• 대한한방내과학회지
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• 제33권2호
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• pp.145-159
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• 2012

Objectives : The object of this study was to obtain acute toxicity information (single oral dose toxicity) of Armeniacae Semen (AS), a medicinal herb used for treating constipation and various respiratory diseases, in rats. Methods : In order to observe the $LD_{50}$ (50% lethal dose), approximate lethal dosage (ALD) and target organs, AS aqueous extracts were orally administered once to female and male Sprague Dawley rats at dose levels of 2,000, 1,000, 500 and 0 (control) mg/kg (body weight). The mortality, changes in the body weight, clinical signs and gross observation were monitored for 14 days after single oral treatment of AS extracts, and the organ weights and histopathological findings of principle organs were observed after sacrifice. Results : After single oral treatment of AS 2,000 and 1,000 mg/kg, all (5/5; 100%) female and male rats died within 30 minutes after treatment, while no mortalities were observed in the female and male rats treated with 500 mg/kg of AS extract. Therefore, $LD_{50}$ in female and male rats was calculated as 741.95 mg/kg. Seizure, loss of locomotion, salivation, increases of respiration and heart-beat were observed after AS extract treatment, which were observed in all rats including the lowest dosage group, 500 mg/kg in the present study. In addition, lung congestion was visible in all mortal rats with AS 2,000 and 1,000 mg/kg, respectively. Conclusions : The results obtained in this study suggest that AS extract ranges in Class III, because the $LD_{50}$ and ALD in both female and male rats were calculated as 741.95 mg/kg and 500~1,000 mg/kg, respectively. However, AS extract should be carefully treated at clinical applications, because salivation, increase of respiration and heart-beat were also observed in the lowest dosage group, 500 mg/kg in the present study.

• 대한치과교정학회지
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• 제26권5호
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• pp.547-556
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• 1996

본 연구는 성장기의 골격성 III급 부정교합 환자에서 face mask를 이용하여 상악골을 전방 견인하였을 때, 골격 및 치아관계와 연조직 측모의 변화를 관찰하고 face mask사용전후의 경조직과 연조직 변화의 유의성을 검정하여 상악골 열성장을 보이는 골격성 III급 부정교합 환자의 진단과 치료계획 수립에 도움을 주고자 하였다. 서울대학교병원 치과진료부 교정과에 내원하여 상악골 열성장에 의한 골격성 III급 부정교합으로 진단받고 face mask를 사용하여 양호한 치료결과를 보인 환자 15명을 대상으로 face mask사용전후 두부 방사선 계측사진을 촬영하고 face mask 사용전 계측치와 face mask사용후의 계측치를 분석하여 다음과 같은 결과를 얻었다. 1. SNA와 상악골의 실제 길이인 Co-A가 통계적으로 유의한 수준으로 증가하여(p<0.001), 상악골은 face mask에 의한 치료후 상당량 전방위치 되었다. 이는 face mask의 orthopedic effect에 의한 것이다. 2. 상, 하악골의 실제길이를 나타내는 Co-A, Co-Gn이 face mask 사용후 모두 유의성있게 증가하였다(p<0.01). 3. 하악골의 위치는 상당량 후하방 회전되었다. FMA(p<0.001), SN-GoGn(p<0.01), Y-axis(p<0.01) 등이 face mask 사용후 유의성있는 증가를 보였다. 4. 상악전치, 하악전치의 face mask사용후 치축의 경사도는 유의성있는 차이를 보이지 않았다. 5. 연조직에 대한 변화에서 상순의 위치가 전방으로 변화하여 정상적인 측모의 평균치에 가깝게 변한 것이 인정되었다(p<0.01).

• Journal of Chest Surgery
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• 제38권1호
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• pp.44-49
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• 2005

흥선종양은 비교적 흔한 종격종 종양이나 이제까지 병리학적 분류가 통일된 것이 없었으며 또한 치료 및 예후와의 연관성이 잘 확립되어 있지 않았다. 최근에서야 WHO 분류가 발표되었고 이에 따른 치료 계획과 치료에 따른 예후와의 상관관계가 보고되기 시작했다. 본 연구는 WHO 분류와 Masaoka병기 그리고 임상양상 간의 상관관계를 조사하였다. 대상 및 방법: 대상환자는 서울아산병원 흉부외과에서 1993년 1월부터 2003년 6월까지 완전절제술을 시행 받았던 흥선종양 환자 98명으로 하였다. WHO 분류의 조사를 위하여 병리조직 slide를 다시 검토하였으며 수술 후 Masaoka병기와의 관련성, 술 후 추가적인 치료와 예후에 대한 관계 및 재발여부에 관하여 의무기록 조사를 통하여 후향적으로 조사하였다. 결과: 98예의 대상 환자 중 남녀 비는 48 : 50이었으며 수술 연령은 평균 $49.6{\pm}13.9$세였다. WHO 분류에 따르면 type A 6명, AB 14명, B1 18명, B2 23명, B3 18명, C 9명이었다. Masaoka 병기와 WHO 분류와의 관계를 보면 Masaoka 병기 I 53명 $(54{\%})$ 중에서 WHO type A 4명, AB 7명, B1 22명, B2 17명, B3 3명이었으며 Masaoka 병기 II 28명$(28.5{\%})$ 중에서는 WHO type A 2명, AB 7명, B1 4명, B2 2명, B3 8명, C 5명이었고 Masaoka병기 III 15명$(15.3{\%})$ 중에서는 WHO type B1 L명, B2 3명, B3 7명, C 4명이었으며 Masaoka병기 IV 2명$(2{\%})$ 중에서는 WHO type B1 1명, B2 1명이었다. 평균 추적 기간은 $28{\pm}6.8$개월이었다. 사망 환자는 3명으로 type B2에서 2명(Masaoka 병기 III, IV), 그리고 type C에서 1명(Masaoka병기 II)이었다 재발 후 생존해 있는 환자는 총 6명이었으며 이 중 type B2에서 2명(Masaoka 병기 III), type B3에서 2명(Masaoka 병기 I, III) type C에서 2명(Masaoka 병기 II)이었다. Kaplan-Meier방법으로 통계 처리한 결과 WHO분류상 type B2에서 5년 생존율은 $90{\%}$ 였으며 type C에서 5년 생존율은 $87.5{\%}$였다. 재발률을 보면 class B2에서 5년 무병 생존율 $80.7{\%}$, B3에서 $81.6{\%}$, C에서 $50{\%}$였다. Log-Rank 방법에서 보면 WHO분류와 생존율, 재발률 사이에 통계학적으로 상관관계가 있는 것으로 나타났다(p<0.05). WHO 분류와 Masaoka분류의 상관 관계를 보면 Spearman correction method출 이용한 통계에서 상관관계 곡선이 slope=0.401 (p=0.023)으로 밀접한 관계가 있다고 하겠다. 결론: WHO분류의 type C의 경우 수술 후 재발률과 사망률이 높으므로 수술 후보다 적극적인 치료와 추적관찰이 필요할 것으로 생각된다. WHO분류와 Masaoka 병기간에는 상호 밀접한 관계가 있는 것으로 생각되며 WHO분류 및 Masaoka병기 모두 흥선종의 예후의 예측 인자가 될 수 있을 것으로 생각된다.

• 대한치과교정학회지
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• 제28권4호
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• pp.533-546
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• 1998

골격성 III급 부정교합은 크게 하악이 과성장인 경우, 상악이 열성장인 경우, 이 두가지의 복합으로 나타나는데 이중 상악의 열성장으로 인한 성장기 골격성 III급 부정교합 환자에서는 상악골에 악정형력을 가하여 상악골을 전방견인 함으로써 보다 효과적인 결과를 얻을 수 있다. 이에 상악골 견인장치 중 현재 많이 쓰이는 RME와 Facial mask를 사용하여 치료한 34명(남자 9명, 여자 25명)의 환자를 대상으로 치료결과 FH/palatal plane, SNA, SNB, LFH의 변화량을 기준으로하여 각각의 변화량에 따라 두군으로 분류하여 치료 전, 후 상악골 및 하악골의 변화 양상과 수직적인 고경에 차이가 있는지를 관찰하여 다음과 같은 결론을 얻었다. 1. 상악골 전방견인 장치를 사용한 모든 환자에서 상악골의 전방이동과 하악골의 후하방회전이 일어났으며 대부분의 환자에서 구개평면은 상방경사되는 경향을 보였다. 2. Facial mask사용결과 구개평면이 상방경사된 군(FH/pal 1군)은 구개평면이 하방경사된군(FH/pal 2군)에 비해 상악골의 전방이동이 많이 일어났다. 3. Facial mask 사용결과 상악골의 전방이동량이 많은 군(SNA 1군)은 상대적으로 하악골의 후방이동량은 적게 나타나고 구개평면이 상방경사되는 경향을 보였다. 4. Facial mask사용결과 하악골의 후방이동이 많이 일어난 군(SNB 1군)은 상대적으로 상악골의 전방이동은 적게 나타나며 하악골의 후방이동은 하방회전과 함께 나타나서 수직적인 증가 특히 전안면부위의 증가를 일으킨다. 5. LFH 증가량에 의해 분류된 두 군 사이의 비교에서 치료 전 saddle angle이 크고 상악골 및 하악골이 후방에 위치하던 군이 saddle angle이 작고 하악골이 전방위치되어 있는 군에 비해 하안면고경의 큰 증가없이 상악골 전방견인이 이루어졌다.

• Restorative Dentistry and Endodontics
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• 제29권1호
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• pp.66-72
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• 2004

All-in-one adhesives were recently developed for reducing the technique sensitivity and chair time, but lots of concerns were made on bondability, longevity, and microleakage. The object of this study was to evaluate microleakage and marginal quality of all-in-one adhesives using electrochemical method and SEM analysis quantitatively. After making Class V cavities, they were bulk filled with Heliomolar(#A1 after surface treatment with three adhesives: Adper Prompt (Group A), One up bond F (Group O), Xeno III (Group X) Electrical conductivity (microamphere, ${\mu}A$) was checked two times: before and after cavity filling. Percentage of leaky margin was estimated from SEM image (${\times}1,000$). The data were statistically analysed: ANOVA and Paired T test for electrical conductivity, Kruskal-Wallis and Mann-Whitney test for marginal quality, Spearman s rho test for checking of relationships between 2 methods. The result were as follows: 1. There was no difference in microleakage between adhesive systems and every specimen showed some of microleakage after filling. 2. Microleakage was reduced about 70% with composite resin filling. 3. Marginal quality was the best in group A. decreasing among groups in the following order: group O, followed by group X. There were significant differences between group A and group X (p=0.015), and between group 0 and group X (p=0.019). 4. There was no relationship between the microleakage measured by electrochemical method and marginal quality measured by SEM analysis. Within the results of this study, there was no difference in microleakage among groups by electrical conductivity. However, significant difference in marginal quality was seen among groups. It was believed that these dissimilar results might be induced because of their own characteristics. Analysis of microleakage needs various methods for accuracy.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제34권3호
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• pp.180-185
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• 2012

Purpose: An accurate preoperative analysis of the patient is essential in orthognathic surgery in order to acquire superior results. In profile, the location of the chin's position may change according to the neck's inclination. This may ultimately affect the amount of surgical movement. During acquisition of cephalometric radiographs, or in supine position, there is a discrepancy in the neck's inclination. This means that there are also various discrepancies between the actual profile and the various preoperative profile images. In the clinical situation, the decision in performing genioplasty usually lies in the analysis of the patient's profile on the operating table at the final stages of orthognathic surgery. This study aims to analyze the different preoperative profile images and to compare their discrepancies. Methods: Fifty eight patients undergoing orthognathic surgery were chosen. These patients were divided into three groups according to angle's classification of malocclusion, as class I, II or III. The right profile of these patients in centric occlusion was taken in natural head position (NHP). This was set as the 'actual profile image.' Another right profile image was taken on the operating table after insertion of the nasotracheal intubation and with muscle relaxants in effect. This was also taken in centric occlusion. The angle (denoted 'A') between the soft tissue glabella-pognion and the true vertical plane was found in the above-mentioned profile images and in the cephalometric radiographs. The differences of these values were analyzed. Results: There were differences in Angle 'A' in all of the preoperative images. These values were however, not statistically significant. Conclusion: In order to gain an esthetic profile during orthognathic surgery, the NHP is shown to be the most reliable position. Images reproducing such head positions should be used in the treatment planning process.

• 대한치과교정학회지
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• 제21권1호
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• pp.17-29
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• 1991

The purpose of this study was to provide quantitative data describing the effect of rapid palatal expansion (RPE) on nasal airway resistance (NAR). RPE is an orthopedic procedure which is commonly used to widen the maxilla in skeletal Class III patients. 18 subjects (9 males and 9 females, mean age: 10 years 7 months) were selected from the Orthodontics in Yongdong Severance Hospital. Recordings of NAR were taken by active anterior method prior to expansion, immediately after desired maximum expansion, and after approximately 3 months and 6 months, and 1 year. All data was recorded and statistically processed with the SPSS program of IBM PC system. The results are as followings . 1. The average initial NAR of the subjects was 3.84 cm $H_2O/LPS\;(SD{\pm}1.34)$. It was greater than the average NAR of the normal subjects. 2. Among 18 subjects, 9 subjects showed reduction of NAR and 9 subjects showed no specific change of NAR after expansion. 3 An average reduction in NAR after immediately expansion was statistically significant at the 0.05 level. 4. The reduction appeared stable throughout the post treatment observation period of 1 year after expansion. From these results, it was suggested that RPE is a useful method to reduce NAR.

• Asian Pacific Journal of Cancer Prevention
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• 제15권10호
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• pp.4153-4158
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• 2014

Background: This study was aimed to establish a novel method to simultaneously detect expression of four genes, ribonucleotide reductase subunit M1(RRM1), X-ray repair cross-complementing gene 1 (XRCC1), thymidylate synthase (TS) and class III ${\beta}$-tubulin (TUBB3), and to assess their application in the clinic for prediction of response of non-small cell lung cancer (NSCLC) to chemoradiotherapy. Materials and Methods: We have designed four gene molecular beacon (MB) probes for multiplex quantitative real-time polymerase chain reactions to examine RRM1, XRCC1, TUBB3 and TS mRNA expression in paraffin-embedded specimens from 50 patients with advanced or metastatic carcinomas. Twenty one NSCLC patients receiving cisplatin-based first-line treatment were analyzed. Results: These molecular beacon probes could specially bind to their target genes in homogeneous solutions. Patients with low RRM1 and XRCC1 mRNA levels were found to have apparently higher response rates to chemoradiotherapy compared with those with high levels of RRM1 and XRCC1 expression (p<0.05). The TS gene expression level was not significantly associated with chemotherapy response (p>0.05). Conclusions: A method of simultaneously detecting four molecular markers was successfully established and applied for evaluation of chemoradiotherapy response. It may be a useful tool in personalized cancer therapy.

• 대한치과교정학회지
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• 제30권3호
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• pp.307-315
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• 2000

교정치료의 진단 및 치료계획의 수립시 이용되는 측모두부방사선 사진을 이용하여 골격성 부정교합의 형태와 성별에 따른 두부위치의 재현성을 파악하고자 성인남녀 90명을 대상으로 자세변수 6항목을 설정하여 연구한 결과 다음과 같은 결과를 얻었다. 1. 자연두부위치의 재현성에 있어서 남,녀 각각의 자세변수는 통계학적인 유의성이 없었다 (P>0.05). 2. 자연두부위치의 재현성에 있어서 각 부정교합군과 전체 표본 각각의 자세변수는 통계학적인 유의성이 없었다(P>0.05). 3. method error를 이용한 자연두부위치의 재현성은 모든군에서 우수하였다. 결론적으로 자연두부위치의 재현성은 골격성 부정교합의 양상과 성별에 관계없이 우수하였는데, 이는 자연두부위치를 이용한 많은 연구에 도움이 될 뿐 아니라 교정적 문제와 관련된 기능과 형태의 관계를 파악하고자 할 때 그 가치를 높이는데 기여할 수 있으리라 생각된다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제41권5호
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• pp.224-231
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• 2015

Objectives: The purpose of this study was to evaluate changes in the pharyngeal airway space and hyoid bone position after mandibular setback surgery with bilateral sagittal split ramus osteotomy (BSSRO) and to analyze the correlation between the amount of mandibular setback and the amount of change in pharyngeal airway space or hyoid bone position. Materials and Methods: From January 2010 to February 2013, a total of 30 patients who were diagnosed with skeletal class III malocclusion and underwent the same surgery (BSSRO) and fixation method in the Division of Oral and Maxillofacial Surgery, Department of Dentistry at the Ajou University School of Medicine (Suwon, Korea) were included in this study. Lateral cephalograms of the 30 patients were assessed preoperatively (T1), immediately postoperatively (T2), and 6 months postoperatively (T3) to investigate the significance of changes by time and the correlation between the amount of mandibular setback and the amount of change in the airway space and hyoid bone position. Results: Three regions of the nasopharynx, oropharynx, and hypopharynx were measured and only the oropharynx showed a statistically significant decrease (P<0.01). A significant posterior and inferior displacement of the hyoid bone was found 6 months after surgery (P<0.01). Analysis of the correlation between the amount of mandibular setback and the amount of final change in the airway space and hyoid bone position with Pearson's correlation showed no significant correlation. Conclusion: In this study, the oropharynx significantly decreased after mandibular setback surgery, and changes in the surrounding structures were identified through posteroinferior movement of the hyoid bone during long-term follow-up. Therefore, postoperative obstructive sleep apnea should be considered in patients who plan to undergo mandibular setback surgery, and necessary modifications to the treatment plan should also be considered.