• BMB Reports
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• 제57권5호
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• pp.256-261
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• 2024

In the context of aging, the susceptibility to infectious diseases increases, leading to heightened morbidity and mortality. This phenomenon, termed immunosenescence, is characterized by dysregulation in the aging immune system, including abnormal alterations in lymphocyte composition, elevated basal inflammation, and the accumulation of senescent T cells. Such changes contribute to increased autoimmune diseases, enhanced infection severity, and reduced responsiveness to vaccines. Utilizing aging animal models becomes imperative for a comprehensive understanding of immunosenescence, given the complexity of aging as a physiological process in living organisms. Our investigation focuses on Cisd2, a causative gene for Wolfram syndrome, to elucidate on immunosenescence. Cisd2 knockout (KO) mice, serving as a model for premature aging, exhibit a shortened lifespan with early onset of aging-related features, such as decreased bone density, hair loss, depigmentation, and optic nerve degeneration. Intriguingly, we found that the Cisd2 KO mice present a higher number of neutrophils in the blood; however, isolated neutrophils from these mice display functional defects. Through mass spectrometry analysis, we identified an interaction between Cisd2 and Calnexin, a protein known for its role in protein quality control. Beyond this function, Calnexin also regulates calcium homeostasis through interaction with sarcoendoplasmic reticulum calcium transport ATPase (SERCA). Our study proposes that Cisd2 modulates calcium homeostasis via its interaction with Calnexin and SERCA, consequently influencing neutrophil functions.

• 정보저장시스템학회논문집
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• 제2권1호
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• pp.43-49
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• 2006

Fractal/angle multiplexing is a $LiNBO_3$ crystal using a X-Y Galvano mirror, and the random access concept in fractal/angle multiplexing are discussed in this paper. First, the brief introduction of the designed holographic digital data storage system is presented. Then, the average access time concept for the storage system is newly defined, and the comparison of the average access time between the holographic storage and a conventional optical disk is performed. Second, the basic simulation and experiment to find the X-Y Galvano mirror dynamics are conducted. From this analysis, we find that the average access time in our HDDS which has 6 degree scan angle is about 5 msec. This result is very high performance when it compared with the average access time of a conventional optical disk. Finally, some recording results using fractal/angle multiplexing are presented, then, the relationship between bit error rate and angle mismatch for the each multiplexing are discussed.

• 대한화학회지
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• 제42권2호
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• pp.161-171
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• 1998

알켄-오존 반응에서 생성된 중간 생성물로써 primary ozonide (POZ),secondary ozonide (SOZ)그리고 carbonyl oxide의 분자구조, vibrational frequencies그리고 infrared(IR)스펙트럼의 세기 등에 대한 이론적 연구를 high level ab initio 양자역학적 방법(CISD,CCSD)을 사용하여 수행하였다. 일반적으로, polarization function은 결합각과 결합길이를 감소시키는 경향을 보였고 반면, electron correlation effect는 결합길이와 결합각을 약간 증가시키는 경향을 보이고 있다. Carbonyl oxide의 분자구조는 zwitterionic form이 diradical form보다 더 안정한 것으로 예측되었으며, 두 형태의 에너지는 차이는 TZ2P CISD level에서 약 22.4 kcal/mol인 것으로 계산되었다. 또한, POZ과 SOZ의 분자구조 및 harmonic vibrational frequencies들을 실험결과와 비교 분석하였으며 IR세기에 근거하여 각 vibrational mode를 assign 하였다.

• 정보저장시스템학회논문집
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• 제8권2호
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• pp.44-49
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• 2012

We measured the surface flatness of both sides for refractive media using the transmitted digital holography method. To enhance the accuracy of the result, phase-shifting system was used. With two different phase modulation of reference beam, the phase profile of object can be easily obtained. Thus, we proposed the surface measurement method which can measure large area fast, compared with conventional methods. To guarantee the reliability of obtained result, we compared with Zygo measurement system. With the proposed method, the surface flatness of $3.45{\mu}m$ resolution could be obtained.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2005년도 춘계학술대회 논문집
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• pp.1099-1102
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• 2005

In this paper, a new visual servo method, which uses 5 axis picomotor to compensate the misalignment generated between a SLM and a CCD in a holographic storage device, was proposed and the effectiveness of it was proved by the experiment. In a holographic storage device, the data processing is done by the SLM and the CCD, and the shape of data is 2 dimensional binary patterns. Therefore, the exact image matching between the SLM and the CCD is very important, and the mismatching of it causes the errors in the data reconstruction. First, the brief introduction of a holographic data storage is given, then, BER concept which is errors caused by pixel mismatch between the SLM and the CCD is defined. Second, the geometric relation between 5 axis picomotor and the CCD movement is studied. Finally, the visual servo method using 5 axis picomotor to reduce the BER in a holographic storage device is proposed and experimented. From the experiment, we find that about 3% BER improvement is obtained by the proposed method.

• 한국응급구조학회지
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• 제13권3호
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• pp.91-105
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• 2009

Purpose : The purpose of this study was to describe the current status of 119 EMT to violence experiences in Korea. Method : The number of 119 EMT in this study 2522. Self-administering questionnaire data were collected from April 27 to March 8 in 2009. Collected data were analyzed using SPSS 14.0 program. Real number, percentage, mean and standard deviation were calculated. Pearson correlation coefficient was analyzed. Result : 119 EMTs experienced 95.32%-verbal insults, 61.54%-violence aggression, 60.51%- potential violence, 38.70%-physical assault. Within 30 days from the most recent period of violence experienced verbal insults and violence aggression-51.07%, potential violence and physical assault-48.41%. The patients(50.59%) and the patients and patient's carers(38.26%) proved to be violent offender. The main reason of violent act was drug or alcohol addiction(56.15%). Recent exposure to violence was 34.82% by 7 point reward of stress level. 5-point scale showed the average of experiences of violence. Response average of emotional reactions was 2.66 points and that of physical reaction was 2.18 points. Social reaction was 2.06 points. Conclusion : This study was based on the violence experience of 119 EMT. It is necessary to prevent the violence from emergency scene. So we proposed the preventive measure against violence as well as critical incident stress debriefing(CISD). Policy for CISD and stress management will be implemented in the near future in Korea.

• 정보저장시스템학회논문집
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• 제8권2호
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• pp.67-71
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• 2012

Page-oriented holographic data storage (HDS) is very sensitive to the tilt error. Therefore, tilt error should be measured and compensated. Especially, mechanical tilt measurement method cannot cope with tilt error measurement because photopolymer medium has shrinkage problem. Therefore, the method to solve this problem is using the reconstructed image which can represent both tilt and shrinkage effect. In this paper, we suggest disc tilt measurement algorithm using image pattern of retrieval data.

• 정보저장시스템학회논문집
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• 제11권2호
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• pp.22-25
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• 2015

In this paper, we demonstrate solid-immersion lens based confocal microscopy using super-continuum generation effect. Using super-continuum generation effect, we could diversify the excitation wavelength of confocal microscopy. Further, high refractive index of solid-immersion lens would increase the resolution of confocal microscopy. As a result, by applying the super-continuum generation effect and solid-immersion lens to confocal microscopy, some problems of confocal fluorescent microscopy, the excitation wavelength and the resolution, could be overcome. To verify it, we made home-built solid-immersion lens based confocal microscopy using super-continuum generation effect, and evaluate the performance of the system.

• 대한화학회지
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• 제42권1호
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• pp.9-15
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• 1998

Dimethyldioxirane$[(CH_3)_2CO_2]$의 분자구조, vibrational frequencies 그리고 infrared(IR) 스펙트럼의 세기(intensity)등에 대한 이론적 연구를 high level ab initio 양자역학적 방법(CISD,CCSD, CCDS(T))을 사용하여 수행하였다. 분자구조의 경우 C-O와 O-O에 대한 결합길이는 parent dixoirane$(CH_2O_2)$과 유사한 결과를 보여주었으며, electron correlation effect의 영향이 C-C나 C-H결합길이 보다 더 크게 작용하였다. 사용된 basis sets(DZ,DZP, TZP, 그리고 TZ2P)에 대해서는 polarization function의 역할이 매우 중요한 것으로 나타났으며 triple zeta(TZ)에 의한 효과는 상대적으로 나타났다. 한편 계산된 harmonic vibrational frequency들을 실험결과 및 다른 이론 계산결과와 비교, 분석하였으며 IR intencity에 근거하여 각 vibrational mode를 assign하였다.

• 정보저장시스템학회논문집
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• 제8권2호
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• pp.61-66
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• 2012

In HDD industry, many technologies have been developed and investigated as means to increase the areal density of drives. Especially, heat assisted magnetic recording (HAMR) system has been considered as the next generation storage device. Most of the HAMR systems use near field optics as heating mechanism. Therefore, light delivery system is indispensable. We considered the light delivery system with laser diode (LD) mount and optical fiber. Mass and stiffness of the HAMR system using these LD mount and optical fiber are changed. The mass and stiffness of the HAMR system affects the slider dynamic behavior. It is necessary to analyze touch down (TD) and take off (TO). And, we performed the TD-TO experiment with HAMR suspension. Finally, we analyzed the result of TD-TO experiments. And we suggested the design of HAMR suspension to improve TD-TO performance.