• 한국컴퓨터그래픽스학회논문지
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• 제22권3호
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• pp.21-29
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• 2016

본 논문은 명시야 (bright-field) 현미경 영상를 위한 데이터 기반 세포 분할 알고리즘을 제시한다. 제시된 알고리즘은 일반적인 사전 학습 기법과 다르게 동시에 두 개의 사전과 관련된 희소 코드 (sparse code)를 통해 정의된 에너지 함수의 최소화를 진행하게 된다. 두 개의 사전 중 하나는 명시야 영상에 대해 학습된 사전이고 다른 하나는 사람에 의해 수작업으로 세포 분할된 영상에 대해 학습된 것이다. 학습된 두 개의 사전을 세포 분할 될 새로운 입력 영상에 대해 적용하여 이와 관련된 희소 코드를 획득한 후 픽셀 단위의 분할을 진행하게 된다. 효과적인 에너지 최소화를 위해 합성곱 희소 코드 (Convolutional Sparse Coding)와 Alternating Direction of Multiplier Method(ADMM)이 사용되었고 GPU를 사용하여 빠른 분산 연산이 가능하다. 본 연구는 이전에 사용된 가변형 모델 (deformable model)을 이용한 세포 분할 방식과는 다르게 제시된 알고리즘은 세포 분할을 위해 사전 지식이 필요없이 데이터 기반의 학습을 통해서 쉽고 효율적으로 세포 분할을 진행할 수 있다.

• 한국환경보건학회지
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• 제44권4호
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• pp.301-314
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• 2018

Objectives: The aim of this study was to introduce the overall progress of exposure assessment to humidifier disinfectant (HD); to present participants' demographic characteristics, exposure characteristics to humidifier disinfectant, and exposure classification; and furthermore to compare those characteristics between survivors and non-survivors. Methods: An assessment of environmental exposure to HD was conducted using modified HD-specific questionnaires that had been previously validated. We analyzed the data from 4,482 participants who had been potentially exposed to HD and had registered with the KEITI (Korea Environmental Industry & Technology Institute) from September 2016 to May 2018 (the fourth survey). Environmental exposure assessments were performed as follows: 1) contact with participants, 2) environmental exposure assessment though face-to-face interviews, 3) assessment review and coding, and 4) exposure rating. Results: Overall, survivors made up 77.1% (3,457 subjects) and non-survivors made up 22.9% (1,025 subjects). When compared with the survivors, non-survivors had a higher proportion of subjects aged >60 years and subjects who answered as suffering lung damage and having purchased HD because it is "Beneficial to health" (p<0.05). For the exposure characteristics compared to survivors, non-survivors had a higher proportion of cases of distance from humidifier to face being less that one meter and the spray direction being toward the face (p<0.05). Overall, respondents who used the "Oxy Ssak Ssak New Gaseupgi Dangbun", "Aekyung Gaseupgi Mate", "Homeplus Gaseupgi Chungjungje", and "E-Mart Gaseupgi Salgyunje" products made up 66.1, 12.3, 4.0, and 3.6%, respectively, and 72.5% of respondents used products with PHMG as the active chemical. When compared with survivors, non-survivors had a higher proportion of use of "Oxy Ssak Ssak New Gaseupgi Dangbun" but a lower proportion of use of products with CMIT/MIT, PGH, or PHMG as the active chemical. Conclusions: This study provided demographic characteristics and exposure assessment for applicants who have been injured by HD. In spite of the limitations of performing past exposure assessment through a questionnaire survey, such as recall bias, useful results may be obtained by comparing survivors with non-survivors. Further studies such as the exposure rating method and so on are necessary to assess past exposure to HD.

• Parasites, Hosts and Diseases
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• 제59권2호
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• pp.139-148
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• 2021

This study was carried out to provide information on the taxonomic classification and analysis of mitochondrial genomes of Spirometra theileri. One strobila of S. theileri was collected from the intestine of an African leopard (Panthera pardus) in the Maswa Game Reserve, Tanzania. The complete mtDNA sequence of S. theileri was 13,685 bp encoding 36 genes including 12 protein genes, 22 tRNAs and 2 rRNAs with absence of atp8. Divergences of 12 protein-coding genes were as follow: 14.9% between S. theileri and S. erinaceieuropaei, 14.7% between S. theileri and S. decipiens, and 14.5% between S. theileri with S. ranarum. Divergences of 12 proteins of S. theileri and S. erinaceieuropaei ranged from 2.3% in cox1 to 15.7% in nad5, while S. theileri varied from S. decipiens and S. ranarum by 1.3% in cox1 to 15.7% in nad3. Phylogenetic relationship of S. theileri with eucestodes inferred using the maximum likelihood and Bayesian inferences exhibited identical tree topologies. A clade composed of S. decipiens and S. ranarum formed a sister species to S. erinaceieuropaei, and S. theileri formed a sister species to all species in this clade. Within the diphyllobothridean clade, Dibothriocephalus, Diphyllobothrium and Spirometra formed a monophyletic group, and sister genera were well supported.

• 대한한방부인과학회지
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• 제30권3호
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• pp.92-116
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• 2017

Objectives: The purpose of this study were to researched a Korean medicine doctors' recognition about coldness of hands and feet, and developing of korean medicine clinical practice guidelines (CPG) for coldness of hands and feet. Methods: We conducted a questionnaire survey targeting 399 Korean medicine doctors belonging to the Association of Korean Medicine by e-mail and analyzed the answers. Results: 1. 86.86% of the respondents agreed about the necessity of CPG for coldness of hands and feet. 2. 84.2% of respondents wanted coding of Korean Standard Classification of Diseases (KCD) on coldness of hands and feet. 3. To diagnosis a coldness of hands and feet, the respondents used a Subjective symptoms (98.5%), Infrared thermographic imaging device (DITI) (26.32%) Heart rate variablity test (HRV) (17.04%), Thermometer (9.77%), Cold stress test (2.76%) 4. Causing of coldness of hands and feet, the respondents considered a constitution or heredity (84.71%), stress (73.66%), lack of exercise (64.91%), irregular eating habits (51.63%), Cold meals (32.83%), depression (31.33%), etc. 5. Treating coldness of hands and feet, the respondents used a herbal medicine (66.85%), acupuncture (70.7%) Pharmacopuncture (23.85%) and moxibustion (60.08%) for $10.91{\pm}8.03week$. Conclusions: We researched a Korean Medicine doctors' recognition of CPG, clinical diagnosis, treatment on a coldness of hands and feet, and policy they required.

• Journal of Microbiology and Biotechnology
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• 제34권4호
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• pp.871-879
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• 2024

Our group had isolated Bifidobacterium breve strain BS2-PB3 from human breast milk. In this study, we sequenced the whole genome of B. breve BS2-PB3, and with a focus on its safety profile, various probiotic characteristics (presence of antibiotic resistance genes, virulence factors, and mobile elements) were then determined through bioinformatic analyses. The antibiotic resistance profile of B. breve BS2-PB3 was also evaluated. The whole genome of B. breve BS2-PB3 consisted of 2,268,931 base pairs with a G-C content of 58.89% and 2,108 coding regions. The average nucleotide identity and whole-genome phylogenetic analyses supported the classification of B. breve BS2-PB3. According to our in silico assessment, B. breve BS2-PB3 possesses antioxidant and immunomodulation properties in addition to various genes related to the probiotic properties of heat, cold, and acid stress, bile tolerance, and adhesion. Antibiotic susceptibility was evaluated using the Kirby-Bauer disk-diffusion test, in which the minimum inhibitory concentrations for selected antibiotics were subsequently tested using the Epsilometer test. B. breve BS2-PB3 only exhibited selected resistance phenotypes, i.e., to mupirocin (minimum inhibitory concentration/MIC >1,024 ㎍/ml), sulfamethoxazole (MIC>1,024 ㎍/ml), and oxacillin (MIC >3 ㎍/ml). The resistance genes against those antibiotics, i.e., ileS, mupB, sul4, mecC and ramA, were detected within its genome as well. While no virulence factor was detected, four insertion sequences were identified within the genome but were located away from the identified antibiotic resistance genes. In conclusion, B. breve BS2-PB3 demonstrated a sufficient safety profile, making it a promising candidate for further development as a potential functional food.

• 보건교육건강증진학회지
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• 제15권1호
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• pp.151-163
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• 1998

The purpose of this study is to find options which reduce the job stress and to enhance morale through a variable analysis, and also apply this data in the legal and administration fields. The data for the research was obtained from 217 dental hygienists working in the dental clinics, dental hospitals and university's dental hospitals' in Seoul. The tool used by this study was a Questionnaire measuring on-the-job stress of dental hygienists, was a modified and revised. The Questionnaire version used to measure bank's job stress and used to suggest options by Dae-ha Yoon(1991). Classification of items for measuring job stress was based on Theoretical Study on Job Stress by Dae-hyon Song(1986). The scale used in study was the two points (yes or no in the job stress) scale measuring for variables. The period of data collection was 30 days from December 4, 1995 to January 5, 1996. The methods of data collection were self-writing, direct visit, and postal Questionnaire answering, 224 copies of Questionnaire data were collected, but only 217 copies were used. 7 copies could not be analyzed, were not used for this study. The data analysis was conducted by SPSS after coding the collected raw data. The general characteristics was obtained from real digits and percentages. In order to analyze the difference of sub-variables against the job stress based on general characteristics. Mean, Standard Deviation, and F test (ANDVA) were conducted. The following were the results of job stress variables: 1. Meaningful variable affecting the working organization, is compensation system(p〈0.03). 2. Meaningful variable affecting the working period, is work overload(p〈0.02). 3. Meaningful variable affecting average patients per day, is the career management and payment(p〈0.04, p〈0.01). 4. Meaningful variable affecting number of staff, is the comrade relationship, role conflict among patients, work overload, and job overload(p〈0.000, p〈0.05, p〈0.04, p〈0.01). The comrade relationship is most affected to the number of staffs aides. 5. Meaningful variables affecting job diversion, are the desire and value, the non-role play, and the environment(p〈0.003, p〈0.02, p〈0.005).

• Journal of Korea Trade
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• 제25권2호
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• pp.75-94
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• 2021

Purpose - This article will take the Korean manufacturing industry as an example to estimate Korea's global value chain status from the perspective of overall and sub-industry, hoping to provide a theoretical reference for Korean manufacturing to climb the global value chain. Design/methodology - Based on the WIOD data. The data is calculated by using MATLAB (2014a) coding. The data for 6 sectors are classified according to the International Standard Industrial Classification revision 3 (ISIC Rev. 3), the WIOD data are used to calculate and compare the position, participation and dynamics of the Korea, China and USA' manufacturing industry in the 1995-2016. Findings - The empirical results supported conclusions of the theoretical model. In the Korean GVC of electrical and optical sector, while stronger forward linkages than backward linkages to GVC are advantageous for an average advanced country, the benefits of downstream tasks are pronounced for non-advanced countries. And proved the correlation for an index to capture a country's upstream position or downstream position, it makes sense to compare that Korea's exports of intermediates in the same sector that are used by China and USA. Originality/value - The first is to re-examine the characteristics of South Korea's participation in global value chains under a more systematic and accurate theoretical framework, which provides a new empirical reference for related research; the second is to content covers of the manufacturing 6 sectors, so as to more completely describe the characteristics of Korean manufacturing's participation in global value chains; The value of this paper is providing empirical evidence of the effect of Korea's the GVC of manufacturing sectors. In the GVC of 6 sectors, first three have a higher position in the value chain and are in the upper middle and upper reaches of the GVC. The latter two have a low GVC position index, which has become the main sector that pulls down the overall position of Korea's manufacturing industry.

• 대한한방내과학회지
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• 제45권1호
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• pp.55-74
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• 2024

Objectives: This study reviewed the status of adverse event (AE) reporting in VigiAccess using anti-obesity agents as examples and explored the possibility of its use and future challenges. Methods: AE reports related to some representative drugs among herbal medicines (HMs), complex HM prescriptions, ingredients of supplements, and over-the-counter and prescription medicines were investigated using VigiAccess on February 1, 2024. Results: AE reports on prescription drugs were overwhelmingly higher than those on HMs or supplements. Although most reports were submitted from North America, reports on Ephedra sinica and green tea extract (GTE) were more from Asia and Europe, respectively. The female population reported more, and the difference in the sex ratio was the smallest for Ephedra spp. The age group was concentrated on young adults, but many older patients reported GLP-1 receptor agonist-related AEs. Symptoms related to the gastrointestinal and nervous systems were most commonly reported, but mental and cardiac disorders were common in Ephedra-type HMs. Hepatobiliary disorders are also commonly found in GTE-related reports. Conclusions: VigiAccess was useful for easily checking the global status of AE reporting for prescription drugs. However, several limitations were observed in using VigiAccess for HMs because of the few reports. Thus, it is necessary to increase the number of reports by education and to promote AE reporting among HM prescribers and users. The full range of HMs should be included in the pharmacovigilance system, and the coding and classification of HMs should be revised.

• 전자공학회논문지CI
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• 제49권3호
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• pp.15-26
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• 2012

최근 공간정보표현을 위해 벡터데이터 기반 디지털 맵의 활용도의 증가와 측량기술의 발전에 기인하여 높은 수준의 해상도를 갖는 고용량의 GIS(geographic information service) 서비스가 활발히 이루어지고 있다. 본 논문은 방대한 범위에서 높은 해상도를 갖는 1cm(센티미터) 단위의 정밀 벡터맵의 효율적인 압축을 위해 공간 영역 상에서의 에너지 집중 기법(spatial energy compaction, SEC)을 이용한 벡터맵 압축 기법을 제안한다. 제안 기법은 벡터맵에서 공간정보를 표현하기 위해 주로 사용되는 폴리곤(polygon) 및 폴리라인(polyline) 오브젝트에 대해 압축을 수행한다. 제안 기법에서는 전체 벡터맵을 국부영역으로 나눈 후, 각 국부영역 내의 오브젝트 인접성 및 방향성을 이용하여 세 가지 종류의 빈으로 분류하여 에너지 집중을 수행하며, 미리 정의된 가변길이부호화를 이용해 부호화하여 압축한다. 실험결과 동일한 벡터맵에 대해 1m 정밀도의 벡터간소화 기법이 약 13%의 압축율을 갖는 데 반해, 제안 기법은 1cm 단위의 정밀도에서 원본 데이터의 80%이상 압축이 수행됨을 확인하였다. 또한 이것은 기존에 제안한 SEC 기반 압축 기법보다 높은 압축율을 가지면서 낮은 계산 복잡도를 유지하며, 기존의 벡터 근사화 기법보다 높은 정밀도에서 높은 압축률로 압축할 수 있음을 실험을 통해 확인하였다.

• 산업융합연구
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• 제21권8호
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• pp.87-96
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• 2023

본 연구는 중등 예비체육교사들이 배움중심수업에 대해 어떠한 의미를 부여하는지 메타포 분석을 통해 알아보고, 체육수업 중 배움중심수업의 적용에 대하여 인식을 점검하고자 하는 데 그 목적이 있다. 연구 목적을 달성하고자 배움중심수업에 대한 인식을 메타포로 표현하는 설문 조사로 실시하였다. 자료 분석은 메타포 분석방벙론에 따라 코딩, 메타포 분류, 분석 단위 결정, 표본의 범주화 등의 과정을 통해 처리되었다. 그 결과 교육의 필요성, 교육의 목표 및 내용, 교수·학습 방법 및 평가, 교사 교육 및 역할이라는 4개의 대분류와 자아실현을 위한 수업, 미래 사회 준비를 위한 수업, 창의성을 기르는 수업, 개방적이고 다양한 수업, 호기심 자극 및 흥미 유발 수업, 개인의 발달 및 특성에 적합한 수업, 실천하기 부담스러운 수업, 교사의 창의성과 독창성이 필요한 수업의 8개 내용유형으로 도출되었다. 본 연구의 결과를 통해 배움중심수업의 필요성 및 방향에 대해 그 시사점을 확인할 수 있었다.