• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제19권2호
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• pp.104-111
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• 2008

Objectives : The purpose of this study was to compare two subtypes of attention-deficit hyperactivity disorder (ADHD) and controls in their attention using ADHD diagnostic system (ADS), a kind of continuous performance test. Methods : Subjects of this study were 8 children with ADHD-predominantly inattentive type, 28 children with ADHD-combined type and 20 control children. Ages ranged from 5 to 14 years. The Korean Educational Development Institute version of the Wechsler Intelligence Scale for Children (KEDI-WISC) and the ADS were administered to all subjects to provide measures of intelligence and attention. Results : Significant differences were found in the ADS variables for the three groups. When compared with controls, the ADHD-predominantly inattentive type children scored significantly higher on the omission error at middle stage and later stage and ADHD-combined type children scored significantly higher on the omission error and reaction time at later stage. When compared with the other two groups, the ADHD-combined type children scored significantly higher on the commission error at all three stages. Conclusion : Our results suggest that the two subtypes of ADHD have different features in attention deficit. And there was a possibility that commission error is available variable to show cognitive characteristics of ADHD-combined type than any other ADS variables. Further studies are needed to evaluate this finding.

• 대한본초학회지
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• 제35권5호
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• pp.33-39
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• 2020

Objectives : Increasing evidence supports the biological and pharmacological activities of essential oils on the central nervous system such as pain, anxiety, attention, arousal, relaxation, sedation and learning and memory. The purpose of present work is to investigate the protective effect and molecular mechanism of cypress essential oil (CEO) against scopolamine (SCO)-induced cognitive impairments in C57BL/6 mice. Methods : A series of behavior tests such as Morris water maze, passive avoidance, and fear conditioning tests were conducted to monitor learning and memory functions. Immunoblotting and RT-PCR were also performed in the hippocampal tissue to determine the underlying mechanism of CEO. Results : SCO induced cognitive impairments as assessed by decreased step-through latency in passive avoidance test, relatively low freezing time in fear conditioning test, and increased time spent to find the hidden platform in Morris water maze test. Conversely, CEO inhalation significantly reversed the SCO-induced cognitive impairments in C57BL/6 mice comparable to control levels. To elucidate the molecular mechanisms of memory enhancing effect of CEO we have examined the expression of brain-derived neurotrophic factor (BDNF) in the hippocampus. CEO effectively elevated the protein as well as mRNA expression of BDNF via activation of cAMP response element binding protein (CREB). Conclusions : Our findings suggest that CEO inhalation effectively restored the SCO-impaired cognitive functions in C56BL/6 mice. This learning and memory enhancing effect of CEO was partly mediated by up-regulation of BDNF via activation of CREB.

• 한국보건간호학회지
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• 제11권2호
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• pp.38-56
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• 1997

A great deal of attention has been paid to the quality of life in citizens due to the increased number of long term life expectancy. reported as effective in the health promotion of the senior citizens. In this study, the principal investigator developed an exercise program for the senior citizens, which could be educated and managed by nursing staff. This kind approach may support the need of exercise program on regular base via the social organization, which may mean the intentional change of life style. The exercise program consisted of exercise, health education, and a direct the population of the senior A regularexercise has been nursing care. A quasi -experimental study was conducted to investigate the effects of excercise program on health of the elderly in senior citizen's center. Independent variable was a 9 weeks exercise program. Dependent variables were: 1) physical health [e.g. physical fitness(cardiopulmonary endurance, back muscle strength, grip strength, muscular tolerance, flexibility and body fat proportion), physiologic parameters(blood pressure, pulse, respiration. and blood glucose), and perceived physical health status; 2) mental health measured by depression score; and 3) cognitive perception of exercise measured by usefulness and self-efficacy. A total of 37 subjects was randomly assigned into either the control group (without the exercise program: n=18) or the intervention group(with the exercise program: n=19). The results of the study analyzed using a SAS, were as follows: 1) In physical fitness of physical health, there was a significant improvement in cardiopulmonary tolerance. back muscle strength. muscular tolerance and flexibility in the intervention group, compared to the control group, while no difference in grip strength and body fat proportion. The exercise program resulted in decreases in blood pressure, pulse, respiration and blood glucose within normal range and improvement of perceived physical health status in the intervention group. 2) There was a slight increase of mental health(depression score) in the intervention group compared to the control group. but without statistical significance. 3) There was a significant improvement in cognitive perception of exercise(e.g. usefulness and self -efficacy) in the intervention group, compared to the control group. It was concluded that the exercise program employed in this study was appropriate for women senior citizens and had a positive effect on health in general.

• 인지과학
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• 제17권3호
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• pp.177-190
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• 2006

본 연구는 예상이나 전략 같은 하향식 처리방식이 정서 자극의 처리에 영향을 주는지 그리고 줄 수 있다면, 관련된 처리 패턴을 어떻게 변화시키는지를 알아보았다. 한 블록 내 특정 정서 자극의 출현 빈도는 피험자로 하여금 그 정서 자극에 대한 출현 예상을 높게 혹은 낮게 가지도록 할 수 있다. 부정 혹은 긍정 자극의 출현 빈도를 증가 시킨 후 정서 자극이 어떻게 목표자극의 처리에 영향을 주는가를 관찰한 결과, 예상성(expectancy) 같은 정보처리의 상위 단계가 정서 정보처리에 관련된 주의 분배에 영향을 미칠 수 있는 것으로 나타났다. 그러나 상향식 처리방식(bottom-up processing)과 하향식 처리방식(top-down processing)이 서로 경쟁적으로 작용하고 있는 것으로 나타났다. 즉 부정자극의 일시적 빈도 증가는 상향식 처리방식에 개입하여 부정자극에 대한 처리와 활성화를 촉진시키는 반면, 빈도 증가 이후에는 하향식 처리방식의 개입으로 부정자극에 대해 주의분배를 억제하고 진행 중인 목표처리를 더욱 강화시키는 것으로 볼 수 있다. 기존 연구들은 불안 같은 정서적 장애를 격고 있는 피험자들이 정서정보에 대한 통제와 억압이 어렵다는 것을 보여주었다면, 본 연구는 정서적으로 각성되지 않은 일반인들은 정서 자극에 대한 하향식 처리가 부분적으로 가능함을 보여주었다.

• 생물정신의학
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• 제24권2호
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• pp.68-74
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• 2017

Objectives It is well known that problem drinking is associated with alterations of brain structures and functions. Brain functions related to alcohol consumption can be determined by the resting state functional connectivity in various resting state networks (RSNs). This study aims to ascertain the alcohol effect on the structures forming predetermined RSNs by assessing their cortical thickness. Methods Twenty-six abstinent male patients with alcohol dependence and the same number of age-matched healthy control were recruited from an inpatient mental hospital and community. All participants underwent a 3T MRI scan. Averaged cortical thickness of areas constituting 7 RSNs were determined by using FreeSurfer with Yeo atlas derived from cortical parcellation estimated by intrinsic functional connectivity. Results There were significant group differences of mean cortical thicknesses (Cohen's d, corrected p) in ventral attention (1.01, < 0.01), dorsal attention (0.93, 0.01), somatomotor (0.90, 0.01), and visual (0.88, 0.02) networks. We could not find significant group differences in the default mode network. There were also significant group differences of gray matter volumes corrected by head size across the all networks. However, there were no group differences of surface area in each network. Conclusions There are differences in degree and pattern of structural recovery after abstinence across areas forming RSNs. Considering the previous observation that group differences of functional connectivity were significant only in networks related to task-positive networks such as dorsal attention and cognitive control networks, we can explain recovery pattern of cognition and emotion related to the default mode network and the mechanisms for craving and relapse associated with task-positive networks.

• 한국노년학
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• 제36권3호
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• pp.727-749
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• 2016

본 연구는 국내 외 지역사회에 거주하는 노인의 근감소증과 인지기능에 관한 연구 동향을 파악하기 위해 수행된 체계적 문헌 고찰이다. 본 연구의 선정 논문은 국내 외 문헌 중 지역사회에 거주하는 노인을 대상으로 근감소증의 유병률 또는 근감소증과 인지기능의 상관관계를 조사하였거나, 근감소증 완화 목적으로 시행된 중재 연구로, 총 43편의 논문이 포함되었다. 국내 외 근감소증의 유병률은 총 25편의 논문에서 2.5-42.4%의 다양한 범위로 보고되었으며, 인지기능과의 관계를 분석한 6편의 논문 중 4편에서 근감소증과 인지기능 저하가 유의한 양의 상관관계로 보고되었다. 근감소증 개선을 위한 중재 연구 12편에서 근육량, 근력 또는 신체 기능 향상에 대한 중재 효과를 확인하였으나, 근감소증 결과지표로 인지기능 평가를 시행한 논문은 없었다. 지역사회거주 노인을 대상으로 근감소증을 예방 및 개선하고 효과를 평가하기 위해서는 표준화된 진단을 적용한 지역사회 내 근감소증 감시체계와 신체기능 뿐만 아니라 인지기능 평가를 포함하는 포괄적이고 지속적인 근감소증 관리체계가 필요하다. 또한 지역사회 기반 근감소증 예방을 위한 근거를 생산하기 위해 지속적인 중재연구의 개발 및 적용이 요구된다.

• 디지털융복합연구
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• 제16권2호
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• pp.415-420
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• 2018

본 연구는 스마트기기를 활용한 체육활동이 유아의 신체 및 정신 발달에 미치는 효과를 살펴보는데 목적을 두었다. 시각자극 스마트기기를 활용한 체육활동을 유아에게 적용하였고 실험전보다 실험 후에 실험집단의 유아가 통제집단의 유아보다 운동능력평가에서 높아졌다. 구체적으로 살펴보면 시각자극 스마트 기기를 활용한 체육활동에 참여한 유아의 앉아서 윗몸 굽히기와 한 발로 중심잡기 능력이 좋아졌다. 또한 시각자극 스마트기기를 활용한 체육활동이 유아의 주의집중력 향상에 도움을 주었다. 따라서 유아들의 운동능력 향상을 보다 효과적으로 향상시키기 위해 시각자극 스마트 기기를 활용한 체육활동이 필요하다. 즉, 정보통신기술(ICT)과 체육활동이 유아에 신체적 발달과 인지적 발달에 모두 영향을 주는 것을 확인하였다.

• 농촌의학ㆍ지역보건
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• 제45권3호
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• pp.121-129
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• 2020

치매가 진행되면서 인지기능 저하로 인해 기억력 감퇴, 언어능력 저하, 시공간 파악능력 저하, 판단력 저하가 오게 되어 일상생활과 관련된 과제들을 수행하는데 어려움이 발생하게 된다. 경도인지장애를 동반한 치매 환자들을 위한 지역사회 기반 비 약물적 중재치료는 인지, 운동치료, 예술과 같은 활동을 포함 작업, 운동, 오락치료가 있고, 환자들의 삶의 질, 라이프케어의 증진에 영향을 준다. 본 연구는 라이프케어 증진을 위한 후마네트 운동 프로그램이 노인의 인지기능, 우울기능에 미치는 영향을 알아보고자, 경기도에 소재한 데이케어센터에서 실험군 15명, 대조군 15명을 8주간 실시하였다. 두 집단간에 지남력, 기억회상, 주의집중 및 계산, 우울기능에 유의한 차이가 있었고, 기억등록, 언어기능, 이해 및 판단에는 유의한 결과를 얻지 못하였다. 후마네트 운동은 치매 노인에게 인지기능 향상과, 우울기능에 효과가 있다고 판단되었다. 집안 내 생활이 많아지고, 운동기능, 우울기능, 인지기능이 감소될 수 있는 노인, 치매, 경도인지장애 환자들을 대상으로 라이프케어 증진을 위한 후마네트 운동 프로그램을 적용할 수 있는 방안을 마련하고 그 효과를 반복 측정하는 연구를 제언한다.

• 수면정신생리
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• 제3권1호
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• pp.38-46
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• 1996

The purpose of this study is to investigate the neurocognitive dysfunction and the degree of severity according to the oxygen desaturation in obstructive sleep apnea patients. We performed nocturnal polysomnographic recording and administered 3 Vienna Test System subtest of Reaction unit, Continuous attention and Cognitrone to 11 obstructive sleep patients and 13 controls. The result were as follows: 1) On Continous attentin and Cognitrone, patients with obstructive sleep apnea showed significant lower score on correct answer, higher score on missed answer and prolonged reaction time than control. But, there was no significant difference on Reaction unit between two groups. 2) Among 3 groups divided by degree of oxygen desaturation, there were no significant differences on Reaction unit. As the oxygen saturation decreased however, the obstructive sleep apnea group revealed significantly poor performance score on continuous attention and cognitrone. We suggested that obstructive sleep apnea patients showed disturbed neurocognitive function with complex cognitive process and the severity of neurocognitive dysfunction was also correlated with oxygen desaturation.

• 대한인간공학회지
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• 제30권4호
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• pp.563-569
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• 2011

Objective: This study focuses on the effects of pre-cues informing the location of upcoming visual stimulus on finger movement response in the context of control-on-display interfaces. Background: Previous research on pre-cues focus on attention allocation and motion studies were limited to indirect control conditions. The design of this study aimed to collect data on the exact landing point for finger-tap responses to a given visual stimulus. Method: Controlled visual stimuli and tasks were presented on a UI evaluation system built using mobile web standards; response accuracy and response time were measured and collected as appropriate. Among the 16 recruited participants, 11 completed the experiment. Results: Providing pre-cue on the location of stimulus affected response time and response accuracy. The response bias, which is a distance from the center of stimulus to the finger-tap location, was larger when the pre-cue was given during a one-handed operation. Conclusion: Given a pre-cue, response time decreases, but with accuracy penalized. Application: In designing touch-screen UI's - more strictly, visual components also acting as controllers - designers would do well to balance human perceptual and cognitive characteristics strategically.