• 약학회지
• /
• 제52권5호
• /
• pp.345-354
• /
• 2008

This study was designed to investigate the anti-diabetic effect and mechanism of Korean red ginseng extract through transcriptomics in C57BL/KsJ db/db mice. The db/db mice were randomly divided into six groups: diabetic control group (DC), red ginseng extract low dose group (RGL, 100 mg/kg), red ginseng extract high dose group (RGH, 200 mg/kg), metformin group (MET, 300 mg/kg), glipizide group (GPZ, 15 mg/kg) and pioglitazone group (PIO, 30 mg/kg), and treated with drugs once per day for 10 weeks. At the end of treatment, we measured blood glucose, insulin, hemoglobin A1c (HbA1c), triglyceride (TG), adiponectin, leptin, non-esterified fatty acid (NEFA). RGL-treated group lowered the blood glucose and HbA1c levels by 19.6% and 11.4% compared to those in diabetic control group. In addition, plasma adiponectin and leptin levels in RGL-treated groups were increased by 20% and 12%, respectively, compared to those in diabetic control. Morphological analyses of liver, pancreas and epidydimal adipose tissue were done by hematoxylin-eosin staining, and pancreatic islet insulin and glucagon levels were detected by double-immunofluorescence staining. RGL-treated group revealed higher insulin contents and lower glucagon contents compared to diabetic control. To elucidate an action mechanism of Korean red ginseng, DNA microarray analyses were performed in liver and fat tissues, and western blot and RT-PCR were conducted in liver for validation. According to hierarchical clustering and principal component analysis of gene expression Korean red ginseng treated groups were close to metformin treated group. In summary, Korean red ginseng lowered the blood glucose level through protecting destruction of islet cells and shifting glucose metabolism from hepatic glucose production to glucose utilization and improving insulin sensitivity through enhancing plasma adiponectin and leptin levels.

• 디지털콘텐츠학회 논문지
• /
• 제19권2호
• /
• pp.351-362
• /
• 2018

본 연구에서는 Schwartz의 가치체계 이론(1992)에 근거하여 개인적 가치가 SNS 이용자의 동기적 특성 및 행태적 반응에 미치는 효과를 분석하였다. 본 조사 결과 크게 '개방성,' '상호호혜성,' '자기 향상성,' '규범 준수성,' '안전성'의 5가지 가치차원이 주요하였으며, 이들 각 가치차원은 SNS 이용동기, 사회적 자본, 광고반응, 구전의도 등에 차별적 영향을 미치는 것으로 나타났다. 또한 이들 제 가치차원을 중심으로 SNS 이용자들을 군집화한 결과 '경험 추구형,' '상호의존적 공감형,' '자기 향상형,' '규범 준수형'의 4개의 가치집단으로 세분화되었다. 각 가치집단은 SNS 인식 및 행태적 특성에 있어서 차별적 특징을 보여주었을 뿐만 아니라, SNS 서비스 유형과도 체계적인 관련성을 갖는 것으로 나타났다. 본 연구의 결과 Schwartz의 가치체계이론은 SNS 이용과 관련된 심리적 기제를 이해하는데 매우 유용한 틀로 활용될 수 있음을 보여주었다.

• 한국항만경제학회지
• /
• 제34권2호
• /
• pp.51-68
• /
• 2018

본 연구는 물류시장의 업종 간의 경영성과 차이를 비교하는 동시에 물류기업의 사업특성 차이를 분석하였다. 나아가 업종과 사업특성의 차이가 경영성과에 미치는 영향을 검정하였다. 분석 방법으로는 분산분석, 군집분석을 이용하였고, 연구의 시사점은 다음과 같다. 첫째. 일본의 물류시장은 업종 간 경영성과 차이가 나타났고, 창고서비스업이 타 업종에 비해 수익성과 안정성이 높았다. 둘째, 업종별 사업행동의 차이가 나타났고, 타 업종에 비해 해상화물운송업은 자본집약도가 높았고, 창고서비스업은 사업선도력과 신용거래도가 높았다. 마지막으로 업종과 사업특성 군집의 두 요인은 경영성과에 미치는 상호작용이 유의미하게 검정되었는데, 수익성에 있어 화물운송업과 창고서비스업의 사업특성의 작용이 달랐다. 반면, 안정성에 있어 전 업종은 공통적으로 자본집약도를 낮추고 사업선도력을 재고하는 사업특성이 유효하게 작용하였다.

• 응용통계연구
• /
• 제20권3호
• /
• pp.487-497
• /
• 2007

일반적인 ARCH 형태의 모형들은 자산수익률의 급첨 (leptokurtic; heavy-tail) 성질과 변동성 집중 (volatility clustering) 현상 등의 특징을 잘 포착해내는 반면, 수익률의 부호에 따른 비대칭 레버리지 효과 (leverage effect)는 반영 할 수 없다는 단점을 가진다. 따라서 최근 금융 시계열 분야에서는 비대칭-조건부-이분산 시계열 모형에 대한 관심이 높아지고 있다. 본 연구에서는 국내 금융 시계열자료 (KOSPI, KOSDAQ, 환율, 채권, 주요종목의 주가)의 수익률 제곱을 그래프화 하여 비대칭 이분산성을 시각적으로 탐지하고 이를 바탕으로 비대 칭 TGARCH(1,1) 모형을 적합한 후 기존의 대칭 GARCH(1,1) 모형과 비교분석하고자 한다.

• 인터넷정보학회논문지
• /
• 제10권6호
• /
• pp.205-217
• /
• 2009

최근 기업들은 조직 내외의 협업 또는 협력에 의해 발생되는 거대량의 업무들을 안정적으로 처리해줄 수 있는 초대형 워크플로우 관리 시스템의 등장을 요구하고 있다. 워크플로우 벤더들은 초대형 워크플로우 서비스를 지원하는 워크플로우 관리시스템을 구현하기 위해, 하드웨어들의 추가적 확장을 통한 워크플로우 관리 시스템의 성능 향상을 모색하고 있다. 그러나 워크플로우 관리 시스템의 소프트웨어적인 아키텍처를 고려하지 않은 단순한 물리적 확장은 시스템 구축에 소요되는 시간적 또는 비용적 낭비를 야기할 수 있다. 이러한 한계를 개선하기 위하여, 본 논문에서는 워크케이스 기반 워크플로우 아키텍처를 제안하고, 해당 아키텍처를 토대로 하는 초대형 워크플로우 관리 시스템을 구현한다. 또한 워크케이스 기반 초대형 워크플로우 관리 시스템에 관한 생성 반응 시간 관련 실험을 통해서, 논리적인 소프트웨어 아키텍처의 개선이 워크플로우 관리 시스템의 초대형성에 매우 큰 영향을 미칠 수 있음을 증명하고자 한다.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• 제12권5호
• /
• pp.2313-2326
• /
• 2018

The method of operating a game could determine the psychological distance between the player and the game character, and thus, in the Virtual Reality, players' control methodologies are important to enhance their immersion. This study has the objective of examining the difference in games according to the method of operation based on the player's movements. This study researched the effect of the method of operating movement conforming to the movement of the character and the physical operation of the body on forming game experiences for the player. The result of performing an experiment increased reality for the game player through a controller in the shape of the actual control, to increase focus in the game. As so, game play through movements, including actual movements by the player displayed to enhance game satisfaction. In the part of media remediation field, Game can be defined as media which has their own unique hypermediacy. Especially, in the motion based game, players' movement mediates players and the game, therefore, players' movement could make players' experience augmented or immediate in accordance with the characteristics of movements. Even though sports and dances genres of motion-based games are common, RPG or adventure genres are rare. It can be explained that the characteristics of the action have been explained in the immediacy. In a game of fantasy, which is difficult to experience in real-life situations, the nature of the player's motion can increase the immersion of the game, which can contribute to utilization of players' motion and experience design in the various genres and suggestion of grounds theory. In addition, through this study, it is able to design motion-based games of various genres.

• 한국식품과학회지
• /
• 제46권3호
• /
• pp.352-357
• /
• 2014

수도권 거주 소비자 100명을 대상으로 전국에서 시판되는 24종의 복분자주의 소비자 기호도 조사를 실시하였다. 24개 복분자주 시료의 전반적인 기호도 평가의 분산분석을 통해 기호도 평가에 연령 및 성별간의 차이보다는 개인 간의 차이가 더 크게 작용한 것으로 나타났다. 전체 소비자 기호도 평가 결과를 바탕으로 군집분석을 실시하여 시료 간 유사한 기호도 평가를 보인 세 개의 군집으로 분류하였다. 세 개의 군집은 기호척도의 빈도수 분포와 실제 기호도 평균 점수에서 군집 간의 차이가 확인되었다. 이러한 군집 분류를 바탕으로 판별분석을 활용하여 군집의 분류가 적절한지 또한 판별함수의 예측력은 적정한지 파악하였다. 판별분석결과 분류율이 100%로 적절한 예측력을 보였고, 세 군집간의 마할라노비스거리와 추출된 요인 내에서의 분포도도 적정한 것으로 나타났다. 향후 다양한 우리술의 품질평가시스템 개발에 소비자 기호도 조사를 활용한 평가방법이 활용 가능하리라 여겨진다.

• Journal of Veterinary Science
• /
• 제22권3호
• /
• pp.37.1-37.14
• /
• 2021

Background: Ticks are one of the most common external parasites in dogs, and are associated with the transmission of a number of major zoonoses, which result in serious harm to human health and even death. Also, the increasing number of pet dogs and pet owners in China has caused concern regarding human tick-borne illnesses. Accordingly, studies are needed to gain a complete understanding of the bacterial composition and diversity of the ticks that parasitize dogs. Objectives: To date, there have been relatively few reports on the analysis of the bacterial community structure and diversity in ticks that parasitize dogs. The objective of this study was to investigate the microbial composition and diversity of parasitic ticks of dogs, and assessed the effect of tick sex and geographical region on the bacterial composition in two tick genera collected from dogs in China. Methods: A total of 178 whole ticks were subjected to a 16S ribosomal RNA (rRNA) next generation sequencing analysis. The Illumina MiSeq platform targeting the V3-V4 region of the 16S rRNA gene was used to characterize the bacterial communities of the collected ticks. Sequence analysis and taxonomic assignment were performed using QIIME 2 and the GreenGene database, respectively. After clustering the sequences into taxonomic units, the sequences were quality-filtered and rarefied. Results: After pooling 24 tick samples, we identified a total of 2,081 operational taxonomic units, which were assigned to 23 phyla and 328 genera, revealing a diverse bacterial community profile. The high, moderate and low prevalent taxa include 46, 101, and 182 genera, respectively. Among them, dominant taxa include environmental bacterial genera, such as Psychrobacter and Burkholderia. Additionally, some known tick-associated endosymbionts were also detected, including Coxiella, Rickettsia, and Ricketssiella. Also, the potentially pathogenic genera Staphylococcus and Pseudomonas were detected in the tick pools. Moreover, our preliminary study found that the differences in microbial communities are more dependent on the sampling location than tick sex in the tick specimens collected from dogs. Conclusions: The findings of this study support the need for future research on the microbial population present in ticks collected from dogs in China.

• 보건행정학회지
• /
• 제32권2호
• /
• pp.205-215
• /
• 2022

Background: The purpose of this study is to identify the factors infecting the medical care utilization from a new perspective by newly classifying the categories of administrative districts using the urban decline index and medical vulnerability index as indicators. Methods: This study targeted 150,940 people who used medical services using the 2015 cohort database (DB), 2010-2015 urban regeneration analysis index DB, and 2014-2015 public health and medical statistics DB. The decline of the region was classified using the urban decline index typed using k-means clustering and the medical vulnerability index typed using the quantile score calculation. Regression analysis was performed 3 times with medical expenditure, length of stay, and the number of outpatient visits as dependent variables. Results: There were 37 stable region (47.4%), 29 health vulnerable region (37.2%), and 12 decline region (15.4%). The health vulnerable region had lower medical expenditure, fewer outpatient visits, and a higher length of stay than the stable region. The decline region was all higher than the stable region but had no significant effect. Conclusion: The factors that cause the health disparity between regions are not only factors related to individual health behavior but also environmental factors of the local community. Therefore, there is a need for a systematic alternative that properly considers the resources within the community and reflects the characteristics of the population.

• Journal of Preventive Medicine and Public Health
• /
• 제55권1호
• /
• pp.80-87
• /
• 2022

Objectives: Dengue remains hyperendemic in Malaysia despite extensive vector control activities. With dynamic changes in land use, urbanisation and population movement, periodic updates on dengue transmission patterns are crucial to ensure the implementation of effective control strategies. We sought to assess shifts in the trends and spatial patterns of dengue in Kelantan, a north-eastern state of Malaysia (5°15'N 102°0'E). Methods: This study incorporated data from the national dengue monitoring system (eDengue system). Confirmed dengue cases registered in Kelantan with disease onset between January 1, 2016 and December 31, 2018 were included in the study. Yearly changes in dengue incidence were mapped by using ArcGIS. Hotspot analysis was performed using Getis-Ord Gi to track changes in the trends of dengue spatial clustering. Results: A total of 10 645 dengue cases were recorded in Kelantan between 2016 and 2018, with an average of 10 dengue cases reported daily (standard deviation, 11.02). Areas with persistently high dengue incidence were seen mainly in the coastal region for the 3-year period. However, the hotspots shifted over time with a gradual dispersion of hotspots to their adjacent districts. Conclusions: A notable shift in the spatial patterns of dengue was observed. We were able to glimpse the shift of dengue from an urban to peri-urban disease with the possible effect of a state-wide population movement that affects dengue transmission.