• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.4
• /
• pp.1649-1654
• /
• 2014

Background: Clinically significant portal hypertension (PHT) is considered as a contraindication for hepatectomy according to the guidelines of the European Association for Study of Liver and the American Association for Study of Liver Diseases. However, this issue remains controversial. Here we performed a metaanalysis to evaluate the impact of PHT on the results of hepatectomy for hepatocellular carcinoma (HCC). Methods: Cohort studies evaluating the impact of clinically significant PHT, defined as oesophageal varices and/or splenomegaly associated with thrombocytopenia, on the results of hepatectomy for HCC were identified using a predefined search strategy. Summary risk ratios (RRs) and 95% confidence intervals (95% CIs) for PHT and outcomes after hepatectomy for HCC were calculated. Results: Seven cohort studies which including 574 cases with PHT and 1,354 cases without PHT were considered eligible for inclusion. The meta-analysis showed that, in all patients, pooled RRs of post-operative liver failure, post-operative ascites, peri-operative blood transfusion, operative mortality, 3- and 5-year overall survival associated with PHT were 2.23 (95% CI: 1.48-3.34, P=0.0001), 1.77 (95% CI: 1.19-2.64, P=0.005), 1.23 (95% CI: 1.03-1.49, P=0.03), 2.58 (95% CI: 1.12-5.96, P=0.03), 0.82 (95% CI: 0.75-0.88, P<0.00001) and 0.76 (95% CI: 0.69-0.85, P<0.00001), respectively. In subgroup analysis, similar results were found in Child-Pugh class A patients. Conclusion: This meta-analysis suggests that presence of oesophageal varices and/or splenomegaly associated with thrombocytopenia is associated with higher rates of post-operative complications and poor long-term survival after hepatectomy for HCC.

• Journal of the Korean Chemical Society
• /
• v.59 no.6
• /
• pp.499-507
• /
• 2015

The purpose of this study is to investigate middle school students’ understanding of ionic equation. Two hundreds and nineteen middle school students were participated in the study. After six class hours of learning ‘electrolyte and ion’ unit, instrument was implemented to evaluate students’ understanding of ionic process and ability to write ionic equation. We analyzed the influence of characteristics of ionic compounds on correct answer rate. In addition, knowledge state of students required for writing ionic equation was analyzed. The results were as follows: First, ionic compounds tested were categorized into six groups. The correct answer rate was different depending on the characteristics of each group. Second, knowledge state required for writing ionic equation was structured. Based on results some suggestion were made to develope effective learning strategy for understanding ionic equation.

• Journal of the Korea Society of Computer and Information
• /
• v.17 no.5
• /
• pp.147-155
• /
• 2012

Police education has shown a pronounced improvement during three eras in American police history. as the Reform Era arrived, the police academy was invented. With it, citizen expectations for the police expanded, and the level of competence exhibited by police grew. After the 1960s came the invention of the FTO and the creation of ongoing, in-service training requirements. in recent years, academics in many places-but by no means everywhere-are taking a more collegial approach to training, aimed especially at COP- style policing and the achievement of genuine professionalism. The Korean police training system is less efficient in education methodology, more inappropriate in the switch system of school education and practice, and poorer in educational environment, among others. Based on my findings, this paper recommends several improvement tips. First, legal stipulations on police training should be integrated and detailed. Second, active participation by preliminary police officers should be emphasized in the class of police training. Third, contents and hours for practice should be emphasized to maximize effects of the "switch system." Fourth, the educational environment of the Academy should be improved.

• Tuberculosis and Respiratory Diseases
• /
• v.81 no.3
• /
• pp.198-215
• /
• 2018

Bronchodilators provide improvements in lung function and reductions in symptoms and exacerbations, and are the mainstay of pharmacological management of chronic obstructive pulmonary disease (COPD). The Global Initiative for Chronic Obstructive Lung Disease strategy recommends the use of a combination of long-acting ${\beta}_2-agonist$/long-acting muscarinic antagonists (LABA/LAMA) as the first-line treatment option in the majority of symptomatic patients with COPD. This review provides an indirect comparison of available LABA/LAMA fixed-dose combinations (FDCs) through discussion of important efficacy and safety data from the key literature, with the objective of providing physicians with a framework for informed decision-making. LABA/LAMA FDCs provided greater benefits compared with placebo and similar or greater benefits compared with tiotropium and salmeterol/fluticasone in improving lung function, dyspnea, health-related quality of life, reducing rescue medication use and preventing exacerbations, although with some variability in efficacy between individual FDCs; further, tolerability profiles were comparable among LABA/LAMA FDCs. However, there is a disparity in the amount of evidence generated for different LABA/LAMA FDCs. Thus, this review shows that all LABA/LAMA FDCs may not be the same and that care should be taken when extrapolating individual treatment outcomes to the entire drug class. It is important that physicians consider the efficacy gradient that exists among LABA/LAMA FDCs, and factors such as inhaler devices and potential biomarkers, when choosing the optimal bronchodilator treatment for long-term management of patients with COPD.

• Journal of Information Technology and Architecture
• /
• v.10 no.2
• /
• pp.181-195
• /
• 2013

This study is to investigate into the factors that influence the use of a military logistics information system in Korean army. We developed the research model based on DTPB (Decomposed Theory of Planned Behavior) because the DTBP is an appropriate model in a mandatary using environment through the study of previous technology-acceptance models. A questionnaire survey was conducted with Korean army solders and civilian components who use the army logistics information system and 266 valid questionnaires are recovered. The collected data were analyzed by SPSS and AMOS. The results show that perceived usefulness and ease of use did not affect the attitude of the use intention. The influence of colleagues and upper class officers was all satisfactory and computer self-efficiency affected perceived control of behavior. The results of this study will contribute to the further use of the military logistics information system and future development strategy.

• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.7
• /
• pp.3471-3476
• /
• 2012

Background and Objective: Histone deacetylase (HDAC) inhibitors represent a promising class of potential anticancer agents for treatment of human malignancies. In this study, we investigated the effect of trichostatin A (TSA), one such HDAC inhibitor, in combination with docetaxel (TXT), a cytotoxic chemotherapy agent or erlotinib, a novel molecular target therapy drug, on lung cancer A549 cells. Methods: A549 cells were treated with TXT, erlotinib alone or in combination with TSA, respectively. Cell viability, apoptosis, and cell cycle distribution were evaluated using MTT (3- (4, 5-dimethylthiazol-2-yl) -2, 5-diphenyltetrazolium bromide) assay, Hochst33258 staining and flow cytometry. Moreover, immunofluorescent staining and Western blot analysis were employed to examine alterations of ${\alpha}$-tubulin, heat shock protein 90 (hsp90), epidermal growth factor receptor (EGFR), and caspase-3 in response to the different exogenous stimuli. Results: Compared with single-agent treatment, co-treatment of A549 cells with TSA/TXT or TSA/erlotinib synergistically inhibited cell proliferation, induced apoptosis, and caused cell cycle delay at the $G_2/M$ transition. Treatment with TSA/TXT or TSA/erlotinib led to a significant increase of cleaved caspase-3 expression, also resulting in elevated acetylation of ${\alpha}$-tubulin or hsp90 and decreased expression of EGFR, which was negatively associated with the level of acetylated hsp90. Conclusions: Synergistic anti-tumor effects are observed between TXT or erlotinib and TSA on lung cancer cells. Such combinations may provide a more effective strategy for treating human lung cancer.

• Journal of the Korean School Mathematics Society
• /
• v.21 no.1
• /
• pp.63-89
• /
• 2018

In this study, the researcher developed a course integrated mathematical problem posing activities in order to enhance pre-service mathematics teachers' ability to carry out problem posing activities in mathematics classroom, and examined the changes of pre-service mathematics teachers' perceptions about problem posing through the course. The problem posing course developed in this study consisted of three stages: education on the theories regarding problem posing; activities with problem posing; development and implementation of problem posing tasks. According to the results of the questionnaires, interviews, and class journals data analysis, the problem posing experiences provided in this study were very effective in improving pre-service mathematics teachers' understanding of the problem posing strategies and the benefit of problem posing activities to student learning. Particularly, the experience in various problem posing activities and the implementation experience of problem posing provided in the course played a key role in the improvement of pre-service mathematics teachers' understanding of problem posing and PCK.

• Asian Pacific Journal of Cancer Prevention
• /
• v.17 no.7
• /
• pp.3605-3610
• /
• 2016

Background: Histone acetylation in chromatin structures plays a key role in regulation of gene transcription and is strictly controlled by histone acetyltransferase (HAT) and deacetylase (HDAC) activities. HDAC deregulation has been reported in several cancers. Materials and Methods: The expression of 10 HDACs (including HDAC class I and II) was studied by quantitative reverse transcription-PCR (qRT-PCR) in a cohort of mesenchymal stem cells (MM-MSCs) from 10 multiple myeloma patients with a median age 60y. The results were compared with those obtained for normal donors. Then, a coculture system was performed between MM-MSCs and u266 cell line, in the presence or absence of sodium butyrate (NaBT), to understand the effects of HDAC inhibitors (HDACi) in MM-MSCs on multiple myeloma cases. Also, the interleukin-6 (IL-6) and vascular endothelial growth factor (VEGFA) gene expression level and apoptotic effects were investigated in MM-MSCs patients and control group following NaBT treatment. Results: The results indicated that upregulated (HDACs) and downregulated (IL6 and VEGFA) genes were differentially expressed in the MM-MSCs derived from patients with multiple myeloma and ND-MSCs from normal donors. Comparison of the MM-MSCs and ND-MSCs also showed distinct HDACs expression patterns. For the first time to our knowledge, a significant increase of apoptosis was observed in coculture with MM-MSCs treated with NaBT. Conclusions: The obtained findings elucidate a complex set of actions in MSCs in response to HDAC inhibitors, which may be responsible for anticancer effects. Also, the data support the idea that MSCs are new therapeutic targets as a potential effective strategy for MM.

• Journal of the Korean School Mathematics Society
• /
• v.14 no.2
• /
• pp.123-142
• /
• 2011

Recently, a number of researches acknowledge the importance of 'reflection' and 'reflective teacher education,' and they highlight the implication of 'reflection' on the teacher's profession or the teacher education. The reflective thought is interpreted as a subject that should be taught or a sort of strategy that a teacher should learn, while the aspect is excluded that reflection is the interaction between the innate knowledge and the practice. As a result, the reflective teacher education programs that increase the level of reflection are developed and practiced, and the reflection is accepted as a tool for increasing teacher professionalism. Reflective teaching is en essential and basic element for the development of teacher knowledge. In particular, such teacher knowledge might be being gradually expanded by a teacher's self-assessment on reflection on his own instruction. For this reason, this study develops an assessment framework on instruction which is comprized of teacher knowledge and instructional process. To accomplish this, in this study, teacher knowledge is considered as a whole practice knowledge combined by subject matter knowledge, understanding of learners, teaching and learning methods and assessment, and instructional environment. Also, success on instruction in mathematics class might depend on the acquisition of teacher knowledge, instructional planning, instructional execution, and furthermore reflection on instruction. Especially, this study emphasizes that 'reflection on instruction', the most important step of instruction be reflected and examined by the teacher himself.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.17 no.8
• /
• pp.691-697
• /
• 2016

Remanufacturing refers to restoring a used product to an acceptable condition for resale in the market of remanufactured items. In this paper, we deal with the acquisition price and remanufacturing decision for remanufacturing systems in the case where the demand for the remanufactured product in a single period is known and the return quantity of the used product is determined by its acquisition price. The quality of the acquired used product is categorized into two classes, high and low, through inspection and different qualities incur different remanufacturing costs. The probability that the acquired used product is categorized as high class can be a constant or random variable. We derive the expected total cost functions, obtain the optimal solutions, and interpret the managerial meaning of the optimal solution for each case. The sensitivity of the optimal solution with respect to the variation of the inspection cost and uncertainty of the quality of the used product is investigated through numerical examples.