• 센서학회지
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• 제26권6호
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• pp.408-413
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• 2017

In this paper, we newly developed a byte-inverted transmission method for flicker-free visible light communication (VLC). The VLC transmitter sends original data in the former half period of the clock, and inverted data and in the latter half period of the clock. The VLC receiver receives the original data in the in the former half period of the clock. In this system, we used 480Hz clock that was generated from the 60Hz power line. The average optical power of the LED array in the transmitter is constant, thus flicker-free, in the observation time longer than the period of the clock that is about 2ms. This period is shorter than the maximum flickering time period (MFTP) of 5ms that is generally considered to be safe. This configuration is very useful in constructing indoor wireless sensor networks using LED light because it is flicker-free and does not require additional transmission channel for clock transmission.

• 전자공학회논문지C
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• 제35C권1호
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• pp.1-9
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• 1998

In the circuit model that outputs are latched and input vectors are successively applied at inputs, the gate resizing approach to reduce the delay of the critical pathe may not improve the performance. Since the clock period is etermined by delays of both long and short paths in combinational circuits, the performance (clock period) can be optimized by decreasing the delay of the longest path, or increasing the delay of the shortest path. In order to achieve the desired clock period of a circuit, gates lying in sensitizable long and short paths can be selected for resizing. However, the gate selection in path sensitization approach is a difficult problem due to the fact that resizing a gate in shortest path may change the longest sensitizable path and viceversa. For feasible settings of the clock period, new algorithms and corresponding gate selection methods for resizing are proposed in this paper. Our new gate selection methods prevent the delay of the longest path from increasing while resizing a gate in the shortest path and prevent the delay of the shortest path from decreasing while resizing a gate in the longest sensitizable path. As a result, each resizing step is guaranteed not to increase the clock period. Our algorithmsare teted on ISCAS85 benchmark circuits and experimental results show that the clock period can beoptimized efficiently with out gate selection methods.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2003년도 하계종합학술대회 논문집 II
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• pp.1157-1160
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• 2003

We proposed a study on optimal clock period selection algorithm for low power RTL design. The proposed algorithm use the way of maintaining the throughput by reducing supply voltage after improve the system performance in order to minimize the power consumption. In this paper, it select the low power to use pipeline in the transformation of architecture. Also, the algorithm is important the clock period selection in order to maximize the resource sharing. however, it execute the optimal clock period selection algorithm.

• 생명과학회지
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• 제27권10호
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• pp.1225-1231
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• 2017

암을 포함한 다양한 인간의 질병 발생이 circadian clock 유전자의 변형된 발현 양상과 깊은 연관관계를 나타내고 있다. 세포 주기와 세포 성장은 circadian rhythm과 연결되어 있으며, 이를 조절하는 clock 유전자의 비정상적인 발현은 결국 종양 발생과 암의 발달을 유발하게 된다. Circadian clock에 관한 분자적 기전은 다수의 clock activator와 clock repressor의 통합적인 조절에 따른 전사 및 번역이 포함된 음성피드백 고리로 구성되어 있다. 이러한 circadian rhythm의 자동조절 기전에 의해 전체 유전체의 약 10~15%가 전사 수준에서 영향받는 것으로 나타났다. 많은 clock 유전자들 중, Period 1 (Per1)과 Period 2 (Per2)는 clock repressor 유전자로 정상적인 생리적 리듬을 조절하는 것에 기여한다. PER1과 PER2는 cyclin, CDK, CKI를 포함하는 세포 주기 조절자의 발현에 관여함이 밝혀졌으며, 다양한 암에서 PER1과 PER2의 발현 감소가 보고되었다. 따라서, 본 논문에서는 PER1과 PER2의 circadian rhythm에서의 분자적 기능과 종양 발생과 관련된 PER1과 PER2의 하위 표적인자에 대해 살펴보고, 암 치료를 위한 새로운 치료 표적과 암의 예후를 예측하기 위한 분자 지표로써의 PER1과 PER2의 가능성에 대해 서술하고자 한다.

• BMB Reports
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• 제49권11호
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• pp.587-589
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• 2016

The circadian clock system enables organisms to anticipate the rhythmic environmental changes and to manifest behavior and physiology at advantageous times of the day. Transcriptional/translational feedback loop (TTFL) is the basic feature of the eukaryotic circadian clock and is based on the rhythmic association of circadian transcriptional activator and repressor. In Drosophila, repression of dCLOCK/CYCLE (dCLK/CYC) mediated transcription by PERIOD (PER) is critical for inducing circadian rhythms of gene expression. Pacemaker neurons in the brain control specific circadian behaviors upon environmental timing cues such as light and temperature cycle. We show that amino acids 657-707 of dCLK are important for the transcriptional activation and the association with PER both in vitro and in vivo. Flies expressing dCLK lacking AA657-707 in $Clk^{out}$ genetic background, homologous to the mouse Clock allele where exon 19 region is deleted, display pacemaker-neuron-dependent perturbation of the molecular clockwork. The molecular rhythms in light-cycle-sensitive pacemaker neurons such as ventral lateral neurons ($LN_vs$) were significantly disrupted, but those in temperature-cycle-sensitive pacemaker neurons such as dorsal neurons (DNs) were robust. Our results suggest that the dCLK-controlled TTFL diversify in a pacemaker-neuron-dependent manner which may contribute to specific functions such as different sensitivities to entraining cues.

• 한국컴퓨터정보학회논문지
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• 제8권4호
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• pp.111-116
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• 2003

본 논문은 저전력 레지스터 전송 단계 설계를 위한 최적 클럭 주기 선택 알고리듬을 제안한다. 제안한 알고리듬은 전력 소비를 최소화하기 위하여 시스템의 성능을 향상시킨 후에 공급 전압을 줄임으로써 처리율을 유지하는 방법을 사용한다. 본 논문은 구조의 변환 중에서 파이프라인을 이용한 저 전력을 선택한다. 또한 제안한 알고리듬은 자원 공유를 최대화하기 위해 클럭 주기 선택이 중요하다. 본 알고리듬은 최적 클럭 주기 선택 알고리듬을 수행한다. 실험결과에서는 상위 레벨 벤치마크 상에서 AR 필터와 HAL 필터는 동일한 결과를 얻을 수 있고, EL 필터인 경우 2파이프 단계에서는 10.5%, 3 파이프 단계에서는 무려33.4% 클럭 주기 감소를 얻을 수 있다.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2017년도 추계학술대회
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• pp.520-521
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• 2017

일반적인 카운터 타입의 시간-디지털 변환기에서 시간간격 신호와 클록신호의 비동기로 인하여 디지털 변환에러가 발생한다. 클록의 주기를 $T_{CLOCK}$라고 하면, 시간간격 신호의 시작신호와 클록의 비동기로 인하여 최대 $T_{CLOCK}$의 변환에러가 발생한다. 그리고 시간간격 신호의 멈춤신호와 클록의 비동기로 인하여 최대 $-T_{CLOCK}$의 변환에러가 발생한다. 그러나 시작신호와 클록을 동기화하고 클록을 시간간격 신호동안 발생시킬 경우 디지털 변환에러의 범위는 0에서 $(1/2)T_{CLOCK}$이다.

• 한국환경독성학회:학술대회논문집
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• 한국환경독성학회 2003년도 춘계학술대회
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• pp.160-160
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• 2003

Plasma melatonin in the seasonal light-period is circadian rhythmically secreted. Maximal secretion showed at 14 o'clock in summer- and winter-like period, but minimal secretion showed at 5 o'clock in summer-like period and at 8 in winter-like period. These times of minimal secretions were at the beginning of light period. Plasma melatonin in the light period is secreted 62.5% more than in the dark period in summer-like period and 45.9% more in winter-like period. Total plasma melatonin in winter-like period is secreted 56.5% more than in summer-like period. The weights of testis(-20.8%) and body(-7.1%) were reduced in the winter-like period. By the increase of plasma melatonin in mice, body- and testis-weights are decreased, on the contrary by the decrease of plasma melatonin in mice, body and testis weights are increased. In view of the results so far achieved melatonin changes on the body weight and reproductive organ in mice. It is presumed that melatonin effects on the metabolism and sex hormone.

• Environmental Analysis Health and Toxicology
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• 제18권1호
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• pp.57-61
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• 2003

Plasma melatonin in the seasonal light-period is circadian rhythmically secreted. Maximal secretion showed at 14 o'clock in summer- and winter-like period, but minimal secretion showed at 5 o'clock in summer-like period and at 8 in winter-like period. These times of minimal secretions were at the beginning of light period. Plasma melatonin in the light period is secreted 62.5％ more than in the dark period in summer- like period and 45.9％ more in winter- like period. Total plasma melatonin in winter-like period is secreted 56.5％ more than in summer-like period. The weights of testis (-20.8％) and body (-7.1％) were reduced in the winter-like period. By the increase of plasma melatonin in mice, body - and testis -weights are decreased, on the contrary by the decrease of plasma melatonin in mice, body and testis weights are increased. In view of the results so far achieved melatonin changes on the body weight and reproductive organ in mice. It is presumed that melatonin effects on the metabolism and sex hormone.

• Biomolecules & Therapeutics
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• 제26권4호
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• pp.358-367
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• 2018

Most organisms have adapted to a circadian rhythm that follows a roughly 24-hour cycle, which is modulated by both internal (clock-related genes) and external (environment) factors. In such organisms, the central nervous system (CNS) is influenced by the circadian rhythm of individual cells. Furthermore, the period circadian clock 2 (Per2) gene is an important component of the circadian clock, which modulates the circadian rhythm. Per2 is mainly expressed in the suprachiasmatic nucleus (SCN) of the hypothalamus as well as other brain areas, including the midbrain and forebrain. This indicates that Per2 may affect various neurobiological activities such as sleeping, depression, and addiction. In this review, we focus on the neurobiological functions of Per2, which could help to better understand its roles in the CNS.