• 제목/요약/키워드: Clinical trial center

검색결과 697건 처리시간 0.02초

The efficacy of low-level diode laser versus laser acupuncture for the treatment of myofascial pain dysfunction syndrome (MPDS)

  • Khalighi, Hamid Reza;Mortazavi, Hamed;Mojahedi, Seyed Masoud;Azari-Marhabi, Saranaz;Parvaie, Parvin;Anbari, Fahimeh
    • Journal of Dental Anesthesia and Pain Medicine
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    • 제22권1호
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    • pp.19-27
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    • 2022
  • Background: Myofascial pain dysfunction syndrome (MPDS) is the most common type of temporomandibular disorder. This study compared the efficacies of low-level diode laser therapy (LLLT) and laser acupuncture therapy (LAT) in the treatment of MPDS. Methods: This double-blind randomized controlled clinical trial included 24 patients with MPDS who were randomly divided into two equally sized groups. Patients in the LLLT group received 12 sessions of low-level diode laser irradiation applied to the trigger points of the masticatory muscles during 1 month. The same protocol was also used in the LAT group according to the specific trigger points. We measured pain intensity and maximum mouth opening in both groups at baseline, during treatment, and 2 months after treatment completion. Results: The pain intensities decreased from 6.58±1.31 to 0.33±0.65 and from 7.08 ± 1.37 to 0 in the LLLT and LAT groups, respectively. The maximum mouth openings increased from 32.25 ± 8.78 mm to 42.58 ± 4.75 mm and from 33 ± 6.57 mm to 45.67 ± 3.86 mm in the LLLT and LAT groups, respectively. Pain intensity (P = 0.839) and level of maximum mouth opening (P = 0.790) did not differ significantly between the groups. Conclusion: Our results showed similar efficacy between LLLT and LAT in the treatment of MPDS signs and symptoms.

A partially hydrolyzed whey formula provides adequate nutrition in high-risk infants for allergy

  • Yang, Jiyeon;Yang, Song I;Jeong, Kyunguk;Kim, Kyung Won;Kim, Yoon Hee;Min, Taek Ki;Pyun, Bok Yang;Lee, Jeongmin;Jung, Ji A;Kim, Jeong Hee;Lee, Sooyoung
    • Nutrition Research and Practice
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    • 제16권3호
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    • pp.344-353
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    • 2022
  • BACKGROUND/OBJECTIVES: Hydrolyzed formula is often fed to infants with gastrointestinal or immune issues, such as malabsorption or cow's milk allergy, because enzymatic treatment has rendered it more digestible and less allergenic than standard cow's milk formula (SF). Partially hydrolyzed formula (PHF) should be considered for those infants who are intolerant to extensively hydrolyzed formula. However, there are concerns about the nutritional insufficiencies of PHF. We aimed to evaluate the effects of PHF on the growth and health indicators in infants who were at high-risk of allergic disease and potential candidates for consuming PHF. SUBJECTS/METHODS: A total of 83 infants aged 0-2 mon with a family history of allergies were assigned to consume either PHF or SF until 24 weeks of age. Anthropometric measures were obtained at baseline, 12 weeks, and 24 weeks; blood samples were drawn and evaluated at the end of the study. RESULTS: No significant differences were observed in weight, height, and weight-for-height at any time point in each sex between the PHF and SF groups. At 24 weeks of age, the weight-for-age and height-for-age z-scores of the SF group were higher than those of the PHF group, but there was no significant difference in the weight-for-height z-score. There were no significant differences in levels of white blood cells, hemoglobin, ferritin, protein, albumin, aspartate aminotransferase, alanine aminotransferase, eosinophil cationic protein, and immunoglobulin E. CONCLUSIONS: In this study, there were no differences in growth and blood panels between the infants consuming PHF or SF. Therefore, infants who are unable to tolerate SF can be fed PHF without nutritional concerns about growth.

다이나믹 테이핑을 적용한 복합 운동프로그램이 긴장성 두통과 전방머리자세를 동반한 만성 목 통증 환자에게 미치는 효과 (Effects of a Complex Exercise Program using Dynamic Taping on Patients with Tension-Type Headache and Chronic Neck Pain with Forward Head Posture)

  • 박삼호;정승화
    • 대한통합의학회지
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    • 제10권4호
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    • pp.23-34
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    • 2022
  • Purpose : This study examined the effects of pain, neck dysfunction, psychosocial level, headache impact test (HIT), postural alignment, and trapezius muscle tone of the complex exercise program using dynamic taping in patients with tension headache and chronic neck pain with forward head posture. Methods : The design of this is a randomized controlled trial (RCT). Thirty-four patients with chronic neck pain were screened using a randomized assignment program and assigned to experimental group (n=17) and control group (n=17). Both groups underwent a complex exercise program. In addition, the experimental group dynamic taping was applied to the upper trapezius muscle. All interventions were applied three times per week for four weeks. The visual analogue scale (VAS), the neck disability index (NDI), short form-12 health survey questionnaire (SF-12), Headache impact test-6 (HIT-6), Craniovertebral angle (CVA), Cranial rotation angle (CRA), upper trapezius muscle tone were compared to evaluate the effect on intervention. Results : Both groups showed significant differences before and after the intervention in VAS, NDI, SF-12, HIT-6, and CVA, CRA (p<.05). In addition, significant differences in NDI and upper trapezius muscle tone were observed between the experimental group and control group (p<.05). Conclusion : A complex exercise program using dynamic taping for patients with tension headache and chronic neck pain with forward head posture are effective method with clinical significance in improving the function and reducing upper trapezius muscle tone.

한의학 신(腎) 기능계에 관한 분자생리학적 고찰 (A Review on "Kidney" Functional System in Korean Medicine : From the Perspective of Molecular Physiology)

  • 박미소;조정효;허왕정;류호룡
    • 동의생리병리학회지
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    • 제36권5호
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    • pp.169-174
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    • 2022
  • In Korean medicine, the "five viscera" theory develops into the theory of homeostasis, in which the dynamic equilibrium state of the yin yang and five elements in the body maintain the balance of the physiological functions. The "five viscera" of the "five elements" can also be referred to as the "functional system," a conceptual system that includes all functional interactions mediated by the organ as well as the organ itself. Nowadays, the structure and function of the organs and tissues in the body are being re-examined, and there is now enough evidence that organs, structures, and their functions that belong to the same "element" are all connected in terms of energy metabolism. The functional system of the "kidney" includes the kidney itself, as well as other components that belong to "water" of the five elements such as bladder, bone, ear, essence, memory, and fear. The authors will discuss the latest findings in science and medicine to expand the understanding of the "Kidney" functional system to the level of molecular physiology.

아동·청소년 대상 정보통신기술(ICT) 기반 국내 건강관련 중재연구의 주제범위 문헌고찰 (A Scoping Review of Information and Communication Technology (ICT)-Based Health-Related Intervention Studies for Children & Adolescents in South Korea)

  • 박지영;배진경;원서현
    • 한국보건간호학회지
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    • 제37권1호
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    • pp.5-24
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    • 2023
  • Purpose: The objective of this review was to identify the research trends in Information and Communication Technology (ICT)-based health-related intervention studies for children and adolescents published in South Korea over the past 10 years. Methods: A scoping review was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta Analyses (PRISMA) and the system classification framework for digital health intervention 1.0 of the World Health Organization (WHO) was applied to analyze how technology was being used to support the needs of the health system. Results: A total of 18 studies were included in the final analysis. The participants were mainly children with a variety of diseases. No studies had used innovative technology platforms such as artificial intelligence (AI), the Internet of Things (IoT), and robotics. In addition, the scope of application of the WHO classification criteria was quite limited. Finally, no intervention study considered technical operational indicators, such as the number of website visits and streaming as outcome measurements. Conclusions: Researchers should introduce advanced technology-based strategies to provide customized and professional healthcare services to children and adolescents in South Korea and continue efforts to integrate innovative ICT for various research purposes, subjects, and environments.

Effects of Non-Contact Complex Exercise Program on the Older over 65 Years of Age on Muscle Strength, Falling Efficacy and Balance Ability

  • Sam Ho Park;Youn Jung Oh;Myung Mo Lee
    • Physical Therapy Rehabilitation Science
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    • 제12권2호
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    • pp.167-176
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    • 2023
  • Objective: The purpose of this study was to investigate the effects of anon-contact complex exercise program on muscle strength, fall efficacy, quality of life, and balance ability in older over 65 years of age. Design: A randomized controlled trial Methods: A total of 37 people in older over 65 years of age participated in the study. Random program was conducted and assigned to the experimental group (n=19) and the control group (n=18). Both groups performed the older people welfare center program. In addition, in the experimental group, a non-contact complex exercise program for muscle and balance exercise was performed. All interventions were performed 2 times a week, for a total of 6 weeks. chair stand test (CST), fall efficacy scale (FES), Euro quality of life 5 dimension (EQ-5D), Berg balance scale (BBS), timed up and go test (TUG), Fullerton advanced balance scale (FAB) were measured before and after the intervention to compare their effectiveness. Results: Both groups showed significant differences in CST, FES, EQ-5D, BBS, and TUG before and after intervention (p<0.05). FAB showed significant differences before and after intervention in all items except for FAB 8 and 9 items in the experimental group. In addition, the experimental group showed significant differences in CST, FES, BBS, TUG, FAB (except 1, 7, 8, 9) compared to the control group (p<0.05). Conclusions: The non-contact complex exercise program is an effective intervention method that has clinical significance in improving muscle strength, fall efficacy and static and dynamic balance abilities for the older over 65 years of age.

Bending 30-gauge needles using a needle guide: fatigue life evaluation

  • Jared Joseph Tuttle;Andrew Doran Davidson;Gregory Kent Tuttle
    • Journal of Dental Anesthesia and Pain Medicine
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    • 제23권5호
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    • pp.281-285
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    • 2023
  • Background: Dentists bend needles prior to certain injections; however, there are concerns regarding needle fracture, lumen occlusion, and sharps handling. A previous study found that a 30-gauge needle fractures after four to nine 90° bends. This fatigue life study evaluated how many 90° bends a 30-gauge dental needle will sustain before fracture when bent using a needle guide. Methods: Two operators at Element Materials Technology, an independent testing, inspection, and certification company tested 48 30-gauge needles. After applying the needle guide, the operators bent the needle to a 90° angle and expressed the anesthetic from the tip. The needle was then bent back to a 0° angle, and the functionality was tested again. This process was repeated until the anesthetic failed to pass through the end of the needle due to fracture or obstruction. Each operator tested 24 needles (12 needles from each lot), and the number of sustained bends before the needle fracture was recorded. Results: The average number of sustained bends before needle failure was 40.33 (95% confidence interval = 37.41-43.26), with a minimum of 20, median of 40, and a maximum of 54. In each trial, the lumen remained patent until the needle fractured. The difference between the operators was statistically significant (P < 0.001). No significant differences in performance between needle lots were observed (P = 0.504). Conclusion: Our results suggest that using a needle guide increases the number of sustained bends before needle fracture (P < 0.000001) than those reported in previous studies. Future studies should further evaluate the use of needle guides with other needle types across a variety of operators. Furthermore, additional opportunities lie in exploring workplace safety considerations and clinical applications of anesthetic delivery using a bent needle.

파킨슨병 환자 대상 음악 및 미술 치료 수요 설문조사 (Music and Art Therapy for Parkinson's Disease Patients: A Demand Survey)

  • 박신영;박미소;허왕정;편우석;류호룡
    • 턱관절균형의학회지
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    • 제13권sup호
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    • pp.9-14
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    • 2023
  • Objectives: The purpose of this study was to investigate patients' demand for music and art therapy in the treatment of Parkinson's disease and to understand how patients view the use of music and art therapy as a complementary form of treatment that can improve their quality of life and increase their self-efficacy in addition to medication. Methods: To this end, 60 Parkinson's patients visiting Daejeon Korean Medicine Hospital at Daejeon University were surveyed about music and art therapy. Results: The survey demonstrated a highly positive response to the music program, with strong belief in its efficacy for Parkinson's disease and significant interest in participation. Group music therapy was perceived as effective for enhancing mental health, respiratory function, language disorders, and overall quality of life. Although the art program was also deemed effective, patients showed slightly lower interest and willingness to participate compared to music therapy. The patients preferred 60-minute sessions once a week for about 8 weeks. Conclusions: We propose the following directions for a Parkinson's music and art therapy program. First, develop a once-a-week, 8-week music and art program for Parkinson's patients. Second, design the music program to focus on improving respiratory function and quality of life. Third, the art program focuses on creating a sense of security and comfort through emotional exchange among patients and improving self-efficacy.

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고혈압 및 당뇨병 환자에서 한식 섭취가 혈청 GGT와 심혈관질환 위험인자에 미치는 영향 (Effects of adherence to Korean diets on serum GGT and cardiovascular disease risk factors in patients with hypertension and diabetes)

  • 정수진;채수완
    • Journal of Nutrition and Health
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    • 제51권5호
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    • pp.386-399
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    • 2018
  • 본 연구는 고혈압 및 당뇨병 치료 중인 환자 41명을 대상으로 한식 섭취가 12주간의 경과 과정에서 4차례의 방문(0주, 4주, 8주, 12주)을 통해 측정한 혈청 GGT, 혈압 및 glycemic control data, 심혈관계 위험지표 및 식이섭취의 변화를 비교 평가한 결과는 다음과 같았다. 1. 연구대상자는 평균 연령은 $61.8{\pm}1.9$세로 한식군 (21명)의 경우 건강한 한식을 1일 3끼씩 12주간 제공된 식사를 섭취하였고, 대조군 (당뇨병 식이 가이드라인에 따른 관리교육을 받은 자) 20명은 평소 섭취하던 당뇨조절 식사를 그대로 유지하게 하였다. 2. 수축기혈압과 이완기혈압은 두군 간 유의한 차이를 확인할 수 없었으나 맥박수는 한식군에서 대조군에 비해 유의적으로 감소하였다 (p = 0.007). 3. 당화혈색소 (HbA1c)는 한식군에서 연구 참여 전과 후 각각 $6.8{\pm}.2%$, $6.1{\pm}.2%$로 감소하고 대조군은 각각 $6.8{\pm}.2%$, $6.5{\pm}.2%$로 감소되어 한식군이 대조군에 비해 유의적으로 감소폭이 컸다 (p = 0.004). 4. 혈청 GGT는 한식군에서 연구 참여 전과 후 각각 $28.8{\pm}4.5IU/L$, $19.8{\pm}3.2IU/L$로 감소하고 대조군은 각각 $30.0{\pm}4.1IU/L$, $33.9{\pm}5.0IU/L$로 증가되어 한식군이 대조군에 비해 유의적으로 감소하였다 (p < 0.001). 5. 총콜레스테롤, LDL 콜레스테롤 및 중성지방은 한식군에서 대조군에 비해 감소한 경향이었으나 두군 간 유의적인 차이가 없었으며 free fatty acid는 한식군에서 대조군 보다 유의적으로 감소하였다 (p = 0.002). 6. 신체계측 지표인 체중 (p = 0.002), 체질량지수 (p = 0.002), 체지방량 (p < 0.001), 체지방율 (p < 0.001)은 연구 참여 전에 비해 연구 참여 12주 후에 한식군에서 대조군에 비해 유의적으로 감소하였다. 7. 치료약물의 변화량은 두군 간 유의한 차이는 없었으나 한식군에서 대조군보다 많은 수의 환자가 실제로 고혈압, 당뇨병 및 고지혈증 치료 약물을 감량할 수 있었다. 8. 한식군은 연구 참여 동안에 전곡류의 밥, 채소류인 나물류, 김치 및 전통 콩발효식품 등의 섭취량은 대조군에 비해 유의하게 증가하였다 (p < 0.001). 9. 한식군은 동물성식품에서 유래한 동물성 단백질 (p < 0.001), 지질 (p < 0.001) 및 콜레스테롤 (p = 0.034)의 섭취량은 대조군에 비해 유의적으로 감소한 반면, 총칼로리(p < 0.001), 엽산 (p < 0.001), 식이섬유 (p < 0.001), 나트륨(p < 0.001), 칼륨 (p < 0.001), 비타민 A, C, E (p < 0.001) 및 비타민 B류 (p < 0.001)의 섭취는 유의적으로 증가하였다. 이상의 결과를 종합해 보면, 적극적인 전곡류로 만든 밥을 중심으로 한 한식 섭취는 당뇨병 및 고혈압 환자에서 대사성질환 및 심혈관계질환 위험인자인 혈청 GGT, 맥박수, 혈당조절 지표 및 비만지표 개선에 긍정적인 영향을 주었다.

심혈관질환 수술을 받은 환자에서 한식식이조절 영양교육이 심혈관질환 위험요인에 미치는 영향 (Effects of Korean diet control nutrition education on cardiovascular disease risk factors in patients who underwent cardiovascular disease surgery)

  • 정수진;채수완
    • Journal of Nutrition and Health
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    • 제51권3호
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    • pp.215-227
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    • 2018
  • 본 연구는 심혈관질환으로 심장수술을 받은 환자 15명 대상에게서 12주 동안 한식으로 식이조절 교육을 통해 한식 섭취가 증가하고 이를 통해 CVD 위험인자 및 약물 투여량의 변화, 영양소 섭취량에 미치는 영향과 관련성에 대한 분석 결과는 다음과 같았다. 1. 대상자의 평균 연령은 $60.7{\pm}2.5$세로 최근 3년 이내에 심혈관질환 수술을 받고 지속적으로 심혈관질환 약물을 복용하고 있는 환자였다. 2. 대상자의 한식 식이조절 교육 순응도 점수는 교육 전 $35.8{\pm}0.9$점에서 교육 후 $43.0{\pm}1.2$점으로 유의적으로 증가하였는데 (p < 0.001), 이는 한식 섭취를 적극적으로 실천하였음을 시사한다. 3. 대상자의 비만지표인 체중 및 체질량지수는 교육 후, 감소 경향을 보였으며 허리둘레 (p = 0.002) 및 허리 엉덩이둘레비인 WHR (p < 0.001)는 유의적으로 감소하였다. 4. 대상자들의 혈당조절 지표인 HbA1c는 교육 전 $7.3{\pm}1.0%$에서 교육 후 $7.0{\pm}1.1%$로 유의적으로 감소하였다 (p < 0.05). 5. 대상자들의 항고혈압제약물의 투여량 변화는 교육 전 2.1개에서 교육 후 1.7개로 줄었음에도 불구하고 혈압은 정상범위에서 안정적으로 유지되었음을 확인하였다. 항당뇨병 약제 복용량은 유의적인 변화는 보이지 않았으나, 안정된 상태로 적절한 혈당을 유지함과 동시에 혈당 조절 지표인 당화혈색소가 감소함을 확인하였는데 이는 혈당조절이 개선되고 있는 것으로 나타났다. 6. 한식 식사유형인 음식군별 섭취량의 변화는 교육 전에 비해 교육동안에 전곡류로 지은 밥 중심의 식사량이 유의적으로 증가하였고 (p = 0.018), 채소류인 나물류 (p = 0.007), 김치 (p < 0.001) 및 전통 콩발효 양념 (p < 0.001) 등의 섭취가 유의적으로 증가하였다. 7. 대상자들의 영양소 섭취는 일일 에너지 섭취량은 변화가 없었으나 교육 전보다 교육 동안에 동물성급원식품에서 유래한 동물성 단백질과 지질 및 콜레스테롤의 섭취량은 유의적으로 감소 (p < 0.05)한 반면 나트륨 (p = 0.019), 칼륨 (p = 0.028), 식이섬유 (p < 0.050), 비타민 A (p = 0.028), 비타민 C (p = 0.010) 및 엽산 (p < 0.001)의 섭취는 유의적으로 증가하였다. 이상의 결과를 종합해 보면, 적극적인 한식 섭취를 권장하고 장려하는 식이조절교육 중재는 심혈관질환 수술을 받은 환자에게서 영양소 섭취와 심혈관계 위험인자인 비만지표, 혈당조절 지표에 대하여 긍정적인 영향을 주었다. 본 연구의 한계로는 교육에 참여한 대상자가 15명으로 다소 적었으며 단기 교육에 의한 전후 비교 평가에 의한 것으로 그 결과를 일반화하기에는 제한점이 있다. 따라서 향후 연구 장기간의 교육과 대조군이 있는 비교 연구가 필요할 것으로 사료된다.