• 한국콘텐츠학회논문지
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• 제20권5호
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• pp.181-192
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• 2020

본 연구의 목적은 갱년기 여성들의 인지기능 감퇴와 극복과정에 대한 경험을 포괄적으로 탐색하여 그들의 인지건강 문제가 무엇인지를 심층적으로 이해하는 데 있다. 연구 참여자는 갱년기 여성 14명으로 하였으며 심층면담을 통해 자료를 수집하였다. 수집된 자료는 Colazzi의 현상학적 연구 방법을 적용하여 분석하였다. 연구결과 210개의 의미 진술, 43개의 진술, 17개의 주제 도출, 5개의 주제 모음이 확인되었다. 5개의 주제 모음은 '일상생활에서 느끼는 망각과 산만함', '극복하기 위한 몸부림', '피할 수 없는 손님맞이', '삶의 변화에 동조하기', '이전의 꿈꾸던 일과 앞으로의 여정' 이었다. 갱년기 여성은 폐경기를 지나면서 인지기능 감퇴를 경험하고 있었으며 동시에 이를 극복하기 위한 많은 노력을 시도하고 있었다. 따라서 인지기능 감퇴를 호소하는 갱년기 여성들에게 도움을 줄 수 있는 효과적인 중재안이 요구되며, 이에 대한 구체적인 안으로 인지기능증진 프로그램 개발과 실제적인 적응 방안이 제공되어야 할 것으로 사료된다.

• 사상체질의학회지
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• 제31권4호
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• pp.57-64
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• 2019

Objectives This study is to investigate the effect of sasang constitutional medicine on the delirium and cognitive decline caused by traumatic subarachnoid hemorrhage in a soeumin alzheimer patient Methods We have treated a 79-year-old Soeumin patient mainly with Doksampalmul-tang. She was already suffering from Alzheimer's disease. After traumatic subarachnoid hemorrhage, there were symptoms of delirium and cognitive decline. The degree of improvement was checked by K-MMSE and K-MOCA scores. Results The K-MMSE score improved from 0 to 11 and the K-MOCA score from 0 to 3. Conclusions Sasang constitutional medicine has been effective in the treatment of delirium and cognitive decline caused by traumatic subarachnoid hemorrhage.

• The Journal of Korean Physical Therapy
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• 제28권6호
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• pp.355-363
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• 2016

Purpose: In this study, we investigated the effectiveness of a 12-week virtual reality exercise program using the Nintendo Wii console (Wii) in improving balance, emotion, and quality of life among patients with cognitive decline. Methods: The study included 30 patients with cognitive decline (12 female, 18 male) who were randomly assigned to an experimental (n=15) and control groups (n=15). All subjects performed a traditional cognitive rehabilitation program and the experimental group performed additional three 40-minute virtual reality based video game (Wii) sessions per week for 12 weeks. The berg balance scale (BBS) was used to assess balance abilities. The short form geriatric depression scale-Korean (GDS-K) and the Korean version of quality of life-Alzheimer's disease (KQOL-AD) scale were both used to assess life quality in patients. Statistical significance was tested within and between groups before and after treatment, using Wilcoxon signed rank and Mann-Whitney u-tests. Results: After 36 training sessions, there were significant beneficial effects of the virtual reality game exercise on balance (BBS), GDS-K, and KQOL-AD in the experimental group when compared to the control group. No significant difference was observed within the control group. Conclusion: These findings demonstrate that a virtual reality-training program could improve the outcomes in terms of balance, depression, and quality of life in patients with cognitive decline. Long-term follow-ups and further studies of more efficient virtual reality training programs are needed.

• 생물정신의학
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• 제15권1호
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• pp.29-34
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• 2008

Objectives : This study aimed to test potential modifying effects of education on the association between apolipoprotein E ${\varepsilon}4$ (Apo E4) and cognitive decline. Methods : A community cohort(N=683) aged 65 or over completed the Korean version of Mini-Mental State Examination(MMSE-K) at baseline and two years later(1999-2001). Apo E polymorphisms were genotyped, and classified into that with or without Apo E4. Educational levels were categorized into people with or without education. Covariates included demographic(age, gender), life style(smoking, alcohol drinking), clinical (depression, sleep disorder, vascular risk factors) characteristics. Results : The association between Apo E4 and cognitive decline was significant only in the old persons with no education. The interaction term between education and Apo E4 on cognitive decline was significant(p=0.040). Conclusion : Elders with no education might be more vulnerable to the impact of Apo E4 on cognitive decline, which suggests gene-environment interaction.

• 디지털융복합연구
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• 제12권2호
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• pp.587-594
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• 2014

본 연구는 지역사회 노인의 인지기능 수준을 파악하고 인기기능저하에 영향하는 요인을 규명함으로써 인기기능을 유지 증진시키기 위한 프로그램을 개발하는데 도움이 될 기초자료를 제공하고자 실시되었다. J시의 65세 이상 노인 481명을 대상으로 2011년 9월 1일부터 9월 7일까지 구조화된 설문지를 이용하여 인구사회학적 특성, 건강관련 특성 및 우울에 대하여 조사하였다. 수집된 자료는 IBM SPSS Statistics V. 20을 사용하여 기술통계, Chi-square test, logistic regression analysis로 분석하였다. 본 연구 결과 대상자의 40.1%가 인지기능저하를 보였으며 인지기능저하와 관련된 요인은 교육수준(p<.001), 연령(p=.000), 우울 및 운동(p<.05)으로 나타났다. 그러므로 운동이나 우울에 대한 중재 프로그램을 집중적으로 시행할 필요가 있으며 특히 교육수준과 연령에 따른 개인차를 고려한 다양한 프로그램이나 교육이 마련되어야 할 것이다.

• Journal of Dairy Science and Biotechnology
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• 제38권1호
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• pp.27-36
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• 2020

The prevention of cognitive decline and dementia is an increasingly important global public health priority due to an increase in the percentage of the elderly population. Dementia, a severe cognitive disorder, not only negatively impacts the patients' quality of life but also creates a substantial burden for caregivers. This review introduced recent advances regarding the protective effects of dairy product intake against dementia and cognitive decline. Recent epidemiological studies have suggested that specific components of dairy products including bioactive peptides, colostrinin, proline-rich polypeptides, α-lactalbumin, vitamin B₁₂, calcium, and probiotics might promote healthy brain function during aging. Additionally, oleamide and dehydroergosterol in Camembert cheese have been suggested as agents capable of reducing microglial inflammatory responses and neurotoxicity. The intake of neuroprotective and anti-inflammatory compounds in meals is safe and easy, hence nutritional approaches, including dairy product consumption, serve as a promising intervention for the prevention of neurodegenerative disorders.

• 보건의료산업학회지
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• 제14권1호
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• pp.137-146
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• 2020

Objectives: The aim of this study was to investigate cognitive function decline by socio-demographic and health-related characteristics (health behaviors and health status) using 5th Korean Longitudinal Study of Aging panel data. Methods: The subjects were 4,440 community-dwelling people aged over 57 years. The data were analyzed with descriptive statistics, frequency analysis, χ²-test, and binary logistic regression analysis using SPSS ver. 25.0. Results: The findings revealed that socio-demographic characteristics (gender, age, area of residence, educational level, marital status, number of children, number of grand-children) and health-related characteristics (smoking, drinking, regular exercise, weight category by body mass index, hypertension and diabetes mellitus) were factors that influenced cognitive function decline (p<.05). Conclusions: Cognitive function decline was closely related to health behaviors and disease types. Future studies must examine related constructs to accurately determine these relationships among various populations. The present study could be used as a tool for the development and implementation of health promotion and prevention strategies.

• 정신신체의학
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• 제29권1호
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• pp.17-25
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• 2021

연구목적 국내의 성인을 대상으로 주관적 인지 저하를 동반한 우울증에서 삶의 질, 우울의 심각도, 자살 관련 특성, 주관적 건강 상태 및 스트레스 인지에 대해 조사하고자 하였다. 방 법 국민건강영양조사 제 7기 자료를 이용하여 Patient Health Questionnaire (PHQ-9)에서 10점 이상인 인구 415명을 대상으로 하였다. 주관적 인지 저하 유무에 따라 두 군의 특성 차이를 비교했다. 주관적 인지 저하와 삶의 질, 우울, 자살사고의 상관성을 보기 위해 상관분석 및 회귀 분석을 실시했다. 결 과 주관적 인지 저하를 동반한 우울증 집단이 삶의 질과 주관적 건강이 더 좋지 않았고 우울의 심각도가 심했다. 주관적 인지 저하와 삶의 질은 음의 상관관계, 자살사고와 우울은 양의 상관관계를 보였다. 회귀 분석을 통해 주관적 인지 저하가 삶의 질에 부정적 영향을 미치는 것을 확인했다. 결 론 주관적 인지 저하를 동반한 우울증은 삶의 질을 저해하고 우울의 심각도가 심하며 삶의 질, 자살사고 및 우울을 악화시키는 것으로 확인되었다.

• 대한간호학회지
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• 제46권1호
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• pp.19-28
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• 2016

Purpose: The purpose of this study was to test the mediating effect of psychological distress in the relationship between chemotherapy related cognitive impairment (CRCI) and quality of life (QOL) in people with cancer. Methods: A purposive sample of 130 patients undergoing chemotherapy was recruited for the cross-sectional survey design. Data were collected from November 2014 to June 2015. The instruments were K-MMSE (Korean Mini-Mental State Examination), Everyday Cognition (ECog), Hospital Anxiety Depression Scale (HADS), and Functional Assessment of Cancer Therapy-General (FACT-G). Data were analyzed using descriptive statistics, correlation, and multiple regression using Baron and Kenny steps for mediation. Results: The mean score for objective cognitive function was 27.95 and 69.32 for perceived cognitive decline. Overall quality of life was 91.74. The mean score was 17.52 for psychological distress. The prevalence was 56.2% for anxiety and 63.1% for depression, and 20.0% for CRCI. There were significant correlations among the variables, objective cognitive function and self-reported cognitive decline, psychological distress, and quality of life. Psychological distress was directly affected by CRCI. ($R^2=29%$). QOL was directly affected by CRCI. Psychological distress and CRCI effected QOL ($R^2=43%$). Psychological distress had a partial mediating effect (${\beta}=-.56$, p <.001) in the relationship between self-reported cognitive decline and quality of life (Sobel test: Z= -5.08, p <.001). Conclusion: Based on the findings of this study, nursing intervention programs focusing on managing cognitive decline, and decreasing psychological distress are highly recommended to improve quality of life in cancer patients.

• Journal of Microbiology and Biotechnology
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• 제32권2호
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• pp.212-219
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• 2022

Recently, the efficacy of probiotics in treatment of neurodegenerative disorders has been reported in animal and clinical studies. Here, we assessed the effects of Bacillus coagulans JA845 in counteracting the symptoms of D-galactose (D-gal)/AlCl₃-induced Alzheimer's disease (AD) in a mice model through behavioral test, histological assessment and biochemical analysis. Ten weeks of pre-treatment with B. coagulans JA845 prevented cognitive decline, attenuated hippocampal lesion and protected neuronal integrity, which demonstrated the neuroprotective features of B. coagulans JA845 in vivo. We also found that supplementation of B. coagulans JA845 alleviated amyloid-beta deposits and hyperphosphorylated tau in hippocampus of D-gal/AlCl₃-induced AD model mice. Furthermore, B. coagulans JA845 administration attenuated oxidative stress and decreased serum concentration of inflammatory cytokines by regulating the Nrf2/HO-1 and MyD88/TRAF6/NF-κB pathway. Our results demonstrated for the first time that B. coagulans has the potential to help prevent cognitive decline and might be a novel therapeutic approach for the treatment of neurodegenerative diseases.