• Transactions of the Korean Society of Automotive Engineers
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• v.14 no.1
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• pp.39-47
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• 2006

Recent trend in pursuit of high performance and effectiveness for automotive cooling system has changed the application of material for impeller of automotive water pump from metal to high ability engineering resin, which can achieve optimization of design of impeller geometry and realize lightweight high efficiency water pump. Closed type water pump improves hydraulic loss of fluid through the clearance between volute casing and impeller compared with that of the existing open type water pump(Although closed type is heavier than open type for the same size and same material, adoption of plastics can solve the problem.). In the present study, the characteristics of hydraulic performance of closed type water pump were investigated with respect to the angle between shroud and hub of impeller and the shape of discharge port of volute casing. Performance tests were carried out for 4 cases, that is, for 2 impellers and 2 casings. The modification of shape of only discharge port can enhance the hydraulic performance by 10 percent and the pump efficiency by 4-6 percent.

• The KSFM Journal of Fluid Machinery
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• v.7 no.1 s.22
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• pp.36-44
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• 2004

Three-dimensional vortical flow and separated flow topology near the casing wall in an axial flow fan having two different tip clearances have been investigated by a Reynolds-averaged Navier-Stokes (RANS) flow simulation. The simulation shows that the tip leakage vortex formed close to the leading edge of the blade tip on suction side grows in the streamwise direction. On the casing wall, a separation line is formed upstream of the leakage vortex center due to the interference between the leakage vortex and main flow. The reverse flow is observed between the separation line and the attachment line generated downstream of the trailing edge, and increased with enlarging tip clearance. The patterns of a leakage velocity vector including a leakage flow rate are also analyzed according to two tip clearances. It is noted that the understanding of the distribution of a limiting streamline on the casing wall is very important to grasp the characteristics of the vortical flow in the axial flow fan.

• Journal of Ginseng Research
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• v.44 no.2
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• pp.194-204
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• 2020

The detrimental impact of air pollution as a result of frequent exposure to fine particles posed a global public health risk mainly to the pulmonary disorders in pediatric and geriatric population. Here, we reviewed the current literature regarding the role of ginseng and/or its components as antimicrobials, especially against pathogens that cause respiratory infections in animal and in vitro models. Some of the possible mechanisms for ginseng-mediated viral inhibition suggested are improvements in systemic and mucosa-specific antibody responses, serum hemagglutinin inhibition, lymphocyte proliferation, cell survival rate, and viral clearance in the lungs. In addition, ginseng reduces the expression levels of proinflammatory cytokines (IFN-γ, TNF-α, IL-2, IL-4, IL-5, IL-6, IL-8) and chemokines produced by airway epithelial cells and macrophages, thus preventing weight loss. In case of bacterial infections, ginseng acts by alleviating inflammatory cytokine production, increasing survival rates, and activating phagocytes and natural killer cells. In addition, ginseng inhibits biofilm formation and induces the dispersion and dissolution of mature biofilms. Most clinical trials revealed that ginseng, at various dosages, is a safe and effective method of seasonal prophylaxis, relieving the symptoms and reducing the risk and duration of colds and flu. Taken together, these findings support the efficacy of ginseng as a therapeutic and prophylactic agent for respiratory infections.

• Journal of the Korean Society for Precision Engineering
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• v.33 no.8
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• pp.661-668
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• 2016

Oil deflector prevents oil leakage that occurs in thermoelectric power plant at operating lubricant facilities. Vibration of rotating rotor-induced wear of aluminum tooth in existing oil deflector leads to oil leakage as well as life shortening of the tooth. In this study, an advanced oil deflector was developed for shock absorption and prevention of wear by decreasing clearance (from 0.5 mm to 0.2 mm) between rotor and tooth to minimize oil leakage, and by replacing 2 aluminum teeth in outmost of the oil deflector with hi-performance seal made of engineering plastic. The CFD results were compared between advanced vs. existing oil deflector to determine the amount of oil loss. Structural safety was verified through impact analyses according to the three kinds of engineering plastics, considering cost efficiency, and optimal material of hi-performance seal was chosen.

• Journal of the Society of Naval Architects of Korea
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• v.53 no.6
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• pp.456-464
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• 2016

To design the modified hull form with relatively unfavorable dimensions and constraints than the parent ship the stepwise design was applied. In each design step the resistance characteristics was estimated by numerical calculations using CFD programs as Wavis 1.4, Wavis 2.1 and Fluent 12.1. The wave profiles along hull surface by potential flow calculations were investigated to improve wave resistance by modifying the bow shapes. To improve the stern shapes with a point of viscous form resistance the pressure distributions on hull surface and the limiting streamlines are investigated by viscous flow calculations. The design objectives such as shortening the LBP, enlarging the propeller tip clearance, moving forward of the LCB location and increasing the displacement were applied by stepwise to develop the new hull form of DWT 75,000 product oil carrier. Finally a new hull form was developed without the resistance performance loss compared with the parent ship.

• Molecules and Cells
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• v.42 no.6
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• pp.480-494
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• 2019

Aggregates of disease-causing proteins dysregulate cellular functions, thereby causing neuronal cell loss in diverse neurodegenerative diseases. Although many in vitro or in vivo studies of protein aggregate inhibitors have been performed, a therapeutic strategy to control aggregate toxicity has not been earnestly pursued, partly due to the limitations of available aggregate models. In this study, we established a tetracycline (Tet)-inducible nuclear aggregate (${\beta}23$) expression model to screen potential lead compounds inhibiting ${\beta}23$-induced toxicity. High-throughput screening identified several natural compounds as nuclear ${\beta}23$ inhibitors, including peucedanocoumarin III (PCIII). Interestingly, PCIII accelerates disaggregation and proteasomal clearance of both nuclear and cytosolic ${\beta}23$ aggregates and protects SH-SY5Y cells from toxicity induced by ${\beta}23$ expression. Of translational relevance, PCIII disassembled fibrils and enhanced clearance of cytosolic and nuclear protein aggregates in cellular models of huntingtin and ${\alpha}$-synuclein aggregation. Moreover, cellular toxicity was diminished with PCIII treatment for polyglutamine (PolyQ)-huntingtin expression and ${\alpha}$-synuclein expression in conjunction with 6-hydroxydopamine (6-OHDA) treatment. Importantly, PCIII not only inhibited ${\alpha}$-synuclein aggregation but also disaggregated preformed ${\alpha}$-synuclein fibrils in vitro. Taken together, our results suggest that a Tet-Off ${\beta}23$ cell model could serve as a robust platform for screening effective lead compounds inhibiting nuclear or cytosolic protein aggregates. Brain-permeable PCIII or its derivatives could be beneficial for eliminating established protein aggregates.

• Tribology and Lubricants
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• v.28 no.1
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• pp.12-18
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• 2012

This application study of a swash-plate type axial piston pump was concerned about the lubrication characteristics between cylinder barrel and valve plate which are the main rotating body and its opposite sliding part respectively. A computer simulation was implemented to assess bearing and sealing functions of the fluid film between cylinder barrel and valve plate. A numerical algorithm was developed to facilitate simultaneous calculations of dynamic cylinder pressure, 3 degree-of-freedom barrel motions considering inertia effect, and fluid film pressure assuming full fluid film lubrication regime. Central clearance, tilt angle, and azimuth angle of the rotating body were calculated for each time step. Surface waviness was found to be an influential factor due to the small fluid film thickness which can appear in flat land bearings. Five surface lays which can form on the lubrication surface in accordance with machining process were defined and analyzed using the simulation tool. Oil leakage flow and frictional torque in the fluid film between cylinder barrel and valve plate were also calculated to discuss in the viewpoint of energy loss. The simulation results showed that in actual sliding conditions proper surface non-flatness can make a positive effect on the energy efficiency and reliability of the thrust bearing.

• The Transactions of the Korean Institute of Electrical Engineers P
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• v.60 no.2
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• pp.82-90
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• 2011

The small precision spindle motors in the high value-added products including the visible home appliances such as DLP projector require not only the energy conversion devices but also high efficiency, low vibration and sound operation. However, the spindle motors using the conventional ball bearing and sintered porous metal bearing have following problems, respectively: the vibration by the irregularity of balls and the short motor life cycle by the ball's abrasion and higher sound noises by dry contact between shaft and sleeve. In this paper, it is proposed that the spindle motor with a fluid dynamic bearing is suitable for the motor to drive the color wheel of the DLP(digital lightening processor) in the visible home appliances. The proposed spindle motor is composed of the fluid dynamic bearing with both the radial force and the thrust force. The fluid dynamic bearing is solved by the finite element analysis of the mechanical field with the Reynolds equations. The magnetic part of spindle motor, which is a type of Brushless DC Motor, is designed by the electro-magnetic field analysis coupled with the Maxwell equation. And the load capacity and the friction loss of fluid dynamic bearing are analyzed to bearing clearance variation by the fabrication error in designed motor. The design of the proposed motor is implemented by the load torque caused by the eccentricity and the unbalance of the fluid dynamic bearing when the motors are fabricated in error. The prototype of the motor with the fluid dynamic bearing is manufactured, and experiment results show the vibration, sound, and phase current at no load and color wheel load of the motors in comparison. The high performance characteristics with the low vibration, the low acoustic noise and the optimal mechanical structure are verified by the experimental results.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.38C no.11
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• pp.982-989
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• 2013

Omni-directional antennas of UHF-Band are located on the top and bottom side of the Smart UAV in order to connect a link always. Therefore one of each antennas should be connected to a ground antenna. Because the communication link of the omni-directional antennas is influenced by the objectives around aircraft, the clearance of LOS(Line of Sight) should be achieved in order to avoid a loss of link. In this paper, the analysis results on the influence of the complex objectives placed around the antenna on the communication link are presented according to the change of attitude angles. The best positions of antennas are selected based on the electromagnetic analysis using XGTD tool which supports the modeling of antenna pattern. The flight tests of the Smart UAV were successfully performed with the selected antenna position.

• Molecules and Cells
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• v.41 no.3
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• pp.214-223
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• 2018

Oligoadenylate synthetase (OAS) protein family is the major interferon (IFN)-stimulated genes responsible for the activation of RNase L pathway upon viral infection. OAS-like (OASL) is also required for inhibition of viral growth in human cells, but the loss of one of its mouse homolog, OASL1, causes a severe defect in termination of type I interferon production. To further investigate the antiviral activity of OASL1, we examined its subcellular localization and regulatory roles in IFN production in the early and late stages of viral infection. We found OASL1, but not OASL2, formed stress granules trapping viral RNAs and promoted efficient RLR signaling in early stages of infection. Stress granule formation was dependent on RNA binding activity of OASL1. But in the late stages of infection, OASL1 interacted with IRF7 transcripts to inhibit translation resulting in down regulation of IFN production. These results implicate that OASL1 plays context dependent functions in the antiviral response for the clearance and resolution of viral infections.