• Journal of Chest Surgery
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• v.36 no.9
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• pp.666-673
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• 2003

Cigarette smoking is the leading cause of the lung cancer. However, mechanism of action underlying the carcinogenesis in the lung still remains to be elucidated. The present study attempted to look into the carcinogenic potential of tobacco-specific nitrosamine, NNK (4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone) and the effects of protein kinase C (PKC) isoforms in an immortalized human epithelial cell model. Material and Method: Immortalized human epithelial cells were exposed with NNK and examined for its carcinogenic potential as measured by saturation density, soft-agar colony formation, and cell aggregation assay. The specific isoform of PKCs involved in the cellular transformation was analysed through western blot with monoclonal antibody and measured separately in cytosolic fraction and membrane fraction. Result: Human epithelial cells exposed with NNK showed prominent carcinogenic potential in saturation density, soft agar colony formation, and cell aggregation assay. PKC isoform analysis results are as follows: PKC- $\alpha$ showed significant translocation of protein levels from cytosolic fraction to membrane fraction, as analyzed by immunoblot. PKC- $\varepsilon$ showed a dose-dependent increase of translocation. PKC- λ was not affected by NNK treatment. Conclusion: The study demonstrated that there was a certain specificity in the patterns of isoform induction following chemical carcinogen exposure. Thus, it is suggested that identification of specific isoform be a clue to find target molecules in the carcinogenesis.

• Journal of Preventive Medicine and Public Health
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• v.31 no.1 s.60
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• pp.59-71
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• 1998

To examine the association of hypertension with cluster of obesity, abnormal glucose and dyslipidemia in Korean urban population, we conducted this cross-sectional study among 3027 men and 2127 women age 20-85 years who visited a prevention center between May 1991 and June 1995 for a multiphasic health check at St. Mary's Hospital, Seoul. By the self-administered questionnaire, the informations of educational attainments, monthly income, alcohol consumption, cigarette smoking, and physical excercise level were obtained. Height, weight, and blood pressure were measured by a trained nurse. The fasting blood sugar (FBS), total cholesterol, high density lipoprotein (HDL) cholesterol and triglyceride were tested by enzyme method. Low density lipoprotein (LDL) cholesterol was calculated by 'total cholesterol - HDL cholesterol - triglyceride/5'. For testing the differences of cardiovascular risk factors between hypertension and normotension group, 1-test and $\chi^2$-test were performed. For the age adjusted odds ratios of hypertension in persons with obesity, abnormal glucose, and dyslipidemia compared with normal, logistic regression was performed by using SAS pakageprograme. The results obtained were as follows: 1. Age, weight, body mass index(BMI), blood glucose, total cholesterol, LDL cholesterol, and triglyceride of hypertension group in men and women were significantly higher than normotension group, but height and HDL cholesterol of hypertension group only in women significantly lower than normotension group. The frequency of obesity $(BMI\geq25kg/m^2)$, abnormal glucose $(\geq\;120mg/dl)$, hypercholesterolemia $(\geq\;240mg/dl)$, lower HDL cholesterol (<45 mg/dl in women only), higher LDL cholesterol $(\geq\;160mg/dl)$, and hyper hypertriglyceridemia $(\geq\;250mg/dl)$ in hypertension group of men and women were significantly higher than normotension group. 2. Systolic and diastolic blood pressure were negatively correlated with hight, but positively with age, weight, BMI, total cholesterol, LDL cholesterol, and triglyceride in men and women. BMI was positively correlated with fasting blood sugar, total cholesterol, LDL cholesterol and triglyceride but negatively with HDL cholesterol. 3. The age adjusted odds ratios of hypertension were as follows in men and women : among persons who were obese compared with those nonobese, 2.53 (95% Confidence Intervals [C.I.] 2.08-3.07) and 2.22 (95%C.I. 1.71-2.87): among persons who were abnormal glucose compared with those normoglycemic, 1.43 (95%C.I 1.13-1.82) and 2.01 (95%C.I 1.36-2.94): and among persons who were dyslipidemia (hypercholesterolemia or lower HDL cholesterol or higher LDL cholesterol or hypertriglyceridemia) compared with those normal lipid, 1.59 (95%C.I 1.30-1.95) and 1.51 (95%C.I 1.16-1.96). After combined more than one risk factor, the odds ratios were increased. Among persons with cluster of obesity, abnormal glucose, and dyslipidemia, the odds ratio of hypertension was 2.25 (95%C.I 1.47-3.37) in men and 3.02 (95%C.I 1.71-5.30) in women. In conclusion, it was suggested that hypertension was associated with cluster of obesity, abnormal glucose, dyslipidemia in this Korean urban population.

• Journal of Korean Ophthalmic Optics Society
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• v.13 no.1
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• pp.131-135
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• 2008

Purpose: To measure and quantify the factors of intraocular pressure (IOP) variation for normal Korean youth. Methods: The IOP of normal youth 805 persons (male: 367, female: 438) were measured as a function of time and quantity for fixation, reclining posture, hard blinking, drinking water, drinking hard liquor, tobacco and coffee by using non-contact tonometer (AT555, Reichert Co.). In the case of fixation, reclining posture and hard blinking, the intraocular pressure of right and left eye were measured for 6 males and 6 females every 10 minutes during 30 minute. In the case of water, liquor, tobacco and coffee, the measurement for 4 or 5 groups (6 persons/ group) having similar IOP were done for the IOP variation of right eye. Results: The mean IOP was 15.2 mmHg for males and 15.8 mmHg for females (slightly higher than male's), respectively and the 99% of those were in the range of the normal IOP. The measured IOP was increased by fixation, reclining posture and hard blinking with males and females. The gradient of increasing slope was 0.15/0.13/0.07/0.08, 0.09/0.08/0.08/0.08 and 0.19/0.08/0.26/0.31, respectively. The IOP variation was elevated by drinking water (especially in the case of 1000 ml) and lowered in proportion to the amount of drinking by hard liquor. Cigarette smoking was associated with rise in intra ocular pressure, but was not shown a definite relation. And coffee had virtually no effect. Conclusions: Fixation, reclining posture, hard blinking and Tobacco caused a transient increase in IOP, but alcohol elicited a slight reduction in IOP overall.

• The Korean Nurse
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• v.22 no.1 s.119
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• pp.47-64
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• 1983

간호원은 비록 그가 양호교사가 아니라고 하더라도 그가 처한 위치에서 거의 매일 건강교육을 실시하고 있다고 할 수 있다. 그러한 비정규직 교육은 상황에 따라 간호활동의 대상자들에게 수시로 별 준비 없이 실시한 경우도 있겠으나 효율적인 결과를 얻을 수 있는 체계적인 보건교육은 구체적인 학습목적과 교육과정이 교육적으로 미리 계획되어 있어야만 가능하다고 할 것이다. 양호교사의 기본적인 역할이 학교 구성원들의 건강증진과 질병예방에 있으며 효율적인 건강교육을 통하여 이러한 목적을 달성한다고 할 때, 양호교사는 자신을 그 학교공동체의 주된 건강교육자로 이해하고 학교에서 이루어지는 모든 보건교육 과정에 적극적인 참여를 하여야만 한다. 그러한 역할중의 하나는 보건에 관한 수업을 실시하는 학과목 교사나 담임교사들이 건강교육에 관련한 협의를 양호교사에게 요청하도록 적극적인 건강교육환경을 학교 내에 조성하여야 하는 일과 중요한 건강주제에 대하여서는 양호교사가 직접 수업을 교실에서 이끌어야 하는 것일 것이다. 이 논문에서 다룬 보건교육 교안 연구는 양호교사에게 또 건강에 관한 주제를 가지고 수업을 하는 일반교사에게 중학생의 건강교육 과정의 한 모델로써 사용하는데 도움이 될 것으로 본다. 건강교육 프로그램을 질병예방, 건강증진에 초점을 두어 설계한다고 할 때 건강교육의 주된 방향은 대상자 하나 하나의 생활에서 건강을 위한 바람직한 행위를 생활화하도록 하는 것이다. 이 목적을 학교에서 달성하기 위해서는 건강교육 프로그램을 통하여 학생들에게 건강에 대한 지식을 전달하고 그 지식 위에 건강을 위한 바람직한 행위를 하도록 동기를 부여하며 그러한 행위를 지속하도록 보강하는 것이 필요하다고 할 것이다. 사람들은 건강에 대한 지식이나 정보를 가지게 되면, 행위는, 그것에 상응하여 바람직하게 행할 것이라고 가정하기가 쉽다. 그리하여 건강에 대한 정보를 주는 것 건강교육을 했다고 간주하기도 한다. 그러나 실제적으로 건강을 위한 정보를 받고 지식을 가졌다 하더라도 바람직한 행위를 실천하지 않거나, 습관된 반건강 행위를 바꾸지 않는 경우가 많다. 그러므로 건강한 행위를 실천하기 위해서는 그에 대한 가치관이나 태도가 먼저 분명하게 세워져야 한다. 학생들의 경우에도 그 가치관이 확립되어야 하겠으므로 이를 위한 효과적인 교육방법이 제시된 교육안 모델이 있어야 할 것이다. 즉 건강문제에 대한 태도의 확립과 그에 따른 올바른 행위를 실천하도록 하기 위하여 구체적으로 치밀하게 계획된 건강교육 안이 연구되어 지는 것이 건강교육의 가장 중요한 과제중의 하나이다. 이 연구에서 제시하는 건강교육 프로그램에서는 많은 부분의 정보가 학생들 스스로에 의해서 수집되도록 하였다. 그렇게 함으로써 그들이 흡연에 관한 사실들을 스스로 명백하게 파악할 수 있었기 때문이다. 또한 소그룹 토의와 논쟁의 방법을 통해서 학생들이 흡연에 대해서 자신들의 생각하고 있는 것을 검토하여 올바른 판단을 하도록 하는 기회를 가질 수 있도록 하였다.

• Journal of muscle and joint health
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• v.5 no.1
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• pp.83-109
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• 1998

This study was carried out to identify the Important modifiable risk factors for reduced bone mass and to construct prediction model which can classify women with either low or high bone mass. Through the literature review, individual characteristics such as age, body weight, height, education level, family history, age of menarche, postmenopausal period, gravity, parity, menopausal status, and breast feeding period were identified and factors of life style such as past milk consumption, past physical activity, present daily activity, present calcium intake, alcohol intake, cigarette smoking, coffee consumption were identified as influencing factors of reduced bone mass in women. Four hundred and eighty women aged between 28 and 76 who had given measurement bone mineral density by dual energy x-ray absortiometry in lumbar vertebrae and femur from July to October, 1997 at 4 general hospitals in Seoul and Pusan were selected for this study. Women were excluded if they had a history of any chronic illness such as rheumatoid arthritis, diabetes mellitus, hyperthroidism, & gastrointestinal disorder and any medication such as calcium supplements, calcitonin, estrogen, thyroxine, antacids, & corticosteroids known affect bone. As a result of these exclusion criteria, four hundred and seventeen women were used for analysis. Multiple logistic regression model was developed for estimating the likelihood of the presence or absence of reduced bone mass. A SAS procedure was used to estimate risk factor coefficient. The results are as follows For lumbar spine, the variables significant were age, body weight, menopause status, daily activity, past milk consumption, and past physical activity(p<0.01), while for femoral Ward's triangle, age, body weight, level of education, past milk consumption, past physical activity(p<0.001). Past physical activity, present daily activity and past milk consumption are the most powerful modifiable predictors in vertebrae and femur among the predictors. When the model performance was evaluated by comparing the observed outcome with predicted outcome, the model correctly identified 74.1% of persons with reduced bone mass and 84.5% of persons with normal bone mass in the lumbar vertebrae and 82.9% of persons with reduced bone mass and 75.0% of persons with normal bone mass in the femoral Ward's triangle. On the basis of these results, a number of recommendations for the management of reduced bone mass may be made : First, those woman who are classified as high risk group of the reduced bone mass in the prediction model should examine the bone mineral density to further examine the usefulness of this model. Second, the optimal amount of milk consumption and a regular weight bearing exercise in childhood, adolescence, and early adult should be ensured.

• Journal of muscle and joint health
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• v.7 no.1
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• pp.89-101
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• 2000

This study was carried out to compare the bone mineral density and risk factors of osteoporosis between normal and rheumatoid arthritis in postmenopausal women. Sixty-eight postmenopausal patients with rheumatoid arthritis(RA) were compared with 124 postmenopausal normal women. Data were collected from october, 1998 to April, 1999 at Dong-a university hospital in Pusan. From all subjects, individual characteristics such as age, body weight, height, age of menarche, duration of menopause, gravity, parity, and breast feeding period and factors of life style such as milk consumption, exercise, alcohol intake, cigarette smoking, coffee consumption were identified as influencing factors of osteoporosis by questionnaire. From RA patients, health assessment score, Ritchie articular index, erythrocyte sedimentation rate, C-reactive protein and steroid dosage were measured by rheumatologist on measuring bone mineral density. Bone mineral density was measured at the Lumbar spine, femoral neck, femur Ward's triangle, and femur trochanter using dual x-ray absorptiometry. The data was analyzed by using a frequency, t-test, Chi-square, ANCOVA with SPSS PC program. The results could be summarized as follows : 1) There was a significant difference in age and breast feeding period between RA patients and normal women. 2) RA patients took less calcium in the past and practiced less regular exercise in past and present than normal women. 3) There was no difference in lumbar bone mineral density between RA patients and normal women. 4) There was a significant difference in femur Ward's triangle and femur trochanter between RA patients and normal women after adjustment for age and breast feeding period. 5) The prevalence of osteoporosis of all subjects was the highest in femur Ward's triangle. In summary, our findings suggest that the bone mineral densities of femur Ward's triangle and trochanter in postmenopausal women with RA is significantly lower than normal women. Also the exercise participation rate of postmenopausal women with RA is lower than normal women. For the further study, we recommend to develop exercise program that improve the bone mineral density in femur Ward's triangle and trochanter and to test the effect of that exercise program.

• The Journal of the Convergence on Culture Technology
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• v.6 no.3
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• pp.125-133
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• 2020

The purpose of this study is to analysis of the difference between dementia policy perception, dementia knowledge, dementia attitude and dementia prevention behavior of middle-aged. The subjects were 217 middle-aged in their 40 to 64 years old who lived in D and G cities. The mean sore of were dementia policy perception 75.42±8.52, dementia knowledge 8.71±1.90, dementia attitude 28.55±5.10, dementia prevention behavior 27.04±3.35. Dementia knowledge were significant differences in gender, number of diseases, source of dementia information. Dementia attitudes were significant differences in gender, age, education, dementia in family, dementia living together, job status, early examination, source of dementia information. Dementia prevention behavior were significant difference in dementia living together and early examination. The most category of dementia prevention behavior was 'cigarette smoking(Inverse question)', and blood pressure and diabetes management' were the lowest. Therefore, development of a professional and systematic dementia education program to raise the awareness of dementia policy among middle-aged adults and form the right dementia knowledge and positive dementia attitude. Development of customized dementia prevention behavior programs to maintain cognitive activities, social activities, proper eating habits, and health care is needed.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.26 no.3
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• pp.277-285
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• 2016

Objectives: This study was performed in order to evaluate whether 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) could be detected among residents living near Camp Caroll in Waegwan and whether serum concentrations of dioxins, including 2,3,7,8-TCDD, and organochlorine pesticides (OCPs) are associated with length of residence. Methods: Study subjects totaled 113 (for dioxins) and 190 (for OCPs) adults who were selected from participants in a medical investigation. Serum concentrations of dioxins and OCPs were measured using HRGC/HRMS. Information on length of residence was obtained through questionnaires. Results: 2,3,7,8-TCDD was not detected in serum among all subjects. When length of residence was classified as a categorical variable, after adjusting for confounding variables, only residents living in Waegwan for 40 years or longer tended to have high total TEQ values and 2,3,4,7,8-PeCDF with marginal significances. There was no dose-response relation between length of residence and serum concentrations of these chemicals. In multiple regression models with continuous values of the length of residence, total TEQ value and 1,2,3,4,6,7,8-HpCDF were positively associated with length of residence. However, they explained about 3-5% of total variations of serum concentrations of these compounds, while age, consumption of fatty fish, body mass index, alcohol drinking, and cigarette smoking were main variables affecting serum concentrations of dioxins or OCPs. Conclusions: In the current study, high concentrations of certain compounds were mainly observed among persons who lived in Waegwan for at least for 40 years without a dose-response relation. Therefore, it seems difficult to conclude that length of residence meaningfully contributed to the current serum concentrations of dioxins or OCPs among residents in Waegwan. However, considering the half-life of 2,3,7,8-TCDD and indirect exposure routes, the limitations of the current study design should be considered in the interpretation of the study findings.

• Journal of the Korean Dietetic Association
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• v.6 no.1
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• pp.9-16
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• 2000

This study was carried out with 436 college students in Chungnam to investigate the relationship between residences and eating patterns of college students. The subjects were devided into two groups; those who live in self-boarding house(SB) and home with parents(HWP). The results were as follows. An average height, weight and BMI were 173.5cm, 66.0kg and 21.9 in male SB and 161.8cm, 50.2kg and 19.2 in female SB and 172.9cm, 67.6kg and 22.6 in male HWP and 161.2cm, 50.9kg and 19.6 in female HWP, respectively. There were no significant differences in the general characteristics between the SB and the HWP. The proportions of disease possession, vitamin/mineral supplements and physical exercise were not significantly different between two groups by residences. Sleeping time of the SB was longer than that of the HWP. And, frequency of cigarette smoking and alcohol drinking of the SB were higher than those of the HWP. The proportions of skipping meals in the SB were higher than those in the HWP. Approximately 40.42% of the SB tended to skip the breakfast, while 11.26% of the HWP did. It turns out that the most common reason why skipped meals was due to a eating habit(44.21%) in the SB and a lack of time(48.85%) in the HWP, respectively. The survey shows that while a great majority of the SB had lunch at campus(50.00%) and home(30.00%), the HWP ate lunch at campus(33.79%) and restaurant(33.33%). About 48% of the SB ate out more than 2-3 times a week compared to 42% of the HWP. The daily intakes of calcium, iron, vitamin A, vitamin $B_2$, niacin and vitamin C in the SB were significantly higher than those in the HWP. The percent RDAs of calcium and iron intakes were lower in female students than in male students. In conclusions, students of self-boarding had more dietary problems than students of home with parents. These results suggest that college students of self-boarding might have low ability of meal management. Therefore, nutrition education for college students is needed, and menus of campus cafeterias should be developed to meet the various needs of students.

• Journal of agricultural medicine and community health
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• v.6 no.1
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• pp.13-24
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• 1981

This study was conducted with 478 farm households located in Pyongtaek Gun of Gyonggi Do, Chongju City and Chongwon Gun of Chung Buk Do, and Hongchon Gun of Gangwon Do for the period of 10, September through 20, October 1980. It dealt with general features of the farmhouseholds, their practices of handling and using pescides, and relationship between safe use of pesticides and poisoning experiences. The results of the study are summarized as follows: 1. Of the total, 63.2% purchased pesticides mainly through the Agricultural Coops, and 95.4% transported them home separately from other goods. 2 Pesticides were sold contained mainly in glass bottles and paper bags. 3. Mixing of the respodents (87.5%) stored pesticides in sheds, warehouses and boxes. 4. Mixing containers and measuring tools were not used by the majority of the group studied. This indicates that there exist serious problems of safety and accuracy with regard to use of pesticides. 5. As to pesticide protective devices, gloves, respirators, goggles and boots were not used in general. Even in case of using them, their quality was not satisfactory. 6. Among the interviewees, 4.2% did not read pesticide label, 33.9% did not wash immediately when pesticide was spilled on the skin, 48.4% did not care the wind direction during pesticide application, and 17.0% did not wash hands when smoking a cigarette while pesticide is being handled. 7. Of the total, 40.4% were found to harvest vegetables within 10 days from the date of pesticide application, which indicates their unawareness of possible hazards by pesticide residues. 8. Empty pesticide containers or bags were not properly disposed of by majority of the respondents. Furthermore, impacts on the environment by the misuse or abuse of pesticides were not understood by 67.6% 9. Of the interviewees, 48.7% were found to have not received instructions on safe use of pesticides. 10. The rate of pesticidal poisoning experience was about 28.0% if minor symptoms excluded, and it rose to about 44.0% if included. Meanwhile, the rate of pesticidal poisoning tends to increase with the size of farm. 11. The study failed to show a statistically significant relationship between the rate of pesticidal poisoning and use of mixing container and/or measuring tools. However, use of gloves showed a statistical significance on the rate of pesticidal poisoning. 12. Among the poisoned cases, 19.0% were cared for in either hospitals or clinics.