• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.32 no.4
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• pp.29-40
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• 2019

Objectives : Hwanglyeonhaedok-tang(黃連解毒湯) is a representative herbal formula with "clear heat(淸熱)" effects. The aim of this study was to evaluate the effects of Hwanglyeonhaedok-tang-based intranasal herbal ointment Biyeom-go based on the cold and heat pattern identification questionnaire(CHPIQ). Methods : We performed a subgroup analysis of the previously published prospective observational study. A total of 58 patients with rhinitis were administered Biyeom-go for 4 weeks, and its effects on the Total Nasal Symptom Score(TNSS), Mini Rhinoconjunctivitis Quality of Life Questionnaire(Mini-RQLQ) score, and nasal endoscopy index score were analyzed based on CHPIQ. Results : Among the 58 patients, the heat and non-heat patterns were shown by 39 and 19 patients, respectively, while the cold and non-cold patterns were shown by 46 and 12 patients, respectively. The change in TNSS from baseline negatively correlated with the heat pattern score(p=0.011). Improvement in TNSS was greater in the heat pattern group than in the non-heat pattern group, with a borderline significant difference(p=0.07). Mini-RQLQ and nasal endoscopy index scores tended to be lower in the heat pattern group than in the non-heat pattern group, but without a statistically significant difference. Conclusion : The findings indicate that CHPIQ is a useful tool for the diagnostic and prognostic evaluation of patients with rhinitis. This study provides fundamental evidence of the close association between the cold-heat pattern in patients with rhinitis and the treatment effects of Biyeom-go.

• Journal of Physiology & Pathology in Korean Medicine
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• v.30 no.6
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• pp.466-473
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• 2016

This study intended to find out the most substantial items in cold and heat pattern identification(CHPI) questionnaire based on usual symptoms through CHPI diagnosis and evaluation by experts. 120 participants, faculties of OO university, filled out CHPI questionnaire based on usual symptoms by the way of self-reporting. Then 2 Korean Medicine doctors independently diagnosed them whether they belonged to cold pattern identification(PI) or heat PI, and scored the result of it. Pearson correlation of 2 experts was 0.649 in cold PI and 0.605 in heat PI. Agreement was 75.8%(Kappa value 0.516) in cold PI and 74.2%(Kappa value 0.465) in heat PI. Pearson correlation of 2 experts was 0.649 in cold PI and 0.605 in heat PI. Agreement between two experts was 75.8%(Kappa value 0.516) in cold PI and 74.2%(Kappa value 0.465) in heat PI. Items of high correlation with experts' evaluation followed next: "do not usually like the cold", "usually like the warm", "usually feel cold" in cold PI and "do not usually like the hot", "usually feel hot", "usually feel burning sensation in the body" in heat PI. We could infer from that facts that experts give weight on 'subjective feeling of cold or heat in participants body' and 'preference on sensation of cold and heat'. We also expect this study to be an epidemiological foundation to disclose correlation between usual CHPI and diseases.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.2
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• pp.482-487
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• 2006

The identification of the exterior-interior pattern and the cold-heat pattern is one of the most frequently used diagnostic methods in Oriental medicine. No systematic studies, however, have yet been conducted to determine the emotional and autonomic factors involved in the exterior-interior and cold-heat. In this study, the relationships between depression, anxiety, and the exterior-interior and cold-heat patterns in 100 healthy female volunteers with a mean age of 42.77 were also investigated. The autonomic nervous system's control of human temperature is a well known fact. Thus, this paper also aimed to investigate the correlationof the autonomic nervous system and patterns of the exterior-interior and cold-heat. The analysis of heart rate variability (HRV), which has become a popular non-invasive tool for assessing the activities of the autonomic nervous system, was conducted in this study. No relationship was found between the exterior-interior and cold-heat pattern scores and the degree-of-depression scores. But there was a significant difference between the exterior-interior and cold-heat pattern scores of the different anxiety types, and between those of the different anxiety levels. The depression and anxiety levels also had an effect on the HRV indices.

• Journal of Physiology & Pathology in Korean Medicine
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• v.32 no.5
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• pp.341-346
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• 2018

The aims of this study were to evaluate the reliability and validity of the cold and heat pattern identification questionnaire (CHPIQ). From July 2015 to December 2015, 120 participants, university faculties, filled out CHPIQ by the way of self-reporting. Then two Korean medical doctors independently diagnosed them whether they belonged to cold pattern (CP) or not, and heat pattern (HP) or not. We evaluated the internal consistency using Cronbach's alpha coefficient, and the validity using the sensitivity and specificity through receiver operating characteristic-curve. The internal consistency (Cronbach's alpha coefficient) showed 0.754 (CP) and 0.753 (HP). The area under the curve was recorded with 0.884 (CP) and 0.786 (HP). The agreements between CHPIQ and experts were 82.8% (CP) and 72.9% (HP). The sensitivities showed 0.707 (CP) and 0.719 (HP), and the specificities were 0.935 (CP) and 0.736 (HP). This study suggests that CHPIQ is a reliable and valid instrument for estimating cold-heat pattern identification.

• The Journal of Internal Korean Medicine
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• v.33 no.2
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• pp.209-221
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• 2012

Objectives : The aim of this study was to investigate the relationship between the autonomic nervous system and the cold-heat pattern in patients with chronic constipation. Methods : Subjects with chronic constipation (n=30) and without chronic constipation (n=20) were recruited, interviewed and measured for heart rate variability (HRV). Chronic constipation was defined as functional constipation and Irritable Bowel Syndrome (IBS) with constipation based on Rome III criteria. We surveyed patients' general characteristics, categorized by cold-heat pattern, and took measurement of HRV for 5 minutes. Analysis was conducted among these three indices. Results : Women accounted for most of the subjects with chronic constipation (96.7%). In groups with or without constipation, the number of cold patterns was more than of heat patterns. The mean heart rate of subjects without chronic constipation was significantly higher than that of subjects with chronic constipation. No other statistical significance was noted among indices of HRV and cold-heat pattern. Conclusions : Through this study, there were few relationships between autonomic nervous system measured by HRV and cold-heat pattern in chronic constipation.

• Journal of Acupuncture Research
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• v.32 no.2
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• pp.147-167
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• 2015

Objectives : The aim of this study is to summarise pattern-identification of shoulder pain based on the classics of oriental medicine, current literature and domestic papers. Methods : The materials selected were sourced from the classics of oriental medicine, current literature and domestic papers which contained data related to pattern-identification of shoulder pain. The pattern-identifications were compared to determine the similarities, and these were classified. Results : Thirty-five studies were reviewed, and thirty-seven pattern-identifications were collated. These were classified into the following groups: wind-cold-dampness group(n = 8), blood stasis group(n = 3), phlegm group(n = 7), dual deficiency of Qi and blood group(n = 4), deficiency cold group(n = 2), liver-kidney deficiency group(n = 1) and meridian-collateral group(n = 12). Conclusions : On the basis of the classification of pattern-identifications, two groups of pattern-identifications for shoulder pain were suggested. The first group included the pattern-identification associated with a disease-cause, which included the wind-cold-dampness pattern(風寒濕型), blood stasis pattern(瘀血型), phlegm pattern(痰飮型), Qi-blood deficiency pattern(氣血兩虛型), deficiency cold pattern(虛寒型), and liver-kidney deficiency pattern(肝腎虧損型). The second included the pattern-identification associated with the meridian-collateral, which included the hand greater Yin meridian pattern(手太陰經型), hand Yang brightness meridian pattern(手陽明經型), hand lesser Yin meridian pattern(手少陰經型), hand greater Yang meridian pattern(手太陽經型), hand reverting Yin meridian pattern(手厥陰經型), hand lesser Yang meridian pattern(手少陽經型), and foot greater Yang meridian pattern(足太陽經型).

• Journal of Sasang Constitutional Medicine
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• v.23 no.1
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• pp.33-43
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• 2011

1. Objectives: This study is aimed to develop the algorithm, which can help clinicians diagnose Soeumin's symptomology, based on the indexes such as dry mouth, water drinking, sweat, urine, appetite, digestion, and stool, etc. 2. Methods: This research analyzes the items of "Donguisusebowon(東醫壽世保元)" to reveal the inevitable and sequential indexes of Soeumin's symptomology diagnosis, in order of exterior-interior pattern differentiation, favorable-unfavorable pattern differentiation, and mild-severe-dangerous-urgent pattern differentiation. 3. Results and Conclusions: 1) 1st step: Soeumin's exterior pattern and interior pattern are differentiated in terms of heat and cold, respectively. Stool and digestion are used to confirm the difference. 2) 2nd step: The existence of sweat is used to find out that an exterior pattern is with or without favor, while the indexes of stool, dry mouth, and generalized pain are used to identify an interior pattern with or without favor. 3) 3rd step: The favorably exterior-heat pattern can be either mild or severe by the indexes of cold-heat, stool, tidal fever, and manic raving, panting and straight looking, while the unfavorably exterior-heat pattern can be either dangerous or urgent by the ones of cold-heat, stool, and urine. And, the favorably interior-cold pattern can be either mild or severe by the indexes of stuffiness and fullness, jaundice, and edema, while the unfavorably interior-cold pattern can be either mild or severe by the ones of vexation level.

• Journal of Physiology & Pathology in Korean Medicine
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• v.24 no.1
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• pp.15-21
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• 2010

Previously standardization study for identifying 5 types of pattern identification of stroke patients has been performed and the Korean standard of pattern identification (II) was developed. In the present study we investigated the interactions between total indices designated by the Korean standard of pattern identification(KSPI II) and indices for PI of Cold-Heat and Deficiency-Excess. Indicators for Cold-Heat and Deficiency-Excess are isolated from 58 indices through the survey of oriental medicine doctors and their relationship with KSPI-II indices was analyzed by corresponding analysis method using data of 1581 stroke patients. Means and standard deviations indicated that 2 Cold indices, 14 Heat indices, 12 Deficiency indices, and 5 Excess indices were included for Cold-Heat and Deficiency-Excess pattern identification. The results of corresponding analysis shows the relationship of 57 indices and 4 types of pattern identification (excluding 1 index and 1 pattern among 58 indices and 5 patterns) using the cross-tabulation which was obtained from the clinical data. Most of Cold and Heat index were divided to dimension 1(inertia 51.9%) obtained from the result of corresponding analysis. Deficiency and Excess index were partially associated with dimension 2(inertia 31.7%). These data suggest that pattern identification of Cold-Heat plays an role in the standardization of pattern identification in stroke, although further studies are required by various trials such as analysis of surveys and clinical data.

• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.1
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• pp.224-228
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• 2006

The pattern identification of exterior-interior syndrome and cold-heat syndrome is one of the diagnostic methods using most frequently in Oriental medicine. There was no systematic studies analyzing the characteristics of the 'exterior-interior and cold-heat' between healthy and disease group. In this study, cold-heat pattern, blood pressure, pulse rate, height and weight are recorded from 100 healthy subjects and 196 disease subjects with age ranging from 30 to 59 years. To analyze the differences between healthy and disease group, we used the descriptive statistics. And linear regression function, linear support vector machine and bayesian classifier were used for distinguishing healthy group from disease group. The score of both exterior-heat and interior-cold in healthy group is higher than the score in disease group. This means that if one belongs to the disease group, his(or her) exterior gets cold and his interior gets hot. And also, these result have no relevance to age. But, the attempt to classify healthy group from disease group with a exterior-interior and cold-heat and other vital signs did not have good performance. It mean that even though they have a different trend each other, only these kinds of information couldn't classify healthy group and disease group.

• The Journal of Internal Korean Medicine
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• v.43 no.6
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• pp.1063-1074
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• 2022

Objectives: The aim of this study was to investigate the differences in the prevalence of metabolic syndrome (MetS) according to the Sasang constitution (SC) and cold and heat pattern identification (CHPI). Methods: SC, CHPI, MetS, and component data were obtained from 2,561 participants in 26 Korean medical clinics from 2007 to 2013. SC, diagnosed by Korean medicine doctors, was confirmed by positive responses to herbal medicines administered according to that constitution. The CHPI was verified by a questionnaire about thermal sensitivity and drinking habits. The diagnosis criteria for MetS were: 1) waist circumference (WC) ≥90 cm (male) and ≥80 cm (female); 2) triglycerides ≥150 mg/dL; 3) high density lipoprotein cholesterol (HDL) <40 mg/dL (male) and <50 mg/dL (female); 4) blood pressure ≧130/85 mmHg; and 5) fasting blood glucose ≥100 mg/dL. Odds ratios (ORs) and differences in MetS and its components were compared using logistic regression and ANCOVA. Results: The MetS prevalence rates were 54.1%, 22.0%, and 33.3% for Taeeumin (TE), Soeumin (SE), and Soyangin (SY), respectively, and 30.5% and 44.5% for the cold and heat patterns, respectively. ANCOVA for MetS components showed significantly higher WC in TE than in SE or SY, and all components except HDL were higher in the heat pattern group than in the cold pattern group. Logistic regression for MetS prevalence showed a significant association between TE and the heat pattern group (OR=1.653) but not for non-TE and the cold pattern group. Conclusions: Considering SC and CHPI together may be more effective in managing MetS than considering SC alone.