• 대한한방내과학회지
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• 제40권5호
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• pp.920-928
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• 2019

Objectives: After epidural hemorrhage, sequelae may cause cognitive impairments, such as attention, memory, and performance disturbances. This case study reports on the use of traditional Korean medicine in a patient with cognitive impairments after a traumatic epidural hemorrhage. Methods: During the 46-day hospitalization period, traditional Korean medicine treatments, including Sunkihwalhyul-tang-gamibang, Ukgan-san-gajinpibanha Granule, Kyungohk-go, acupuncture, and cupping, were administered. The degree of cognitive impairment was measured based on the Mini Mental State Examination-Korea (MMSE-K), Modified Barthel Index (MBI), and correct answer ratio. Results: After traditional Korean medicine treatment, the MMSE-K score increased from 13 to 19 and the MBI score increased from 63 to 71. The patient's conversations in daily life also proceeded more smoothly than before hospitalization, and the correct answer ratio rose. Conclusion: This case reports the improvement of cognitive impairment after traumatic epidural hemorrhage in response to traditional Korean medicine treatment; further study is needed.

• 동의생리병리학회지
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• 제36권1호
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• pp.18-22
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• 2022

To investigate effects of cognitive function improvement whether against Taegeuk ginseng on scopolamine-induced memory impairment in rats. All experiments were conducted in three groups: the control group (CTR), the scopolamine 0.4mg/kg (SCP), and the scopolamine (SCP+T) treated with Taegeuk ginseng 100 mg/kg. Taegeuk ginseng 100 mg/kg daily was orally administered for one month and treated with scopolamine was only for 7 consecutive days on the Morris water maze task. 3 weeks after oral administration of Taegeuk ginseng, subjects were performed the Morris water maze test for 8 days and then the open-field exploration test which to assessed for cognitive function improvement. After behavioral testing, subjects were sacrificed and microdissected brains for neurochemical analysis. In the cognitive-behavioral test, long-term administration of Taegeuk ginseng improved spatial navigation learning task compared with the impeded by scopolamine treatment. In neurochemistry, the expression of the synaptic marker PSD95 (postsynaptic density protein 95) was increased in the hippocampus compared to the scopolamine group. Also, brain-derived neurotrophic factor (BDNF) expression was significantly increased in the taegeuk ginseng administration group. These data suggested that long-term administration of taegeuk ginseng might improve cognitive-behavioral functions on hippocampal related spatial learning memory, and it was correlated with neurotropic and synaptic reinforcement. In conclusion, treatment with taegeuk ginseng may positive outcome on learning and memory deficit disorders.

• 대한수의학회지
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• 제62권3호
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• pp.25.1-25.9
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• 2022

Canine cognitive dysfunction syndrome (CDS) is a neurodegenerative disease that causes cognitive and behavioral disorders and reduces the quality of life in dogs and their guardians. This study reviewed the complementary and alternative medicine (CAM) for CDS and compared the diagnosis and therapy of CAM between CDS in canines and dementia in humans. The evaluation tools for the diagnosis of CDS and dementia were similar in the neurological and neuropsychiatric examinations, daily life activity, cognitive tests, and neuroimaging, but the evaluation for dementia was further subdivided. In CAM, pattern identification is a diagnostic method for accurate, personalized treatment, such as herbal medicine. For herbal medicine treatment of cognitive impairment in canines and humans, a similar pattern identification classified as deficiency (Qi, blood, and Yin) and Excess (phlegm, Qi stagnation, and blood stasis) is being used. However, the veterinary clinical basis for verifying the efficacy and safety of CAM therapies for CDS is limited. Therefore, based on CAM evidence in dementia, it is necessary to establish CDS-targeted CAM diagnostic methods and therapeutic techniques considering the anatomical, physiological, and pathological characteristics of dogs.

• 대한의사협회지
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• 제61권12호
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• pp.758-764
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• 2018

Dementia is a clinical syndrome characterized by a cluster of symptoms and signs that manifest as difficulties in cognitive functions such as memory, psychological and psychiatric changes, and impairments in activities of daily living. As a result of worldwide trends of population aging, dementia has had a huge impact on public health in almost all countries. Disease modification therapies for dementia have not yet been developed. However, pharmacotherapy is essential in patients with dementia to combat delays in their cognitive and functional decline. In this article, we review the current pharmacotherapy for dementia. Three acetylcholinesterase inhibitors-donepezil, rivastigmine, galantamine-and memantine are the only medications that have been approved for the treatment of dementia. We present the indications, dose recommendations, side effects, and criteria for National Health Insurance coverage in Korea of these medications for dementia treatment. Although the Ministry of Food and Drug Safety in Korea has not approved any medications for managing the behavioral and psychological symptoms of dementia, some antipsychotics and antidepressants have been studied and used clinically for those purposes. Clinicians may consider vitamin E, Ginkgo biloba extract, choline alfoscerate, or omega-3 fatty acids as additional treatment options. Non-steroid anti-inflammatory drugs, estrogen hormone therapy, and statins are not generally recommended for dementia treatment. We believe that our findings will aid clinicians in the treatment of patients with cognitive decline.

• 재활치료과학
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• 제2권2호
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• pp.37-45
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• 2013

본 연구는 최근 많은 관심이 되고 있는 경도인지장애 환자의 특징과 수단적 일상생활활동에 대해 알아봄으로써 임상가들에게 작업치료에서 경도인지장애환자를 평가 및 치료하는데 도움이 되고자 하였다. 현재 치매환자를 위한 작업치료는 매우 활발하게 이루어지고 있으나 치매로 전환될 위험이 높은 경도인지장애 환자에 대하여 작업치료적 접근은 아직 이루어지지 않고 있다. 본 고찰에서는 정상노인과 감별하기 어려운 경도인지장애 환자의 작업영역 중 수단적 일상생활활동에 대해 초점을 맞추어야 한다는 근거들을 다루었으며, 경도인지장애 환자가 치매로 발전하는 것을 예방하기 위해서는 수단적 일상생활활동에 대한 고려가 필수적으로 이루어져야 함을 고찰하였다. 결론적으로, 치매로 발전 될 가능성이 높은 위험 집단인 경도인지장애 환자군의 작업영역을 고려한 수단적 일상생활활동에 대한 주기적인 평가와 그에 따른 작업치료적 개입이 필요할 것으로 보인다.

• 디지털융복합연구
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• 제16권9호
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• pp.391-397
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• 2018

본 연구는 레크리에이션 치료 프로그램이 치매 노인들의 인지기능과 균형감각에 미치는 영향을 조사 분석하고자 실시되었다. 연구대상은 알츠하이머형 치매를 진단받은 노인 16명을 대상으로 6 개월 동안 레크리에이션 치료 프로그램을 제공하였으며, 실험군과 대조군 두 그룹의 프로그램 제공전과 후의 인지기능과 균형감각의 변화를 분석하였다. 연구결과 레크리에이션 치료 프로그램은 알츠하이머형 치매 노인의 인지기능과 균형감각을 유지시키거나 증진시키는 것으로 보고되었다. 연구 대상자 모집과 손실 및 레크리에이션 치료 프로그램 기간과 같은 변수 통제의 어려움을 제한점으로 볼 수 있으나 레크리에이션 치료와 같은 비약리적 방법의 개발과 효과성 검증의 측면에서 치매 노인의 재활치료 연구에 기여하였다고 판단된다.

• 보건의료산업학회지
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• 제10권3호
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• pp.75-84
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• 2016

Objectives : The aim of this study was to compare a treatment focusing on the physical function to an intervention focusing on a cognitive strategy in stroke patients which improves their performance skills of daily activities. Methods : This study design was a randomized control trial selecting 43 people with stroke patients. This study consisted of a control group, which received conventional occupational therapy focusing on physical function, and an experimental group which was trained to develop a cognitive strategy by themselves. Both groups each received 10 sessions of the treatment. This study compared the skills for performing daily activities before and after the intervention and analyzed the data with SPSS Ver. 18.0. Results : This study showed a significant improvement in all performance skills in the experimental group (p<.05). There was no statistically significant difference in the performance skills before and after the intervention in the control group (p>.05). Conclusions : It was verified that stroke patients to develop a cognitive strategy by themselves is more effective than to improve the physical function in performance skills for daily activities.

• 성인간호학회지
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• 제20권2호
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• pp.239-250
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• 2008

Purpose: The purpose of this study was to determine the effect of a 2-week somatosensory stimulation program on cognitive function and ADL of patients with brain damage. Methods: The sample consisted of two groups of patients with stroke: 10 patients with a mean age of 59.0 years who were treated with somatosensory stimulation, and 9 patients with a mean age of 51.78 years, who were not treated with somatosensory intervention. A nonequivalent control group non-synchronized design was used to assess the functional recovery after stroke. Instruments used in this study were MMSE-K for cognitive function and FIM for ADL. Results: The hypothesis 1 that "Patients with stroke who were treated with the somatosensory stimulation program will show higher MMSE-K score than that of the non-treatment group" was supported(Z = -2.390, p = .017). The hypothesis 2 that "Patients with stroke who were treated with the somatosensory stimulation program will show higher FIM score than that of the non-treatment group", however, was partially supported(social cognition: Z = -2.204, p = .045). Conclusion: Somatosensory stimulation was effective to patients with stroke in improving their cognitive function. These findings suggest that somatosensory input can be adopted to nursing intervention for functional recovery after stroke.

• 생물정신의학
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• 제5권1호
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• pp.71-82
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• 1998

The neuropsychiatric sequelae of traumatic brain injury are effects on complex aspect of cognition, emotion and behavior. They include problems with attention and arousal, concentration, executive function, intellectual changes, memory inpairments, personality changes, affective disorders, anxiety disorders, psychosis, apathy, aggression, and irritability. There are many useful therapeutic approaches available for people who have been brain injuries. Although a multifactioral, multidisciplinary, collaborative approach to treatment is proposed, for purposes of exposition the author have divided treatment into psychopharmacological, cognitive, behavioral, psychological, and social interventions.

• 가정과삶의질연구
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• 제25권4호
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• pp.31-41
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• 2007

This study aimed to develop a cognitive-behavioral group counseling program for depression and aggressiveness in adolescents with delinquent propensity and to examine its efficacy through pre- and post-tests. The program included cognitive restructuring, exposure training, social skills training and relaxation training. Juvenile Delinquency Scale, BDI, K-YSR, and BDHI were administered to 520 3rd grade middle-school female students to assess their levels of delinquency, depression and aggressiveness. Initially 41 students who met all the following criteria were selected: 1) top 15% scores on Juvenile Delinquency Scale, 2) top 30% scores on BDI, K-YSR and BDHI respectively. Individuals currently receiving clinical treatment were excluded. Finally 39 students were selected and randomly assigned to either a treatment group(n=20) or a control group(n=19). Then the students in the treatment group were divided into 4 subgroups. The program consisted of 12 weekly sessions, approximately $1.5{\sim}2$ hours in duration. Pre- and post-tests administered to both groups included Juvenile Delinquency Scale, BDI, K-YSR, BDHI, and CLAB. Additionally, MESSY for teachers was added at pre- and post-tests. The collected data were statistically analyzed through independent t-test and paired t-test. The results of the study were as follows: 1) The students in the treatment group showed a significant reduction in the level of depression and aggressiveness in comparison with those in the control group. 2) Teachers reported a significant reduction in internalizing/externalizing behaviors of the students in the treatment group.