• 대한기계학회논문집A
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• 제27권7호
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• pp.1071-1075
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• 2003

In this paper, we present a DNA manipulation device in the reaction chamber, which consists of a center electrode and circular outer electrodes of a reaction unit. The charged bio-molecules, DNA, are manipulated by the charge of the electrode in reaction unit. Controlling the induced dynamic electric field between the center electrode and the outer electrodes, concentration / repulsion / manipulation of bio-molecules are enabled at a periphery of electrode. Concentration of the fluorescent DNA at the center electrode is observed by applying ＋2V. Subsequently, applying －2V, the concentrated DNA is repelled rapidly from the center electrode, which makes dispersion completely in 0.5second. Furthermore, repeated applying ＋1V/－1V every 5 seconds at each outer electrode, we can circulate the DNA. We also investigate a micro-heater and sensor for DNA manipulation and reaction temperature. The coefficient of heat-resistance and heater temperature characteristic is 0.0043 and 100$^{\circ}C$/sec, respectively.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2006년도 추계학술대회 논문집 Vol.19
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• pp.223-224
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• 2006

This paper present a new disk-type piezoelectric transformer. The input side of the transformer has a crescent-shaped electrode and the output side has a focused poling direction. This transformer has multi-layered structure. The piezoelectric transformers operated m each transformer's resonance vibration mode. The electrodes and poling directions on commercialy available piezoelectric ceramic disks were designed so that the planar or shear mode coupling factor ($k_p,\;k_{15}$) becomes effective rather than the transverse mode coupling factor ($k_{31}$). The Resonance frequency is 65.22[kHz] and maximum voltage step-up ratio is 149. Multi-layered transformer has better efficiency and step-up ratio than the single-layered transformer.

• 센서학회지
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• 제31권3호
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• pp.175-179
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• 2022

The physical properties of biomaterials are important for their isolation and separation from body fluids. In particular, the precise evaluation of the multi-physical properties of single biomolecules is essential in that the correlation between physical and biological properties of specific biomolecule. However, the majority of scientific equipment, can only determine specific-physical properties of single nanoparticles, making the evaluation of the multi-physical properties difficult. The improvement of analytical techniques for the evaluation of multi-physical properties is therefore required in various research fields. In this study, we developed a motion-tracking algorithm to evaluate the multi-physical properties of single-nanoparticles by analyzing their behavior. We observed the Brownian motion and electric-field-induced drift of fluorescent nanoparticles injected in a microfluidic chip with two electrodes using confocal microscopy. The proposed algorithm is able to determine the size of the nanoparticles by i) removing the background noise from images, ii) tracking the motion of nanoparticles using the circular-Hough transform, iii) extracting the mean squared displacement (MSD) of the tracked nanoparticles, and iv) applying the MSD to the Stokes-Einstein equation. We compared the evaluated size of the nanoparticles with the size measured by SEM. We also determined the zeta-potential and surface-charge density of the nanoparticles using the extracted electrophoretic velocity and the Helmholtz-Smoluchowski equation. The proposed motion-tracking algorithm could be employed in various fields related to biomaterial analysis, such as exosome analysis.

• 한국정보기술학회논문지
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• 제16권11호
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• pp.35-41
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• 2018

전기 임피던스 단층촬영법 (EIT, electrical impedance tomography)은 비파괴검사의 일종으로 관심영역 외부에 설치된 전극에서 측정된 전압으로부터 내부의 저항률분포를 얻는 기술이다. 그러나 EIT에서 영상복원은 타고난 비선형성 (non-linearity)과 부정치성 (ill-posedness) 때문에 만족할만한 복원결과를 얻기 어렵다. 일반적으로 신경회로망은 비선형 시스템의 입력 및 출력 관계를 효율적으로 모델링 할 수 있다. 이 논문은 다층 신경회로망을 이용하여 원형인 표적의 위치(중심좌표)와 크기(반지름)를 추정하는 방법을 제안한다. 제안한 방법의 성능을 알아보기 위해, 신경회로망을 학습시키고 다양한 컴퓨터 모의실험을 수행하였고 결과로부터 제안한 방법의 만족할만한 추정성능을 확인할 수 있었다.