• The Korean Journal of Physiology and Pharmacology
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• 제21권2호
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• pp.251-257
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• 2017

Inhibition of $K^+$ outward currents by linopirdine in the outer hair cells (OHCs) of circling mice (homozygous (cir/cir) mice), an animal model for human deafness (DFNB6 type), was investigated using a whole cell patch clamp technique. Littermate heterozygous (+/cir) and ICR mice of the same age (postnatal day (P) 0 -P6) were used as controls. Voltage steps from -100 mV to 40 mV elicited small inward currents (-100 mV~-70 mV) and slow rising $K^+$ outward currents (-60 mV~40 mV) which activated near -50 mV in all OHCs tested. Linopirdine, a known blocker of $K^+$ currents activated at negative potentials ($I_{K,n}$), did cause inhibition at varying degree (severe, moderate, mild) in $K^+$ outward currents of heterozygous (+/cir) or homozygous (cir/cir) mice OHCs in the concentration range between 1 and $100{\mu}m$, while it was apparent only in one ICR mice OHC out of nine OHCs at $100{\mu}m$. Although the half inhibition concentrations in heterozygous (+/cir) or homozygous (cir/cir) mice OHCs were close to those reported in $I_{K,n}$, biophysical and pharmacological properties of $K^+$ outward currents, such as the activation close to -50 mV, small inward currents evoked by hyperpolarizing steps and TEA sensitivity, were not in line with $I_{K,n}$ reported in other tissues. Our results show that the delayed rectifier type $K^+$ outward currents, which are not similar to $I_{K,n}$ with respect to biophysical and pharmacological properties, are inhibited by linopirdine in the developing (P0~P6) homozygous (cir/cir) or heterozygous (+/cir) mice OHCs.

• 교육녹색환경연구
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• 제9권3호
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• pp.49-58
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• 2010

The Ministry of educational science and technology is about to conduct its 7th &8th curriculum. However, there are some problems in achieving its goals under the current class model system in both educational and architectural. This study finds the characteristics of the arrangements and architectural planning in the departmental system - designed high schools. As a result, the arrangement was tend to be 'overall type' or 'central type' depending on the teaching-learning efficiency. Liberal arts and science&technology groups were placed close, and foreign languages and general cultural studies were arranged close as well. Importantly, there were supporting facilities such as a gymnasium, a cafeteria, a library, a computer lab, and an all-purpose-room, and this arrangement provided convenience. It is for the better learning effect and the high efficiency. It is worthy noticing that the placement and formation of individual or study space is regarded importantly. In flow planning, it seemed that it was designed to reduce the users' movement to a minimum. However, there are still some problems compared to Japan or the States, who already has an established departmental system. I think that the government should enforce its necessity of planning to schools, relevant divisions, or architects to bring it up. Furthermore, it is urgently needed a practical and future-oriented study that can forecast any changes in architectural spaces within the ever-changing teaching and learning environment in the information-oriented society.

• 한국자기학회지
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• 제8권4호
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• pp.241-248
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• 1998

본 연구에서는 micro magnetic device의 제작과 특성 분석을 위하여 고주파수 대역에서 사용가능한 자성체의 개발과 meander형 마이크로 코일의 가공 기술 확립에 그 목적을 두었다. 자성체로서는 DC magnetron reactive sputtering system에 의해 제조된 초 미세결정구조를 갖는 FeTaC, FeTaN막을 사용하였으며, 그 자기적 특성은 다음과 같다. Bs:13~17kG, Hc:0.1~0.2Oe, $\mu$':2000~4000. 전기 도금법에 의해 제작된 Cu코일은 2$\mu$$\Omega$-cm의 비저항을 나타내었으며, 공심형 5turn 언덕터의 경우에는 50nH의 인덕턴스와 700MHz의 공진 주파수 그리고 200MHz에서 30의 성능 지수를 보였다. 또한 meandergudxo의 폐자로 인덕터에서 인덕턴스는 150nH, 공진 주파수는 100MHz, 그리고 성능지수는 10~30 MHz에서 4의 값을 나타내었다.

• 한국소음진동공학회논문집
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• 제17권7호
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• pp.632-637
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• 2007

The dynamic behavior of two steel bridges crossed by the Korean High Speed Train(KHST) has been investigated experimentally and the results are compared with the specification requirement of BRDM and other typical PSC Box bridge's responses. The investigated bridges are a 2-girder steel bridge of 1@40m span length(E-Won Bridge), 2@50m span length (Ji-Tan Bridge), and a PSC Box girder bridge of 2@40m span length (Yeon-Jae Bridge). A set of experimental tests were performed during operation of KHST, and a number of accelerometers, LVDTs and ring-type displacement transducers were utilized for measurement of three kinds of dynamic responses (acceleration, deflection, and end-rotation angle). Measured responses show that the vertical deflections and end-rotation angles of the three bridges are all satisfying the spec. requirement with large margin, but it was also found acceleration responses which are very close or exceed the limit value. Most of the excessive acceleration responses were found when the passing velocity of the KHST is close to the critical velocity ($V_{cr}$) which causes resonance. No noticeable differences of dynamic responses due to the different materials(steel or concrete) could be found within these experimental results.

• Earthquakes and Structures
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• 제12권1호
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• pp.91-108
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• 2017

Superstructures and isolation systems of seismically isolated buildings located close to active faults may observe increased seismic demands resulting from long-period and high-amplitude velocity and displacement pulses existent in near-fault ground motions as their fundamental periods may be close to or coincident with these near-fault pulse periods. In order to take these effects into account, the 1997 Uniform Building Code (UBC97) has specified near-source factors that scale up the design spectrum depending on the closest distance to the fault, the soil type at the site, and the properties of the seismic source. Although UBC97 has been superseded by the 2015 International Building Code in the U.S.A., UBC97 near-source factors are still frequently referred in the design of seismically isolated buildings around the world. Therefore it is deemed necessary and thus set as the aim of this study to assess the necessity and the adequacy of near-source factors for seismically isolated buildings. Benchmark buildings of different heights with isolation systems of different properties are used in comparing seismic responses obtained via time history analyses using a large number of historical earthquakes with those obtained from spectral analyses using the amplified spectrums established through UBC97 near-source factors. Results show that near-source factors are necessary but inadequate for superstructure responses and somewhat unconservative for base displacement response.

• 한국소성가공학회:학술대회논문집
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• 한국소성가공학회 2004년도 제5회 압연심포지엄 신 시장 개척을 위한 압연기술
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• pp.72-82
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• 2004

The deformation mechanism of hexagonal close-packed materials is quite complicate including slips and twins. A deformation mechanism, which accounts for both slip and twinning, was investigated for polycrystalline hop materials. The model was developed in a finite element polycrystal model formulated with initial strain method where the stiffness matrix in FEM is based on the elastic modulus. We predicted numerically the texture of Mg alloy(AZ31B) sheet by using FEM based on crystal plasticity theory. Also, we introduced the recrystallized texture employed the maximum energy release theory after rolling. From the numerical study, it was clarified that the shrink twin could not be the main mechanism for shortening of c-axis, because the lattice rotation due to twin rejects fur c-axis to become parallel to ND(normal direction of plate). It was showed that the deformation texture with the pyramidal slip gives the ring type pole figure having hole in the center.

• 천문학회보
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• 제41권1호
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• pp.77.1-77.1
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• 2016

We investigate the properties and detection conditions for the planetary caustic perturbation of close-separation planets. To find the properties of the planetary caustic perturbation, we construct deviation maps by subtracting the single-lensing magnification of the lens star from the planetary lensing magnification for various lensing parameters. We find that each deviation area of the positive and negative perturbations disappears at the same normalized source radius according to a given deviation threshold regardless of mass ratio but disappears at a different normalized source radius according to the separation. We also estimate the upper limit of the normalized source radius to detect the planetary caustic perturbation. We find simple relations between the upper limit of the normalized source radius and the lensing parameters. From the relations, we obtain an analytic condition for the detection limit of the planet, and which show that we can sufficiently discover a planet with the mass of sub-Earth for typical microlensing events. Therefore, we expect to add the number of low-mass planets in the next-generation microlensing experiments and conclude that our detection condition of the planet can be used as a important criteria for maximal planet detections considering the source type and the photometric accuracy.

• 한국주거학회논문집
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• 제19권6호
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• pp.85-93
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• 2008

This study analyzes areas, traffic lines and characteristics of block of traditional villages in order to suggest how to build urban village in the way that can solve problems occurring in residential areas these days. The study showed the following results: 1) Traditional villages have definite boundary and entrance, and the community area for the villages is close to the entrance to encourage community activities of villagers. 2) With an access in the form of a blind alley branched from the main road, traditional villages form a small-sized clustering and encourage community activities in a natural way. 3) Formed of block with a pattern of net, blind alley or standing in a line on both sides, traditional villages help residents to form close relations between. These findings suggest that for building desirable urban villages, 1) they should have definite boundary, 2) size and location of community area should be determined in the way to activate community activities of residents, 3) roads inside the village should have branched form rather than standardized check pattern so that small-sized clustering could be formed along the branched inner roads, and 4) clustering in villages should be arranged in a line on both sides or in the form of a blind alley giving consideration to the length and width of roads. The roads should be also of a closed type so that residents could create strong bonds with their neighbors.

• 한국기계가공학회지
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• 제20권7호
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• pp.25-32
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• 2021

In the previous study, a study was conducted to improve the exhaust gas intake efficiency by improving the existing soot measurement probe in the shape and angle of the exhaust port. As a result, it can be seen that the smoke measurement performance according to the shape and angle is improved. In previous studies, the performance of the soot probe was not confirmed for the Korean KD 147 mode, which has a low suction flow rate and a long inspection time. So, we would like to confirm the improvement of the smoke probe performance of the Korean KD 147 mode, which is close to the actual driving conditions. The probe used in this study is another type of probe, and has a circular ring shape instead of a rib and variable center position unit, so the probe center hole is located close to the center of the exhaust pipe.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제48권4호
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• pp.232-236
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• 2022

A ranula is a pseudocyst that originates from the sublingual gland after trauma. Acute cases of ranulas that progress rapidly and cause respiratory distress are rare. Holoprosencephaly is a complex brain malformation caused by incomplete cleavage of the prosencephalon. Children with holoprosencephaly may experience upper airway obstruction due to the associated dentoalveolar malformations and oromotor dysfunctions. We present the case of an eight-year-old female patient with holoprosencephaly and a plunging ranula that manifested as an acute course due to difficult airway management. She required gastrostomy for oromotor dysfunctions related to feeding and swallowing and difficulty managing oral secretions. The sublingual gland and ranula were removed under general anesthesia. Postoperatively, urgent reintubation and close monitoring in the intensive care unit were required due to upper airway obstruction. We successfully managed the patient with close cooperation of a pediatrician and an anesthetist, and no recurrence was observed at the one-year follow-up. A ranula can be caused by trauma to the floor of the mouth in association with lingually inclined mandibular teeth, a type of dentoalveolar compensation seen in maxillary hypoplasia associated with holoprosencephaly. Careful consideration is needed in such cases since airway management can be difficult due to postoperative swelling and oromotor dysfunctions.