• Korean Circulation Journal
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• 제54권3호
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• pp.158-159
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• 2024

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제19권3호
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• pp.193-198
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• 2016

Purpose: Spontaneous colon perforations are usually encountered as necrotizing enterocolitis in the neonatal period, but occur rarely in infants and children without pathological conditions. This study was conducted to describe its clinical implication beyond the neonatal period. Methods: Cases of spontaneous colon perforation confirmed after the operation were reviewed retrospectively and the clinicopathological characteristics were analyzed. Clinical data were compared according to the presence of pneumoperitoneum as initial findings. Results: Eleven patients were included in the study period and showed a history of hospitalization before transfer due to management for fever, respiratory or gastrointestinal problems. Six patients showed a sudden onset of abdominal distention and only seven patients showed a pneumoperitoneum as initial radiologic findings, however there were no significant clinicopathological differences. Perforation was found evenly in all segments of the colon, most commonly at the sigmoid colon in four cases. There were no specific pathologic or serologic causes of perforation. Conclusion: When previously healthy infants and children manifest a sustained fever with a sudden onset of abdominal distention during management for fever associated with respiratory or gastrointestinal problems, there is a great likelihood of colon perforation with no pathological condition. Prompt surgical management as timely decision-making is necessary in order to achieve a good progress.

• Journal of Korean Neurosurgical Society
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• 제45권5호
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• pp.289-292
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• 2009

Objective : Although there are several descriptions of this vessel, there is no detailed angiographic study of the accessory middle cerebral artery (AMCA) in Korea. We describe the angiographic characteristics of the cortical territory and origin of AMCA and discuss the clinical significance of this anomaly. Methods : We searched for patients with AMCAs from a retrospective review of 1,250 conventional cerebral angiograms. We determined the origins, diameters and cortical territories of these AMCAs. Results : Fifteen patients (15 of 1250 = 1.2%) had 16 AMCAs (one patient had bilateral AMCAs). AMCAs originated from the distal A1 in eleven cases, middle A1 in two, proximal A1 in two, and proximal A2 in one case. All AMCAs followed a course parallel to the main middle cerebral artery (MCA). All but three of these arteries were smaller than the main MCA. Thirteen of the smaller diameter AMCAs had cortical distribution to the orbito-frontal and prefrontal, and precentral areas. Three AMCAs had diameter as large as the main MCA. These three supplied the orbito-frontal, prefrontal, precentral, central and anterior-parietal arteries. Conclusion : The AMCAs originated from A1 or A2. Most had smaller diameter than the main MCA. The AMCAs coursed along the horizontal portion of the MCA, but supplied the orbital surface, the anterior frontal lobe and sometimes wider cortical territory, including the precentral, central, anterior-parietal areas.

• Korean Journal of Otorhinolaryngology-Head and Neck Surgery
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• 제60권3호
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• pp.99-106
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• 2017

Listening effort is defined as a listener's mental exertion required to understand a speaker's auditory message, especially when distracting conditions are present. This review paper analyzed several subjective scaling tools used to measure the listening effort in order to suggest the best tool for use with hearing-impaired listeners who have to expend much effort even in everyday life. We first explained the importance of measuring listening effort and discussed various kinds of measurements. We then analyzed and categorized 15 recently published articles (i.e., from 2014 to 2016) into three topics: performance and listening effort, listening effort and fatigue, and clinical implication of listening effort. We compared the articles in terms of pros and cons and also identified 10 tools for use in the subjective scaling. Although none of these tools were unified or standardized easily, we concluded that 7-point scale would be the most reasonable as a less time-consuming measurement for compartmentalizing the degree of listening effort. If used with objective tools for measuring the listening effort, the subjective scaling could be a powerful tool for clinical use.

• 한국지능시스템학회논문지
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• 제18권6호
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• pp.849-855
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• 2008

The Diagnostic Unit of CLINAID can infer working diagnoses for general diseases from the information provided by a user. This user-provided information in the form of signs and symptoms, however, is usually not sufficient to make a final decision on a working diagnosis. In order for the Diagnostic Unit to reach a diagnostic conclusion, it needs to select suitable clinical investigations for the patients. Because different investigations can be selected for the same patient, we need a process that can optimize the selection procedure employed by the Diagnostic Unit. This process, called a selection algorithm, must work with the fuzzy relational method because CLINAID uses fuzzy relational structures extensively for its knowledge bases and inference mechanism. In this paper we present steps of the selection algorithm along with simulation results on this algorithm using fuzzy relational products, both harsh product and mean product. The computation results of applying several different fuzzy implication operators are compared and analyzed.

• BMB Reports
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• 제38권1호
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• pp.1-8
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• 2005

Transforming growth factor-$\beta$ is a pleiotropic growth factor that has enthralled many investigators for approximately two decades. In addition to many reports that have clarified the basic mechanism of transforming growth factor-$\beta$ signal transduction, numerous laboratories have published on the clinical implication/application of transforming growth factor-$\beta$. To name a few, dysregulation of transforming growth factor-$\beta$ signaling plays a role in carcinogenesis, autoimmunity, angiogenesis, and wound healing. In this report, we will review these clinical implications of transforming growth factor-$\beta$.

• Clinical and Experimental Reproductive Medicine
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• 제13권2호
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• pp.129-136
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• 1986

While the technique of In Vitro Fertilization and Embryo Transfer has been proven undoutedly, it is for from reaching a consensus on the legal implication. Legal authority regarding clinical therapeutic In Vitro Fertilization and Embryo Transfer is, for all practical purpose, nonexistant. In this paper, it is discussed existing regulation dealing with In Vitro Fertilization and Embryo Transfer and related areas i.e. the regulation related medical technologies, the use of donor sperm, donor eggs, surrogate uteri, multiple pregnancy, miscarriages, extra embryos, the technique of cryopreservation. The legality of embryo donation, the responsibility for embryo preservation or destruction and the legal status of the embryos are surveyed. Finally the various legal theories that may give rise to physician liability in connection with clinical In Vitro Fertilization are also reviewed.

• Tuberculosis and Respiratory Diseases
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• 제82권3호
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• pp.179-189
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• 2019

Although recent advances in molecular targeted therapy and immuno-oncology have revolutionized the landscape of lung cancer therapeutics, cytotoxic chemotherapy remains an essential component of lung cancer treatment. Extensive evidence has demonstrated the clinical benefit of chemotherapy, either alone or in combination with other treatment modalities, on survival and quality of life of patients with early and advanced lung cancer. Combinational approaches with other classes of anti-neoplastic agents and new drug-delivery systems have revealed promising data and are areas of active investigation. Chemotherapy is recommended as a standard of care in patients that have progressed after tyrosine kinase inhibitors or immune checkpoint inhibitors. Chemotherapy remains the fundamental means of lung cancer management and keeps expanding its clinical implication. This review will discuss the current position and future role of chemotherapy, and specific consideration for its clinical application in the era of precision medicine.

• 간호행정학회지
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• 제15권1호
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• pp.37-44
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• 2009

Purpose: The purpose of this study was to investigate the relationship between professional self-concept, self-efficacy and job satisfaction of clinical nurse in schoolwork. Method: Data was collected from convenient sample of 407 nurses in 3 cities. The questionnaire measured the level of professional self-concept, self-efficacy and job satisfaction of clinical nurse in schoolwork. The data were analyzed using descriptive statistics, t-test, ANOVA, and Pearson's correlation coefficient, partial correlation. Result: The mean score of professional self-concept was 2.83(${\pm}.34$) self-efficacy was 3.64(${\pm}.31$), job satisfaction was 3.12(${\pm}.38$). There were significant differences on three variables according to age, a clinical career, level of education. There was a significant positive correlation between professional self-concept and self-efficacy, job satisfaction. The self-efficacy was a significant positive correlation with job satisfaction. Conclusions: From the studies reviewed, it can expect the positive effect to improve the self-efficacy, professional self-concept and job satisfaction when the nurses who have continuous education and organizational support. These findings would be important resource to nurse administrators for clinical implication.

• 한국유전체학회:학술대회논문집
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• 한국유전체학회 2006년도 The 15th Korean Genome Organization Conference KOGO 2006 Annual Meeting
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• pp.51-51
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• 2006