• YAKHAK HOEJI
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• v.36 no.1
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• pp.46-55
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• 1992

Methoxyverapamil, $Ca^{2+}$ channel blocker, when given intravenously by means of bolus, produced the transient increase of urine flow, and then methoxyverapamil was infused in this experiments. Methoxyverapamil, when infused into vein, elicited the increase of urine flow ancampanied with the increased glomeralar filtration rate(GFR), renal plasma flow(RPF), excretion amounts of sodium and potassium in urine($E_{Na},\;E_k$) and osmolar clearance(Cosm), wherease produced the no change of free water clearance($C_{H2O}$) and the reduction of reabsorption rates of sodium and potassium in reral tubules($R_{Na},\;R_k$). Methoxyverapamil, when infused into a renal artery, exhibited the diuretic action in only infused Kidney, at this time changes of renal function were the same aspect to that of intravenously infused methoxyverapamil. Methoxyverapamil, when infused into a carotid artery, exhibited the decreased urine flow along with the reduction of Cosm, $C_{H2O}\;and\;E_{Na}$. Above results suggest that methoxyverapamil possess both the diuretic action by direct action in kidney and antidiuretic action through the central function.

• International Journal of Highway Engineering
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• v.14 no.6
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• pp.159-165
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• 2012

PURPOSES : The lack of details of guidelines on how to install the Chicane for traffic calming leads the practical difference across the calming areas, so the benefits expected from these facilities are not hardly observed. In this context, this study analysed the relationship between the geometric design alternatives of Chicane with the dynamic behaviour of vehicles in terms of speed and trajectory. METHODS : The study analysed vehicle dynamic behaviour using dynamic analysis program Auto-Turn under various geometric conditions of Chicane. RESULTS : This study suggested the design alternatives of Chicane using terms such as "longitudinal displacement value", "lateral displacement value", etc. which are defined in the study. The suggested combination set is fulfilling the desired or target speed of vehicles and clearance between vehicle and roadside at the same time. CONCLUSIONS : The results from this study can be applied to install Chicane corresponding to the local condition where target speed is 30km/h. The study showed the design alternatives of chicane corresponding to the given road cross-sectional design and clearance to roadside for passenger cars and light truck respectively.

• Geomechanics and Engineering
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• v.16 no.3
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• pp.321-329
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• 2018

Classic braced walls use struts and wales to minimize ground movements induced by deep excavation. However, the installation of struts and wales is a time-consuming process and confines the work space. To secure a work space around the retaining structure, an anchoring system works in conjunction with a braced wall. However, anchoring cannot perform well when the shear strength of soil is low. In such a case, innovative retaining systems are required in excavation. This study proposes an innovative earth-retaining wall that uses in situ soil confined in dual sheet piles as a structural component. A numerical study was conducted to evaluate the stability of the proposed structure in cohesionless dry soil and establish a design chart. The displacement and factor of safety of the structural member were monitored and evaluated. According to the results, an increase in the clearance distance increases the depth of safe excavation. For a conservative design to secure the stability of the earth-retaining structure in cohesionless dry soil, the clearance distance should exceed 2 m, and the embedded depth should exceed 40% of the wall height. The results suggest that the proposed method can be used for 14 m of excavation without any internal support structure. The design chart can be used for the preliminary design of an earth-retaining structure using in situ soil with dual steel sheet piles in cohesionless dry soil.

• Transactions of Materials Processing
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• v.17 no.8
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• pp.586-593
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• 2008

In warm press forming of magnesium alloy sheet, it is important to control the sheet temperature by heating the sheet in closed die. When forming a commercial AZ31 magnesium alloy sheets which are 0.5mm and 1.0mm thick, respectively, time arriving at target temperature and temperature variation in magnesium alloy sheet have been investigated. The deep drawing process with rectangular shape alone at the first stage and with both circular and rectangular shapes at the second stage was employed. At the first stage, through deep drawing process with rectangular shape alone according to various forming temperature($150{\sim}350^{\circ}C$) and velocity($0.1{\sim}1.0mm/s$), optimum forming condition was obtained. At the second stage, deep drawing process with the circular and rectangular shapes were performed following deep drawn square cups with Limited Drawing Height(LDH) obtained at the first stage. Here, clearance which is defined a gap between the die and the punch including sheet was set to ratio of 20, 40 and 100% to thickness in sheet. Accordingly, temperature, velocities, and clearances suitable for forming were suggested through investigating the thickness variation of the product.

• Korean Journal of Clinical Pharmacy
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• v.8 no.1
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• pp.23-28
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• 1998

The pharmacokinetics of atenolol (25 mg/kg, i.v.) in the folate-induced renal failure rabbits was studied. Renal failure was induced by the i.v. injection of folate (50, 100, and 200 mg/kg). At folate dose of 100 and 200 mg/kg, the serum creatinine concentration (Scr) and blood urea nitrogen (BUN) increased significantly compared with control rabbits. Plasma concentrations and AUC of atenolol increased significantly at folate dose of 100 and 200 mg/kg. The elimination rate constant $(K_{el})$ and total body clearance $(CL_t)$ of atenolol decreased significantly, and half-life ($t_{1/2}$) and mean residence time (MRT) of atenolol increased significantly at folate dose of 100 and 200 mg/kg. The serum creatinine concentration $(S_{cr})$ correlated well (p<0.05) with half-life $(t_{1/2})$ and elimination rate constant $(K_{el})$ of atenolol, as well as BUN with AUC and total body clearance $(CL_t)$ of atenolol.

• Korean Journal of Clinical Pharmacy
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• v.9 no.1
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• pp.55-61
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• 1999

The object of this work was to study the pharmacokinetic differences and the cause of these differences in cirrhotic rats induced by N,N-dimethylnitrosamine or carbon tetrachloride treatment when aminophylline (8 mg/kg as theophylline, i.v.) was injected. The concentrations of theophylline and its major metabolite (1,3-dimethyluric acid) in plasma were determined by HPLC. In addition, formation of 1,3-dimethyluric acid from theophylline in microsomes was determined. In cirrhotic rats, the systemic clearance of theophylline was reduced to $17\%$ of the control value while AUC (area under the plasma concentration-time curve) and $(t_{1/2})_{\beta}$ were increased to about 6 fold and 10 fold, respectively. The formation of 1,3-dimethyluric acid was decreased to $33-41\%$ of the control value in microsomes of cirrhotic rat liver. From these results, it can be concluded that in cirrhotic rats induced by N,N-dimethylnitrosamine or carbon tetrachloride the total body clearance of theophylline is markedly reduced due to a reduced hepatic metabolism.

• Design & Manufacturing
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• v.15 no.4
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• pp.51-56
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• 2021

Piercing is the process of shearing a circular hole in sheet metal, whose high shear force makes it difficult to secure the durability of tools. In addition, uneven clearance between tools due to poor alignment of the piercing punch causes accelerated die wear and breakage of the tool. This study reviewed the feasibility of in-situ determining alignment failure during the piercing process by analyzing the signal deviation of a bolt-type piezo sensor installed inside the tool whose alignment level was controlled. Finite element analysis was performed to select the optimal sensor location on the piercing tool for sensitive detection of process signals. A well-aligned piercing process results in uniform deformation in the circumferential direction, and shearing is completed at a stroke similar to the sheet thickness. Afterward, a sharp decrease in shear load is observed. The misaligned piecing punch leads to a gradual decrease in the load after the maximum shear load. This gradual decrease is due to the progressive shear deformation that proceeds in the circumferential direction after the initial crack occurs at the narrow clearance site. Therefore, analyzing the stroke at which the maximum shear load occurs and the load reduction rate after that could detect the misalignment of the piercing punch in real-time.

• Journal of Electrical Engineering and information Science
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• v.2 no.5
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• pp.89-99
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• 1997

The application for real-time database systems must satisfy timing constraints. Typically the timing constraints are expressed in the form of deadlines which are represented by priorities to e used by schedulers. In any real-time applications, since the system maintains sensitive information to be shared by multiple users with different levels of security clearance, security is another important requirement. As more advanced database systems are being used in applications that need to support timeliness while managing sensitive information, protocols that satisfy both requirements need to be developed. In this appear, we proposed a new priority-driven secure multiversion locking (PSMVL) protocol for real-time secure database systems. The schedules produced by PSMVL are proven to e one-copy serializable. We have also shown tat the protocol eliminates covert channels and priority inversions. The details of the protocol, including the compatibility matrix and the version selection algorithms are presented. the results of the performance comparisons of our protocol with other protocols are described.

• Microbiology and Biotechnology Letters
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• v.36 no.1
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• pp.12-20
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• 2008

Validation of viral safety is essential in ensuring the safety of mammalian cell culture-derived biopharmaceuticals, because numerous adventitious viruses have been contaminated during the manufacture of the products. Mammalian cells are highly susceptible to minute virus of mice(MVM), and there are several reports of MVM contamination during the manufacture of biopharmaceuticals. In order to establish the validation system for the MVM safety, a real-time PCR method was developed for quantitative detection of MVM in cell lines, raw materials, manufacturing processes, and final products as well as MVM clearance validation. Specific primers for amplification of MVM DNA was selected, and MVM DNA was quantified by use of SYBR Green I. The sensitivity of the assay was calculated to be $6{\times}10^{-2}TCID_{50}/mL$. The real-time PCR method was proven to be reproducible and very specific to MVM. The established real-time PCR assay was successfully applied to the validation of Chinese hamster ovary (CHO) cell artificially infected with MVM. MVM DNA could be Quantified in CHO cell as well as culture supernatant. When the real-time PCR assay was applied to the validation of virus removal during a virus filtration process, the result was similar to that of virus infectivity assay. Therefore, it was concluded that this rapid, specific, sensitive, and robust assay could replace infectivity assay for detection and clearance validation of MVM.

• Journal of KSNVE
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• v.3 no.1
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• pp.29-37
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• 1993

This study is concerned about the impact type damper for effectively restraining the high vibration amplitude in the resonance regions. The theoretical analysis is based on the assumption that the impacts occur twice per cycle at an equal time interval. Simple but reasonable approximations have been derived for the optimum collision clearance and maximum amplitude ratio. Using the impact dampers which is rigidly attached to the primary vibration system, we have experimented for mass ratios and restitution coefficients. The experimental results are in good agreement with theoretical results.