• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2017년도 제48회 춘계학술대회논문집
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• pp.517-520
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• 2017

본 논문은 추진기관 기밀체결부의 설계변수가 기밀조립부의 갭 거동과 오링의 기밀성능에 미치는 영향을 분석하고 효과적인 설계변수 설정 방안을 도출하였다. 체결부의 설계변수를 구성하는 요소로서 노즐 플랜지 두께, 체결볼트에 가하는 예비하중을 단계별로 변화하여 연소관 내압거동에 따른 기밀조립부 갭 벌어짐을 최소화하고 나아가서 기밀용 오링의 기밀성능을 효과적으로 유지할 수 있는 설계변수 조건을 평가함으로써 추진기관 연소관 노즐 기밀체결부의 효율적인 설계 방법론을 제시하였다.

• Archives of Pharmacal Research
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• 제24권4호
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• pp.333-337
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• 2001

The pharmacokinetic changes of diltiazem (DTZ) and its main metabolite, deacetyldiltiazem (DAD) were studied after oral administration of DTZ to normal rabbits and mild and medium folate-induced renal failure rabbits. DTZ 10 mg/kg was given to the rabbits either orally (n=6). Plasma concentrations of DTZ and DAD were determined by a high performance liquid chromatography assay. The area under the plasma concentration-time curves (AUC) and maximum plasma concentration ($C_{max}$) of DTZ were significantly increased in mild and medium folate-induced renal failure rabbits. The metabolite ratio of the DTZ to DAD were significantly decreased in mild and medium folate-induced renal failure rabbits. The volume of distribution ($V_{d}$) and total body clearance ($CL_{t}$) of DTZ were significantly decreased in mild and medium folate-induced renal failure rabbits. The elimination rate constant ($\beta$) of DTZ was significantly decreased in folate-induced renal failure rabbits, but that of DAD was significantly increased. These findings suggest that the hepatic metabolism of DTZ was inhibited and the $V_{d}$, $CL_{t}$ and $\beta$ of DTZ were significantly decreased in mild and medium folate-induced renal failure rabbits.

• 전력전자학회:학술대회논문집
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• 전력전자학회 2001년도 전력전자학술대회 논문집
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• pp.193-196
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• 2001

This paper describes an improved short-circuit protection for a multilevel ac/dc power converter The output do power of the proposed converter can be disconnected from the load within several hundred microseconds at the instant of short-circuit fault. Once the fault has been cleared the dc power is reapplied to the load. The rising time of the do load voltage is as small as several hundred microseconds, and there is no overshoot of the dc voltage because the do output capacitors hold undischarged state. Therefore, the proposed converter can be used for a power supply, which requires a rapid disconnection of the load from the power supply in the case of a short circuit, as well as a rapid connection the load to the power supply after the clearance of the short circuit condition.

• 동력기계공학회지
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• 제10권4호
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• pp.119-126
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• 2006

Gerotor hydraulic motor is widely used in hydraulic systems due to its low speed, high torque output and compactness in rotational direct driving of a heavy weight. Gerotor is a Planar mechanism consisted of a pair of rotor and circular teeth of stator assembly which forms a closed space, so called a chamber. The motion of rotor relative to the circular tooth is produced by the pressure difference of hydraulic operating fluid between the adjacent chamber. As all active contact points of rotor and circular teeth are subjected to very high sliding friction, a reduction in the performance of the gerotor hydraulic motor can not be avoided. Therefore, the core design parameters of gerotor profile used in hydraulic motors is to minimize a friction force by high contact stresses. The analytical design method of gerotor profile, based on envelope of a family of curves, is proposed. In this study, the influence of the tip clearances on three critical contact points between rotor and circular teeth of stator assembly has been explored by experimental data in this paper. At the same time a improvement method to reduce the friction force is proposed and the tip clearances on three critical points for getting an optimum gerotor profile are also analyzed.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제18권1호
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• pp.55-59
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• 2015

Gastroesophageal reflux disorder (GERD) is the most common esophageal disorder in children. Achalasia occurs less commonly but has similar symptoms to GERD. A nine-year old boy presented with vomiting, heartburn, and nocturnal cough. The esophageal impedance-pH monitor revealed nonacidic GERD (all-refluxate clearance percent time of 20.9%). His symptoms persisted despite medical treatment for GERD, and he was lost to follow up. Four years later, he presented with heartburn, solid-food dysphagia, daily post-prandial vomiting, and failure to thrive. Endoscopy showed a severely dilated esophagus with candidiasis. High-resolution manometry was performed, and he was diagnosed with classic achalasia (also known as type I). His symptoms resolved after two pneumatic dilatation procedures, and his weight and height began to catch up to his peers. Clinicians might consider using high-resolution manometry in children with atypical GERD even after evaluation with an impedance-pH monitor.

• Journal of Mechanical Science and Technology
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• 제19권7호
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• pp.1478-1487
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• 2005

A small mixed-type turbine with a diameter of 19.9 mm has been substituted for a rotational part of pencil-type air tool. Usually, a vane-type rotor is applied to the rotational part of the air tool. However, the vane-type rotor has some problems, such as friction, abrasion, and necessity of accurate assembly etc.,. These problems make the life time of the vane-type air tool short, but air tools operated by mixed-type turbines are free of friction and abrasion because the turbine rotor dose not contact with the casing. Moreover, it is assembled easily because of no axis offset. These characteristics are merits for using air tools, but loss of power is inevitable on a non-contacting type rotor due to flow loss, tip clearance loss, and profile loss etc.,. In this study, four different rotors are tested, and their characteristics are investigated by measuring the specific output power. Additionally, optimum nozzle location against the rotor is studied. Output powers are obtained through measured pressure, temperature, torque, rotational speed, and flow rate. The experimental results obtained with four different rotors show that the rotor blade shape greatly influences to the performance, and the optimum nozzle location exists near the mid span of the rotor.

• Archives of Pharmacal Research
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• 제25권4호
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• pp.541-545
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• 2002

Pharmacokinetic characteristics of Acebutolol and its main metabolite, diacetolol, following a single 10 mg/kg oral dose, were investigated in rabbits with carbon tetrachloride-induced hepatic failure. Plasma concentrations of acebutolol and diacetolol were determined by a high performance liquid chromatography assay. The area under the plasma concentration-time curves (AUC) and maximum plasma concentration ($C_{max}$) of acebutolol were significantly increased in moderate and severe carbon tetrachloride-induced hepatic failure rabbits. The ratio of the diacetolol to total acebutolol in plasma (i.e., metabolite percentage rate) was significantly decreased in moderate and severe carbon tetrachloride-induced hepatic failure rabbits. Volume of distribution ($V_{d}$) and total body clearance ($CL_{t}$) of acebutolol were significantly decreased in moderate and severe carbon tetrachloride-induced hepatic failure rabbits. Slope of terminal phase ($\beta$) of acebutolol was significantly decreased in hepatic failure rabbits. These findings suggest that the $V_{d},{\;}CL_{t}$ and $\beta$ of acebutolol were significantly decreased as a result of inhibition of the hepatic metabolism in moderate to severe hepatic failure rabbits. Therefore, dose adjustment may be necessary for acebutolol in hypertensive patients with hepatic damage.

• Mass Spectrometry Letters
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• 제10권3호
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• pp.88-92
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• 2019

A sensitive analytical method of rhodanthpyrone A in rat plasma was developed using a liquid chromatography-tandem mass spectrometry (LC-MS/MS). Rhodanthpyrone A and rhodanthpyrone B (internal standard) in rat plasma were extracted by a liquid-liquid extraction method with ethyl acetate. This extraction method gave results in high and reproducible extraction recovery in the range of 73.75-79.90% with no interfering peaks around the peak elution time of rhodanthpyrone A and B. The standard calibration curves for rhodanthpyrone A ranged from 0.5 to 2000 ng/mL were linear with $r^2$ > 0.994 and the inter- and intra-day accuracy and precision and the stability were within acceptance criteria. Using this validated analytical method, pharmacokinetics of rhodanthpyrone A following intravenous and oral administration of rhodanthpyrone A at doses of 2 mg/kg and 30 mg/kg, respectively, were investigated. Rhodanthpyrone A in rat plasma showed multi-exponential elimination pattern with high clearance and volume of distribution values. The absolute oral bioavailability of this compound was calculated as 3.7%. Collectively, the newly developed sensitive LC-MS/MS analytical method of rhodanthpyrone A could be successfully applied to investigate the pharmacokinetic properties of this compound and would be useful for the further studies on the efficacy, toxicity, and biopharmaceutics of rhodanthpyrone A.

• The Journal of Asian Finance, Economics and Business
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• 제8권1호
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• pp.145-156
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• 2021

The research purpose of this paper is to empirically examine the effects of technological readiness and innovation on logistics performance. To build up and maintain an important role in global supply chains, nowadays it is obvious that countries and logistics providers need to achieve competitive advantage in terms of digitalization. However, there is a lack of empirical studies about the impacts of information technologies and innovation potential on the logistics efficiency of countries. Hence, the study analyzes whether the corresponding pillars of the Global Competitiveness Index (GCI) matter for the Logistics Performance Index (LPI) and its dimensions. For determining the effects, the pooled regression approach is applied. The results show that technological readiness and innovation are positively and statistically significantly correlated with logistics performance: competence and quality of logistics services, efficiency of customs clearance processes, ability to track and trace consignments, frequency with which shipments reach consignee within scheduled or expected time, and ease of arranging competitively priced shipments. The findings of this study suggest that investments in innovations and technology progress improve countries' logistics efficiency, which is an important prerequisite for enabling Logistics 4.0 and thus, Industry 4.0 and the digital transformation of the economy and society.

• 한국항만경제학회지
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• 제37권4호
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• pp.145-160
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• 2021

본 연구는 국제무역에 있어서 물류규제와 물류역량에 대한 물류업계 종사자들의 평가지표라 할 수 있는 물류성과지표를 활용하여 한국과 아세안 FTA의 상품무역 증가에 미치는 영향을 분석하고자 하였다. World bank에서 발표한 물류성과지표는 관세통관, 물류인프라, 선적의 용이성, 물류서비스, 운반의 적시성, 물품추적역량의 6가지 세부항목과 총점으로 구성되어 있다. 본 연구에서는 이러한 물류성과지표를 관측변수로 하여 페널데이터 중력모형 분석을 실시하였다. 분석 결과는 물류성과지표의 총점과 세부항목 모두 상품무역량 증가에 긍정적인 효과를 나타내었다. 이러한 연구 결과는 한국과 아세안 양국교역 증대를 위해 물류비용을 현실화하고 물류 규제를 철폐하며, 물류 환경을 개선하기 위한 노력이 필요하다는 사실을 확인해주는 것이다.