• 한국통신학회논문지
• /
• 제39C권5호
• /
• pp.435-446
• /
• 2014

비디오 센서 망을 이용한 무인 감시 체계에서는 고용량의 영상 정보를 왜곡 없이 전송하는 것이 중요하다. 하지만, 무선 채널의 특성상 왜곡 발생이 최소화 되도록 처리할 경우, 불필요한 전송 신호의 추가 또는 정보의 재전송 등으로 인해, 전송 자체의 지연을 초래하는 효과로 연결된다. 따라서 비디오 센서 망 기반의 감시 체계는 무인 체계와 운용자 사이 또는 무인체계들 사이에 고용량의 영상 정보를 압축하면서, 실시간 정보의 특성에 알맞도록 지연시간을 줄이고 시시각각 변화하는 감시 체계에 적합하게 전송할 수 있는 저지연/적응형 영상 전송 기술을 설계하는 것이 중요하다. 본 고에서는, 무인체계의 전체 시스템 프로토콜을 상기의 목표에 맞게 설계하고, 다양한 무선 환경에서 실현할 수 있는 영상전송 기술을 소개 한다. 원활한 무인체계 통신단말 운용을 위해 대용량의 다채널 영상 정보를 효율적이면서 지연이 적게 압축하고, 통신 상태 변화에 따라 유연하게 크로스 레이어 관점에서 영상의 정보를 계층적 부호화 (Layered Coding)를 기반으로 우선 순위에 기반하여 저지연 및 적응적으로 전송하는 기술을 소개한다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권21호
• /
• pp.9071-9075
• /
• 2014

Background: microRNAs are small non-coding RNA that control gene expression by mRNA degradation or translational inhibition. These molecules are known to play essential roles in many biological and physiological processes. miR-205 may be differentially expressed in head and neck cancers; however, there are conflicting data and localization of expression has yet to be determined. Materials and Methods: miR-205 expression was investigated in 48 cases of inflammatory, benign and malignant tumor tissue array of the neck, oronasopharynx, larynx and salivary glands by Locked Nucleic Acid in situ hybridization (LNA-ISH) technology. Results: miR-205 expression was significantly differentially expressed across all of the inflammatory, benign and malignant tumor tissues of the neck. A significant increase in miR-205 staining intensity (p<0.05) was observed from inflammation to benign and malignant tumors in head and neck tissue array, suggesting that miR-205 could be a biomarker to differentiate between cancer and non-cancer tissues. Conclusions: LNA-ISH revealed that miR-205 exhibited significant differential cytoplasmic and nuclear staining among inflammation, benign and malignant tumors of head and neck. miR-205 was not only exclusively expressed in squamous epithelial malignancy. This study offers information and a basis for a comprehensive study of the role of miR-205 that may be useful as a biomarker and/or therapeutic target in head and neck tumors.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권11호
• /
• pp.4623-4628
• /
• 2015

Breast cancer still remains as the most frequent cancer with second mortality rate in women worldwide. There are no validated biomarkers for detection of the disease in early stages with effective power in diagnosis and therapeutic approaches. Cancer/testis antigens are recently promising tumor antigens and suitable candidates for targeted therapies and generating cancer vaccines. We conducted the present study to analyze transcript changes of two cancer/testis antigens, OIP5 and TAF7L, in breast tumors and cell lines in comparison with normal breast tissues by quantitative real time RT-PCR for the first time. Significant over-expression of OIP5 was observed in breast tumors and three out of six cell lines including MDA-MB-468, T47D and SKBR3. Not significant expression of TAF7L was evident in breast tumors but significant increase was noted in three out of six cell lines including MDA-MB-231, BT474 and T47D. OIP5 has ssignificant role in chromatin organization and cell cycle control during cell cycle exit and normal chromosome segregation during mitosis and TAF7L is a component of the transcription factor IID, which is involved in transcription initiation of most protein coding genes. TAF7Lis located at X chromosome and belongs to the CT-X gene family of cancer/testis antigens which contains about 50% of CT antigens, including those which have been used in cancer immunotherapy.

• 한국정보통신학회논문지
• /
• 제16권2호
• /
• pp.259-265
• /
• 2012

최근에 초경량 비디오 압축 기술로써 분산 비디오 부호화 기법 (DVC)이 많은 주목을 받고 있다. 대부분의 DVC 시스템들은 우수한 비트율-왜곡 성능을 얻기 위해 피드백 채널을 통해 패리티 비트 제어를 수행하고 있으나, 높은 복호화 시간 지연을 초래하여 실시간 구현에 가장 큰 문제점이 되고 있다. 이러한 문제점을 해결하기 위해 본 논문에서는 LDPCA 프레임별 적응적 패리티 요구 비트량에 대한 적응적 예측을 통한 효과적인 분산 비디오 부호화 방법을 제안한다. 제안된 방법은 화소영역 위너-지브 부호화기법에서 각 비트 플레인 내의 LDPCA 프레임간에 존재하는 통계적 특성을 이용하여 비트 요구량을 적응적으로 예측하는 방식을 이용한다. 모의실험을 통하여, 제안 방식은 LDPCA 복호화기에 사용한 경우 패리티 비트 요구량 예측을 사용하지 않는 방식보다 평균적으로 80% 이상의 복호화 지연 시간을 절감함을 보인다.

• 한국정보통신학회논문지
• /
• 제16권8호
• /
• pp.1675-1685
• /
• 2012

분산 비디오 부호화 기법(DVC)은 매우 낮은 복잡도를 갖는 비디오 부호화기를 제공하는데 중요한 역할을 담당하고 있다. 그러나 우수한 비트율-왜곡 성능을 얻기 위해 기존의 대부분의 DVC 기법은 피드백 채널을 통해 패리티 비트 제어를 수행하고 있으며, 이것은 비디오 복호화에 있어 많은 시간을 초래하여 실시간 구현을 위해 꼭 극복해야 할 문제점으로 남아 있다. 이러한 문제점을 해결하고 상업화를 촉진하기 위해, 본 논문에서는 LDPCA 프레임 크기가 복호화 지연 및 전체적인 부호화 성능에 미치는 영향을 분석한다. 먼저 화소 영역 위너-지브 부호화 기법에서 각 비디오 프레임을 일정한 크기의 LDPCA 프레임으로 분할하고, 분할된 LDPCA 프레임별로 시간적 상관성을 이용한 예측 방식과 공간적 상관성을 갖는 예측 방식에 따른 성능을 비교 분석한다. 모의실험을 통하여, 현재 가장 많이 연구되고 있는 QCIF크기의 영상에 대해서는 LDPCA 프레임 크기가 3168크기일 때, 가장 우수한 부호화 성능 및 고속화에 유리함을 보인다.

• Journal of Communications and Networks
• /
• 제2권1호
• /
• pp.5-17
• /
• 2000

cdma2000 offers several enhancement as compared to TIA/EIA-95, although it remains fully compatible with TIA/EIA-95 systems and allows for a smooth migration from one to the other-Major new capability include:1)connectivity to GSM-MAP in addition to IP and IS-41 networks; 2) new layering with new LAC and MAC architectures for improved service multiplexing and QoS management and efficient use of radio resource ;3) new bands and band widths of operation in support of various operator need and constraints, as well as desire for a smooth and progressive migration to cdma 2000; and 4) flexible channel structure in support of multiple services with various QoS and variable transmission rates at up to 1 Mbps per channel and 2 Mbps per user. Given the phenomenal success of wireless services and desire for higher rate wireless services. improved spectrum efficiency was a major design goal in the elaboration of cdma2000. Major capacity enhancing features include; 1) turbo coding for data transmission: 2)fast forward link power control :3) forward link transmit diversity; 4) support of directive antenna transmission techniques; 5) coherent reverse link structure; and 6) enhanced access channel operation. As users increasingly rely on their cell phone at work and at home for voice and data exchange, the stand-by time and operation-time are essential parameters that can influence customer's satisfaction and service utilization. Another major goal of cdma2000 was therefore to enable manufacturers to further optimize power utilization in the terminal. Major battery life enhancing features include; 1) improved reverse link performance (i.e., reduced transmit power per information bit; 2) new common channel structure and operation ;3) quick paging channel operation; 4) reverse link gated transmission ; and 5) new MAC stated for efficient and ubiquitous idle time idle time operation. this article provides additional details on those enhancements. The intent is not to duplicate the detailed cdma2000 radio access network specification, but rather to provide some background on the new features of cdma2000 and on the qualitative improvements as compared to the TIA/EIA-95 based systems. The article is focused on the physical layer structure and associated procedures. It therefore does not cover the MAC, LAC, radio resource management [1], or any other signaling protocols in any detail. We assume some familiarity with the basic CDMA concepts used in TIA/EIA-95.

• BMB Reports
• /
• 제32권1호
• /
• pp.20-24
• /
• 1999

The first step of the branch pathway in tryptophan biosynthesis is catalyzed by anthranilate synthase, which is subjected to feedback inhibition by the end product of the pathway. The $trpE^{FBR}$ gene from a mutant Escherichia coli strain coding for anthranilate synthase that was insensitive to feedback inhibition by tryptophan has been cloned. To identify the amino acid changes involved in the feedback regulation of anthranilate synthase, the nucleotide sequence of the mutant $trpE^{FBR}$ gene was determined. Sequence analysis of the $trpE^{FBR}$ gene revealed that four bases were changed in the structural gene while alteration was not found in the 5' control region. Among these base changes, only two base substitutions caused the alterations in amino acid sequences. From the results of restriction fragment exchange mapping, the 61st nucleotide, C to A substitution, that changed $Pro^{21}{\rightarrow}Ser$ was identified as the cause of the desensitization to feedback inhibition by tryptophan. Additional feedback-resistant enzymes of the E. coli anthranilate synthases were constructed by site-directed mutagenesis to examine the effect of the $Ser^{40}\;{\rightarrow}\;Arg^{40}$ change found in the $trpE^{FBR}$ gene of Brevibacterium lactofermentum. From the feedback inhibition analysis, the $Pro^{21}{\rightarrow}Ser$ and $Ser^{40}{\rightarrow}Arg$ mutants maintained about 50% and 90% of their maximal activities, respectively, even at the extreme concentration of 10 mM tryptophan. From these results, we suggest that the $Pro^{21}$ and $Ser^{40}$ residues are involved in the tryptophan binding in the E. coli enzyme.

• 한국콘텐츠학회논문지
• /
• 제12권12호
• /
• pp.14-24
• /
• 2012

분산 비디오 부호화 기법은 우수한 비트율-왜곡 성능을 달성하기 위해 패리티 비트 제어용으로 피드백 채널을 필요로 하고 있다. 그러나 이 방법은 분산 비디오 부호화기법에서 매우 높은 복호화 지연을 야기한다. 실시간 환경에 구현하고 상용화를 촉진하기 위해서, 많은 연구가 고속 복호화 알고리즘 개발에 집중되어 오고 있다. 실시간 구현의 한 방법으로서 본 논문에서는 복호화기에서 부호화기측으로 움직임 정보와 같은 부호화 통계 특성을 제공할 수 있는 응용 환경에 적합한 새로운 분산 비디오 부호화 기법을 다룬다. 즉, 본 논문에서는 보조 정보 생성시에 얻어지는 움직임 정보를 피드백함으로써 복호화 속도를 개선하기 위한 고속 분산 복호화 방식을 제안한다. 모의실험을 통하여, 제안 방식은 기존의 고속 분산 복호화 방식들 보다 우수함을 보인다.

• 한국버섯학회지
• /
• 제9권1호
• /
• pp.3-16
• /
• 2011

In the bipolar basidiomycete Pholiota nameko, a pair of homeodomain protein genes located at the A mating-type locus regulates mating compatibility. In the present study, we used a DNA-mediated transformation system in P. nameko to investigate the homeodomain proteins that control the clamp formation. When a single homeodomain protein gene (A3-hox1 or A3-hox2) from the A3 monokaryon strain was introduced into the A4 monokaryon strain, the transformants produced many pseudo-clamps but very few clamps. When two homeodomain protein genes (A3-hox1 and A3-hox2) were transformed either separately or together into the A4 monokaryon, the ratio of clamps to the clamp-like cells in the transformants was significantly increased to approximately 50%. We, therefore, concluded that the gene dosage of homeodomain protein genes is important for clamp formation. When the sip promoter was connected to the coding region of A3-hox1 and A3-hox2 and the fused fragments were introduced into NGW19-6 (A4), the transformants achieved more than 85% clamp formation and exhibited two nuclei per cell, similar to the dikaryon (NGW12-163 ${\times}$ NGW19-6). The results of real-time RT-PCR confirmed that sip promoter activity is greater than that of the native promoter of homeodomain protein genes in P. nameko. So, we concluded that nearly 100% clamp formation requires high expression levels of homeodomain protein genes and that altered expression of the A mating-type genes alone is sufficient to drive true clamp formation.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권18호
• /
• pp.7763-7768
• /
• 2014

Background: Gastritis and gastric cancer are the most common diseases in the Kazakh population. Polymorphisms in genes coding of cytokines have been played important role with gastric disease risk. The risk alleles of cytokines in patients with gastritis can predict the risk of developing gastric cancer. The aim of this study was to investigate cytokine gene polymorphisms as risk factors for the development of gastritis in a case-control study with gastritis patients and healthy individuals from the Kazakh ethnic group, living in North Kazakhstan. Materials and Methods: The polymerase chain reaction followed by direct sequencing were used for detection of two functional polymorphisms in the IL1 gene family, and TaqMan SNP Genotyping Assay Sets were applied for three potentially functional polymorphisms in the IL10 gene, and one in the TNFA promoter. Results: Association analysis of studied allelic variants and the development of gastritis in H. pylori-positive patients showed that IL1B -31C/C, IL1B -511T/T and IL1RN -2/2 allelic variants were associated with development of gastritis (OR=1.8 (1.07-3.16), p=0.025; OR=1.7 (1.04-2.99), p=0.035, and OR=4.92 (2.45-9.85), p<0.001) respectively. Haplotype C-Т that combines both homozygous allelic variants of IL1B gene also had a statistically significant association with slightly higher OR (OR: 1.43, 95% CI: 1.08-1.88). Conclusions: The data from the current study showed that the genotype IL-1B -511Т/-31C-IL1-RN-2 and H. pylori infection increase risk of gastritis in the Kazakh population. That genotype combination might be a factor increasing the risk of developing gastric cancer.