• BMB Reports
• /
• v.57 no.5
• /
• pp.256-261
• /
• 2024

In the context of aging, the susceptibility to infectious diseases increases, leading to heightened morbidity and mortality. This phenomenon, termed immunosenescence, is characterized by dysregulation in the aging immune system, including abnormal alterations in lymphocyte composition, elevated basal inflammation, and the accumulation of senescent T cells. Such changes contribute to increased autoimmune diseases, enhanced infection severity, and reduced responsiveness to vaccines. Utilizing aging animal models becomes imperative for a comprehensive understanding of immunosenescence, given the complexity of aging as a physiological process in living organisms. Our investigation focuses on Cisd2, a causative gene for Wolfram syndrome, to elucidate on immunosenescence. Cisd2 knockout (KO) mice, serving as a model for premature aging, exhibit a shortened lifespan with early onset of aging-related features, such as decreased bone density, hair loss, depigmentation, and optic nerve degeneration. Intriguingly, we found that the Cisd2 KO mice present a higher number of neutrophils in the blood; however, isolated neutrophils from these mice display functional defects. Through mass spectrometry analysis, we identified an interaction between Cisd2 and Calnexin, a protein known for its role in protein quality control. Beyond this function, Calnexin also regulates calcium homeostasis through interaction with sarcoendoplasmic reticulum calcium transport ATPase (SERCA). Our study proposes that Cisd2 modulates calcium homeostasis via its interaction with Calnexin and SERCA, consequently influencing neutrophil functions.

• Transactions of the Society of Information Storage Systems
• /
• v.2 no.1
• /
• pp.43-49
• /
• 2006

Fractal/angle multiplexing is a $LiNBO_3$ crystal using a X-Y Galvano mirror, and the random access concept in fractal/angle multiplexing are discussed in this paper. First, the brief introduction of the designed holographic digital data storage system is presented. Then, the average access time concept for the storage system is newly defined, and the comparison of the average access time between the holographic storage and a conventional optical disk is performed. Second, the basic simulation and experiment to find the X-Y Galvano mirror dynamics are conducted. From this analysis, we find that the average access time in our HDDS which has 6 degree scan angle is about 5 msec. This result is very high performance when it compared with the average access time of a conventional optical disk. Finally, some recording results using fractal/angle multiplexing are presented, then, the relationship between bit error rate and angle mismatch for the each multiplexing are discussed.

• Journal of the Korean Chemical Society
• /
• v.42 no.2
• /
• pp.161-171
• /
• 1998

The geometrical parameters, vibrational frequencies, and IR intensities for primary ozonide (POZ), secondary ozonide (SOZ) and carbonyl oxide as the intermediates of alkene-ozone reaction have been predicted using high level ab initio quantum mechanical method with various basis sets. In general, the polarization function decreases bond lengths and bond angles, while the electron correlation effect increases bond lengths slightly. The electronic structure of carbonyl oxide has been predicted to be zwitterionic structure and energy difference between zwitterionic and diradical structure is evaluated to be 22.4 kcal/mol at TZ2P CISD level of theory. The experimental vibrational frequencies and IR intensities of POZ and SOZ will be compared and discussed with our high level theoretical predictions.

• Transactions of the Society of Information Storage Systems
• /
• v.8 no.2
• /
• pp.44-49
• /
• 2012

We measured the surface flatness of both sides for refractive media using the transmitted digital holography method. To enhance the accuracy of the result, phase-shifting system was used. With two different phase modulation of reference beam, the phase profile of object can be easily obtained. Thus, we proposed the surface measurement method which can measure large area fast, compared with conventional methods. To guarantee the reliability of obtained result, we compared with Zygo measurement system. With the proposed method, the surface flatness of $3.45{\mu}m$ resolution could be obtained.

• Proceedings of the Korean Society of Precision Engineering Conference
• /
• 2005.06a
• /
• pp.1099-1102
• /
• 2005

In this paper, a new visual servo method, which uses 5 axis picomotor to compensate the misalignment generated between a SLM and a CCD in a holographic storage device, was proposed and the effectiveness of it was proved by the experiment. In a holographic storage device, the data processing is done by the SLM and the CCD, and the shape of data is 2 dimensional binary patterns. Therefore, the exact image matching between the SLM and the CCD is very important, and the mismatching of it causes the errors in the data reconstruction. First, the brief introduction of a holographic data storage is given, then, BER concept which is errors caused by pixel mismatch between the SLM and the CCD is defined. Second, the geometric relation between 5 axis picomotor and the CCD movement is studied. Finally, the visual servo method using 5 axis picomotor to reduce the BER in a holographic storage device is proposed and experimented. From the experiment, we find that about 3% BER improvement is obtained by the proposed method.

• The Korean Journal of Emergency Medical Services
• /
• v.13 no.3
• /
• pp.91-105
• /
• 2009

Purpose : The purpose of this study was to describe the current status of 119 EMT to violence experiences in Korea. Method : The number of 119 EMT in this study 2522. Self-administering questionnaire data were collected from April 27 to March 8 in 2009. Collected data were analyzed using SPSS 14.0 program. Real number, percentage, mean and standard deviation were calculated. Pearson correlation coefficient was analyzed. Result : 119 EMTs experienced 95.32%-verbal insults, 61.54%-violence aggression, 60.51%- potential violence, 38.70%-physical assault. Within 30 days from the most recent period of violence experienced verbal insults and violence aggression-51.07%, potential violence and physical assault-48.41%. The patients(50.59%) and the patients and patient's carers(38.26%) proved to be violent offender. The main reason of violent act was drug or alcohol addiction(56.15%). Recent exposure to violence was 34.82% by 7 point reward of stress level. 5-point scale showed the average of experiences of violence. Response average of emotional reactions was 2.66 points and that of physical reaction was 2.18 points. Social reaction was 2.06 points. Conclusion : This study was based on the violence experience of 119 EMT. It is necessary to prevent the violence from emergency scene. So we proposed the preventive measure against violence as well as critical incident stress debriefing(CISD). Policy for CISD and stress management will be implemented in the near future in Korea.

• Transactions of the Society of Information Storage Systems
• /
• v.8 no.2
• /
• pp.67-71
• /
• 2012

Page-oriented holographic data storage (HDS) is very sensitive to the tilt error. Therefore, tilt error should be measured and compensated. Especially, mechanical tilt measurement method cannot cope with tilt error measurement because photopolymer medium has shrinkage problem. Therefore, the method to solve this problem is using the reconstructed image which can represent both tilt and shrinkage effect. In this paper, we suggest disc tilt measurement algorithm using image pattern of retrieval data.

• Transactions of the Society of Information Storage Systems
• /
• v.11 no.2
• /
• pp.22-25
• /
• 2015

In this paper, we demonstrate solid-immersion lens based confocal microscopy using super-continuum generation effect. Using super-continuum generation effect, we could diversify the excitation wavelength of confocal microscopy. Further, high refractive index of solid-immersion lens would increase the resolution of confocal microscopy. As a result, by applying the super-continuum generation effect and solid-immersion lens to confocal microscopy, some problems of confocal fluorescent microscopy, the excitation wavelength and the resolution, could be overcome. To verify it, we made home-built solid-immersion lens based confocal microscopy using super-continuum generation effect, and evaluate the performance of the system.

• Journal of the Korean Chemical Society
• /
• v.42 no.1
• /
• pp.9-15
• /
• 1998

The geometrical parameters, vibrational frequencies, and IR intensities of dimethyldioxirane had been investigated using high level ab initio quantum mechanical methods with various basis sets. The polarization function decreases C-O and C-C bond distances significantly and the electron correlation effect increases those bond lengths slightly, while other bond lengths and bond angles are relatively stable for basis set size and correlation effect. The experimental and other theoretical vibrational frequencies and IR intensities of dimethyldioxirane will be compared and discussed with our high level theoretical predictions.

• Transactions of the Society of Information Storage Systems
• /
• v.8 no.2
• /
• pp.61-66
• /
• 2012

In HDD industry, many technologies have been developed and investigated as means to increase the areal density of drives. Especially, heat assisted magnetic recording (HAMR) system has been considered as the next generation storage device. Most of the HAMR systems use near field optics as heating mechanism. Therefore, light delivery system is indispensable. We considered the light delivery system with laser diode (LD) mount and optical fiber. Mass and stiffness of the HAMR system using these LD mount and optical fiber are changed. The mass and stiffness of the HAMR system affects the slider dynamic behavior. It is necessary to analyze touch down (TD) and take off (TO). And, we performed the TD-TO experiment with HAMR suspension. Finally, we analyzed the result of TD-TO experiments. And we suggested the design of HAMR suspension to improve TD-TO performance.