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The Effects of Automatically Controlled Rotating Acupuncture on Thermal Allodynia in a Rat Model of Neuropathic Pain: Mediation by Endogenous Opioid System (신경병증성 통증에 대한 자동염전침의 진통효과 및 opioid 기전)

  • Park, Jung-Hyuk;Kim, Sun-Kwang;Na, Hyo-Suk;Moon, Hak-Jin;Min, Byung-Il;Kim, Ki-Hong;Rhim, Sung-Soo;Lee, Soon-Geul;Lee, Sang-Hoon
    • Journal of Acupuncture Research
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    • v.23 no.5
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    • pp.23-29
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    • 2006
  • Objectives : The present study was conducted to evaluate the effects of automatically controlled rotating acupuncture (ACRA) on thermal allodynia in neuropathic pain rats, and to examine whether the endogenous opioid system mediates the effects of ACRA. Methods : For the neuropathic surgery, the right superior caudal trunk was resected at the level between S1 and S2 spinal nerves innervating the tail. Two weeks after the nerve injury, ACRA stimulation with 4 different stimulation conditions (i.e., angle and frequency of rotation: 90o+1Hz, 90o+1/4Hz, 360o+/1Hz, and 360o+1/4Hz) was delivered to the Zusanli (ST36) acupoint for 15 min. The behavioral signs of thermal allodynia were evaluated by the tail immersion test (i.e., immersing the tail in cold $(4^{\circ}C)$ or warm $(4^{\circ}C)$ water and measuring the latency to an abrupt tail movement) before and after the stimulation. In an additional set of experiments, we examined the effects of naloxone (opioid Results : ACRA stimulations under all of the conditions above significantly relieved thermal antagonist, 2mg/kg, i.p.) on the action of ACRA stimulation. allodynia. There is no difference in the anti-allodynic effects among the 4 stimulation conditions. In addition, the effect of ACRA on thermal allodynia was reversed by naloxone pretreatment. Conclusion : These results indicate that ACRA stimulations have relieving effects on thermal allodynia in neuropathic pain rats, irrespective of stimulation parameters, and that this is mediated by the endogenous opioid system.

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Quality Characteristics of Wheat Flours from New Released Iksan370 with Long Spike and Domestic Wheat Cultivars (신육성 다수확 밀 익산370호의 원맥과 밀가루의 품질 특성)

  • Choi, Yong-Seok;Lee, Jae-Kang;Choi, Yong-Hyun;Kim, Young-Hwan;Kang, Chon-Sik;Shin, Malsik
    • Korean journal of food and cookery science
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    • v.31 no.5
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    • pp.551-556
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    • 2015
  • Iksan370 is a long-spike wheat developed by the Rural Development Administration yielding excellent features components such as cold resistance, disease resistance, and viviparous germination. The physicochemical and material properties of the raw wheat and milled flour of Iksan370 were analyzed to derive its appropriate uses. The raw wheat of Iksan370 showed high contents of ash and proteins at 1.71% and 13.7%, respectively. Its test weight of 763.0 g/L was similar to those of other varieties and its 1,000 kernel weight was high at 45.38 g. The milled flour of Iksan370 had an ash content of 0.45%, which corresponds with a class 1 flour, and its protein content is 12.18%, corresponding with strong flour. The damaged starch was 5.41%, which was lower than that of other varieties. The average grain size was $70.67{\mu}m$ and the grain distribution was at the level of a typical hard wheat. In the farinogram, the water absorption was 58.63%, which corresponded to the level of medium flour. The development time was 7.00 minutes, which was significantly lower than those of Jokyung and Keumkang. The degree of softening was 67.00 BU, similar to those of Yunbaek and Baekjoong. Among the physico-chemical characteristics, the high protein content and typical hard wheat grain distribution of Iksan370 were similar to those of strong wheat, usually used for bread making. However, in the farinogram, the dough development time was short and the degree of softening was high. As a result, Iksan370 was expected to have poor breadmaking properties and a small volume of the final bread product due to insufficient dough durability. On the other hand, Iksan370 showed the highest maximum gelatinization viscosity at 864.00 BU. Therefore, Iksan370 is expected to show glutinous texture when used for noodles and its flour appears to be appropriate for frying powders as well.

Comparative Studies of Thermal Insulation Performance of Life Vests by Numerical Analysis and Experiment (보온 재료에 따른 구명 조끼 별 단열성능의 비교 실험 및 해석)

  • Kim, Sung-Chan;Lee, Kyung-Hoon;Hwang, Se-Yun;Jang, Ho-Sang;Lee, Jang-Hyun
    • Journal of Navigation and Port Research
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    • v.40 no.1
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    • pp.7-14
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    • 2016
  • Although the life jacket can provide the buoyance with the drowner, heat loss can make the drowned individual be subject to the hypothermia. In this study, The thermal insulation of two types life jacket including inflatable and foam type were evaluate by both experiments and numerical analysis. To estimate the thermal resistance of the jackets, experiments on the heat flux were conducted by the thermal manikin exposed to cold water. Heat flux loss on the surface of thermal manikin were measured for both foam and inflatable type life jacket. Also, finite element method is applied to a body section in order to understand the level of hypothermia of each life jacket. The segmental of human thigh is represented by a multi-layered section which considers the heat conduction within tissue, bone and fat. As a result, the thermal resistance and hypothermia time of each jackets have been compared based on the finite element analysis. It was found that the insulation ability of suggested life jackets is better than that of conventional type.

Literature Review on Spirit and Qi Regimen (정.기(精.氣) 양생법(養生法)에 관한 문헌연구)

  • Baek, Suk-Hee;Sok, So-Hyun;Oh, Hae-Kyung;Moon, Hee-Ja
    • Journal of East-West Nursing Research
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    • v.2 no.1
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    • pp.96-106
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    • 1997
  • In Chinese medicine, the activities of removing and solving the inner cause are called the regimen in preventing the disease and the good condition of mind emphasizes us to practice ourselves the doctrine of regimen of the mind to promote the health and long life of the living body, in other words, it means we should have clean mind, less desire, less thought, less agony and widely open our emotion and will, and it also means the raising of good nature, the moral cultivation, and we can be healthy when we live by good virtus as the root of regiem. The meaning of the Qi has been expanded more and more since its origination throught the process of practice and perception of man. 1) Matter is changed to the smoke when burned, the energy of water becomes the rain in the sky and the rain raises all living creatures by making them wet. Throught these changes of circulation, men could realize the energy to be the common and original matter of forming all the creatures. 2) The direction of showing the breathing of men in and out has been expended. 3) It was widely understood as the meaning of showing vitality of men, and it was the original root of chinese medicine. 4) It was expended to be showing spirit of nature such as the sun, moon, star, sky, land, mountain and the moral spirit of men as peacefullness. By the original meaning of the word of energy expanded to the wider side of sky, land, men and things, nature, society, man and the moral spirit could get the unified basis of the matter. As the above, the word of Qi has been used in wider meaning at this time from the past. In other words, all things in the universe come into being and extinct by the chang of motion of the Qi and it is recognized to be the living activity in human body. The Qi-kong based on this energy and the motion applied to our daily life are very extensive (Lee, Hye - lung, 1997). Here are the summaries of the effect of the Qi-kong ; 1) The physical constitution is strenthened, physiological function is prosperous and we are free from various geriatric disease and psychosomatic disease not to mention the cold and indigestion. 2) It maintains the clear spirit, elevates intelligence, strengthens the spiritual power and demonstrates the potentiality at the amximum. 3) It maintain beautiful figure and clean skin never losing the charm but full of energy and vitality. 4) It keeps the balanced body never suffering from the unbalance of the bones, various and neuralgia. 5) It maintain the spiritual comfort, the natural posture in everything and real happiness (Lee, Hye-Jung, 1997 : Suh, Yong Kyu, 1989). Chinese medicine mentions the motion by Qi with Qi - kong. But the motion does not require special method in Western medicine. I t is the only way of living of our ancestor indaily life. It is maintaining the healthy lifr by training the Qi, and it is the motion of being with the nature with the open mind in breathing rather than artificially restricting our daily life, it is the motion of the body.

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Basic performance analysis of ocean thermal energy conversion using the refrigerant mixture R32/R152a (R32/R152a 혼합냉매를 적용한 해양온도차발전의 기초성능해석)

  • Cha, Sang Won;Lee, Ho Saeng;Moon, Deok Soo;Kim, Hyeon Ju
    • Journal of Advanced Marine Engineering and Technology
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    • v.38 no.4
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    • pp.502-507
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    • 2014
  • In this paper, performance characteristics of cycles were studied when mixed working fluid was used for ocean thermal energy conversion (OTEC). Among the various mixed refrigerants for industrial heat-pump, R32/R152a used in ocean thermal energy conversion system. For simulations, R32/R152a were used in existing closed cycle and Kalina cycle which is used only ammonia and water as mixed refrigerant. Temperature of the warm heat source was 26 and 29 celsius degree, temperature of the cold heat source was 5 celsius degree. In results of simulation, Gross power of the closed cycle on R32 was 22kW, and efficiency of the cycle was 2.02%. When the mixed refrigerant of R32/R152a, in the ratio of 90 to 10, gross power of the closed cycle was 29.93kW, and efficiency of the cycle was 2.78%. Gross power and cycle efficiency of R32/R152a increased by 36% and 37% than those of existing single refrigerant. Additionally, the same simulations were conducted in Kalina cycle with the same various composition ratio of mixed refrigerant.

Change in quality characteristics of yellow paprika according to drying methods (건조방법을 달리한 노란 파프리카의 품질특성 변화)

  • jung, Hyeon-A;Hong, Ju-Yeon
    • Food Science and Preservation
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    • v.24 no.8
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    • pp.1079-1087
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    • 2017
  • The study attempted to investigate the variation in the quality of the yellow paprika according to the duration of the yellow paprika and to use the basic materials for the development of various processed foods. The moisture content of dried paprika was 11.19% on the freeze-drying paprika (FD), and the amount of water was increased by 18.19% on the 15th day of the storage cycle. The pH has been significantly changed depending on the length of the storage period, and the sugar content in FD. The acidity contents was increased during storage in all dried paprikas showed the highest acidity, but hot air-drying paprika(HAD) was lowest in the acidity. The L value was decreased during storage period from the paprika outside and inside. The a value was not significantly dependent on the length of storage period from paprika outside and inside, and the b value increased the during storage period from paprika outside and inside. The texture of strongness, hardness, chewiness, and brittleness were decreased during storage period from all drying paprika except for FD, showing the increasing trend in cohesiveness, springiness, chewiness, and brittleness. The total aerobes changes was the lowest in HAD.

A Study on the Hardware Cost Estimation Equation of Professional Service Robot (전문서비스 로봇 하드웨어 비용추정 관계식 개발에 관한 연구)

  • Lee, Jungsoo;Min, Jeongtack;Choi, Yeon-Seo;Park, Myeongjun;Sohn, Dongseop
    • Journal of Digital Convergence
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    • v.16 no.7
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    • pp.89-96
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    • 2018
  • In this paper, we proposed a parametric estimation method for estimating H/W cost by using the development data of professional service robot in Korea. In addition, we derived the factors and weights that we can estimate the costs depending on the application environmental conditions of the robot. For the analysis, we developed the equation of professional service robot cost estimation using parametric method. We also derived the adjustment factors and following weights through FGI and Delphi for environmental conditions. We have developed a cost estimation equation that reflects the weight, volume, and manufacturing difficulty, and can derive a relational equation that reflects the environmental factors(dust/water, heat/cold, safety, test, technology innovation). This provides an objective basis for estimating the cost of professional service robots and will lead to ongoing research for estimating the H/W development cost of professional service robots. In the future, we will increase reliability by collecting abundant data, and will strengthen models through finding functional factors.

Extraction Conditions and Green Index of Green Pigments from Discolored Garlic (녹변된 마늘의 색소 추출 조건과 Green Index)

  • Hwang, Jin-Bong;Ha, Jae-Ho;Shin, Dong-Bin;Park, Wan-Soo;Nahmgung, Bae;Lee, Young-Chun
    • Korean Journal of Food Science and Technology
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    • v.37 no.4
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    • pp.678-684
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    • 2005
  • Extraction conditions, spectrometric, and sensory properties of pigment extracts from green discolored garlic (GDG) were studied for development of green index to evaluate degree of green discoloration of garlic. GDG pigments were extracted using polar solvents, such as methanol, ethanol, and water. Methanol with 1% HCl resulted in highest extraction of green pigments. Extraction of pigments was affected by temperature, and extracted pigments were partially destroyed at high temperatures. Optimum conditions for extraction of green pigments were $20^{\circ}C$ for 30 min. Because green pigments are unstable at room temperature, and no method has been reported to evaluate degree of green discoloration of garlic, color chart was designed by mixing varying amounts of control and GDG. High correlation was observed between sensory scores and "a" value of color chart samples (y=-3.465x - 11.676) with $R^2$ of 0.993. Green index (GI) was developed based on linear regression equation between sensory scores and "a" values. Sensory panel recognized green discoloration of garlic at $GI{\geq}3.0$. GI developed in this study could be utilized to evaluate degree of green discoloration of garlic during cold storage and distribution of garlic.

Study on Correlation between Dynamic Cone Resistance and Shear Strength for Frozen Sand-Silt Mixtures under Low Confining Stress (낮은 구속응력에서 모래-실트 혼합토의 동결강도 평가를 위한 동적 콘 저항력 및 전단강도 상관성 연구)

  • Kim, Sangyeob;Lee, Jong-Sub;Hong, Seungseo;Byun, Yong-Hoon
    • Journal of the Korean GEO-environmental Society
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    • v.17 no.1
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    • pp.5-12
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    • 2016
  • Investigation of in-situ ground in cold region is difficult due to low accessibility and environmental factors. In this study, correlation between dynamic cone resistance and shear strength is suggested to estimate the strength of frozen soils by using instrumented dynamic cone penetrometer. Tests were conducted in freezing chamber after preparing sand-silt mixture with 2.3% water content. Vertical stresses of 5 kPa and 10 kPa were applied during freezing, shearing, and penetration phase to compare the dynamic cone resistance and shear strength. The dynamic cone resistance, additionally, is calculated to minimize the effect of energy loss during hammer impact. Experimental results show that as the shear strength increases, the dynamic cone penetration index (DCPI) decreases nonlinearly, while the dynamic cone resistance increases linearly. This study provides the useful correlation to evaluate strength properties of the frozen soils from the dynamic cone penetration and direct shear tests.

Study of Macrophage Stimulating Activity of the Polysaccharide Isolated from Leaves of Carthamus tinctorius L. (홍화(Carthamus tinctorius L.)잎으로부터 분리한 다당류의 Macrophage 활성화에 대한 연구)

  • Kwak, Ji-Eun;Kim, Kyung-Im;Jeon, Hyuck;Hong, Bum-Shick;Cho, Hong-Yon;Yang, Han-Chul
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.31 no.3
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    • pp.527-533
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    • 2002
  • In the screening of Korean traditional tea sources for the cellular lysosomal enzyme activity of peritoneal macrophage from mice, CT-0, a cold-water extract from Carthamus tinctorius L., showed the highest macro-phage-stimulating activity. CT-1-IIa-2-1, a purified macrophage-stimulation polysaccharide was obtained by a series of purification steps such as anion exchage chromatography with DEAE-Toyopearl 650M, gel permeation chromatography with Sepharose CL-6B, Sephacryl S-200, and HPLC with Superdex G-75. The molecular weight of homogeneous purified polysaccharide was estimated about 68 kDa. CT-1-IIa-2-1 consisted of xylose 27.44%, arabinose 16.14%, mannose 15.92% and glucose 14.47%. To measure acute toxicity, dose of 50, 100, 500, and 1000 mg/kg were intraperitoneally injected to ICR mice. The LD$\_$50/ was about 397 mg/kg.