• Journal of Pharmaceutical Investigation
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• 제8권3호
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• pp.1-10
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• 1978

The purpose of this paper was to investigate the bioavailability of sulfadimethoxine in pathological rats and rabbits pretreated with carbon tetrachloride and mercuric chloride. The results are as follows: The absorption of sulfadimethoxine was decreased in rats damaged liver and kidney as compared with that of normal rats. Especially, absorption of sulfadimethoxine in rats damaged liver was more decreased than that of rats damaged kidney. Blood level of sulfadimethoxine administered orally was mostly decreased significantly in rabbits damaged kidney and liver, and in rabbits severely damaged kidney the blood level of sulfadimethoxine was not significant at 4 to 6 hours. Urinary clearance of sulfadimethoxine in rabbits severely damaged kidney was inhibited at 5 to 6 hours. but in rabbit damaged liver. Hepatic clearance of sulfadimethoxine was accelerated in rabbits damaged kidney but in rabbits damaged liver. Protein binding percentage of sulfadimethoxine was not affected by the various concentration of carbon tetrachloride and mercuric chloride respectively.

• Journal of Pharmaceutical Investigation
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• 제9권2호
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• pp.1-10
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• 1979

The purpose of this paper was to investigate the bioavailability of oxytetracycline in pathological rats and rabbits pretreated with carbon tetrachloride and mercuric chloride. The results are as follows: The blood level of oxytetracycline administered orally was mostly decreased significantly in rabbits damaged kidney and liver, and in rabbits severely damaged kidney, the blood level of oxytetracycline was not significant at 4 to 6 hours. Urinary clearance of oxytetracycline in rabbits severely damaged kidney was inhibited at 5 to 6 hours but in rabbits damaged liver. Hepatic clearance of oxytetracycline was accelerated in rabbits damaged kidney but in rabbits damaged liver. AUC of oxytetracycline orally administered in rabbits damaged liver and kidney was largely decreased. The absorption of oxytetracycline was decreased in rats damaged liver and kidney as compared with that of normal rats. Especially, absorption of oxytetracycline in rats damaged liver was more decreased than that of rats damaged kidney. The absorption of oxytetracycline was inhibited by combinated administration of carbon tetrachloride and mercuric chloride.

• Journal of Biosystems Engineering
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• 제29권5호
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• pp.425-432
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• 2004

In harvesting rice and barley using combine, the inclination of the body caused by the irregular surface condition of the field and the soil sinking from the unbalanced weight during the grain collection used to make harvesting operation difficult and even impossible. To overcome such a problem hydraulic system far automatic and manual leveling control of a combine has been developed. The system was composed of the combine body and the hydraulic level control system mounted on it. The maximum height of ground clearance was set up to be 290mm. And the limit angle of the leveling control was set up to be $\pm7^{\circ}$. The proposed controller and hydraulic system was implemented to the prototype combine. The prototype combine was designed and built as a separable structure with the body and the track of it. This paper shows results of a specification and design testing with the hydraulic level control system far body of combine.

• 한국방사성폐기물학회:학술대회논문집
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• 한국방사성폐기물학회 2018년도 추계학술논문요약집
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• pp.303-304
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• 2018

• 한국방사성폐기물학회:학술대회논문집
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• 한국방사성폐기물학회 2018년도 춘계학술논문요약집
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• pp.285-286
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• 2018

• Tuberculosis and Respiratory Diseases
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• 제38권4호
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• pp.372-378
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• 1991

Some kinds of newer fluoroquinolone antibiotics are known to interact with theophylline, which is widely used as a potent bronchodilator in asthma or chronic obstructive lung disease. To evaluate the effect of enoxacin and ciprofloxacin on the metabolism of theophylline, aminophylline was administered intravenously in bolus (6 mg/kg) over 30 minutes to 6 healthy volunteers (age: $23.3{\pm}4.2$ year, body weight: $63.2{\pm}9.0\;kg$, height: $169.0{\pm}6.5\;cm$, female 3, male 3) before and after per oral 5-day medication of enoxacin and ciprofloxacin, respectively and we measured the level of theophylline in serum. The results were as follows: 1) Enoxacin and ciprofloxacin did not influence the volume of distribution significantly. 2) Enoxacin decreased the clearance of theophylline significantly (from $42.9{\pm}14.6\;ml/min$ to $30.1{\pm}6.3\;ml/min$: p<0.05), but ciprofloxacin did not cause significant decrease (to $32.8{\pm}6.2\;ml/min$: p>0.005). 3) Enoxacin increased the elimination half life of theophylline significantly (from $496{\pm}83\;min$ to $693{\pm}32\;min$: p<0.001), but ciprofloxacin did not cause significant increase (to $687{\pm}222\;min$: p>0.05). These results suggested that enoxacin influenced clearance and elimination half life significantly and thorough monitoring of the level of theophylline in patients with coadminstration of enoxacin and theophylline was necessary. In case of ciprofloxacin, the influence on the metabolism of theophylline was not statistically significant, but one exceptionally large decrease of the clearance and increase of the elimination halflife of theophylline suggested the necessity of monitoring of theophylline level during coadministration of ciprofloxacin and theophylline.

• Journal of Biosystems Engineering
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• 제43권4호
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• pp.263-272
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• 2018

Purpose: The load on the planet gear of a planetary gear set is uniformly distributed. However, manufacturing and assembly errors cause uneven load sharing in the planetary gear set. To solve this problem, most studies have suggested applying a floating sun gear to the planetary gear set. However, the effect of the floating ring gear and floating carrier has not been extensively studied. This study aimed to investigate the effect of the floating ring gear. Methods: Two models were developed; one was the fixed ring gear model, and the other was the floating ring gear model. In the fixed ring gear model, the clearance between the ring gear and the housing was $0{\mu}m$, and in the floating ring gear model, the clearance was from $10{\mu}m$ to $100{\mu}m$. The load sharing of the planetary gear set was evaluated by the load sharing factor. Results: Our study showed that with increase in clearance, the load sharing factor of the planetary gear set approached unity. In addition, when the clearance increased above a certain level by which a fully floating ring gear was achieved, the load sharing factor was not affected by the clearance. Conclusions: This indicates that the fully floating ring gear increased the power density of the planetary gearbox by uniformly dividing the load of the planetary gear set. For this reason, the size of the gearbox could be decreased by using a fully floating ring gear.

• 한국의학물리학회지:의학물리
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• 제31권4호
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• pp.194-204
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• 2020

This study investigated and analyzed the Korean and international status of radioactive waste management for medical linear accelerators (linacs) and proceed prior research to suggest radiation safety regulations and guidelines for the safe use of radiation. We analyzed the number of linacs installed in the radiation oncology departments of 103 institutions. In addition, we analyzed the procedures and standards for disposal in Korea and foreign countries. For foreign countries, we analyzed the status based on reports from the United States, Japan, Europe, and Canada. A total of 182 linacs are installed in Korea and 95% of them use more than 10 MV of energy. In Korea, standards for managing radioactive waste from a linac, disposal procedures, and clearance criteria have yet to be established. Therefore, radioactive waste is disposed of in different ways depending on the hospitals where they originate. Japan, the US, and Canada have recommended clearance levels and procedures for linacs. Other countries have provided management guidelines for research or large-scale accelerators, but not for medical purposes. In this study, we investigated the management of radioactive waste from medical linacs in Korea and abroad. Several foreign countries have suggested a clearance level and criteria for disposing of waste storage drums. For the safe management of medical linacs, it is necessary to establish safety management regulations. In Korea, standards for disposal, such as radiation or dose limits, are required for medical linacs. A system for clearance when disposing at a medical institution should be created.

• Archives of Pharmacal Research
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• 제25권4호
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• pp.397-415
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• 2002

This paper deals with a crucial mechanism for interaction of basic drugs and cardiac glycosides at the hepatic uptake level. Available literature data is provided and new material is presented to picture the differential transport inhibition of bulky (type2) cationic drugs by a number of cardiac glycosides in rat liver. It is shown that the so called organic anion transporting peptide 2 (oatp2) is the likely interaction site: differential inhibition patterns as observed in oocytes expressing oatp2, could be clearly identified also in isolated rat hepatocytes, isolated perfused rat liver and the rat in vivo. The anticipation of transport interactions at the hepatic clearance level should be based on data on the relative affinities of interacting substrates for the transport systems involved along with knowledge on the pharmacokinetics of these agents as well as the chosen dose regimen in the studied species. This review highlights the importance of multispecific tranporter systems such as OATP, accommodating a broad spectrum of organic compounds of various charge, implying potential transport interactions that can affect body distribution and organ clearance.

• 정보보호학회논문지
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• 제9권1호
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• pp.15-28
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• 1999

다단계 보안 데이타베이스 관리 시스템(multilevel secure database management system (MLS/DBMS)은 시스템이 사용자를 위한 여러 개의 보안 인가등급(security clearance level)과 시스템내의 데이타를 위한 여러 개의 분류 등급(classification level)을 가진 데이타베이스 관리 시스템으로써 이러한 시스템의 목적은 기밀 정보를 인가 받지 않은 사용자로부터 보호하는 것이다. 이미 연구되어온 알고리즘들은 로킹이나 타임스탬프 기법을 변형하여 비밀채널을 제거하는데 주안점을 두었기 때문에 상위 등급 트랜잭션들이 하위 등급 트랜잭션에 의해 반복적으로 지연되는 기아현상을 유발시켰다. 이러한 문제를 해결하기 위해 본 논문에서는 오렌지 로크를 기반으로 하는 다단계 보안 DBMS에서 직렬화 순서의 동적인 재조정 방식을 이용하여 상위 등급 트랜잭션의 기아현상을 완화하는 알고리즘을 제안한다 기존의 보안 알고리즘이 다중버전상에서 수행되었던 것과는 달리 제안된 알고리즘은 단일버전상에서 수행함으로써 트랜잭션의 병행성 정도를 높일 수 있는 알고리즘을 제안한다. 제안한 알고리즘이 병행수행 상에서 직렬성을 만족함을 증명하고, 보안성을 만족함을 보인다.