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Serum Ferritin and Risk of the Metabolic Syndrome in Some Korean Rural Residents  

Ryu, So-Yeon (Department of Preventive Medicine, Chosun University College of Medicine)
Kim, Ki-Soon (Department of Preventive Medicine, Chosun University College of Medicine)
Park, Jong (Department of Preventive Medicine, Chosun University College of Medicine)
Kang, Myeng-Guen (Department of Preventive Medicine, Chosun University College of Medicine)
Han, Mi-Ah (Department of Preventive Medicine, Chosun University College of Medicine)
Publication Information
Journal of Preventive Medicine and Public Health / v.41, no.2, 2008 , pp. 115-120 More about this Journal
Abstract
Objectives : The purpose of this study was to examine the relationship between serum ferritin and the metabolic syndrome (MS). Methods : We conducted a cross-sectional study of 1,444 adults over age 40 and under age 70 that lived in a rural area and participated in a survey conducted as part of the Korean Rural Genomic Cohort Study (KRGCS). The MS was defined as the presence of at least three of the followings : elevated blood pressure, low high density lipoprotein cholesterol, elevated serum triglycerides, elevated plasma glucose, or abdominal obesity. After adjustment for age, alcohol intake, menopausal status, body mass index (BMI), high sensitivity C-reactive protein (hs-CRP), and alanine aminotransferase (ALT), odds ratios (ORs) for the prevalence of the MS by sex were calculated for quartiles of serum ferritin using logistic regression analysis. Results : The MS was more common in those persons , with the highest levels of serum ferritin, compared to persons with the lowest levels, in men (37.1% vs. 22.4%, p=0.006) and women (58.8% vs. 34.8, p<0.001). In both sexes, the greater the number of MS components presents, the greater the serum ferritin levels. After adjustment for age, alcohol intake, and menopausal status, the OR for metabolic syndrome, comparing the fourth quartile of ferritin with the first quartile, was 2.21 (95% confidence interval; CI=1.26-3.87; p-trend=0.024) in men and 2.10 (95% CI=1.40-3.17; p-trend=0.001) in women. However, after further adjustment for BMI, hs-CRP, and ALT, the ORs were statistically attenuated in both sexes. Conclusions : Moderately elevated serum ferritin levels were not independently associated with the prevalence of the MS after adjusting for other risk factors. Further studies are needed to obtain evidence concerning the association between serum ferritin levels and the MS.
Keywords
Cross-sectional study; Ferritin; Iron; Metabolic syndrome;
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1 Salonen JT, Tuomainen TP, Nyyssonen K, Lakka HM, Punnonen K. Relation between iron stores and non-insulin dependent diabetes in men: Case-control study. BMJ 1998; 317(7160): 727   DOI   PUBMED   ScienceOn
2 Vari IS, Balkau B, Kettaneh A, Philippe A, Jean T, Frederic F, et al. Ferritin and transferrin are associated with metabolic syndrome abnormalities and their change over time in a general population: Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR). Diabetes Care 2007; 30(7): 1795-1801   DOI   ScienceOn
3 Niederau C, Berger M, Stremmel W, Starke A, Strohmeyer G, Ebert R, et al. Hyperinsulinemia in non-cirrhotic hemochromatosis: Impaired hepatic insulin degradation? Diabetologia 1984; 26(6): 441-444   PUBMED
4 Choi KM, Lee KW, Kim HY, Seo JA, Kim SG, Kim NH, et al. Association among serum ferritin, alanine aminotransferase levels, and metabolic syndrome in Korean postmenopausal women. Metabolism 2005; 54(11): 1510-1514   DOI   ScienceOn
5 Oberly LW. Free radicals and diabetes. Free Radic Biol Med 1988; 5(2): 113-124. 25. Hsiao TJ, Chen JC, Wang JD. Insulin resistance and ferritin as major determinants of nonalcoholic fatty liver disease in apparently healthy obese patients. Int J Obes Relat Metab Disord 2004; 28(1): 167-172   DOI   PUBMED   ScienceOn
6 Williams MJ, Poulton R, Williams S. Relationship of serum ferritin with cardiovascular risk factors and inflammation in young men and women. Atherosclerosis 2002; 165(1): 179-184   DOI   ScienceOn
7 Jehn ML, Guallar E, Clark JM, Couper D, Duncan BB, Ballantyne CM, et al. A prospective study of plasma ferritin level and incident diabetes: The atherosclerosis risk in communities (ARIC) study. Am J Epidemiol 2007; 165(9): 1047-1054   DOI   ScienceOn
8 Witte DL, Crosby WH, Edwards CQ, Fairbanks VF, Mitros FA. Practice guideline development task force of the college of american pathologist. Hereditary hemochromatosis. Clin Chim Acta 1996; 245(2): 139- 200   DOI   ScienceOn
9 Jehn M, Clark JM, Guallar E. Serum ferritin and risk of the metabolic syndrome in US adults. Diabetes Care 2004; 27(10): 2422-2428   DOI   ScienceOn
10 Jiang R, Manson JE, Meigs JB, Ma J, Rifai N, Hu FB. Body iron stores in relation to risk of type 2 diabetes in apparently healthy women. JAMA 2004; 291(6): 711-717   DOI   ScienceOn
11 Ridker PM, Buring JE, Cook NR, Rifai N. Creactive protein, the metabolic syndrome, and risk of incident cardiovascular events. An 8- year follow-up of 14719 initially healthy Am women. Circulation 2003; 107(3): 391-397   DOI   ScienceOn
12 Gillum RF. Association of serum ferritin and indices of body fat distribution and obesity in Mexican American men: The Third National Health and Nutrition Examination Survey. Int J Obes Relat Metab Disord 2001; 25(5): 639-645   DOI   PUBMED   ScienceOn
13 Cho YS, Kang JH, Kim SA, Shim KW, Lee HS. Association of serum ferritin and abdominal obesity and insulin resistance. J Korean Soc Study Obes 2005; 14(2): 76-81. (Korean)
14 Andrews NC. Disorders of iron metabolism. N Engl J Med 1999; 341(26): 1986-1995   DOI   PUBMED   ScienceOn
15 Piperno A, Trombini P, Gelosa M, Mauri V, Pecci V, Vergani A, et al. Increased serum ferritin is common in men with essential hypertension. J Hypertens 2002; 20(8): 1513-1518   DOI   ScienceOn
16 Ferrannini E. Insulin resistance, iron and liver. Lancet 2000; 355(9222): 2181-2182   DOI   ScienceOn
17 Gonzalez AS, Guerrero DB, Soto MB, Diaz SP, Martinez-Olmos M, Vidal O. Metabolic syndrome, insulin resistance and the inflammation markers C-reactive protein and ferritin. Eur J Clin Nutr 2006; 60(6): 802-809   DOI   ScienceOn
18 Heeney MM, Andrews NC. Iron homeostasis and inherited iron overload disorders: An overview. Hematol Oncol Clin North Am 2004; 18(6): 1379-1403   DOI   ScienceOn
19 Tuomainen TP, Nyyssonen K, Salonen R, Tervahauta A, Korpela H, Lakka T, et al. Body iron stores are associated with serum insulin and blood glucose concentrations. Population study in 1013 eastern Finnish men. Diabetes care 1997; 20(3): 426-428   DOI   ScienceOn
20 Halle M, Konig D, Berg A, Keul J, Baumstark MW. Relationship of serum ferritin concentrations with metabolic cardiovascular risk factors in men without evidence for coronary artery disease. Atherosclerosis 1997; 128(2): 235-240   DOI   ScienceOn
21 Fernandez-Real JM, Ricart-Engel W, Arroyo E, Balanca R, Casamitjana-Abella R, Cabrero D, et al. Serum ferritin as a component of the insulin resistance syndrome. Diabetes Care 1998; 21(1): 62-68   DOI   ScienceOn
22 Wolff Sp. Diabetes mellitus and free radicals : free radicals, transition metals and oxidative stress in the aetiology of diabetes mellitus and complications. Br Med Bull 1993; 49(3): 642- 652   PUBMED
23 Zacharski L, Ornstein D, Woloshin S, Schwartz L. Association of age, sex and race with body iron stores in adults: analysis of NHANES III data. Am Heart J 2000; 140(1): 98-104   DOI   ScienceOn
24 Sheu WHH, Chen YT, Lee WJ, Wang CW, Lin LY. A relationship between serum ferritin and insulin resistance syndrome is present in non-diabetic women but non-diabetic men. Clin Endocrinol 2003; 58(3): 380-385   DOI   ScienceOn