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Difference of Gene Expression between Hypertrophic Scar Keratinocytes and Normal Keratinocytes (비후성 반흔 각질세포와 정상 각질세포의 유전자 비교분석)

  • Choi, Sung-Won;Chung, Ho-Yun;Lim, Young-Kook;Kim, Hoon-Nam;Oh, Ji-Won;Kim, Moon-Kyu;Jeon, Sae-Hwa;Hong, Yong-Taek
    • Archives of Plastic Surgery
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    • v.37 no.4
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    • pp.317-322
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    • 2010
  • Purpose: There is no clear evidence of the original cause of hypertrophic scar, and the effective method of treatment is not yet established. Recently the steps of searching in gene and molecular level are proceeding. we are trying to recognize the difference between keratinocytes of hypertrophic scar and normal skin. Then we do support the comprehension of the scar formation mechanism and scar management. Methods: Total RNAs were extracted from cultured keratinocytes from 4 hypertrophic scars and normal skins. The cDNA chips were prepared. A total of 3063 cDNAs from human cDNA library were arrayed. And the scanning data were analyzed. Results: On microarray, heat shock protein, pyruvate kinase, tumor rejection antigen were more than 2 fold intensity genes. Among them, heat shock 70 kd protein showed the strongest intensity difference. Conclusion: In this study, it can be concluded that heat shock proteins play an important role in the process of wound healing and scar formation. This study provides basic biologic information for scar research. The new way of the prevention and treatment of scar formation would be introduced with further investigations.

Effect of Annealing Temperatures on the Properties of Zn2SnO4 Thin Film (열처리 온도에 따른 Zn2SnO4 박막의 특성)

  • Shin, Johngeon;Cho, Shinho
    • Journal of the Korean Society for Heat Treatment
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    • v.32 no.2
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    • pp.74-78
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    • 2019
  • $Zn_2SnO_4$ thin films were deposited on quartzs substrates by using radio-frequency magnetron sputtering system. Thermal treatments at various temperatures were performed to evaluate the effect of annealing temperatures on the properties of $Zn_2SnO_4$ thin films. Surface morphologies were examined by using field emission-scanning electron microscopy and showed that sizes of grains were slightly increased and grain boundaries were clear with increasing annealing temperatures. The deposited $Zn_2SnO_4$ thin films on quartzs substrates were amorphous structures and no distinguishable crystallographic changes were observed with variations of annealing temperatures. The optical transmittance was improved with increasing annealing temperatures and was over 90% in the wavelength region between 350 and 1100 nm at the annealing temperature of $600^{\circ}C$. The optical energy bandgaps, which derived from the absorbance of $Zn_2SnO_4$ thin films, were increased from 3.34 eV to 3.43 eV at the annealing temperatures of $450^{\circ}C$ and $600^{\circ}C$, respectively. As the annealing temperature was increased, the electron concentrations were decreased. The electron mobility was decreased and resistivity was increased with increasing annealing temperatures with exception of $450^{\circ}C$. These results indicate that heat treatments at higher annealing temperatures improve the optical and electrical properties of rf-sputtered $Zn_2SnO_4$ thin films.

Wet Surface Air-Side Performance of Fin-and-Tube Heat Exchangers Having Sine Wave Fins and Oval Tubes (사인 웨이브 핀과 타원관으로 구성된 핀-관 열교환기의 공기측 습표면 성능)

  • Kim, Nae-Hyun
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.16 no.4
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    • pp.2415-2423
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    • 2015
  • Experiments were conducted on sine wave fin-and-tube heat exchangers having oval tubes under wet condition. Oval tubes having an aspect ratio of 0.6 were made, by deforming 12.7mm round tubes. Twelve samples, having different fin pitch and tube row, were tested. Results showed that, for oval tube samples, the effect of fin pitch on j and f factor was not significant. As for the effect of tube row, the lowest j factor was obtained for one row configuration(81% of two row configuration), which is clear contrast to round tube samples, where the highest j factor was obtained for one row configuration. Possible reasoning is provided considering the flow and heat transfer characteristics of sine wave channel combined with connecting oval tubes. Comparison of $j/f^{1/3}$ with plain fin-and-tube heat exchanger having 15.9mm O.D. round tube reveals that present oval fin-and-tube heat exchanger shows superior thermal performance except for one row configuration. In other words, $j/f^{1/3}$ of the two row oval tube heat exchanger was 1.6~2.5 times larger than those of round tube heat exchanger, 1.4~2.4 times larger for three row configuration and 1.2~2.8 times for four row configuration.

An Outlook of the Oriental and Western Medical Diagnosis and Treatment on Gastric Cancer (위암(胃癌)의 동서의학적(東西醫學的) 진치(診治) 개황(槪況))

  • Kim, Byeong-Ju;Moon, Goo
    • The Journal of Korean Medicine
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    • v.17 no.2 s.32
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    • pp.100-116
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    • 1996
  • Gastric cancer shows the most high friquency in cancers that occurs in Korea. The western medicine treatment for gastric cancer has radiation and surgery, chemical treatment. While, oriental medicine cures the gastric cancer by herb-drugs, acupunture , moxa and srigma. With just one way of treating gastric cancer can't be effective remedy. Because each medicine has a strength and weakness. Thus, it is effective treatment when two medicine combins and supplement each other. We got the following result about a trend of oriental and westernal combination treatment for gastric cancer through studing records. 1. The western medicine treats gastric cancer patient with surgery first and right after surgery. They need on assembly treatent such as chemical and immune treatment. In oriental medicine, they treats gastric cancer patients with differentiation of symptone and signs and treatment(辨證施治)[for example:incoordination between liver and stomach(肝胃不和), insufficiency of spleen and stomach(脾胃虛弱), stagnation of blood stasis and toxic agent(瘀毒內阻), deficiency of yin by stomach heat(胃熱傷陰), reinforcing both qi and blood(氣血雙虧), stagnation of damp-phlegm(痰濕凝結)] and cure for them by acupuncture and stigma, too. 2. In combination with oriental and western medical treatment principle of gastric cancer by each stage is as follows. First stage and second stage gastric cancer is cured with radical surgery mainly. After operation, the herb of invigoration of the spleen(健脾), coordination of the stomach(和胃), and smoothing the liver and regurating the circulation of qi(疏肝理氣), is used for good gastroenteric condition. The second stage patients can be concidered using in combination with chimical treatment. The third stage gastric cancer is treated with radical surgery or with temporizing surgery. After those surgery, herb-drugs treatment is used jointly. The fourth stage patients who have no extensively metastasis or local contraindication can undergo temporizing and curcuit surgical operation. Herb-drugs and chemical treatments are used together for patients after operating. If he has operating contraindication, he would be treated with herb-drugs and chemical treatment. 3. In case of using in combination with oriental and western medical treatment as follows. As for herb-drugs with chemical treatment, reinforcing both qi and blood(補益氣血), invigorate the spleen and the stomach(健脾和胃), reinforcing liver and kidney(滋補脾腎), clear out the heat and relieve the toxic agent(淸熱解毒), can be used and with radiation treatment, clear out the heat and relieve the toxic agent(淸熱解毒), promoting the production body fluid and moisturizing the vicera(生津潤燥), reinforcing both qi and blood(補益氣血), invigorate the spleen and the stomach (健脾和胃), reinforcing liver and kidney(滋補肝腎) etc, can be used. 4. According to the research of oriental and western medical combination treatment are the 5-year-survival degree with oriental and western medicine combination treatment was for better than that just with oriental or western medical treatment. Especially, it has good effect on the third, fourth stage gastric cancer. That is, the middle and the end of stage gastric cancer. 5. The merits of oriental and western medicine combination treatment are lengthers one's life and diminish the bad effect of chemical treatment and radiation treatment be near completion, prevent from relapsing, maintain the balance in their eveirenment of body and improve immunity.

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Studies on Fibrinolytic Activity of Jujube (Zizyphus mauritiana) Extract (대추 추출물의 fibrinolytic activity에 관한 연구)

  • Lee Min-Kyung
    • Journal of Life Science
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    • v.16 no.2 s.75
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    • pp.357-359
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    • 2006
  • Crude extract prepared from jujube (Zizyphus mauritiana) possseses fibrinolytic activity hydrolyzing fibrin. A clear transparent region is observed where fibrin is hydrolyzed, and its diameter increased as the added jujube extract increased. The fibrinolytic activity of jujube extract seems to be heat and acid stable since its activity was retained after heat treatment at $100^{\circ}C$ for 10 min or an acid treatment by incubating at pH 2.0, 3.0, and 4.0 for 3 hours. But the jujube extract dialyzed with a cellulose membrane with molecular weight cutoff of 12,000 and 2,000 lost its activity, which suggests the fibrinolytic activity might be compounds of low molecular weight.

A Study on the Characteristics of Amorphous TiAl by P/M Processing

  • Han, Chang-Suk;Jeon, Seung-Jin
    • Journal of the Korean Society for Heat Treatment
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    • v.29 no.2
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    • pp.51-55
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    • 2016
  • The P/M processing of titanium aluminide using amorphous TiAl is developed by which it is possible to overcome inherent fabricability problems and to obtain a fine microstructure. A high quality amorphous TiAl powder produced by reaction ball milling shows clear glass transition far below a temperature at the onset of crystallization in differential scanning calorimetry above a heating rate of 0.05 K/s. We obtained a fully dense compact of amorphous TiAl powders, encapsulated in a vacuumed can, via viscous flow by hot isostatic pressing (HIP). Isothermally annealing of HIP'ed amorphous compact under a pressure of 196 MPa shows a progressive growth of ${\gamma}-TiAl$ phase with ${\alpha}2$ ($Ti_3Al$), which is characterized by increasing sharpness of X-ray peaks with temperature. Fully dense HIP'ed compact of titanium aluminide TiAl shows a high hardness of 505 Hv, suggesting strengthening mechanisms by sub-micron sized grain of ${\gamma}-TiAl$ and particle-dispersion by second phase constituent, ${\alpha}2$.

A Study on the City Wind Trail in Daegu (대구시 도시풍도에 대한 연구)

  • Choi, Young-Sik
    • Journal of the Korean Society of Industry Convergence
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    • v.9 no.1
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    • pp.29-35
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    • 2006
  • The population of Daegu, the third biggest city in Korea, is two point six million. Daegu is known as a basin or a city where it is not only too hot in summer but also too cold in winter. Recently with redevelopment apartment house boom, a 40-story or more apartment complexes are under construction near Shin-cheon and Dondaegu-ro, the south-north axis of Daegu. It is necessary to raise several points about blocking a road of the wind by high-rise apartment buildings and apartment complexes. As a kind of the green policy, Daegu enlarge the distance between apartment building by reconstructing low-rise apartment into high-rise and impose a duty of a green space on the ground by making a parking zone into an underground. Through this process, apartment complexes changed from a '一'shape to a '口'shape. It increases heat island phenomenon of a city by blocking a road of the wind that comes from Shin-cheon and Dondaegu-ro. To circulate the polluted air of Daegu basin, we need local wind. There are four effective measures. 1) Throw three greens into one in the center of the road at the north side in the same way of the south side of Dongdaegu-ro, 2) reflect the information of roads of the wind including heights, spaces and directions of buildings, 3) steer clear of a high-rise buildings and development apartment house constructions, and 4)select a city for benchmarking to be the environmental capital.

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Melt-Crystal Interface Shape Formation by Crystal Growth Rate and Defect Optimization in Single Crystal Silicon Ingot (단결정 실리콘 잉곳 결정성장 속도에 따른 고-액 경계면 형성 및 Defect 최적화)

  • Jeon, Hye Jun;Park, Ju Hong;Artemyev, Vladimir;Jung, Jae Hak
    • Current Photovoltaic Research
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    • v.8 no.1
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    • pp.17-26
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    • 2020
  • It is clear that monocrystalline Silicon (Si) ingots are the key raw material for semiconductors devices. In the present industries markets, most of monocrystalline Silicon (Si) ingots are made by Czochralski Process due to their advantages with low production cost and the big crystal diameters in comparison with other manufacturing process such as Float-Zone technique. However, the disadvantage of Czochralski Process is the presence of impurities such as oxygen or carbon from the quartz and graphite crucible which later will resulted in defects and then lowering the efficiency of Si wafer. The heat transfer plays an important role in the formation of Si ingots. However, the heat transfer generates convection in Si molten state which induces the defects in Si crystal. In this study, a crystal growth simulation software was used to optimize the Si crystal growth process. The furnace and system design were modified. The results showed the melt-crystal interface shape can affect the Si crystal growth rate and defect points. In this study, the defect points and desired interface shape were controlled by specific crystal growth rate condition.

A Study on the Simulation of Natural Ventilation Effect for Single-sided Casement Window as Opening Types (케이스먼트 창호 개폐방식에 따른 자연환기 효과에 관한 시뮬레이션 연구)

  • Choi, Taehwoan;Kim, Taeyeon;Leigh, Seung-Bok
    • KIEAE Journal
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    • v.7 no.4
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    • pp.57-62
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    • 2007
  • At the moment, the reduction of building energy consumption is a unavoidable task of mankind for conserving global environment. Decreasing overall U-value of building envelope and air infiltration, especially in Korean climate condition with clear four seasons, are the obvious solutions for the objective. Thus low glazing ratio with small window openings are required for heating and cooling load reduction in buildings. Using larger window openings could provide better natural ventilation but it also increases the direct solar radiation penetration into indoor space, heat gain in summer and heat loss in winter. On the other hand, the ventilation rates decreasing problem with smaller window openings could be occurred. As a solution for it, the use of casement window can cause increasing natural ventilation rates by wing wall effect. This paper focuses on deduce the most efficient opening type of casement window in Korean climate. To estimate ventilation performance of each opening types, CFD simulation was used. The best performance of opening type in every wind direction is opening both windows to the center and the most appropriate opening type for Korean climate is also opening both windows to center.

Variable Polarity Arc Welding of Aluminum Thin Plate (가변 극성을 이용한 박판 알루미늄 아크 용접)

  • Cho, Jungho
    • Journal of the Korean Society of Manufacturing Process Engineers
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    • v.13 no.2
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    • pp.89-93
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    • 2014
  • Variable polarity (VP) arc welding is known as an effective solution for aluminum thanks to the cleaning effect, which means oxide removal, during the DCEP (direct current electrode positive) period. In this research, VP GTAW (gas tungsten arc welding) is adopted for lap joint fillet welding of 3mm thickness 5052 aluminum alloy. Various welding currents and DCEP duty cycles are applied as welding conditions with a fixed welding speed to investigate the influence of DCEP characteristics on weld bead formation. Results show a tendency of higher heat input for higher DCEP duty cycle, which result does not follow conventional arc theory because it is known that DCEN (DC electrode negative) polarity is more efficient for heat input than is DCEP. This phenomenonhas recently been reported by several VP-GTA researchers and is still controversial because the mechanism of oxide removal is not yet clear except for the previous, well-known idea of "ion bombardment", which cannot explain the situation. Finally, proper usage conditions for VP-GTAW are suggested; then, further, related theoretical topics in the field of cathode physics are brieflyintroduced.