• Journal of Nutrition and Health
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• 제32권3호
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• pp.239-247
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• 1999

With the increasing elderly population in Korea, dementia has become a mojor health problem in Korea. Several studies have been conducted on the association between dementia and dietary intake, especially vitamin E and vitamin C. The purpose of this study was to investigate the effect of vitamin E and vitamin C supplementation on the decrease in cognitive function induced by scopolamine(300mg/kg) in rats. Rats were divided into three groups : control, vitamin C, and vitamin E supplementation(2.4g Vit C or Vit E /100g diet) and fed the diets for 6 weeks. There were significant decreases in active avoidance response and brain acetylcholinesterase activity in the control group, but no significant differences were observed in the vitamin E and C groups after scopolamine treatment. Brain dopamine concentration of vitamin E and C groups was significantly higher than those of control group after scopolamine injection. The concentrations of brain norepinephrine also showed similar tendence, even though it was not statistically significant. These results indicate that vitamin E and vitamin C may protect against the cognitive function decrease induced by scopolamine. However, it is still unclear how vitamin E and C influence brain neurotransmitters and improve cognitive function. Further study is need to elucidate the role of vitamin E and C supplementation in the prevention of dementia.

• 한국의류학회지
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• 제36권11호
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• pp.1222-1236
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• 2012

This study examined the effects of product recommendation services as an atmosphere for online mass customization shopping sites on consumers' cognitive and affective responses. We conducted a between-subject experimental study using a convenience sample of college students. A total of 196 participants provided usable responses for structural equation modeling analysis. The findings of the study support the S-O-R model for a product recommendation system as an element of the shopping environment with an influence on OMC product evaluations and arousal. The results showed that OMC product recommendation service positively affected cognitive and affective responses. The findings of the study suggest that OMC retailers might pay attention to the affective and cognitive responses of consumers through product recommendation services that can enhance product evaluations and OMC usage intentions.

• 대한화학회지
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• 제53권4호
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• pp.445-452
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• 2009

이 연구에서는 불일치 사례의 맥락이 인지 갈등 전략을 이용한 개념 변화 과정에 미치는 영향을 인지 갈등, 상황 흥미, 주의집중, 노력, 개념 이해도 등의 인지적․정의적 변인 측면에서 조사하였다. 중학교 1학년 536명을 대상으로 선개념 검사를 실시했다. 이후 불일치 사례에 대한 반응 검사와 상황 흥미 검사를 실시했다. 과학적 맥락이나 일상적 맥락의 불일치 사례는 학생들에게 무작위로 제시되었다. 밀도 개념 학습 후, 주의집중과 노력, 개념 이해도 검사를 실시했다. 목표 오개념을 지닌 194명의 응답을 분석한 결과, 과학적 맥락의 불일치 사례가 일상적 맥락의 불일치 사례보다 더 높은 인지 갈등을 유발하는 것으로 나타났다. 그러나 불일치 사례의 맥락은 상황 흥미, 주의집중, 노력, 개념 이해도와 유의미한 상관관계를 보이지 않았다. 경로 분석 결과, 불일치 사례의 맥락은 인지갈등에 직접적으로 영향을 주고, 인지 갈등을 매개로 개념 이해도에는 간접적인 영향을 주는 것으로 나타났다.

• 동의신경정신과학회지
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• 제18권2호
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• pp.89-100
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• 2007

Objective : The purpose of this study is to examine relationship between cognitive function and sasang constitution by analyzing EEG status of company workers in Cheon-An. Method : 59 company workers were tested with cognitive assessment EEG program and questionaire for the Sasang Constitution Classification II. They were assorted by Sasang Constitutions, and we analyzed its correlation with cognitive assessment score and EEG data. Results : 1. According to mean active EEG rhythm of Alpha. H-Beta, Gamma wave, there were no significant difference among Sasang Constitution. 2. According to mean success, error, concentration, response, workload and left/right brain activity score, there were no significant difference among Sasang Constitution. 3. According to mean active EEG rhythm of Theta, SMR, M-Beta wave, Soyangin(少陽人)'s value was significantly higher than that of Taeumin(太陰人) 4. According to mean cognitive strenghth score, Soyangin(少陽人)'s value was significantly higher than that of Taeumin(太陰人). Conclusion : In conclusion, Sasang Constitutional difference has no relevance with cognitive abilities However, Soyangin(少陽人) showed higher mean active EEG rhythm of Theta, SMR, M-Beta wave than that of Taeumin(太陰人). In addition, Soyangin(少陽人) also showed higher mean cognitive strenghth score than that of Taeumin(太陰人).

• 인지과학
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• 제20권2호
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• pp.183-195
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• 2009

이 연구의 목적은 IAPS 자극에 대한 한국인의 정서 반응을 측정하여 평가하는데 있다. 특히 Lang 등(2005)이 제작한 956장의 IAPS 그림자극 전체에 대한 반응을 측정하여 IAPS 자극에 대한 한국인 정서 반응의 평가 척도를 작성하였다. 또한 IAPS 자극에 대한 한국인의 평가 결과를 Lang 등(2005)이 제시한 미국인의 평가 결과와 비교함으로써 두 집단 간 차이를 알아보고자 하였다. 연구 결과, IAPS 자극에 대한 각성과 정서가 반응 모두에서 한국인과 미국인은 서로 높은 상관을 보였다. 그러나 세부적인 측면에서 집단 간 차이가 뚜렷하게 드러났는데, 한국인이 미국인에 비해 IAPS 자극에 대해 더 높은 각성 반응과 덜 극단적인 정서반응을 보였다. 또한 성별에 따른 차이를 비교한 결과, 두 나라 모두 여성이 남성에 비해 높은 각성 반응을 보였다는 점은 일치했지만, 정서가 반응에 있어서는 한국 여성은 부정적으로, 미국 여성은 극단적으로 반응했다. 이 연구 결과는 정서 반응에 있어서 문화와 성별에 따른 차이가 존재함을 보여주는 것으로서 IAPS 자극을 활용한 연구에서 이 요인들을 고려해야 함을 시사한다.

• Biomolecules & Therapeutics
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• 제23권6호
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• pp.571-581
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• 2015

${\beta}$-asarone (BAS) is an active component of Acori graminei rhizoma, a traditional medicine used clinically in treating dementia and chronic stress in Korea. However, the cognitive effects of BAS and its mechanism of action have remained elusive. The purpose of this study was to examine whether BAS improved spatial cognitive impairment induced in rats following chronic corticosterone (CORT) administration. CORT administration (40 mg/kg, i.p., 21 days) resulted in cognitive impairment in the avoidance conditioning test (AAT) and the Morris water maze (MWM) test that was reversed by BAS (200 mg/kg, i.p). Additionally, as assessed by immunohistochemistry and RT-PCR analysis, the administration of BAS significantly alleviated memory-associated decreases in the expression levels of brain-derived neurotrophic factor (BDNF) and cAMP-response element-binding protein (CREB) proteins and mRNAs in the hippocampus. Also, BAS administration significantly restored the expression of Bax and Bcl-2 mRNAs in the hippocampus. Thus, BAS may be an effective therapeutic for learning and memory disturbances, and its neuroprotective effect was mediated, in part, by normalizing the CORT response, resulting in regulation of BDNF and CREB functions and anti-apoptosis in rats.

• 한국콘텐츠학회논문지
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• 제22권10호
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• pp.861-869
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• 2022

투렛증후군 환자에게서 뮤파(Mu wave) 동기화가 깨졌을 때 틱이 발생하고, 그 반대로 뮤파 동기화를 이루면 틱이 발생하지 않는다. 연구시험 결과는 전운동피질(Frontal Cortical 3 사이트)에서 뮤파 동기화를 틱 환자가 인위적으로 하지 않고 뉴로피드백 훈련처럼 자율적으로 뇌파 조절이 이뤄진다면 마찬가지 결과로 틱이 발생하지 않는다는 사실을 시사한다. 피시험자에게 틱을 억제시켰을 때 인지 제어 반응 프로세스가 변경된다. 변경된 인지 제어를 뇌파 주파수 파워를 조절하는 뉴로피드백으로 훈련하면 환자가 인위적으로 틱을 억제하지 않아도 자율적으로 치료가 된다. 연구시험 결과는 뇌 운동영역의 뮤파 통제를 통해 틱이 발생하지 않는 생체신호 지표가 뉴로피드백 훈련의 치료프로토콜이 될 수 있는 단초를 마련하였다. 기존 뉴로피드백 치료 프로토콜인 SMR강화, 세타파-베타파 불균형 수정, 알파파 강화 등에 뮤파 강화를 추가할 수 있게 되었다. 본 연구가 투렛증후군 환자 치료법인 뉴로피드백 치료 프로토콜을 보다 과학적으로 검증하는 후속 연구와 임상시험에 활용될 것이다.

• 대한물리의학회지
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• 제7권1호
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• pp.11-20
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• 2012

Purpose : This study is intended to examine the repetitive transcranial magnetic stimulation on cognitive function in the focal ischemic stroke rat model. Methods : This study selected 30 Sprague-Dawley rats of 8 weeks. The groups were divided into two groups and assigned 15 rats to each group. Control group: Non-treatment after injured by focal ischemic stroke; Experimental group: application of repetitive transcranial magnetic stimulation(0.1 Tesla, 25 Hz, 20 min/time, 2 times/day, 5 days/2 week) after injured by focal ischemic stroke. To assess the effect of rTMS, the passive avoidance test, spatial learning and memory ability test were analyzed at the pre, 1 day, $7^{th}$ day, $14^{th}$ day and immunohistochemistric response of BDNF were analyzed in the hippocampal dentate gyrus at $7^{th}$ day, $14^{th}$ day. Results : In passive avoidance test, the outcome of experimental group was different significantly than the control group at the $7^{th}$ day, $14^{th}$ day. In spatial learning and memory ability test, the outcome of experimental group was different significantly than the control group at the $7^{th}$ day, $14^{th}$ day. In immunohistochemistric response of BDNF in the hippocampal dentate gyrus, experimental groups was more increased than control group. Conclusion : These result suggest that improved cognitive function by repetitive transcranial magnetic stimulation after focal ischemic stroke is associated with dynamically altered expression of BDNF in hippocampal dentate gyrus and that is related with synaptic plasticity.

• International Journal of Quality Innovation
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• 제6권3호
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• pp.38-55
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• 2005

Consumption has generally become more fragmented, hedonic and individual specific, satisfying not only functional but also emotional needs. In parallel, customer satisfaction is now thought to be both a cognitive and affective response, and the closely related concept of job satisfaction is commonly seen as an emotional reaction. The reasoning within quality management does, however, still lean heavily toward cognitive judgements (i.e. performance ratings), the emotional component clearly being under explored. Further, performance variables have shown not to be significant in predicting satisfaction for certain 'experience products', the effect fully mediated by emotions. As a consequence a cognitive judgement based quality concept has lost its ability to predict satisfaction, which clearly contradicts with the modem quality definition, stressing quality as the ability to satisfy the customer. Emotions have however entered the quality discourse and it has been proposed that having customers that are merely feeling satisfied will not suffice. Instead, there has been a plethora of executive exhortations in the trade press calling on business to 'delight the customer'. Strategies for doing so have however usually been imprecise and unclear, and the different drivers of delight and satisfaction are not well explored. This paper aims to complement the previous cognitive dominance by exploring the multiple emotional responses involved in customer satisfaction. A conclusion being that we currently are measuring something, in terms of satisfied, that is more or less independent of what we aim for, in terms of delight. It is also most likely that - depending on the situation, product, and person - other positive and negative emotions are more important outcomes of purchase and usage than merely satisfaction. It is questioned whether a single, summary response such as satisfaction is feasible or even desirable.

• 대한본초학회지
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• 제35권5호
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• pp.33-39
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• 2020

Objectives : Increasing evidence supports the biological and pharmacological activities of essential oils on the central nervous system such as pain, anxiety, attention, arousal, relaxation, sedation and learning and memory. The purpose of present work is to investigate the protective effect and molecular mechanism of cypress essential oil (CEO) against scopolamine (SCO)-induced cognitive impairments in C57BL/6 mice. Methods : A series of behavior tests such as Morris water maze, passive avoidance, and fear conditioning tests were conducted to monitor learning and memory functions. Immunoblotting and RT-PCR were also performed in the hippocampal tissue to determine the underlying mechanism of CEO. Results : SCO induced cognitive impairments as assessed by decreased step-through latency in passive avoidance test, relatively low freezing time in fear conditioning test, and increased time spent to find the hidden platform in Morris water maze test. Conversely, CEO inhalation significantly reversed the SCO-induced cognitive impairments in C57BL/6 mice comparable to control levels. To elucidate the molecular mechanisms of memory enhancing effect of CEO we have examined the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus. CEO effectively elevated the protein as well as mRNA expression of BDNF via activation of cAMP response element binding protein (CREB). Conclusions : Our findings suggest that CEO inhalation effectively restored the SCO-impaired cognitive functions in C56BL/6 mice. This learning and memory enhancing effect of CEO was partly mediated by up-regulation of BDNF via activation of CREB.