• Journal of Sensor Science and Technology
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• v.26 no.6
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• pp.408-413
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• 2017

In this paper, we newly developed a byte-inverted transmission method for flicker-free visible light communication (VLC). The VLC transmitter sends original data in the former half period of the clock, and inverted data and in the latter half period of the clock. The VLC receiver receives the original data in the in the former half period of the clock. In this system, we used 480Hz clock that was generated from the 60Hz power line. The average optical power of the LED array in the transmitter is constant, thus flicker-free, in the observation time longer than the period of the clock that is about 2ms. This period is shorter than the maximum flickering time period (MFTP) of 5ms that is generally considered to be safe. This configuration is very useful in constructing indoor wireless sensor networks using LED light because it is flicker-free and does not require additional transmission channel for clock transmission.

• Journal of the Korean Institute of Telematics and Electronics C
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• v.35C no.1
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• pp.1-9
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• 1998

In the circuit model that outputs are latched and input vectors are successively applied at inputs, the gate resizing approach to reduce the delay of the critical pathe may not improve the performance. Since the clock period is etermined by delays of both long and short paths in combinational circuits, the performance (clock period) can be optimized by decreasing the delay of the longest path, or increasing the delay of the shortest path. In order to achieve the desired clock period of a circuit, gates lying in sensitizable long and short paths can be selected for resizing. However, the gate selection in path sensitization approach is a difficult problem due to the fact that resizing a gate in shortest path may change the longest sensitizable path and viceversa. For feasible settings of the clock period, new algorithms and corresponding gate selection methods for resizing are proposed in this paper. Our new gate selection methods prevent the delay of the longest path from increasing while resizing a gate in the shortest path and prevent the delay of the shortest path from decreasing while resizing a gate in the longest sensitizable path. As a result, each resizing step is guaranteed not to increase the clock period. Our algorithmsare teted on ISCAS85 benchmark circuits and experimental results show that the clock period can beoptimized efficiently with out gate selection methods.

• Proceedings of the IEEK Conference
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• 2003.07b
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• pp.1157-1160
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• 2003

We proposed a study on optimal clock period selection algorithm for low power RTL design. The proposed algorithm use the way of maintaining the throughput by reducing supply voltage after improve the system performance in order to minimize the power consumption. In this paper, it select the low power to use pipeline in the transformation of architecture. Also, the algorithm is important the clock period selection in order to maximize the resource sharing. however, it execute the optimal clock period selection algorithm.

• Journal of Life Science
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• v.27 no.10
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• pp.1225-1231
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• 2017

Disruptive expression patterns of the circadian clock genes are highly associated with many human diseases, including cancer. Cell cycle and proliferation is linked to a circadian rhythm; therefore, abnormal clock gene expression could result in tumorigenesis and malignant development. The molecular network of the circadian clock is based on transcriptional and translational feedback loops orchestrated by a variety of clock activators and clock repressors. The expression of 10~15% of the genome is controlled by the overall balance of circadian oscillation. Among the many clock genes, Period 1 (Per1) and Period 2 (Per2) are clock repressor genes that play an important role in the regulation of normal physiological rhythms. It has been reported that PER1 and PER2 are involved in the expression of cell cycle regulators including cyclins, cyclin-dependent kinases (CDKs), and CDK inhibitors. In addition, correlation of the down-regulation of PER1 and PER2 with development of many cancer types has been revealed. In this review, we focused on the molecular function of PER1 and PER2 in the circadian clock network and the transcriptional and translational targets of PER1 and PER2 involved in cell cycle and tumorigenesis. Moreover, we provide information suggesting that PER1 and PER2 could be promising therapeutic targets for cancer therapies and serve as potential prognostic markers for certain types of human cancers.

• BMB Reports
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• v.49 no.11
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• pp.587-589
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• 2016

The circadian clock system enables organisms to anticipate the rhythmic environmental changes and to manifest behavior and physiology at advantageous times of the day. Transcriptional/translational feedback loop (TTFL) is the basic feature of the eukaryotic circadian clock and is based on the rhythmic association of circadian transcriptional activator and repressor. In Drosophila, repression of dCLOCK/CYCLE (dCLK/CYC) mediated transcription by PERIOD (PER) is critical for inducing circadian rhythms of gene expression. Pacemaker neurons in the brain control specific circadian behaviors upon environmental timing cues such as light and temperature cycle. We show that amino acids 657-707 of dCLK are important for the transcriptional activation and the association with PER both in vitro and in vivo. Flies expressing dCLK lacking AA657-707 in $Clk^{out}$ genetic background, homologous to the mouse Clock allele where exon 19 region is deleted, display pacemaker-neuron-dependent perturbation of the molecular clockwork. The molecular rhythms in light-cycle-sensitive pacemaker neurons such as ventral lateral neurons ($LN_vs$) were significantly disrupted, but those in temperature-cycle-sensitive pacemaker neurons such as dorsal neurons (DNs) were robust. Our results suggest that the dCLK-controlled TTFL diversify in a pacemaker-neuron-dependent manner which may contribute to specific functions such as different sensitivities to entraining cues.

• Journal of the Korea Society of Computer and Information
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• v.8 no.4
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• pp.111-116
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• 2003

We proposed a optimal clock period selection algorithm for low power Register Transfer Level design. The proposed algorithm use the way of maintaining the throughput by reducing supply voltage after improve the system performance in order to minimize the power consumption. In this paper, it select the low power to use pipeline in the transformation of architecture. Also, the proposed algorithm is important the clock period selection in order to maximize the resource sharing. however, it execute the optimal clock period selection algorithm. The experiment result is to set the same result AR and HAL filter on the high level benchmark and to reduce in the case of two pipe stage 10.5% and three pipe stage as many as 33.4%.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2017.10a
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• pp.520-521
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• 2017

The converted error is occurred by the time difference between the time interval signal and the clock in a Time-to-Digital Converter of counter-type. If the clock period is $T_{CLOCK}$ the converted error is a maximum $T_{CLOCK}$ by the time difference between the start signal and the clock. And the converted error is a maximum $-T_{CLOCK}$ by the time difference between the stop signal and the clock. However, when the clock is synchronized with the start signal and the colck is generated during the time interval signal the range of converted digital error is from 0 to $(1/2)T_{CLOCK}$.

• Proceedings of the Korea Society of Environmental Toocicology Conference
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• 2003.05a
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• pp.160-160
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• 2003

Plasma melatonin in the seasonal light-period is circadian rhythmically secreted. Maximal secretion showed at 14 o'clock in summer- and winter-like period, but minimal secretion showed at 5 o'clock in summer-like period and at 8 in winter-like period. These times of minimal secretions were at the beginning of light period. Plasma melatonin in the light period is secreted 62.5% more than in the dark period in summer-like period and 45.9% more in winter-like period. Total plasma melatonin in winter-like period is secreted 56.5% more than in summer-like period. The weights of testis(-20.8%) and body(-7.1%) were reduced in the winter-like period. By the increase of plasma melatonin in mice, body- and testis-weights are decreased, on the contrary by the decrease of plasma melatonin in mice, body and testis weights are increased. In view of the results so far achieved melatonin changes on the body weight and reproductive organ in mice. It is presumed that melatonin effects on the metabolism and sex hormone.

• Environmental Analysis Health and Toxicology
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• v.18 no.1
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• pp.57-61
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• 2003

Plasma melatonin in the seasonal light-period is circadian rhythmically secreted. Maximal secretion showed at 14 o'clock in summer- and winter-like period, but minimal secretion showed at 5 o'clock in summer-like period and at 8 in winter-like period. These times of minimal secretions were at the beginning of light period. Plasma melatonin in the light period is secreted 62.5％ more than in the dark period in summer- like period and 45.9％ more in winter- like period. Total plasma melatonin in winter-like period is secreted 56.5％ more than in summer-like period. The weights of testis (-20.8％) and body (-7.1％) were reduced in the winter-like period. By the increase of plasma melatonin in mice, body - and testis -weights are decreased, on the contrary by the decrease of plasma melatonin in mice, body and testis weights are increased. In view of the results so far achieved melatonin changes on the body weight and reproductive organ in mice. It is presumed that melatonin effects on the metabolism and sex hormone.

• Biomolecules & Therapeutics
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• v.26 no.4
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• pp.358-367
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• 2018

Most organisms have adapted to a circadian rhythm that follows a roughly 24-hour cycle, which is modulated by both internal (clock-related genes) and external (environment) factors. In such organisms, the central nervous system (CNS) is influenced by the circadian rhythm of individual cells. Furthermore, the period circadian clock 2 (Per2) gene is an important component of the circadian clock, which modulates the circadian rhythm. Per2 is mainly expressed in the suprachiasmatic nucleus (SCN) of the hypothalamus as well as other brain areas, including the midbrain and forebrain. This indicates that Per2 may affect various neurobiological activities such as sleeping, depression, and addiction. In this review, we focus on the neurobiological functions of Per2, which could help to better understand its roles in the CNS.