• 대한치과의사협회지
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• 제48권8호
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• pp.576-586
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• 2010

Recent advancement in molocular biology enhanced further understanding of the carcinogenesis of oral cancer and its relation with various genetic backgrounds. Familial risk factors includes similar habits of the family and polymorphic variations of the genes. Recently, human papilloma virus has been suggested to be linked with oral cancer progression. Enhancement of understanding of the damage or alteration in molecular pathway in various cellular response of oral cancer progression would lead the targeted therapy or precise early diagnosis of the oral cancer.

• 대한간호학회지
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• 제34권5호
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• pp.838-848
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• 2004

Purpose: This study was to describe nurses' research activities, perceptions and performances of evidence-based practice and barriers to the use of research evidence in nursing practice in Korea. Method: A cross-sectional survey design was used. A questionnaire, except for Barriers Scale, was developed for the study. Data was collected from a convenient sample of 437 registered nurses working at research and education oriented university hospitals. Result: Nurses' research-related activities were relatively low compared to previous studies. Also perceptions and performances of evidence based nursing practice were low. Preferred informational resources for clinical decision making were identified as ward manuals/clinical guidelines, manager/senior nurses, and literature/research. The major barriers to research utilization were a lack of implication for practice along with inadequate facilitation to implement research evidence and difficulty understanding research written in English. Priorities of barriers factor were Administrator, Communication, Adopter, and Research. Conclusion: The findings provide directions for future training, education, and managerial policy to achieve successful evidence based nursing practice.

• 한국동물학회:학술대회논문집
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• 한국동물학회 1996년도 한국생물과학협회 국제학술대회
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• pp.151.2-151
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• 1996

No Abstract, See Full Text

• The Journal of Advanced Prosthodontics
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• 제2권2호
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• pp.50-53
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• 2010

BACKGROUND. In order to restore severely attrited teeth properly, surgical intervention in the form of a crown-lengthening procedure may be required. And also, proper diagnosis and treatment sequencing is critical to obtain a successful results. Adequate diagnostic wax-up ensures good esthetics and healthy periodontal tissue. CASE DESCRIPTION. This clinical case report describes a diagnostically based protocol for restoration on mandibular anterior teeth with crown lengthening procedure and the treatment of partially edentulous mandible combined with an edentulous maxilla. In addition, the effort to prevent the combination syndrome was described. CLINICAL IMPLICATION. An interdisciplinary diagnosis and examination through visualization of the desired results ensure conservative and more predictable outcome.

• BMB Reports
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• 제55권1호
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• pp.3-10
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• 2022

Extracellular vesicles (EVs) released from different types of kidney cells under physiologic conditions contribute to homeostasis maintenance, immune-modulation, and cell-to-cell communications. EVs can also negatively affect the progression of renal diseases through their pro-inflammatory, pro-fibrotic, and tumorigenic potential. Inhibiting EVs by blocking their production, release, and uptake has been suggested as a potential therapeutic mechanism based on the significant implication of exosomes in various renal diseases. On the other hand, stem cell-derived EVs can ameliorate tissue injury and mediate tissue repair by ameliorating apoptosis, inflammation, and fibrosis while promoting angiogenesis and tubular cell proliferation. Recent advancement in biomedical engineering technique has made it feasible to modulate the composition of exosomes with diverse biologic functions, making EV one of the most popular drug delivery tools. The objective of this review was to provide updates of recent clinical and experimental findings on the therapeutic potential of EVs in renal diseases and discuss the clinical applicability of EVs in various renal diseases.

• Journal of Chest Surgery
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• 제37권3호
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• pp.252-260
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• 2004

다량의 흉수는 수술 전 방사선 검사로 쉽게 평가할 수 있지만, 미량의 흉수나 흉막의 미세전이를 평가하는 것은 매우 어렵다. 본 연구는 원발성 폐암 환자에서 미량의 흉수나 흉막의 미세전이 여부가 예후에 미치는 영향을 연구하기 위해 흉강 세척액 세포검사를 시행해서 그 결과를 분석하였다. 1998년 11월부터 2002년 8월까지 서울아산병원 흉부외과에서 원발성 폐암으로 폐절제술을 시행받은 환자 중 수술 전 방사선 검사에서 흉수가 없고, 수술 소견에서 종양의 흉벽 침범 소견이 없고, 광범위한 흉막 유착 소견이 없었던 315명을 대상으로 삼아 전향적으로 연구하였다. 흉강 세척액은 개흉 직후와 수술이 끝나고 흉강을 봉합하기 직전에 생리식염수 100 mL로 흥강을 세척해서 검체를 얻어 세포조직학적 검사를 시행하였다. 대상 환자는 남자 237명, 여자 78명이며, 평균 연령은 60.8$\pm$9.7세(27∼82세)였다. 315명의 흉강 세척액 세포검사에서 악성세포가 발견된 경우는 총 28예(8.9%)였으며, 20예(6.3%)는 개흉 직후 시행한 흉강 세척액 세포검사에서 악성세포가 발견되었다. 흉강 세척액 세포검사에서 악성세포의 양성률은 조직학적 세포형, 림프절 전이, 장측 흉막 침범 여부 등과 통계학적으로 유의한 차이가 없었다. Stage I 및 II 환자 중 흉강 세척액 세포검사에서 악성세포가 음성인 군은 1년 생존율이 93.9%인 반면 양성인 군은 85.7%로 통계학적으로 유의한 차이가 없었다. 재발은 31예(13.6%)에서 있었고, 2-year recurrence-free rate는 흉강 세척액 세포검사에서 악성세포가 음성인 군(90.1%)과 양성인 군(87.5%) 사이에 유의한 차이를 보이지 않았다. 대상 환자들의 중간 추적기간은 16.4개월(1∼48개월)였다. 원발성 폐암으로 폐절제술을 받은 환자에서 시행한 흉강 세척액 세포검사에서 악성세포의 존재 유무는 수술 후 생존율이나 재발률에 있어 통계학적으로 유의한 영향을 미치지 않았지만 대상 환자들의 평균 추적기간이 짧은 점 등을 고려할 때 향후 지속적인 연구가 필요하다고 생각한다.

• Clinical and Experimental Pediatrics
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• 제51권10호
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• pp.1031-1037
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• 2008

Macrolide antimicrobial agents including erythromycin, roxithromycin, clarithromycin, and azithromycin are commonly used in the treatment of respiratory tract infections in children. Newer macrolides that have structural modifications of older drug erythromycin show improved change in the spectrum of activity, dosing, and administration. However, recent studies reported that increasing use of macrolide antibiotics is the main force driving the development of macrolide resistance in streptococci. In particular, azithromycin use is more likely to select for macrolide resistance with Streptococcus pneumoniae than is clarithromycin use, a possible reflection of its much longer half life. Recently, erythromycin resistance rates of S. pneumoniae and Streptococcus pyogenes are rapidly increasing in Korea. Two main mechanisms of acquired macrolide resistance have been described, altered binding site on the bacterial ribosome encoded by the ermB gene and active macrolide efflux pump encoded by the mef gene. Relationship between the susceptibility of S. pneumoniae and the response to macrolides has been shown in studies of acute otitis media, but less clear in cases of pneumonia. This article reviews the spectrum of activity, pharmacokinetic properties, mechanisms of action and resistance, and clinical implication of resistance on the treatment of respiratory tract infections in children.

• 생물정신의학
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• 제19권1호
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• pp.9-16
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• 2012

This article aimed to describe typical event-related potentials (ERP) components of emotional processing in patients with anxiety disorder and highly anxious individuals. ERP components associated with emotional processing could be broadly divided into three components with short, middle and long, respectively. Many studies show that patients with anxiety disorders are characterized by different emotional bias to specific stimuli and more sensitive to emotional stimuli than normal individuals. In addition, these emotional biases were stronger and quicker in patients with anxiety disorder than normal individuals. Some studies reported that anxious people show abnormality at the initial stage (e.g. P1) of emotional processing. However, other studies reported the abnormality at the late stage (e.g. LPP) or wholeness of emotional processing in anxious individuals. We summarized the updated finding of possible ERP components of emotional processing in patients with anxiety disorder and highly anxious individuals. The significance and clinical implication were discussed.

• The Korean Journal of Pain
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• 제8권2호
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• pp.319-323
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• 1995

The implication of cervical pain associated with an elongated styloid process is credited to W.W.Eagle. Even though there were earlier reports of ossification of the stylohyoid ligament, findings in more than 200 cases in 1980s and 1940s resulted in the naming of a clinical syndrome that continues to bear his name, Eagle's syndrome. It is also sometimes called styloid process neuralgia or elongated styloid process syndrome is more common than generally recognized. The clinical symptoms range from a dull nagging pain with occasional radiation to ear, or to a foreign body sensation. Dysphagia and odynophagia may also occur. We successfully treated one case by removal of the elongated styloid process under the general anesthesia and C2 ganglion block. We then reported the clinical feature of one case of the Eagle's syndrome and further researched with the foreign literature.

• 한국재난정보학회 논문집
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• 제17권4호
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• pp.778-785
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• 2021

연구목적: 본 연구의 목적은 팬데믹 상황에서 의료정보관리방식이 가져다 줄 국가적 통제 가능성과 그 한계를 제시하고자 하는 것으로 의료정보 관리와 정보의 이용허가가 의료산업에 미치는 영향을 분석하고자한다. 연구방법: 연구목적을 위해 본조사는 국가별 대응 움직임의 유일한 표준화 근거인 임상시험등록플랫폼(International Clinical Trial Registry Platform, ICTRP)의 primary registry, 2019년 12월 첫 발생 시점부터 2020년 3월 30일, 해당 기간 기준, 780명의 등록자료를 확보해 임상시험계획 승인을 위한 '임상 시험등록정보'공개 정도를 검토하고 그 영향을 분석하였다. 연구결과: 연구 결과는 임상시험등록의 정보 이용은 COVID-19와 관련된 새 치료제 개발, 백신 개발 등에 효과가 있음을 입증하였다. 결론: 연구의 결론은 각 국가는 이번 COVID-19의 신약 개발을 위해 다양한 임상 시험방법을 시도하고 있는 것으로 나타났으며 제약회사들은 CRIS에 임상시험 결과를 등록하여 많은 나라가 데이터를 공유하도록 하여 치료제나 백신 개발에 전념해야 한다.