Nutrition Research and Practice

The Korean Nutrition Society (한국영양학회)
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A partially hydrolyzed whey formula provides adequate nutrition in high-risk infants for allergy

  • Yang, Jiyeon (Department of Integrated Biomedical and Life Science, Graduate School, Korea University) ;
  • Yang, Song I (Department of Pediatrics, Hallym University Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Jeong, Kyunguk (Department of Pediatrics, Ajou University School of Medicine) ;
  • Kim, Kyung Won (Department of Pediatrics, Yonsei University College of Medicine) ;
  • Kim, Yoon Hee (Department of Pediatrics, Yonsei University College of Medicine) ;
  • Min, Taek Ki (Department of Pediatrics, Soonchunhyang University Hospital) ;
  • Pyun, Bok Yang (Department of Pediatrics, Soonchunhyang University Hospital) ;
  • Lee, Jeongmin (Department of Pediatrics, Ajou University School of Medicine) ;
  • Jung, Ji A (Maeil Innovation Center, Maeil Dairies Co., Ltd.) ;
  • Kim, Jeong Hee (Department of Pediatrics, Inha University Hospital, Inha University College of Medicine) ;
  • Lee, Sooyoung (Department of Pediatrics, Ajou University School of Medicine)
  • Received : 2021.02.23
  • Accepted : 2021.08.25
  • Published : 2022.06.01
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Abstract

BACKGROUND/OBJECTIVES: Hydrolyzed formula is often fed to infants with gastrointestinal or immune issues, such as malabsorption or cow's milk allergy, because enzymatic treatment has rendered it more digestible and less allergenic than standard cow's milk formula (SF). Partially hydrolyzed formula (PHF) should be considered for those infants who are intolerant to extensively hydrolyzed formula. However, there are concerns about the nutritional insufficiencies of PHF. We aimed to evaluate the effects of PHF on the growth and health indicators in infants who were at high-risk of allergic disease and potential candidates for consuming PHF. SUBJECTS/METHODS: A total of 83 infants aged 0-2 mon with a family history of allergies were assigned to consume either PHF or SF until 24 weeks of age. Anthropometric measures were obtained at baseline, 12 weeks, and 24 weeks; blood samples were drawn and evaluated at the end of the study. RESULTS: No significant differences were observed in weight, height, and weight-for-height at any time point in each sex between the PHF and SF groups. At 24 weeks of age, the weight-for-age and height-for-age z-scores of the SF group were higher than those of the PHF group, but there was no significant difference in the weight-for-height z-score. There were no significant differences in levels of white blood cells, hemoglobin, ferritin, protein, albumin, aspartate aminotransferase, alanine aminotransferase, eosinophil cationic protein, and immunoglobulin E. CONCLUSIONS: In this study, there were no differences in growth and blood panels between the infants consuming PHF or SF. Therefore, infants who are unable to tolerate SF can be fed PHF without nutritional concerns about growth.

Keywords

Acknowledgement

We are grateful to the participating infants and their parents. We also thank the clinicians for contacting caregivers to recruit participants.

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