing schemes. It also reduces the overall energy consumption and network traffic by maintaining accuracy and high detection rate which is more safe and reliable for future work.

• Journal of Construction Engineering and Project Management
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• v.9 no.4
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• pp.1-15
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• 2019

Since its adoption by the transportation sector in the early 1990s, partnering has been broadly used with the traditional delivery method by many agencies with significant reported benefits. During the same era, a number of transportation agencies (DOTs) started experimenting with a wide variety of alternative project delivery methods (APDMs) aimed at improving the delivery of highway construction projects. The effect of collaborative working strategies such as partnering, together with the APDMs have become somehow interrelated posing a potential challenge on how to effectively integrate partnering as a concept in the APDMs. The salient question has been if the collaborative nature of these APDMs has affected how partnering is being used by state DOTs. Through an extensive literature review, analysis of 32 CMGC RFPs/RFQs and review of three CMGC case studies, the study found that there is limited information in state DOT documents that show procedures on the usage of partnering with CMGC projects. Majority of DOTs are relying on the inherent nature of the CMGC contract to promote healthy collaborative practices and there is the need to consider partnering during preconstruction and construction separately to cater for any personnel change over. The study also revealed that partnering may become less important at the construction phase due to overlap between partnering and CMGC practices. In support of this finding, a CMGC partnering model was developed that can be adopted by DOTs. This paper contributes to both research and practice by expanding the existing knowledge on partnering on APDMs.

• Journal of Ginseng Research
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• v.44 no.2
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• pp.222-228
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• 2020

Background: 20(S)-ginsenoside-Rg3 (C₄₂H₇₂O₁₃), a natural triterpenoid saponin, is extracted from red ginseng. The increasing use of 20(S)-ginsenoside Rg3 has raised product safety concerns. Methods: In acute toxicity, 20(S)-ginsenoside Rg3 was singly and orally administrated to Kunming mice and Sprague-Dawley (SD) rats at the maximum doses of 1600 mg/kg and 800 mg/kg, respectively. In the 26-week toxicity study, we used repeated oral administration of 20(S)-ginsenoside Rg3 in SD rats over 26 weeks at doses of 0, 20, 60, or 180 mg/kg. Moreover, a 4-week recovery period was scheduled to observe the persistence, delayed occurrence, and reversibility of toxic effects. Results: The result of acute toxicity shows that oral administration of 20(S)-ginsenoside Rg3 to mice and rats did not induce mortality or toxicity up to 1600 and 800 mg/kg, respectively. During a 26-week administration period and a 4-week withdrawal period (recovery period), there were no significant differences in clinical signs, body weight, food consumption, urinalysis parameters, biochemical and hematological values, or histopathological findings. Conclusion: The mean oral lethal dose (LD₅₀) of 20(S)-ginsenoside Rg3, in acute toxicity, is above 1600 mg/kg and 800 mg/kg in mice and rats, respectively. In a repeated-dose 26-week oral toxicity study, the no-observed-adverse-effect level for female and male SD rats was 180 mg/kg.

• Journal of Families and Better Life
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• v.17 no.3
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• pp.217-228
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• 1999

The purpose of this study is to explore the model for the family welfare service delivery system in Korea. In order to provide more effective and efficient delivery system it is necessary to evaluate the existng family welfare delivery system. By the review of literature family welfare delivery system is fragmentary and inconsistent. Then the role of informal voluntary public and commercial sector in the delivery system is examined Lastly the models for family welfare service delivery system are proposed. Major suggestions are as follows: 1, It is necessary to reform the family welfare service delivery system for considering the integration of the family life. 2. Family welfare worker ought to coordinate the service to meet the complex needs of individuals and the family 3. The intersector collaborative model for family welfare service delivery system in proposed.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2003.06a
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• pp.877-880
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• 2003

In a competitive and globalized business environment, the need for the green products becomes stronger. To meet these trends, the environmental assessment besides delivery, cost and quality of products should be considered as an important factor in new product development phase. In this paper. a knowledge-based approximate life cycle assessment system (KALCAS) for the collaborative design environment is developed to assess the environmental impacts in context of product concept development. It aims at improving the environmental efficiency of the product using artificial neural networks consisting of high-level product attributes and LCA results. The overall framework of the collaborative environment including KALCAS is proposed. This architecture uses the CO environment to allow users on a wide variety of platforms to access the product data and other related information. It enables us to trade-off the evaluation results between the objectives of the product development including the approximate environmental assessment in the collaborative design environment.

• Journal of Aerospace System Engineering
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• v.14 no.6
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• pp.1-9
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• 2020

Global e-commerce and delivery companies are actively pursuing last-mile delivery service using drones, and various delivery schedule planning studies have been conducted. In this study, separate individual route networks were constructed to reflect drone route constraints such as prohibited airspace and truck route constraints such as rivers, which previous studies did not incorporate. The A* algorithm was used to calculate the shortest path distance matrix between the starting point and destinations. In addition, we proposed an optimal delivery schedule plan using genetic algorithms and applied it to compare the efficiency with that of vehicle-only delivery.

• Journal of Information Technology Services
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• v.10 no.3
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• pp.203-212
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• 2011

In the every day life of the people, the Internet is widely used. Currently over 1.9 billion people have one or more email addresses and over 600 million people use the Facebook. People are collaborating via the Internet more and more. When people are collaborating through the Internet, the differences of the message delivery delay are the biggest problem that disturbs the collaborative work over the network. To solve the differences of the message delivery delay, we introduce the delay-gap method. An experimental code have been implemented and the efficiency of the delay-gap is presented through the results from the experiment that have many participants.