• Journal of Periodontal and Implant Science
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• v.48 no.1
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• pp.47-59
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• 2018

Purpose: To evaluate the clinical and microbiological effects of the local use of egg yolk immunoglobulin against Porphyromonas gingivalis (anti-P.g. IgY) as an adjunct to scaling and root planing (SRP) in the treatment of moderate to severe chronic periodontitis. Methods: This was a randomized, placebo-controlled, double-blind trial involving 60 systematically healthy patients with moderate to severe chronic periodontitis. Subjects (n=20/group) were randomly assigned to receive SRP combined with subgingival irrigation of anti-P.g. IgY and anti-P.g. IgY mouthwash, subgingival irrigation of 0.2% chlorhexidine and 0.2% chlorhexidine mouthwash, or subgingival irrigation of placebo and placebo mouthwash for 4 weeks. Probing pocket depth, clinical attachment level, bleeding on probing, and the plaque index were evaluated at baseline and at 4 weeks. Subgingival plaque, gingival crevicular fluid, and saliva were simultaneously collected for microbiological analysis. Results: Our results showed that anti-P.g. IgY mouthwash was as effective as chlorhexidine at improving clinical parameters over a 4-week period. All the groups showed a significant reduction in levels of P.g. at 4 weeks. No significant difference was observed in the test group when compared to placebo regarding the reduction in the levels of P.g. Anti-P.g. IgY significantly suppressed the numbers of red complex bacteria (RCB) in subgingival plaque and saliva in comparison with placebo. No adverse effects were reported in any of the subjects. Conclusions: Within the limitations of the study, the present investigation showed that passive immunization with anti-P.g. IgY may prove to be effective in the treatment of chronic periodontitis due to its ability to improve clinical parameters and to reduce RCB. No significant differences were found between the anti-P.g. IgY and placebo groups in the reduction of P.g.

• Journal of Yeungnam Medical Science
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• v.39 no.1
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• pp.39-45
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• 2022

Background: The current guidelines for the diagnosis of acute pyelonephritis (APN) recommend that APN be diagnosed based on the clinical features and the presence of pyuria. However, we observed that some of the patients who are diagnosed with APN do not have characteristic clinical features or pyuria at the initial examination. We performed this study to investigate the characteristics of APN without pyuria. Methods: A retrospective, cross-sectional study was conducted on 391 patients diagnosed with APN based on clinical and radiologic findings, between 2015 and 2019. The clinical features, laboratory results, and computed tomography (CT) findings were compared between patients with normal white blood cell (WBC) counts and those with abnormal WBC counts (WBC of 0-5/high power field [HPF] vs. >5/HPF) in urine. Results: More than 50% of patients with APN had no typical urinary tract symptoms and one-third of them had no costovertebral angle (CVA) tenderness. Eighty-eight patients (22.5%) had normal WBC counts (0-5/HPF) on urine microscopy. There was a negative correlation between pyuria (WBC of >5/HPF) and previous antibiotic use (odds ratio, 0.249; 95% confidence interval, 0.140-0.441; p<0.001), and the probability of pyuria was reduced by 75.1% in patients who took antibiotics before visiting the emergency room. Conclusion: The diagnosis of APN should not be overlooked even if there are no typical clinical features, or urine microscopic examination is normal. If a patient has already taken antibiotics at the time of diagnosis, imaging studies such as CT should be performed more actively, regardless of the urinalysis results.

• Journal of Korean Dental Science
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• v.16 no.2
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• pp.172-181
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• 2023

Purpose: To investigate the effect of epidermal growth factor (EGF) with collagen matrix (CM) for increasing gingival thickness. Materials and Methods: In five mongrel dogs, bilateral gingival defects were surgically made on the maxillary canines. After two months, either a subepithelial connective tissue graft (group SCTG) or CM with EGF (0.1 ug/ml, group EGF) was grafted, and the flap was coronally positioned to cover the graft materials. The animals were sacrificed after three months. Intraoral scanning was performed for soft tissue analysis. Histologic and histomorphometric analyses were performed. Result: Two animals exhibited wound dehiscence during the healing phase, leaving three for analysis. No statistically significant difference was found in soft tissue changes (P>0.05). The level of gingival margin (GM) increased in both groups (1.02±0.74 mm in group SCTG vs. 1.24±0.83 mm in group EGF). Linear increases at the GM pre-augmentation in the soft tissue profile were 1.08±0.58 mm in group SCTG and 0.96±0.73 mm in group EGF. Histomorphometric parameters (keratinized tissue height, tissue thickness, and rete peg density) were not significantly different between the groups (P>0.05). Conclusion: EGF loaded onto CM led to comparable gingival phenotype enhancement to SCTG.

• Communications for Statistical Applications and Methods
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• v.15 no.5
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• pp.727-735
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• 2008

Consider a clinical trial in which the main end-point is survival. Suppose after the start of the study an intermediate event occurs which may be influenced by a covariate(or treatment). In many clinical studies the occurrence of an intermediate event may change the survival distribution. This investigation develops two-stage model which, in the first stage, models the effect of covariate on the intermediate event and models the relationship between survival time and covariate as well as the intermediate event. In this paper, the two-stage model is presented in order to model intermediate event and a test based on this model is also provided. A numerical simulations are carried out to evaluate its overall significance level.

• Journal of Oriental Neuropsychiatry
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• v.18 no.3
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• pp.97-112
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• 2007

Objectives : This study aimed for desirable cure through the investigation of The Patient-Doctor Relationship in Eastern Medicine. Methods : Research materials is data of the patient the doctor and the Patient-Doctor Relationship in Eastern Medicine bibliography except medical theory and clinical contents. Results and Conclusion :. 1. Relatively the doctor's position origin from exorcist has it over patient's that. 2. In spite of clinical doctor, Confucian physician have Confucianism and the ethics so they set The Patient-Doctor Relationship in Eastern Medicine essentially. 3. Each of doctor(the doctor-doctor relationship) emphasize the partnership in the Patient-Doctor Relationship. 4. Patient's choice for doctor is source of the Patient-Doctor Relationship basically and the choice are prudent. 5. The patient must carry into practice psychological and body medical affairs related to health preserving 6. For desirable Patient-Doctor Relationship, doctor's inquire is considered with temper and circumstance and a consultation room are also required stability. 7. Poor Patient-Doctor Relationship are come about when patient is not trust doctor, patient is not follow doctor's order and doctor's indifference to patient.

• Korean Journal of Clinical Laboratory Science
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• v.47 no.1
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• pp.11-16
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• 2015

This paper presents an investigation into factors influencing the level of prostate specific antigens (PSAs) in men with a focus on abdominal obesity. Data were collected from the exam results and medical records of male clients that visited a university hospital in Suwon for a general check-up. The data of total 1,039 were put to frequency analysis, descriptive statistics, independent-sample t-test, one-way ANOVA, chi-squared test, and multiple regression analysis. The subjects were men in their twenties to in their seventies. The study analyzed whether there would be differences in mean PSAs according to the characteristics of the subjects and found significant differences according to age, BMI, and waist. The findings indicate that abdominal obesity influences the level of PSAs in men and that men with abdominal obesity should not neglect the level of PSAs even in the normal range.

• Sleep Medicine and Psychophysiology
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• v.10 no.1
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• pp.5-11
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• 2003

Sleep apnea syndrome is a common clinical disorder characterized by intermittent cessation of airflow at nose and mouth during sleep. The clinical significance of this syndrome is that it is one of the most common causes of excessive daytime sleepiness. It can also cause neuropsychiatric, cardiovascular, and cerebrovascular complications. The standard for diagnosis of sleep apnea syndrome is nocturnal polysomnography. Because polysomnography is a time-consuming and expensive test, many efforts have been made to replace polysomnography with a simpler system of monitoring, but no method has yet been approved as a definitive investigation method. The goals of treatment for this syndrome are to eliminate excessive daytime sleepiness and to reduce the risk of possible cardiovascular complications. Continuous positive airway pressure is the most definite and widely accepted treatment for achieving these goals. Other treatments such as surgical treatment, oral appliances, and behavioral therapy may be useful for selected patients who are mildly affected.

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.5
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• pp.1147-1150
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• 2003

Modern Objectification of Pulse Diagnosis, One of the Four Diagnosis Method of Oriental Medicine, is necessarily project to improving Oriental medical clinic status and quality by standardization of diagnosis database. At that, accurate measurement equipment or devices(sensor, system and instruments, etc,) to exactly detect MacSang(脈診 : the parameter and subject of pulse diagnosis) have not developed yet. Existing Pulse diagnosis devices are not satisfy clinical needs and medical equipments quality. We study for pulse diagnosis system, that CD is satisfying oriental medical clinic needs, is ensuring accuracy and reappearance to support in clinical diagnosis and treatment, is guaranteeing the quality of medical equipments. theoretical base and convenience.

• Annals of Clinical Neurophysiology
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• v.7 no.1
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• pp.22-24
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• 2005

We report a case of thoracolumbar radiculopathy presented with first symptom of leptomeningeal metastasis. A 65-year old man with non-Hodgkins lymphoma with complete remission was referred for further investigation of dull pain and numbness of right lower quadrant of abdomen. Electromyogram revealed right thoracolumbar radiculopathy. After two weeks, he complained severe continuous bilateral frontal dull headache. An examination of the cerebrospinal fluid revealed malignant lymphoid cells. We would like to emphasize that radiculopathy sometimes presents with first symptom of leptomeningeal metastasis.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.4
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• pp.1525-1527
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• 2015

Objective: To investigate the clinical effect of riboflavin sodium phosphate on prevention of radiotherapy related esophagitis (RRE). Methods: This retrospective study involved 55 patients with middle and advanced esophageal cancer who were divided into an experimental group of 28 and a control group of 27 patients. Those in the experimental group were treated with riboflavin sodium phosphate combined with conventional symptomatic treatment during radiotherapy; while patients in control group received the latter alone. The incidence and degree of RRE were compared after radiotherapy. Results: The incidences of RRE in experimental and control group were 53.5% and 81.4%, respectively (p<0.05); the incidence of stages III and IV RRE in the experimental group was 17.8%, while in the control group it was 44.4% (p<0.05). Conclusion: Riboflavin sodium phosphate could significantly prevent RRE and reduce the incidence of stage III and IV disease. These results were worthy of further confirmation by randomized controlled trials.