• 한국콘텐츠학회논문지
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• 제16권6호
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• pp.225-235
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• 2016

본 연구의 목적은 우리나라의 65세 이상 노인 집단에 총점으로 사용할 수 있는 단축형 회상기능척도(RFS-S)를 개발하고 정상노인 집단과 경도인지장애 집단에게 RFS-S를 시행하여 RFS-S의 내적신뢰도 및 준거타당도 검증과 인구학적 특성이 회상기능에 영향을 미치는 요인을 알아보고자 하였다. 연구 대상자는 65세 이상 정상대조군 60명, 경도인지자애군 58명으로 두 집단 간 일반적 특성은 유의한 차이가 없었다. 문항 간 내적신뢰도는 0.63이었고, RFS-S와 이야기회상검사, 치매임상평가척도 박스총점과의 수렴타당도는 각 0.20(p<.05), -0.25(p<.001)로 모두 유의한 상관관계를 보였다. ROC 곡선 아래의 면적을 분석한 준거타당도 결과 0.68(p<.001)로 덜 정확한(less accurate) 검사로 최적 절단점은 17점이었고 이에 따른 민감도는 0.59, 특이도는 0.72였다. 인구학적 변인에 따른 회상기능은 모두 유의한 차이를 보이지 않았다. RFS-S는 정상과 경도인지장애 차이를 판별하는 신뢰도와 타당도가 높은 진단 보조 도구이자 회상치료의 효과를 평가하는 유용한 도구임을 나타낸다.

• Journal of Oral Medicine and Pain
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• 제23권3호
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• pp.295-299
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• 1998

Pain is a multidimensional experience that involves a complex interaction of sensory,affective and cognitive components. And especially, because of the emotional significance of orofacial pain, it is often a puzzing problem that clinicians are forced with from day to day. This case report describes differential diagnosis and management of dental and myofacial pain affected by psychological factors.

• 동의신경정신과학회지
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• 제28권4호
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• pp.381-390
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• 2017

Objectives: The purpose of this study is to study the personality traits and cognitive characteristics of the Sasang constitution by comparing the Personality Test and Neuropsychological Test. Methods: A total of 121 subjects were analyzed with the results of a Two Step Questionnaire for the Sasang Constitution Diagnosis (TS-QSCD). Among them, the Personality Tests (SPQ, EPQ, TCI) and the Neuropsychological Tests (A-VLT, CPM, Stroop-CWIT, WCST) were processed and analyzed for Soyangin, Taeeumin, Soeumin. Results: 1. In the results of the SPQ, the Soyangin showed a significantly higher score than did the Taeeumin and Soeumin in Behavior, Emotionality, Cognition, as well as the Total Score. The SPQ-C score and SPQ-T were significantly higher for Soyangin, Soeumin and Taeeumin, in that order. 2. In the results of the EPQ, the Soyangin showed a significantly higher score than did the Taeeumin and Soeumin in Extraversion - introversion. Soeumin showed a significantly higher score than did the Soyangin and Taeeumin in Neuroticism. Soyangin also showed a significantly higher score than Taeeumin in Venturesomeness. 3. For the results of the TCI, the Soyangin showed a significantly lower score than did Taeeumin and Soeumin in Harm-Avoidance, but a significantly higher score in Persistence and Self-Directedness. Soyangin and Taeeumin showed a significantly higher score than did Soeumin for the total score of Self-Directedness+Cooperativeness. 4. The results of the Computerized Neuropsychological Tests (A-VLT, CPM, Stroop-CWIT, WCST) showed no significant differences between the Sasang constitution. Conclusions: The EPQ, TCI score showed significant differences between the Sasang constitution. But the Computerized Neuropsychological Tests developed to evaluate cognitive abilities did not show differences between the constitutional individuals and showed limitations as a research tool. Further studies are needed to devise a research method for ascertaining the cognitive behavioral characteristics of the Sasang constitution.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제22권4호
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• pp.211-218
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• 2011

Objectives : Intellectual impairment in children with attention-deficit hyperactivity disorder (ADHD) is often associated with relatively severe cognitive dysfunction. This study was designed to investigate cognitive function using auditory and visual event-related potential P300 in children with ADHD with relatively higher and lower IQ. Methods : A total of 20 children aged 6-12 years with DSM-IV-TR diagnosis of ADHD-combined type were recruited. For 10 children with lower IQ (${\leq}$100) and 10 children with higher IQ (>100), auditory and visual P300 using oddball paradigm (target 0.2, standard 0.8, in probability) were employed. Results : No significant differences were found in P300 amplitude and latency between ADHD children with higher and lower IQ in both modalities. However, auditory P300 amplitude in the right parietal area (P8 electrode) was negatively correlated with verbal IQ in ADHD subjects (R=-.50, p<.05). Visual P300 amplitude in the left parietal area (P3 electrode) was positively correlated with performance IQ in ADHD subjects (R=.57, p<.01). Conclusion : This study suggests intellectual impairment, as evidenced by lower IQ, could not be associated with cognitive dysfunction reflected in event-related potential P300 in ADHD children. However, cognitive function reflected in intellectual subcomponents and P300 might be processed in a stimulus modality-specific and asymmetric pattern.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제1권1호
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• pp.77-88
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• 1990

주의력 결핍장애아동의 치료는 악물치료가 중요하지만 중복장애아동과 같은 원칙에서 인지-행동적, 교육적 접근과 상호보완이 필요하다. 치료의 첫단계는 진단을 확립하고, 아동, 부모, 교사에게 이장애의 특성을 설명해 주고 치료의 대책을 세운다. 약물치료는 주로 중추신경자극제-그중에서도 메칠페니데이트를 중심으로 논의하였고, 그외에 삼환계 항우울제, 클로니딘, 항정신병약물이 소개되었다. 약물치료이외의 방법들로는 정신요법, 인지행동요법, 교육적 방법과 부모및 가족상담의 원칙들을 논의하였다. 이들 전통적인 치료방법이외에 논란되고 있는 식이요법, 비타민요법, 저당분요법, 미네랄요법, 정제된 당분의 투여, 신경학적 조직의 이론에 근거한 운동요법들을 소개하고 설명하였다.

• 대한핵의학회지
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• 제38권3호
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• pp.209-217
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• 2004

Evaluation of dementia in patients with early symptoms of cognitive decline is clinically challenging, but the need for early, accurate diagnosis has become more crucial, since several medication for the treatment of mild to moderate Alzheimer' disease are available. Many neurodegenerative diseases produce significant brain function alteration even when structural imaging (CT or MRI) reveal no specific abnormalities. The role of PET and SPECT brain imaging in the initial assessment and differential diagnosis of dementia is beginning to evolve vapidly and growing evidence indicates that appropriate incorporation of PET into the clinical work up can improve diagnostic and prognostic accuracy with respect to Alzheimer's disease, the most common cause of dementia in the geriatric population. in the fast few years, studios comparing neuropathologic examination with PET have established reliable and consistent accuracy for diagnostic evaluations using PET - accuracies substantially exceeding those of comparable studies of diagnostic value of SPECT or of both modalities assessed side by side, or of clinical evaluations done without nuclear imaging. This review deals the role of functional brain imaging techniques in the evaluation of dementias and the role of nuclear neuroimaging in the early detection and diagnosis of Alzheimer's disease.

• BMB Reports
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• 제39권6호
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• pp.766-773
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• 2006

Fragile-X-syndrome (FXS) is the most common type of inherited cognitive impairment. The underlying molecular alteration consists of a CGG-repeat amplification within the FMR-1 gene. The phenotype is only apparent once a threshold in the number of repeats has been exceeded (full mutation). The aim of this study was to characterize the FMR-1 CGG-repeat status in Argentine patients exhibiting mental retardation. A total of 330 blood samples from patients were analyzed by PCR and Southern blot analysis. Initially, DNA from 78 affected individuals were studied by PCR. Since this method is unable to detect high molecular weight alleles, however, we undertook a second approach using the Southern blotting technique to analyze the CGG repeat number and methylation status. Southern blot analysis showed an altered pattern in 14 out of 240 (6%) unrelated patients, with half of them presenting a mosaic pattern. Eight out of 17 families (47%) showed a (suggest deleting highlight). The characteristic FXS pattern was identified in 8/17 families (47%), and in 4 of these families 25% of the individuals presented with a mosaic model. The expansion from pre-mutation to full mutation was shown to occur both at the pre and post zygotic levels. The detection of FXS mutations has allowed us to offer more informed genetic counseling, prenatal diagnosis and reliable patient follow-up.

• 정신신체의학
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• 제24권2호
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• pp.184-190
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• 2016

연구목적 본 연구는 알츠하이머병(Alzheimer's disease, AD), 경도인지장애(Mild Cognitive Impairment, MCI), 정상군에서 체질량지수(Body Mass Index, BMI)의 차이를 분석하여 낮은 BMI 수치와 인지기능 저하와의 연관을 확인하고자 하였다. 또한, 한국판 간이정신상태검사(Mini Mental State Examination-Korean version, MMSEK), 치매임상평가척도(Clinical Dementia Rating, CDR), 전반적 퇴화척도(Global Deterioration Scale, GDS)과 BMI 사이에 연관성이 있는지도 알아보고자 하였다. 방 법 총 257명의 연구대상자들이 이 연구에 포함되었고, AD 및 MCI 진단을 위해 병력 청취, 정신상태검사, 신경인지기능검사, 신체 검사가 시행되었다. 대상자의 성별 및 연령과 신체 질환도 함께 조사하였다. 전반적인 인지기능과 질병의 심각도 단계 평가는 MMSE-K, GDS, CDR으로 측정하였다. 결 과 MMSE-K 점수는 정상군>MCI>AD 순이었으며 통계적으로 유의한 차이를 나타내었다(p=0.000). CDR과 GDS점수는 정상군이 가장 높았고, AD군이 가장 낮았으며 역시 통계적으로 유의한 차이를 나타내었다 BMI와 MMSE 점수 사이에는 유의한 양의 상관관계가 있었다(r=0.238, p=0.000). BMI와 CDR과는 음의 상관관계를 나타내었으며(r=-0.174, p=0.008), BMI와 GDS 역시, 음의 상관관계를 보였다(r=-0.233, p=0.000). 결 론 BMI와 인지기능과의 연관성이 있으므로, 치매나 경도인지장애 환자를 대상으로 BMI를 측정하는 것은 임상적 표지자로서 의미가 있을 것으로 예상된다. 본 연구는 AD의 진단 및 예방, 그리고 치료적 접근에 도움을 줄 수 있을 것으로 기대하며, 향후 이에 대한 대규모의 장기 추적 연구가 필요할 것으로 생각된다.

• Clinical and Experimental Pediatrics
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• 제60권11호
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• pp.337-343
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• 2017

Attention deficit hyperactivity disorder (ADHD) is one of the most common psychiatric disorders in childhood. This disorder, in addition to its main symptoms, creates significant difficulties in education, social performance, and personal relationships. Given the importance of rehabilitation for these patients to combat the above issues, the use of virtual reality (VR) technology is helpful. The aim of this study was to highlight the opportunities for VR in the rehabilitation of children with ADHD. This narrative review was conducted by searching for articles in scientific databases and e-Journals, using keywords including VR, children, and ADHD. Various studies have shown that VR capabilities in the rehabilitation of children with ADHD include providing flexibility in accordance with the patients' requirements; removing distractions and creating an effective and safe environment away from real-life dangers; saving time and money; increasing patients' incentives based on their interests; providing suitable tools to perform different behavioral tests and increase ecological validity; facilitating better understanding of individuals' cognitive deficits and improving them; helping therapists with accurate diagnosis, assessment, and rehabilitation; and improving working memory, executive function, and cognitive processes such as attention in these children. Rehabilitation of children with ADHD is based on behavior and physical patterns and is thus suitable for VR interventions. This technology, by simulating and providing a virtual environment for diagnosis, training, monitoring, assessment and treatment, is effective in providing optimal rehabilitation of children with ADHD.

• 대한예방한의학회지
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• 제14권3호
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• pp.63-75
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• 2010

Vascular dementia(VaD) is currently considered to be the second most common type of dementia. VaD is not a single diagnostic entity, but a heterogeneous syndrome which encompasses several clinicopathological forms of dementia resulting from cerebrovascular diseases. A common form of VaD is subcortical VaD which is characterized by lacunar infarcts and deep white matter changes, leading to a progressive decline in memory and cognitive function. The neuropsychological and cognitive profiles of subcortical VaD have been reported relatively homogeneous. At present, subcortical vascular dementia is regarded as the most important subtype of VaD with getting the attention of vascular dementia. The aims of this study are to discuss the concept of subcortical VaD and its importance focusing on diagnosis, prevention and treatment with a case report.