• Asian Pacific Journal of Cancer Prevention
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• 제15권2호
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• pp.775-780
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• 2014

Objectives: TCR-gamma-delta+T cells (${\gamma}{\delta}$ T cells) are non-conventional T lymphocytes that can recognize and eradicate tumor cells. Our previous studies showed that infiltration and function of ${\gamma}{\delta}$ T cells were substantially attenuated in hepatocellular carcinoma (HCC). However, their prognostic value was not clarified. Methods: The association between ${\gamma}{\delta}$ T cells and the clinical outcomes was determined by immunohistochemistry (IHC) in a HCC patient cohort (n = 342). Results:Immunohistochemistry showed decreased infiltration of ${\gamma}{\delta}$ T cells in tumoral tissues compared with paired peritumoral tissues. The counts of ${\gamma}{\delta}$ T cells in peritumoral tissues were negatively correlated with tumor size (P = 0.005). Survival analysis showed that the levels of peritumoral ${\gamma}{\delta}$T cells were related to both time to recurrence (TTR) and overall survival (OS) (P = 0.010 and P = 0.036, respectively) in univariate analysis, and related to TTR in multivariate analysis (P = 0.014, H.R. [95% CI] = 0.682 [0.502-0.927]). Furthermore, the level of peritumoral ${\gamma}{\delta}$ T cells showed independent prognostic value for TTR in Barcelona Clinic Liver Cancer (BCLC) stage A patients (P = 0.038, H.R. [95% CI] = 0.727 [0.537-0.984]). However, tumoral ${\gamma}{\delta}$ T cells did not show independent prognostic value for either TTR or OS in HCC patients. Conclusions: Low counts of ${\gamma}{\delta}$ T cells in peritumoral liver tissue are related to a higher incidence of recurrence in HCC and can predict postoperative recurrence, especially in those with early-stage HCC.

• 한국대기환경학회지
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• 제23권5호
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• pp.563-574
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• 2007

There seems to be a consensus among most people that visibility impairment is the most obvious indicator of air pollution. While considerable evidence on the association between air pollution and health outcomes including death and disease have been established, based on industrial complex areas or huge urban cities, time-series, case-crossover and cohort studies, scarce literature exists on the direct evidence for the association between visibility and adverse health outcomes. Our study is assessed the effect of air pollution measured by visibility impairment on respiratory mortality over a period of six years. Relative risks in respiratory deaths were estimated by a Poisson regression model of daily deaths between $1999{\sim}2004$. Daily counts of respiratory deaths as dependent variable was modelled with daily 24-hr mean visibility measurements (kilometers) as independent variable by means of Poisson regression. This model is controlled for confounding factors such as day of weeks, weather variables, seasonal variables and $PM_{10}$. The results in this study is observed the statistically significant association between an inverse health effect and visibility during the study period for respiratory mortality (percentage change in the relative risk for all aged -0.57%, 95% Cl, $-1.01%{\sim}-0.12%$; for $0{\sim}15$ aged -7.12%, 95% Cl, $-13.29%{\sim}-0.51%$; for 65+ aged -0.43%, 95% Cl, $-0.93%{\sim}-0.06%$ per 1 km increased in visibility). The effect size was much reduced during warm season. Visibility impairment resulting from air pollution is strongly associated with respiratory mortality, especially for children may be spent at outdoor. Our result provides a quick and useful indicator for eliciting the contribution of air pollution to the excess risk of respiratory mortality in Seoul, Korea.

• Nutrition Research and Practice
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• 제8권4호
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• pp.453-462
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• 2014

BACKGROUND/OBJECTIVES: The inverse relationships of combined fruits and vegetables intake with blood pressure have been reported. However, whether there are such relationships with salty vegetables has rarely been investigated in epidemiologic studies. We evaluated the relation of combined and separate intake of fruits, vegetable intakes, and salty vegetables, as well as sodium and potassium, with blood pressure among the middle-aged and elderly populations. SUBJECTS/METHODS: The present cross-sectional analysis of a prospective cohort baseline survey was performed with 6,283 subjects (2,443 men and 3,840 women) and free of hypertension, diabetes, cardiovascular diseases, and cancer. Dietary data were collected by trained interviewers using food frequency questionnaire. RESULTS: The significantly inverse linear trend of diastolic blood pressure (DBP) was found in fruits and non-pickled vegetables (81.2 mmHg in the lowest quintile vs 79.0 mmHg in the highest quintile, P for trend = 0.0040) and fruits only (80.9 mmHg in the lowest quintile vs 79.4 mmHg in the highest quintile, P for trend = 0.0430) among men. In contrast, sodium and sodium to potassium ratio were positively related with blood pressure among men (DBP, 78.8 mmHg in the lowest quintile vs 80.6 mmHg in the highest quintile, P for trend = 0.0079 for sodium; DBP, 79.0 mmHg in the lowest quintile vs 80.7 mmHg in the highest quintile, P for trend = 0.0199 and SBP, 123.8 mmHg in the lowest quintile vs 125.9 mmHg in the highest quintile for sodium/potassium). Kimchies consumption was positively related to DBP for men (78.2 mmHg in the lowest quintile vs 80.9 mmHg in the highest quintile for DBP, P for trend = 0.0003). Among women, these relations were not found. CONCLUSION: Fruits and/or non-pickled vegetables may be inversely, but sodium, sodium to potassium, and Kimchies may be positively related to blood pressure among men.

• BMB Reports
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• 제37권6호
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• pp.691-699
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• 2004

Osteoporosis is a disease characterized by exaggerated loss of bone mass, with as much as 50 to 85% of the variation in bone mineral density (BMD) commonly accepted as being genetically determined. Although intensive studies have attempted to elucidate the genetic effects of polymorphisms on BMD and/or osteoporosis in several genes, the genes involved are still largely unknown. The possible associations of genetic variants in five-candidate genes (IL10, CCR3, MCP1, MCP2 and GC) with spinal BMD were investigated in Korean postmenopausal women (n = 370). Fourteen SNPs in five candidate genes were genotyped, and the haplotypes of each gene constructed. The associations of adjusted spinal BMD by age, year since menopause (YSM) and body mass index (BMI), with genetic polymorphisms, were analyzed using multiple regression models. Genetic association analysis of Korean postmenopausal women revealed that IL10 -592A > C and/or IL10 ht2 were associated with decreased bone mass, whereas no significant associations were observed with all polymorphisms in other genes. The levels of spinal BMD in individuals bearing the IL10 -592CC genotype were lower ($0.78{\pm}0.16$) than those in others ($0.85{\pm}0.17$) (P = 0.02), and the BMD of IL10 ht2 bearing individuals were also lower ($0.82{\pm}0.15$) than those in others ($0.85{\pm}0.17$) (P = 0.04). Our results suggest that variants of IL10 might play a role in the decreased BMD, although additional study might need to be followed-up in a more powerful cohort.

• 동의생리병리학회지
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• 제24권3호
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• pp.504-511
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• 2010

Diabetes is a disease that contains a high concentration of glucose in blood and due to defects in either insulin secretion or insulin action. Although the distinctive causes and factors of diabetes have not been clarified, the genetic factors are suggested as a main susceptibility until now. SNP (Single Nucleotide Polymorphism), as the most common genetic variation, has an influence on personal susceptibility for diseases. A nonsynonymous SNP, which changes the amino acid of the protein and its function, is especially important. Therefore, this study hypothesized that there are associations between specific SNPs of the targeted genes. Transcription factor 7-like 2 (TCF7L2) and fat mass and obesity associated (FTO) genes were selected as target genes from the results of genome-wide association and other related research studies. Second, four nonsynonymous SNPs (three in TCF7L2 and one in FTO gene) were selected as target SNPs by using public database of NCBI (National Center for Biotechnology Information). The recruited personnel was classified into three subgroups of diabetes, impaired fasting glucose (IFG) and normal groups. The individual genotypes of each group were analyzed by resequencing. None of genetic variations at four targeted SNP sites was revealed in all samples of this study. However, this study found two new SNPs that were not reported in TCF7L2 gene. One is synonymous SNP, which is heterozygous of C/T and no amino acid change of asparagine/asparagines, was located at c1641 and found in one normal person. Another is nonsynonymous SNP, which is heterozygous of G/A, was located at c1501 and found in two samples. This new discovered nonsynonymous SNP induce the amino acid change from alanine to threonine. Moreover, this new nonsynonymous SNP was found among two persons, one of whom was a diabetes patient and the other one was a person at boundary between IFG and normal, suggesting that this variant might be associated with IFG or diabetes. Even if there is a limitation of sample number for statistical power, this study has an importance due to the discovery of new SNPs. In the future study, a large sample number of diabetes cohort will be needed to investigate the frequency and association with new discovered SNP.

• 한국인구학
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• 제26권2호
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• pp.63-90
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• 2003

이 연구는 결혼, 출산, 취업 시기와 순서에 기초하여 한국 여성의 생애과정의 유형적 특성을 분석하고 있다. 또한 생애 유형의 변화와 집단간 차이에 유의하면서 결혼코호트와 여성의 가족ㆍ개인 특성에 따라 생애 유형의 차이를 설명하고 있다. 분석에 활용한 자료는 2002년 한국여성개발원이 조사한 '제4차 여성 취업실태조사'이다. 초혼 경험이 있는 기혼 여성의 생애는 크게 다섯 유형으로 구분되었다. 결혼과 출산기간에도 쉬지 않고 계속 일한 여성(일ㆍ가족역할 중복형, 13.7%), 결혼 전에 일하였지만 출산/육아기간 동안 일을 그만두고 공백기 이후 다시 일자리로 돌아온 여성(M형, 18.6%), 결혼과 출산 직후 일을 그만 둔 여성(잠재 M형, 26.9%), 결혼 전에 일한 경험이 없지만 결혼/육아 이후 일자리를 처음 가진 여성(양육 후 입직형, 23.5%), 마지막으로 전혀 일한 경험이 없는 여성(17.3%)이다. 각 생애유형의 상대적 구성은 결혼코호트에 따라 유의한 차이가 존재하였다 최근의 결혼코호트일수록 M형(잠재 M형 포함)이 지배적인 생애 유형이 되고 있다. 양육 후 처음 일을 하거나, 전혀 일한 경험이 없는 기혼여성의 비율은 최근 결혼코호트일수록 작아지고 있다. 또한 1990년 이후 결혼한 여성에서 일가족 중복형의 생애 패턴이 증가하는 경향이 확인된다. 동일 코호트 내에서 살펴보면, 생애 유형은 여성의 교육수준 성장기 일하는 여성의 역할 모델의 존재(어머니의 취업), 남편과 여성의 성역할태도, 가구의 주 생업에 따라 유의미한 차이가 나타났다. 마지막으로 여성의 생애유형별 일과 가족역할의 의미를 조망하고 있다.

• Journal of Genetic Medicine
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• 제12권1호
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• pp.38-43
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• 2015

Purpose: Spinocerebellar ataxias (SCAs) are progressive neurodegenerative disorders with diverse modes of inheritance. There are several subtypes of SCAs. SCA 8, SCA 12, and SCA 17 are the less common forms of SCAs with limited information available on their epidemiological profiles in Korea. The purpose of this study was to investigate the prevalence of SCA8, SCA12, and SCA17 in Korea. Materials and Methods: Ninety-six unrelated Korean patients were enrolled and showed normal trinucleotide repeats through polymerase-chain reaction (PCR) for the genes ATXN1, ATXN2, ATXN3, CACNA1A, and ATXN7, which correspond to SCA1, SCA2, SCA3, SCA6, and SCA7, respectively. PCR products from patients were further analyzed by capillary electrophoresis using fluorescence labeled primers for the genes ATXN8OS, PPP2R2B, and TBP, which correspond to SCA8, SCA12, and SCA17. Results: Three patients had 104, 97, and 75 abnormal expanded repeats in the ATXN8OS gene, the causative gene for SCA8. None of the patients exhibited abnormal repeats in SCA12 and SCA17. Normal trinucleotide repeat ranges of the cohort in this study were estimated to be 17-34 copies (average, $24{\pm}4copies$) for SCA8, 7-18 copies (average, $13{\pm}3copies$) for SCA12, and 26-43 copies (average, $35{\pm}2copies$) for SCA17. Conclusion: This study demonstrated that SCA8, SCA12, and SCA17 are rare in Korean patients with SCA, and further genetic studies are warranted to enhance the mutation detection rate in the Korean SCA population.

• 지역사회간호학회지
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• 제11권2호
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• pp.358-372
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• 2000

The purpose of this study was to describe the way of life (such as smoking habits, alcohol consumption, exercise, duration of sleep, eating habits etc.), physical. psychological and overall health complaints and to identify the relationship between the way of life and health complaints of the nursing students. Data was collected with the self-administered OMI( Okayama Medical Index Health Questionnaire, devised Cornell Medical Index) from 766 nursing students and was analyzed. For data analysis, descriptive statistics and an ANOVA with an SPSS/PC+ program were used. The results were as follows: 1. The mean age of subjects was 21.0557(2.7618) years old in their 1st, 2nd, 3rd and 4th year-classes of nursing departments and college students in 4 regions of Korea. 62.1% of subjects were of the proper body weight, 2.0% were overweight, and 28.3% were underweight. Most subjects did not have a past history of disease, but 1.8% of subjects had experienced a blood transfusion. 2. 28.3% of the subjects had averaged 7 hours of sleep, 98.5% were nonsmokers, 91.2% were nondrinkers, 74.7% of subjects had milk intake sometimes, 53.7% of the subjects had an average salt intake, 49.6% of the subjects usually had a green vegetable intake, 45.4% of the subjects sometimes had fatty food intake, 64.8% of the subjects had good taste, 29.5% of the subjects enjoyed physical exercise. 3. The highest percentages of 'yes' among physical. psychological and overall health complaints were observed in the question 'Do you have gastric pain?'(60.2%), 'Are you confused of disorderly?' (37.2%), 'Physical body was burdensome and fatigued.'(57.3%). 4. The total O.M.I. score ranged from 1 to 89 with an average of 22.91(SD=12.10). A statistically significant difference was observed for the physical. psychological complaints for alcohol consumption. and for the psychological complaints for salt and fatty food intake. These conclusions should provide grounds for future studies of strategies for health promoting lifestyle for nursing students and their health concerns. Further research is required to investigate the life environmental and psychological factors affecting the way of life for nursing students and their health status, to analyze the health behavior of nursing students related with their culture and consciousness. Also epidemiologic research methodology, such as prospective cohort study should be considered to explore the performing process of nursing student's health behavior related with the occurrence of diseases.

• 한국식품영양과학회지
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• 제42권9호
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• pp.1387-1394
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• 2013

본 연구는 대구 지역 초등학교 5~6학년 학생을 대상으로 알레르기 질환 환자군과 대조군으로 분류한 후, 알레르기 유병과 관련이 있는 환경적 요인을 분석하고 알레르기 유병여부에 따른 대상자의 성장 수준 및 영양 섭취 상태를 비교 분석하였다. 본 연구의 결과를 요약하면, 첫째, 대조군과 비교하여 환자군의 어머니 교육수준이 더 높았으며, 부모 및 형제의 알레르기 질환 유병 비율이 더 높은 경향을 보였다. 둘째, 환자군이 대조군보다 출생 순위가 더 낮은 경향을 보였고, 출생 당시 질병을 가지고 있는 경우와 이유식 섭취 후 부작용을 경험한 비율이 더 높았다. 셋째, 현재 대상자의 건강상태를 반영하는 최근 병원 진료 경험 빈도와 감기 및 소화질환 경험 빈도는 대조군과 비교하여 환자군에게서 더 높은 경향을 보였다. 넷째, 아동의 알레르기 질환 위험을 높이는 가장 강력한 요인은 부모 및 형제의 알레르기 질환력이었다. 전 세계적으로 알레르기 질환의 유병률이 증가하고 있는 가운데, 위와 같은 본 연구의 결과는 향후 알레르기 질환의 예방을 위한 기초 자료로 사용될 수 있을 것이다.

• 한국콘텐츠학회논문지
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• 제17권9호
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• pp.235-254
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• 2017

본 연구는 간호관리과정의 5요소에 기반을 둔 간호관리실습 사례시뮬레이션 구성틀을 개발하고, 이를 실제 간호 대학생의 간호관리실습에 적용한 후 내용 분석을 실시함으로써, 향후 간호관리실습 교육에서의 성과중심 교육과정 개발에 필요한 기초 자료를 마련하고자 한 것이다. 본 연구의 대상은 일 대학의 간호학과 4학년 105명 학생이 간호관리실습 과제로 제출한 간호관리실습 사례시뮬레이션 보고서이다. 연구도구는 간호관리실습 사례시뮬레이션 구성틀로 본 연구자가 간호관리과정의 기획, 조직, 인적자원관리, 지휘, 통제의 5요소에 기반하여 기존 시뮬레이션 실습에서 활용된 브레인스토밍과 디브리핑 과정을 반영하여 개발하였다. 연구 결과 32개의 임상 간호 사례에 대해 간호 대학생은 간호관리과정 5요소별 간호관리 문제해결에 있어 1차 브레인스토밍과 디브리핑 과정에서는 79.6%의 적절률과 11.6%의 개념 오류율, 5.6%의 분류 오류율을 보인 반면, 재추론 과정인 2차 브레인스토밍과 디브리핑 과정에서는 94.6%의 적절률 상승과 0.0 % 의 개념 오류율, 4.4%의 분류 오류율 감소를 보였다. 이는 본 연구의 간호관리실습 사례시뮬레이션 구성틀이 간호 대학생의 간호관리과정 적용에 필요한 사고력과 논리적 추론 역량을 증진하는 효과적임을 보여주는 결과라 할 수 있다. 본 연구는 간호 대학생의 간호관리실습과 간호관리 이론 교과목에 활용할 수 있을 뿐 아니라, 향후 임상간호사의 간호관리 역량 강화를 위한 시뮬레이션 기반 직무교육 또는 보수교육으로도 활용할 수 있을 것이다. 아울러 향후 다양한 간호관리 임상 현장에서의 후속 연구와 간호 대학생의 졸업 후 간호관리 직무 능력에 미치는 영향을 파악하기 위한 종단적 코호트 연구도 필요함을 제안한다.