• 대한기계학회논문집B
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• 제35권11호
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• pp.1205-1211
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• 2011

본 논문은 말기 심질환 환자의 생존율과 치료효과를 증대시키기 위한 심실보조장치용 심박조율기의 개발에 대한 내용이다. 심실보조장치만을 이식 받은 환자는 부정맥이 발생할 가능성을 항상 갖고 있으며 심박조율기를 동시에 적용함으로써 혈류의 체순환량을 유지하고 부정맥으로 인한 장기의 손상을 예방한다. 심박조율기의 전극과 도선은 심실보조장치의 도관을 이용하여 제작되었으며, 전극은 심실보조장치의 도관이 삽관되는 좌심실의 심첨부에 도관과 함께 이식된다. 심박조율기는 0 bpm에서부터 191.4 bpm까지 자극 빈도를 조절할 수 있으며, 60 bpm의 빈도로 자극이 가하여 질 때 0.25 J 의 에너지가 심장으로 인가된다. 심실보조장치용 심박조율기의 성능과 안정성을 검증하기 위하여 돼지를 이용한 동물실험을 수행하였다. 실험동물의 심장에 86.4 bpm, 100.2 bpm, 126.6 bpm의 자극을 순차적으로 가하였고 ECG 및 대동맥혈압의 변화 대동맥 혈류를 관찰하였다.

• 한국동물학회지
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• 제8권1호
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• pp.1-7
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• 1965

The short-necked clam is distributed widely in Korean tidal flats and it is a much an important bivalve quantitatively as to control the production of the tidal flat. The shell of this clam tends to show remarkable morphological variations depending on the habitat. Under a seemingly favorable condition for the growth , the color pattern of shell of the clam is clear and obvious and having less weight and elongated shape, the ratios of shell length to both height and width are small . On the contrary , when the environment appears to be an unfavorable one, the shell is found to be heavy and stunted with smudgy color pattern. If this correlation between could be a basis for the judgement in suitability of growth environment for the clam. In the Ikawazu Bay, Japan, it is revealed that the elongated shell is produced from the coast outside of the Bay (1) , the stunted from the esturay (2) and the intermediate from the floodgate area (3) and the middle of the Bay (4). Followings are the results obtained from the morphological investigation of the claim in this Bay. 1. Relationship between the shell length and the largest shell rib length is linear and between the shell length and the shell width is also linear but with a critical point at the shell length of 17-20 mm. The ratio between the width and the largest rib length at a given shell length increases with the order of 1, 3, 4, and 2. 2. A gradual decreases of the ratio of the shell length to the largest rib length is observed when the former is less than 17-18 mm, and this ratio increases with the shell of longer. Also there is a different range of this ratio in each different location ; the greatest range in 2, the smallest in 1 and 4 being in between. 3. A similar biometric finding is apparent with the ratio between the length and width of the shell and the order in value is 2, 4, 1 and 3. 4. The ratios between the length and the largest rib length of elongated and stunted shell are 0.84-0.86 and 0.89-0.92, respectively , and those between the length and width are 0.40-0.51 and 0.49-0.58, respectively. 5. Generally , the elongated short necked clam shells are products of the tidal flat of good circulation of sea water with high salinity and smaller fluctuations of salinity and temperature within a day. The stunted shells are produced for tidal flats of opposite of above conditions.

• Nuclear Engineering and Technology
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• 제52권10호
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• pp.2204-2220
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• 2020

An open-pool type research reactor is designed and operated considering the accessibility around the pool top area to enhance the reactor utilization. The reactor structure assembly is placed at the bottom of the pool and filled with water as a primary coolant for the core cooling and radiation shielding. Most radioactive materials are generated from the fuel assemblies in the reactor core and circulated with the primary coolant. If the primary coolant goes up to the pool surface, the radiation level increases around the working area near the top of the pool. Hence, the hot water layer is designed and formed at the upper part of the pool to suppress the rising of the primary coolant to the pool surface. The temperature gradient is established from the hot water layer to the primary coolant. As this temperature gradient suppresses the circulation of the primary coolant at the upper region of the pool, the radioactive primary coolant rising up directly to the pool surface is minimized. Water mixing between these layers is reduced because the hot water layer is formed above the primary coolant with a higher temperature. The radiation level above the pool surface area is maintained as low as reasonably achievable since the radioactive materials in the primary coolant are trapped under the hot water layer. The key to maintaining the stable hot water layer and keeping the radiation level low on the pool surface is to have a stable flow of the primary coolant. In the research reactor with a downward core flow, the primary coolant is dumped into the reactor pool and goes to the reactor core through the flow guide structure. Flow fields of the primary coolant at the lower region of the reactor pool are largely affected by the dumped primary coolant. Simple, circular, and duct type discharge headers are designed to control the flow fields and make the primary coolant flow stable in the reactor pool. In this research, flow fields of the primary coolant and hot water layer are numerically simulated in the reactor pool. The heat transfer rate, temperature, and velocity fields are taken into consideration to determine the formation of the stable hot water layer and primary coolant flow. The bulk Richardson number is used to evaluate the stability of the flow field. A duct type discharge header is finally chosen to dump the primary coolant into the reactor pool. The bulk Richardson number should be higher than 2.7 and the temperature of the hot water layer should be 1 ℃ higher than the temperature of the primary coolant to maintain the stability of the stratified thermal layer.

• 과학교육연구지
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• 제33권1호
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• pp.44-55
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• 2009

본 연구는 고등학교 생물 수업에서 POE를 적용한 논술형 탐구학습 프로그램의 개발 및 수업에의 적용으로 학생들의 학업 성취도와 과학 관련 태도에 미치는 효과를 알아보고자 하였다. 연구 대상으로 부산시 소재의 남자 인문계고등학교 2학년 4개 반을 선정하였다. 수업은 생물 I '순환' 단원으로 4주에 걸쳐 6차 시로 이루어졌으며, 실험집단은 POE를 적용한 논술형 탐구학습 프로그램에 의거한 수업을 진행 하였으며, 통제집단은 실험집단과 동일한 학습 목표와 주요 학습 내용을 기준으로 생물 I 교과서에 제시되어 있는 학습내용과 탐구활동을 토대로 실시하였다. 현장 적용결과, 첫째, POE를 적용한 논술형 탐구학습 프로그램은 이미 알고 있는 지식과 실험을 통해 새롭게 알게 된 지식을 적절하게 연결하는 활동과 학생들의 고차원적인 사고유발을 위한 교사의 다양한 질문을 통해 문제해결력 향상뿐만 아니라 논리적인 사고능력에 도움을 주어 학업 성취도에 긍정적인 효과를 미친 것으로 나타났다. 둘째, POE를 적용한 논술형 탐구학습 프로그램은 실험에 대한 사전 예측활동으로 실험에 대한 관심을 유발하게 하고 직접 관찰한 것과 예측한 것 사이의 모순을 해결해 가는 과정을 통해 학습과정에 적극적인 참여의 유도로 과학 관련 태도에 긍정적인 효과가 나타난 것으로 판단된다.

• 한국정보통신학회논문지
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• 제10권6호
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• pp.991-997
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• 2006

우리에게 농업은 단순히 식생활의 문제를 떠나 사회에 근간이 되는 분야이다. 하지만 급속히 정보화가 추진되고 있는 다른 분야에 비해 농업분야의 정보화는 그 발전 속도가 현저히 떨어지는 것은 살아있는 생물을 다루는 분야이기 때문이다. 하지만 정보화는 어쩔 수 없는 당면 과제이기에 정부 산하의 농업 관련 기관들은 개별적인 정보화 시스템을 구축 운용해오고 있다. 현재의 농업 정보화 시스템은 농업관측정보시스템과 농산물 유통 종합정보 시스템 그리고 농축산물 생산 및 수급정보 분석 시스템 등으로 볼 수 있지만 이러한 시스템은 초기의 기대와는 달리 비효율적으로 운영되어진 것이 현실이다. 여기에는 농업 관측 모형이 현실을 제대로 반영하지 못하는 문제점도 있지만 정부 산하의 각 기관들의 개별적인 개발로 인한 중복 투자와 시스템의 비효율적인 윤용 등의 문제점을 들 수 있다. 이에 따라 본 논문에서는 현재 개별적으로 운용되고 있는 농업 관측 정보 시스템, 농산물 유통 종합 정보 시스템 그리고 농축산물 생산 및 수급 정보 분석 시스템을 통폐합하고 유통관리 시스템과 기술지원 시스템의 구현과 종합 DB 시스템 구축과 이를 통합한 농업 종합 정보 시스템을 제안하며 농업 종합 정보 시스템의 활성화를 위한 각종 시책 등을 제시하고자 한다.

• 대한의용생체공학회:의공학회지
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• 제40권5호
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• pp.197-205
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• 2019

The existing Extracorporeal membrane oxygenation(ECMO) and Cardiopulmonary bypass system(CPB) have been developed and applied to various devices according to their respective indications. However, due to the complicated configuration and difficult usage method, it causes inconvenience to users and there is a risk of an accident. Therefore, smart all-in-one cardiopulmonary circulation device is being developed recently. The smart all-in-one cardiopulmonary assist device consists of a blood pump for cardiopulmonary bypass, a blood oxidizer for cardiopulmonary bypass, a blood circuit for cardiopulmonary bypass, and an artificial cardiopulmonary device. It is an integrated cardiopulmonary bypass device that can be used for a variety of purposes such as emergency, intraoperative, post-operative intensive care, and long-term cardiopulmonary assist, combined with CPB used in open heart surgery and ECMO used when patient's cardiopulmonary function does not work normally. The smart all-in-one cardiopulmonary assist device does not exist as a standard and international standard applicable to advanced medical devices. Therefore, in this study, we will refer to the International Standard for Blood Components, the International Standard for Blood, the Guideline for Blood Products, and prepare applicable performance and safety guidelines to help quality control of medical devices, and contribute to the improvement of the health of people. The guideline, which is the result of conducted a survey of the method of safety and performance test, is based on the principle of all-in-one cardiopulmonary aiding device, related domestic foreign standards, the status of domestic and foreign patents, related literature, blood pump(ISO 18242), blood oxygenator (ISO 7199), and blood circuit (ISO 15676) for cardiopulmonary bypass.The items on blood safety are as follows: American Society for Testing and Materials ASTM F1841-97R17), and in the 2010 Food and Drug Administration's Safety Assessment Guidelines for Medical Assisted Circulatory Devices. In addition, after reviewing the guidelines drawn up through expert consultation bodies including manufacturers / importers, testing inspectors, academia, etc. the final guideline was established through revision and supplementation process. Therefore, we propose guidelines for evaluating the safety and performance of smart all-in-one cardiopulmonary assist devices in line with growing technology.

• 유기물자원화
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• 제27권1호
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• pp.65-75
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• 2019

정부는 '자원순환기본법'의 제정 및 '폐기물관리법'의 개정으로 폐자원의 재활용 방향성을 확대하고 재활용 다양화 등 처리개선을 통한 미처리폐기물의 매립제로화를 추진하고 있다. 2015년 기준 국내 전체 폐기물 매립처분량은 38,308 톤/일이며 그중 사업장배출시설계폐기물의 매립처분량은 23,577 톤/일로 매립폐기물 중 약 62 %를 차지하고 있다. 본 연구에서는 주로 유기성 및 가연성 물질의 연소 및 소각, 특정 성분의 추출 및 공정 구성에서 활용된 후 폐기처분되는 열적처리잔재물의 특성을 파악하여 재활용 관련 기준에 따른 매립저감 효과 예측 및 매립 처분 감소 가능량을 추산하여 고찰하였다. 그 결과, 사업장배출시설계폐기물의 매립처분량은 전체 매립량의 약 62 %로, 이 중 소각재, 연소재 등의 열적처리잔재물류가 45.1 %을 차지하고 있다. 2035년 국가 매립목표 1 % 달성을 위해 열적처리 잔재물이 매립억제 주요대상 폐기물로 판단되었다. 또한 열적처리 잔재물의 재활용 기준을 확대하고 매립억제 정책 추진 시 현재 매립처분량 대비 약 5~42 %의 매립감소가 가능할 것으로 추산되었으며 매립처분 최소화를 위해 폐자원 재활용 유형의 다양성 확대와 재활용 제품의 의무사용 확대 방안이 필요할 것으로 판단되었다.

• Natural Product Sciences
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• 제27권2호
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• pp.86-98
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• 2021

This study was designed to characterize the effect of ginsenoside-Rg2 (Rg2), one of panaxatriol saponins isolated from Korean ginseng root, on the release of catecholamines (CA) in the perfused model of the rat adrenal medulla, and also to establish its mechanism of action. Rg2 (3~30 µM), administered into an adrenal vein for 90 min, depressed acetylcholine (ACh)-induced CA secretion in a dose- and time-dependent manner. Rg2 also time-dependently inhibited the CA secretion induced by 3-(m-chloro-phenyl-carbamoyl-oxy)-2-butynyltrimethyl ammonium chloride (McN-A-343), 1.1-dimethyl-4-phenyl piperazinium iodide (DMPP), and angiotensin II (Ang II). Also, during perfusion of Rg2, the CA secretion induced by high K⁺, veratridine, cyclopiazonic acid, methyl-1,4-dihydro-2,6-dimethyl-3-nitro-4-(2-trifluoro-methyl-phenyl)-pyridine-5-carboxylate (Bay-K-8644) depressed, respectively. In the simultaneous presence of Rg2 and N^ω-nitro-L-arginine methyl ester hydrochloride ʟ-NAME), the CA secretion induced by ACh, Ang II, Bay-K-8644 and veratridine was restored nearly to the extent of their corresponding control level, respectively, compared to those of inhibitory effects of Rg2-treatment alone. Virtually, NO release in adrenal medulla following perfusion of Rg2 was significantly enhanced in comparison to the corresponding spontaneous release. Also, in the coexistence of Rg2 and fimasartan, ACh-induced CA secretion was markedly diminished compared to the inhibitory effect of fimasartan-treated alone. Collectively, these results demonstrated that Rg2 suppressed the CA secretion induced by activation of cholinergic as well as angiotensinergic receptors from the perfused model of the rat adrenal gland. This Rg2-induced inhibitory effect seems to be exerted by reducing both influx of Na⁺ and Ca²⁺ through their ionic channels into the adrenomedullary cells as well as by suppressing Ca²⁺ release from the cytoplasmic calcium store, at least through the elevated NO release by activation of NO synthase, which is associated to the blockade of neuronal cholinergic and AT₁-receptors. Based on these results, the ingestion of Rg2 may be helpful to alleviate or prevent the cardiovascular diseases, via reduction of CA release in adrenal medulla and consequent decreased CA level in circulation.

• Journal of Veterinary Science
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• 제23권1호
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• pp.8.1-8.15
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• 2022

Background: Brucella infection induces brucellosis, a zoonotic disease. The intracellular circulation process and virulence of Brucella mainly depend on its type IV secretion system (T4SS) expressing secretory effectors. Secreted protein BspJ is a nucleomodulin of Brucella that invades the host cell nucleus. BspJ mediates host energy synthesis and apoptosis through interaction with proteins. However, the mechanism of BspJ as it affects the intracellular survival of Brucella remains to be clarified. Objectives: To verify the functions of nucleomodulin BspJ in Brucella's intracellular infection cycles. Methods: Constructed Brucella abortus BspJ gene deletion strain (B. abortus ∆BspJ) and complement strain (B. abortus pBspJ) and studied their roles in the proliferation of Brucella both in vivo and in vitro. Results: BspJ gene deletion reduced the survival and intracellular proliferation of Brucella at the replicating Brucella-containing vacuoles (rBCV) stage. Compared with the parent strain, the colonization ability of the bacteria in mice was significantly reduced, causing less inflammatory infiltration and pathological damage. We also found that the knockout of BspJ altered the secretion of cytokines (interleukin [IL]-6, IL-1β, IL-10, tumor necrosis factor-α, interferon-γ) in host cells and in mice to affect the intracellular survival of Brucella. Conclusions: BspJ is extremely important for the circulatory proliferation of Brucella in the host, and it may be involved in a previously unknown mechanism of Brucella's intracellular survival.

• Journal of Cerebrovascular and Endovascular Neurosurgery
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• 제25권1호
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• pp.50-61
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• 2023

Objective: To describe the roadmapping technique and our three-year experience in the management of intracranial aneurysms in the hybrid operating room. Methods: We analyzed all patients who underwent surgical clipping for cerebral aneurysms with the roadmapping technique from January 2017 to September 2019. We report demographic, clinical, and morphological variables, as well as clinical and radiological outcomes. We further describe three illustrative cases of the technique. Results: A total of 13 patients were included, 9 of which (69.2%) presented with subarachnoid hemorrhage, with a total of 23 treated aneurysms. All patients were female, with a mean age of 47.7 years (range 31-63). All cases were anterior circulation aneurysms, the most frequent location being the ophthalmic segment of the internal carotid artery (ICA) in 11 cases (48%), followed by posterior communicating in 8 (36%), and ICA bifurcation in 2 (8%). Intraoperative clip repositioning was required in 9 aneurysms (36%) as a result of the roadmapping technique in the hybrid operating room. There were no residual aneurysms in our series, nor reported mortality. Conclusions: The roadmapping technique in the hybrid operating room offers a complementary tool for the adequate occlusion of complex intracranial aneurysms, as it provides a real time fluoroscopic-guided clipping technique, and clip repositioning is possible in a single surgical stage, whenever a residual portion of the aneurysm is identified. This technique also provides some advantages, such as immediate vasospasm identification and treatment with intra-arterial vasodilators, balloon proximal control for certain paraclinoid aneurysms, and simultaneous endovascular treatment in selected cases during a single stage.