• Nutrition Research and Practice
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• 제16권2호
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• pp.173-193
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• 2022

BACKGROUND/OBJECTIVES: Alzheimer's disease (AD) is one of the most representative neurodegenerative disease mainly caused by the excessive production of amyloid beta (Aβ). Several studies on the antioxidant activity and protective effects of Populus tomentiglandulosa (PT) against cerebral ischemia-induced neuronal damage have been reported. Based on this background, the present study investigated the protective effects of PT against cognitive impairment in AD. MATERIALS/METHODS: We orally administered PT (50 and 100 mg/kg/day) for 14 days in an Aβ_25-35-induced mouse model and conducted behavioral experiments to test cognitive ability. In addition, we evaluated the levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in serum and measured the production of lipid peroxide, nitric oxide (NO), and reactive oxygen species (ROS) in tissues. RESULTS: PT treatment improved the space perceptive ability in the T-maze test, object cognitive ability in the novel object recognition test, and spatial learning/long-term memory in the Morris water-maze test. Moreover, the levels of AST and ALT were not significantly different among the groups, indicating that PT did not show liver toxicity. Furthermore, administration of PT significantly inhibited the production of lipid peroxide, NO, and ROS in the brain, liver, and kidney, suggesting that PT protected against oxidative stress. CONCLUSIONS: Our study demonstrated that administration of PT improved Aβ_25-35-induced cognitive impairment by regulating oxidative stress. Therefore, we propose that PT could be used as a natural agent for AD improvement.

• 감성과학
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• 제10권4호
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• pp.523-538
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• 2007

본 연구는 의인화된 인터페이스 에이전트와 사용자의 성별이 에이전트에 대한 사용자의 평가에 미치는 효과를 알아보기 위해 실시되었다. 또한 에이전트의 시각적인 사실성의 수준에 관계없이 성별과 정서 표현 방식의 효과가 나타나는지를 알아보고자 하였다. 연구 1은 공감적인 정서를 표현하는 얼굴 사진을 에이전트로 제시하고 에이전트의 성별과 사용자의 성별에 따라 사용자의 평가가 어떻게 달라지는지 알아보았다. 참가자로 하여금 에이전트와 함께 과제에 참가하게 한 다음 에이전트에 대한 느낌을 대인 평가 척도를 이용해 평정하도록 한 결과, 전반적으로 여성 에이전트를 선호하는 경향이 나타났다. 또한 참가자가 이성의 에이전트를 보다 긍정적으로 평가하는 경향을 나타내었다. 연구 2는 시각적인 사실성이 떨어지는 그래픽 캐릭터를 이용하여 에이전트로 제시하고 성별과 정서 표현 방식을 조작하였다. 참가자로 하여금 에이전트와 함께 과제에 참가하게 한 다음 에이전트에 대한 느낌을 평정하도록 한 결과, 연구 1과 마찬가지로 여성 에이전트를 더 긍정적으로 평가하는 경향이 나타났다. 또한 참가자는 참가자의 상태에 호응하는 방식으로 공감적인 정서를 표현하는 에이전트를 에이전트 자신의 정서를 표현하는 조건이나 정서를 표현하지 않는 조건보다 더 긍정적으로 평가하였다. 본 연구의 결과로부터 시각적인 사실성이 떨어지는 에이전트가 사용자와 상호작용할 경우에도 에이전트의 성별의 효과와 공감적인 정서 표현 방식의 효과는 여전히 사용자의 평가에 영향을 미친다는 것을 지지하였다.

• The Korean Journal of Physiology and Pharmacology
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• 제21권1호
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• pp.55-64
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• 2017

Progressive memory impairment such as that associated with depression, stroke, and Alzheimer's disease (AD) can interfere with daily life. In particular, AD, which is a progressive neurodegenerative disorder, prominently features a memory and learning impairment that is related to changes in acetylcholine and abnormal ${\beta}$-amyloid ($A{\beta}$) deposition in the brain. In the present study, we investigated the effects of dehydroevodiamine HCl (DHED) on cognitive improvement and the related mechanism in memory-impaired rat models, namely, a scopolamine-induced amnesia model and a $A{\beta}_{1-42}$-infused model. The cognitive effects of DHED were measured using a water maze test and a passive avoidance test in the memory-impaired rat models. The results demonstrate that DHED (10 mg/kg, p.o.) and Donepezil (1 mg/kg, p.o.) ameliorated the spatial memory impairment in the scopolamine-induced amnestic rats. Moreover, DHED significantly improved learning and memory in the $A{\beta}_{1-42}$-infused rat model. Furthermore, the mechanism of these behavioral effects of DHED was investigated using a cell viability assay, reactive oxygen species (ROS) measurement, and intracellular calcium measurement in primary cortical neurons. DHED reduced neurotoxicity and the production of $A{\beta}$-induced ROS in primary cortical neurons. In addition, similar to the effect of MK801, DHED decreased intracellular calcium levels in primary cortical neurons. Our results suggest that DHED has strong protective effects against cognitive impairments through its antioxidant activity and inhibition of neurotoxicity and intracellular calcium. Thus, DHED may be an important therapeutic agent for memory-impaired symptoms.

• 한국식품영양학회지
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• 제33권3호
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• pp.347-355
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• 2020

Cognitive impairment is considered to be key research topics in the field of neurodegenerative diseases and in understanding of learning and memory. In the present study, we investigated neuroprotective effects of Schisandra chinensis (SC) and Ribes fasciculatum (RF) extracts in hydrogen peroxide-induced neuronal cell death in vitro and scopolamine-induced cognitive impairment in Sprague Dawley^® (SD) rat in vivo. Apoptotic cell death in neuroblastic PC12 cell line was induced by hydrogen peroxide for 1 hour at 100 μM. However, mixture of SC and RF treatment prevented peroxide induced PC12 cell death with no neurotoxic effects. For in vivo experiment, the effect of SC and RF extracts on scopolamine-induced cognitive impairment in SD rat was evaluated by spontaneous alternation behavior in Y-Maze test. After 30 min scopolamine injection, the scopolamine-induced rats presented significantly decreased % spontaneous alteration and acetylcholine level, compared to non-induced group. However, treatment of SC+RF extracts rescued the reduced % spontaneous alteration with acetylcholine concentration from hippocampus in scopolamine-induced rats. These results suggested that mixture of SC and RF extract may be a potential natural therapeutic agent for the prevention of cognitive impairment.

• Journal of Ginseng Research
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• 제40권3호
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• pp.211-219
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• 2016

Background: Panax ginseng root is used in traditional oriental medicine for human health. Its main active components such as saponins and polysaccharides have been widely evaluated for treating diseases, but secondary active components such as oligosaccharides have been rarely studied. This study aimed to assess the impact of water-soluble ginseng oligosaccharides (WGOS), which were isolated from the warm-water extract of Panax ginseng root, on scopolamine-induced cognitive impairment in mice and its antineuroinflammatory mechanisms. Methods: We investigated the impact of WGOS on scopolamine-induced cognitive impairment in mice by using Morris water maze and novel object recognition task. We also analyzed the impact of WGOS on scopolamine-induced inflammatory response (e.g., the hyperexpression of proinflammatory cytokines IL-$1{\beta}$ and IL-6 and astrocyte activation) by quantitative real-time polymerase chain reaction and glial fibrillary acid protein (GFAP) immunohistochemical staining. Results: WGOS pretreatment protected against scopolamine-induced learning and memory deficits in the Morris water maze and in the novel object recognition task. Furthermore, WGOS pretreatment downregulated scopolamine-induced hyperexpression of proinflammatory cytokines interleukin (IL)-$1{\beta}$ and IL-6 mRNA and astrocyte activation in the hippocampus. These results indicate that WGOS can protect against scopolamine-induced alterations in learning and memory and inflammatory response. Conclusion: Our data suggest that WGOS may be beneficial as a medicine or functional food supplement to treat disorders with cognitive deficits and increased inflammation.

• Biomolecules & Therapeutics
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• 제24권3호
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• pp.298-304
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• 2016

Dianthus superbus (D. superbus) is a traditional crude drug used for the treatment of urethritis, carbuncles and carcinomas. The objective of this study was to confirm the cognitive enhancing effect of D. superbus in memory impairment induced mice and to elucidate the possible potential mechanism. Effect of D. superbus on scopolamine induced memory impairment on mice was evaluated using the Morris water maze and passive avoidance tests. We also investigated acetylcholinesterase (AChE) activity and brain-derived neurotropic factor (BDNF) expression in scopolamine-induced mice. HPLC-DAD analysis was performed to identify active compounds in D. superbus. The results revealed that D. superbus attenuated the learning and memory impairment induced by scopolamine. D. superbus also inhibited AChE levels in the hippocampi of the scopolamine-injected mice. Moreover, D. superbus increased BDNF expression in the hippocampus. Eight compounds were identified using HPLC-DAD analysis. The content of 4-hydroxyphenyl acetic acid was higher than contents of other compounds. These results indicated that D. superbus improved memory functioning accompanied by inhibition of AChE and upregulation of BDNF, suggesting that D. superbus may be a useful therapeutic agent for the prevention or treatment of Alzheimer's disease.

• 동의생리병리학회지
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• 제31권5호
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• pp.270-276
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• 2017

The aim of this study was to investigate the effects of the water extract of Albizziae Cortex (AC) on the learning and memory impairments. AC was administered to normal mouse and scopolamine-injected amnesia mouse model. Passive avoidance test, Y-maze test, and Morris water maze test were conducted to confirm the cognitive-enhancing activities of AC. Acetylcholinesterase (AChE) activity and acetylcholine (Ach) content were measured after oral administration of AC. On the passive avoidance test, AC (200 mg/kg) significantly increased latency time and recovered scopolamine-impaired learning and memory in mice. In addition, AC (200 mg/kg) reduced Exploration time in target quadrant and reversed the scopolamine-induced cognitive impairments in the Y-maze test. Moreover, AC (200 mg/kg) increased exploration time in target quadrant and improved scopolamine-reduced escape latencies in the Morris water maze test. These effects were presented by regulatory effects of AC on AChE activity and Ach content. Taken together, AC increases cognitive-enhancing activities and ameliorates scopolamine-induced learning and memory impairment. AC might be a potential agent for prevention and treatment of amnesia and dementia.

• 융합보안논문지
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• 제4권3호
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• pp.91-99
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• 2004

학생의 건전한 심신의 발달을 도모하고 국민의 식생활 개선과 학부모의 도시락 만들기 고충을 덜어드리기 위하여 실시하고 있는 학교 급식이 초등학교에서 고등학교까지 실시되고 있다. 이에 본 연구는 급식에 종사하는 사용자의 과중한 업무를 간단하고 신속하게 처리하며, 재사용성과 사용의 용이성, 효율성을 고려한 설계를 하므로서 인지과학에 기반한 시스템을 구현하였다.

• 인지과학
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• 제13권1호
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• pp.1-11
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• 2002

본 논문에서는 먼저 Anchor Text의 단어들이 키워드로 적합한지 TFIDF를 이용하여 테스트하였다. 그 결과는 가중치가 높아서 키워드로 적합한 단어가 있었는가 하면. 아예 문서에 나오지도 않는 단어가 있어 키워드로 적합하지 않은 단어도 있었다. 이를 해결하기 위하여 새로운 키워드 추출 방법을 제시하였다. 본 논문에서는 적합하지 않은 키워드를 제거함으로써 새로운 키워드를 만들어 내고 TFIDF값을 각 키워드의 가중치로 이용하여 Ranking이 가능하게 하였다. 이렇게 추출된 키워드는 기존의 방법보다 정확도가 높아졌음 증명했다.

• 한국지능정보시스템학회:학술대회논문집
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• 한국지능정보시스템학회 2006년도 춘계학술대회
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• pp.203-213
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• 2006

대량의 정보를 취급하는 현대사회에서는 획득하는 정보를 모두 처리할 수 없어 이용자의 요구에 맞는 정보를 얻기 위해 정보 필터링 시스템을 사용한다. 그러나 정보 필터링 시스템이 이용자의 의도와 다르게 정보를 분류하거나 이용자의 다양한 요구를 반영하지 못할 때는 정보 필터링을 사용하지 않은 경우 보다 못할 수 있다. 본 연구에서는 정보 필터링의 정확도를 향상시키기 위해 인간의 뇌에서의 정보처리 과정을 시뮬레이션하는 인지적 매핑의 정보 필터링 시스템을 제안하고자 한다. 본 연구에서 제안하는 시스템은 특정 단어 또는 패턴만을 이용하여 필터링하는 기존 시스템과는 달리 단어의 존재, 단어와 단어의 연결이 창출하는 의미와 단어의 가중치를 종합하여 정보를 필터링하는 점에서 의의가 있다.