• Journal of Haehwa Medicine
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• v.26 no.1
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• pp.19-24
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• 2017

Objectives:Spring water is widely known to relax muscles by promoting blood circulation. This study was conducted to analyze theantithrombotic effect of naturally carbonated hot spring water (NCHW) to assess its influence on blood circulation. Methods:Atopic dermatitis was induced in the skin of the mice used in this experiment. NCHW was applied, and the antithrombotic effect was assessed and compared with that of other interventions. The positive control group was treated orally with aspirin. Results:After 3 weeks of exposure to NCHW, the experimental groupshowed a significant antithrombotic effect. NCHW also produced inhibitory responses to both collagen- and ADP-induced platelet aggregation, whereas the group given aspirin reacted only to collagen-induced platelet aggregation. Conclusions:The experiment demonstrated the intrinsic antithrombotic effects of NCHW compared with those of artificially carbonated water, tap water, and aspirin. This result suggests the possibility that NCHW can be used as a supportive and alternative treatment for vascular diseases.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.27 no.9
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• pp.484-490
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• 2015

The winter stack effect that occurs in vertical construction passages such as the stairwell or elevator shaft of a high-rise building negatively affects living environments, energy usage, and personal safety; therefore, a mitigation of the stack effect is required to improve building conditions. Recently, circulation-type facilities that comprise the usage of air blowers and vertical ducts were proposed as part of a mechanical approach to quantitatively control the stack effect. In this study, these circulation-type facilities were installed in a building stairwell and the performance of the device was evaluated during its operation. A numerical-analysis result was obtained under the test conditions using a network-model-based, numerical-analysis method, and the result was then used for a comparison with the test result.

• Journal of Chest Surgery
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• v.25 no.5
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• pp.458-468
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• 1992

With the aid of extracorporeal circulation, nine dogs underwent orthotopic cardiopulmonary transplantation after preservation of the donor heart in a hypothermic amino acid[glutamate, aspartate] enriched high potassium extracellular solution, and preservation of the donor lung with hypothermic low potassium dextran solution from June 1990 to May 1991. The mean body weights of dogs were 20kg and the recipients` preoperative hematologic and hemodynamic pictures were within normal range except slightly decreased level of albumin and total protein, which was supposed to be due to malnutrition. The following modifications of the original Stanford technique were emphasized: [1] the posterior mediastinum is dissected as little as possible with meticulous hemostasis; [2] the surgical procedure is kept away from the phrenic and vagus nerves; [3] the tracheal anastomosis may be wrapped with recipient`s pulmonary artery flap or surrouding soft tissues. A combination of Cyclosporine, Azathioprine, corticosteroid was used as perioperative immunosuppressive therapy. Postoperatively all recipients could be weaned from extracorporeal circulation, showing favorable vital signs, but within 24 hours, irreversible congetive heart failure, ascites, arrhythmias developed with a mean survival time 13.6$\pm$6.6[n=9, range=6~26] hours. Hemoglobin and platelet counts were significantly[p<0.05] decreased postoperatively, which is thought to be attributed to blood damage by cardiopulmonary bypass and hemodilution. Postmortem finding included multiple subendocardial patch hemorrhage in both atrial and ventricular cavities, pulmonary and liver congestion, and all tracheal anastomoses were intact. Further consideration about quality control of the animal, infection, rejection, the effect of cardiopulmonary bypass on the experimental animal is required to improve the results.

• Proceedings of the Ginseng society Conference
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• 2002.10a
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• pp.27-34
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• 2002

Clinical study on hemodynamics of healthy elders before and after tread mill. Using doubleblind, placebo-controlled study design. Seventy-five 50-70 years old volunteers without organic disease were divided into two groups, Ginseng group and control group. Each subject was received 3 g Korea Red Ginseng (KRG) capsules or placebo per day for 4 weeks. Before and after administration 4 weeks, the symptoms were asked and hemodynamics parameter such as pump function, systolic function, preload and afterload were recorded before and after tread mill 1,5, 10 minutes by the method of thoracic impedance cardiograph. The result showed that Ginseng could improve quality of life, had obvious effect of increasing PEP (pre-ejection period), PEP/LVET (pre-ejection period/left ventricular ejection period), PCWP (wedged pressure pulmonary capillary). The change rate of HR (heart rate), SV (stroke volume) in KRG group were much lowered, while EF (ejection fraction), LVET (left ventricular ejection period), LVEDP (left ventricular end diastolic pressure) was recovered much quickly. The circulation showed Ginseng could improve the quality of life though its promoting circulation function which are increasing both the systolic function and the preload.

• Korean Circulation Journal
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• v.48 no.12
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• pp.1135-1144
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• 2018

Background and Objectives: Mitochondria play a key role in the pathophysiology of heart failure and mitochondrial permeability transition pore (MPTP) play a critical role in cell death and a critical target for cardioprotection. The aim of this study was to evaluate the protective effects of cyclosporine A (CsA), one of MPTP blockers, and morphological changes of mitochondria and MPTP related proteins in monocrotaline (MCT) induced pulmonary arterial hypertension (PAH). Methods: Eight weeks old Sprague-Dawley rats were randomized to control, MCT (60 mg/kg) and MCT plus CsA (10 mg/kg/day) treatment groups. Four weeks later, right ventricular hypertrophy (RVH) and morphological changes of right ventricle (RV) were done. Western blot and reverse transcription polymerase chain reaction (RT-PCR) for MPTP related protein were performed. Results: In electron microscopy, CsA treatment prevented MCT-induced mitochondrial disruption of RV. RVH was significantly increased in MCT group compared to that of the controls but RVH was more increased with CsA treatment. Thickened medial wall thickness of pulmonary arteriole in PAH was not changed after CsA treatment. In western blot, caspase-3 was significantly increased in MCT group, and was attenuated in CsA treatment. There were no significant differences in voltage-dependent anion channel, adenine nucleotide translocator 1 and cyclophilin D expression in western blot and RT-PCR between the 3 groups. Conclusions: CsA reduces MCT induced RV mitochondrial damage. Although, MPTP blocking does not reverse pulmonary pathology, it may reduce RV dysfunction in PAH. The results suggest that it could serve as an adjunctive therapy to PAH treatment.

• Journal of Bio-Environment Control
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• v.11 no.2
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• pp.81-87
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• 2002

This study was conducted to investigate the cooling efficiency and growth of tomatoes by root zone cooling device using a pad-box and cultivated system. The structure of the root zone cooling system using a pad-box was four piece of pads bonded an the side and a fan set at the bottom. Cool wind was generated by the outside air which was punched at intervals of 10 cm along three rows. Cold wind flowed to the root zone in the culture medium. The root zone cooling efficiency of cold wind generation by using a pad-box flowing through a wet-pad was determined. Major characteristic of this cuttural system consist of bed filled with a perlite medium and a ventilation pipe using PVC. The cold wind generation by a pad box (CWP) was compared to that of cold wind generation by a radiator (CWR), cold water circulation using a XL-pipe (CWX) and the control (non-cooling). When the temperature of water supplied was 16.2-18.4$^{\circ}C$, temperatures in the medium were 20.5~23.2$^{\circ}C$ for CWP 22.7~24.2$^{\circ}C$ for CWR, 22.8~24.27$^{\circ}C$ for CWX and 23.1~-29.6$^{\circ}C$ for the control. The results show that the cold wind temperature using the pad-box was lower by 1~2$^{\circ}C$ than that of cold water circulation in the XL-pipe and lower by 5~6$^{\circ}C$ than that of the control. Growth such as leaf length, leaf width, fresh weight and dry weight, was greater in three root zone cooling methods than in the control. Root activity was higher in the rat zone cooling methods than in the control. However, there was no significant difference among root zone cooling methods.

• Journal of the Society of Naval Architects of Korea
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• v.37 no.2
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• pp.70-76
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• 2000

A numerical study on the viscous flow around a 2-dimensional circulation control foil is carried out for application on the field of naval architecture and ocean engineering. The governing equations are the RANS and the continuity equations. The equations are discretized by finite difference method and MAC method and the pressure poisson equation is calculate by a SOR method and an O-type non-staggered boundary fitted coordinate system which is overlapped near the slot is used to improve the numerical accuracy. Turbulence is approximated by a modified Baldwin-Lomax turbulence model. In the present paper, the Coanda effect on a 2-dimensional foil of a 20% thickness ellipse with modified rounded trailing edge has been numerically studied. The change in drag and lift of the foil with various jet momentums are calculated and compared to the experimental results to show good agreements.

• Journal of Pharmaceutical Investigation
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• v.22 no.4
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• pp.301-306
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• 1992

The influence of phenobarbital (PB) pretreatment (75 mg/kg/day, i.p. for 4 days) on the metabolite kinetics of diltiazem (DTZ) was studied in rats in order to elucidate the effect of esterase induced by PB on the formation of DTZ to desacetyldiltiazem (DAD), DAD was injected via portal vein (3 mg/kg) to the control and PB-pretreated rats, The intrinsic hepatic clearance of DAD was significantly increased by PB pretreatment and the absolute bioavailability of DAD was significantly decreased in the PB-pretreated rats. According to the hepatic biotransformation model of DTZ, the fraction of systemic clearance of DTZ which forms DAD $(G_{mi})$ was different from that of DTZ which furnishes the available DAD to the systemic circulation $(F_{mi})$ in control rats. This result shows that DTZ was suspected of the sequential hepatic first-pass metabolism. On the other hand, PB pretreatment enhanced the $G_{mi}$ value of DTZ by 44%. It may be concluded that the deacetylation of DTZ to DAD in rats is increased by the esterase induced by PB but the transfer rate of DAD immediately formed from DTZ into systemic circulation is not affected by PB due to the 27% decreased absolute bioavailability of DAD resulting from PB pretreatment.

• Journal of Applied Tourism Food and Beverage Management and Research
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• v.13 no.1
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• pp.29-41
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• 2002

Controlling food materials, is getting more significant in hotel management nowadays as the selling of food beverage continue to rise. F&B managers have been required to have new management of the food materials by a fierce competition, an increase in cost, the shortened span of product life and customer's demand that is becoming more various and sophisticated since Korea was placed under the influence of IMF. I'm going to analyze the factors that cause waste and loss through a series of the process to purchase inspect, store food materials, make a product with that materials and sell the product in order to make more profits by making the circulation of the food materials easier and more efficiently. I studied how 3 chain hotels of A group purchase, store the food materials and control stock. I made up questionnaires about the circulation and control of food materials to 107 cooks in order to know what the cooks who are working at the hotel regard as a real problem and a practical solution. This research indicates that purchasing, producing and selling departments don't establish the mutual connection, a professional purchasing manager is strongly needed and there is difficulty in predicting the proper timing to supply. Also the research shows that A hotel group controls the food materials by analyzing the amount of consumption, stock, setting up the period of validity and uses slowly moving food materials in stock mainly by introducing the menu that aims at four seasons. As a result, the research suggests that we should introduce the concept of food producing factory, as it were, Central Kitchen that is based on the network among various kitchens to improve the flow of the food materials.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.20 no.3
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• pp.113-119
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• 2020

This paper proved the reason why the Batdam does not collapse in the 50m/s typhoon by the Circulation of the Stack Effect and traced the correlation with crops in spring, summer, autumn and winter. Batdam, which is built with oedam, is a magic wall wich is played the role of 3rd layer over 22,000km, when stacked in a field, has the inertia like a linear motion of constant velocity and resists winds no matter how strong it blows. We analyzed the reason of Batdam 1.5 meters, Oreum 200 times of Batdam, and Hallasan 1,300 times Batdam, and analyzed the resonance of the characteristic function. In this paper, we adapted to natural climate change, and we built a batdam to derive the height of the batdam and neutral plane for farming according to the seasonal characteristics, and designed the relationship between natural intelligence control.