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http://dx.doi.org/10.6114/jkood.2019.32.4.029

Effectiveness of herbal ointment Biyeom-go according to cold-heat pattern identification: a subgroup analysis on patients with rhinitis  

Son, Mi-Ju (Clinical Medicine Division, Korea Institute of Oriental Medicine)
Lee, Dong-Hyo (Dept. of Ophthalmology & Otolaryngology & Dermatology, College of Korean Medicine, Woo-Suk University)
Publication Information
The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology / v.32, no.4, 2019 , pp. 29-40 More about this Journal
Abstract
Objectives : Hwanglyeonhaedok-tang(黃連解毒湯) is a representative herbal formula with "clear heat(淸熱)" effects. The aim of this study was to evaluate the effects of Hwanglyeonhaedok-tang-based intranasal herbal ointment Biyeom-go based on the cold and heat pattern identification questionnaire(CHPIQ). Methods : We performed a subgroup analysis of the previously published prospective observational study. A total of 58 patients with rhinitis were administered Biyeom-go for 4 weeks, and its effects on the Total Nasal Symptom Score(TNSS), Mini Rhinoconjunctivitis Quality of Life Questionnaire(Mini-RQLQ) score, and nasal endoscopy index score were analyzed based on CHPIQ. Results : Among the 58 patients, the heat and non-heat patterns were shown by 39 and 19 patients, respectively, while the cold and non-cold patterns were shown by 46 and 12 patients, respectively. The change in TNSS from baseline negatively correlated with the heat pattern score(p=0.011). Improvement in TNSS was greater in the heat pattern group than in the non-heat pattern group, with a borderline significant difference(p=0.07). Mini-RQLQ and nasal endoscopy index scores tended to be lower in the heat pattern group than in the non-heat pattern group, but without a statistically significant difference. Conclusion : The findings indicate that CHPIQ is a useful tool for the diagnostic and prognostic evaluation of patients with rhinitis. This study provides fundamental evidence of the close association between the cold-heat pattern in patients with rhinitis and the treatment effects of Biyeom-go.
Keywords
Biyeom-go; cold-heat pattern identification; intranasal herbal ointment; rhinitis; subgroup analysis;
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Times Cited By KSCI : 8  (Citation Analysis)
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