• Proceedings of the Korean Society of Plant Biotechnology Conference
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• 2005.04a
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• pp.189-189
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• 2005

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.154.2-154.2
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• 2003

Mammalian cell cycles are tightly regulated by cyclins, cyclin dependent kinase (CDK), Retinoblatoma (Rb) protein, and cellular CDK inhibitors (CDKI). Cyelin dependent kinases (CDK) are key enzymes regulating eukaryotic cell cycle. And also it is recognized that the abnormal increase of CDK activities is one of the common events in human cancer and CDK inhibitors have therapeutic values in cancer treatment. Until now it is known that over 10 different CKDs participate in cell cycle regulation. (omitted)

• Korean Journal of Microbiology
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• v.25 no.3
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• pp.189-197
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• 1987

The aim of the present study was to investigate the effect of glutamate on the biosynthesis of tylosin. Activities of enzymes involved in the metabolic pathway of glutamate to form tylactone, an essential precursor of tylosin, were determined using Streptomyces fradiae grown at different concentration of glutamate. As results, it was found that cell growth and tylactone formation was controlled by the metabolic flux of oxaloacetate. It was clear that cell growth was favored by the activities of citrate synthase and aspartate aminotransferase, while the tylactone synthesis was stimulated by the activity of methylmalonyl-CoA carboxyltransferase. Therefore it was concluded that channelling of oxaloacetate was a point for favoring either cell growth or tylosin biosynthesis.

• Molecules and Cells
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• v.42 no.10
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• pp.693-701
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• 2019

Plants monitor changes in day length to coordinate their flowering time with appropriate seasons. In Arabidopsis, the diel and seasonal regulation of CONSTANS (CO) protein stability is crucial for the induction of FLOWERING LOCUS T (FT) gene in long days. FLAVIN-BINDING, KELCH REPEAT, F-BOX 1 (FKF1) and ZEITLUPE (ZTL) proteins control the shape of CO expression profile antagonistically, although regulation mechanisms remain unknown. In this study, we show that GIGANTEA (GI) protein modulates the stability and nuclear function of FKF1, which is closely related to the stabilization of CO in the afternoon of long days. The abundance of FKF1 protein is decreased by the gi mutation, but increased by GI overexpression throughout the day. Unlike the previous report, the translocation of FKF1 to the nucleus was not prevented by ZTL overexpression. In addition, the FKF1-ZTL complex formation is higher in the nucleus than in the cytosol. GI interacts with ZTL in the nucleus, implicating the attenuation of ZTL activity by the GI binding and, in turn, the sequestration of FKF1 from ZTL in the nucleus. We also found that the CO-ZTL complex presents in the nucleus, and CO protein abundance is largely reduced in the afternoon by ZTL overexpression, indicating that ZTL promotes CO degradation by capturing FKF1 in the nucleus under these conditions. Collectively, our findings suggest that GI plays a pivotal role in CO stability for the precise control of flowering by coordinating balanced functional properties of FKF1 and ZTL.

• Corrosion Science and Technology
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• v.7 no.4
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• pp.219-223
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• 2008

In 2006, as a means to minimize early corrosion failure of ships, thus to enhance marine safety, International Maritime Organization (IMO), proposed a mandatory regulation for Performance Standards for the Protective Coatings (PSPC) for ballast tanks of newly built ships to satisfy 15 years of target useful life. In this regulation, several unprecedented strict rules are adopted as minimum, mandatory requirements for protective coatings of ship's water ballast tanks, and all type of ships sailing international sea are subjected to this regulation which is to be effective as early as June of 2008. The PSPC addresses many technical issues in the areas of surface pretreatment (primary and secondary), coating materials, coating application procedure and inspection as well as necessary documentation. The PSPC rules are new and unproven concepts, which calls for rigorous incorporation of reality-based evidences currently available, since there are no practical experiences in terms of the validity of the PSPC rules. There has been much controversy surrounding these regulations and considerable effort has been made by both shipyards and ship owners alike to achieve a performance standard for ballast tank coatings, which is acceptable to all. In this paper, the background and overview of the PSPC rules are given, and several issues in the PSPC are reviewed as a base to achieve robustness of the proposed PSPC, which will serve as a means to minimize early corrosion and to ensure 15 year target useful life of ships.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.18 no.3
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• pp.14-25
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• 2019

From 2019 onwards, more stringent regulations (from Stage 4 to Stage 5) are to be implemented in Europe in order to reduce the air pollutant emissions. In South Korea, the government authorities started to make new regulation to meet the European regulation. As a first step, the air pollutant emissions such as CO, NOx, SOx, TSP, $PM_{10}$, $PM_{2.5}$, VOC, $NH_3$ by agricultural machinery were analyzed based on CAPSS inventory along with the analysis in the general aspect in this study. Three levels of analysis was conducted each in agricultural machinery aspect along with in the general aspect. Per agricultural tractor, all kinds of the air pollutant emissions decreased by 25, 25, 99, 25, 25, 25, 25% for the CO, NOx, SOx, TSP, $PM_{10}$, VOC, $NH_3$ emissions each from the year 2000 to the year 2014. Per combine harvester, all kinds of the air pollutant emissions decreased by 63, 63, 91, 63, 63, 63, 63% for the CO, NOx, SOx, TSP, $PM_{10}$, VOC, $NH_3$ emissions each from the year 2000 to the year 2014.

• Journal of Korean Society of Water and Wastewater
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• v.32 no.2
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• pp.145-152
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• 2018

This study is focused on manganese (Mn(II)) removal by ozonation in surface water. Instant ozone demand for the water was 0.5 mg/L in the study. When 0.5 mg/L of Mn(II) is existed in water, the optimum ozone concentration was 1.25 mg/L with reaction time 10 minutes to meet the drinking water regulation. The ozone concentration to meet the drinking water regulation was much higher than the stoichiometric concentration. The reaction of soluble manganese removal was so fast that the reaction time does not affect the removal dramatically. When Mn(II) is existed with Fe, the removal of Mn(II) was not affected by Fe ion. However As(V) is existed as co-ion the removal of Mn(II) was decreased by 10%. Adding ozone to surface water has limited effect to remove dissolved organic matter. When ozone is used as oxidant to remove Mn(II) in the water, the existing co-ion should be evaluated to determine optimum concentration.

• Transactions of the Korean hydrogen and new energy society
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• v.20 no.2
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• pp.161-167
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• 2009

The regulation of the $CO_2$ emit from vehicles have become much more stringent in recent years. This stringent regulation is more request vehicle manufacturers to develop the alternative fuel vehicles for reducing exhaust emissions. LPG fuel is more clean energy compares with gasoline and diesel fuel. Especially, $CO_2$ emission of LPG Vehicle is less than gasoline vehicle and almost equal to diesel vehicle. For this reason, recently korean government is extending LPG fuel for hybrid car and light duty vehicle. In domestic, Propane is mixing $15{\sim}30%$ to butane for improvement of cold start at winter season. Therefore, In this paper was investigated that the characteristics of emissions according to propane mixing rate with 0, 10, 20, 30% were compared and analyzed by the vehicle test using LPG vehicle according to the FTP75 mode. It was also investigated the characteristics of nano-particle emit with propane mixing rate.

• Biomedical Science Letters
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• v.16 no.4
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• pp.239-246
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• 2010

It is suggested that ovariectomy induces body weight gain primarily in the form of adipose tissue in rodents. Since liver peroxisome proliferator-activated receptor ${\alpha}$ (PPAR${\alpha}$) and uncoupling 2 (UCP2) are involved in the regulation of energy expenditure, it was investigated whether swim training regulates ovariectomy-induced adiposity and steatosis through liver PPAR${\alpha}$ and UCP2 activation in female ovariectomized mice, an animal model of postmenopausal women. Swim-trained mice had significantly decreased adipose tissue weights compared with sedentary control mice. Histological analysis showed that hepatic lipid accumulation was inhibited by swim training. Concomitantly, swim training significantly increased mRNA levels of PPAR${\alpha}$ and its target genes responsible for peroxisomal fatty acid ${\beta}$-oxidation, such as acyl-CoA oxidase, enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase and thiolase in the liver. Moreover, swim training induced the mRNA expression of UCP2. These results suggest that swim training can effectively prevent adiposity and steatosis caused by ovariectomy, in part through activation of liver PPAR${\alpha}$ and UCP2 in female obese mice.

• Proceedings of the KIPE Conference
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• 2007.07a
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• pp.32-34
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• 2007

전자산업 부문의 친환경 대응이 이슈화 되면서 전자기기의 대기전력 소비감소를 위한 연구가 지속적으로 수행되고 있다. 전자기기의 대표적인 전원공급장치인 Switched Mode Power Supply(SMPS)의 경우 부하기기의 대기모드 시 극도로 낮은 출력전력에서 고효율을 달성해야 하는 요구가 높다. 특히 많은 SMPS들이 부하기기의 요구에 의하여 다출력 컨버터로 설계되어 있는데, 이러한 다출력 구조에서 대기모드 시 불필요한 출력을 절체함과 동시에 저전력에서 고효율을 내기가 쉽지 않다. 또한 다출력 구조로 인한 Cross Regulation 문제를 극복해야 하는 과제가 있다. 따라서 본 논문에서는 단일 컨버터 혹은 복수의 컨버터로 구성되어 있는 다출력 컨버터에서 대기전력 개선을 위한 Secondary Side Post Regulator(SSPR), 전류모드, Power Sequence 제어기술을 제안하고, 대기전력과 더불어 SSPR의 Cross Regulation 특성 개선을 검토하였다. 그리고 제안한 기술이 구현된 다출력 구조의 110W와 270W급 SMPS를 제작하여 회로의 타당성 및 우수성을 검증하였다.