Journal of Korean Society of Occupational and Environmental Hygiene (한국산업보건학회지)

Korean Industrial Hygiene Association (한국산업보건학회)
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Serum Concentration and Exposure History of Dioxins and Organochlorine Pesticides among Residents around the Camp Carroll Area

캠프캐럴 인근 주민에서 다이옥신류 및 유기염소계 농약의 혈중 농도 및 노출력

  • Bae, Sang Geun (Regional Cardiocerebrovascular Disease Center, Kyungpook National University Hospital) ;
  • Kim, Geun-Bae (Environmental Health Division, National Institute of Environmental Research) ;
  • Cho, Yong-Sung (Research Development and Education Division, National Institute Chemical Safety) ;
  • Lee, Yu-mi (Department of Preventive Medicine, Kyungpook National School of Medicine) ;
  • Lee, Duk Hee (Department of Preventive Medicine, Kyungpook National School of Medicine) ;
  • Yang, Wonho (Department of Occupational Health, Catholic University of Daegu) ;
  • Ju, Young-Su (Department of occupational and environmental medicine, Hallym university sacred heart hospital) ;
  • Lee, Kwan (Department of Preventive Medicine, College of Medicine, Dongguk University) ;
  • Min, Young-Sun (Department of Preventive Medicine, College of Medicine, Dongguk University) ;
  • Lim, Hyun-Sul (Department of Preventive Medicine, College of Medicine, Dongguk University)
  • 배상근 (경북대학교병원 권역심뇌혈관질환센터) ;
  • 김근배 (국립환경과학원 환경보건연구과) ;
  • 조용성 (화학물질안전원 연구개발교육과) ;
  • 이유미 (경북대학교 의학전문대학원 예방의학교실) ;
  • 이덕희 (경북대학교 의학전문대학원 예방의학교실) ;
  • 양원호 (대구가톨릭대학교 산업보건학과) ;
  • 주영수 (한림대성심병원 직업환경의학과) ;
  • 이관 (동국대학교 의과대학 예방의학교실) ;
  • 민영선 (동국대학교 의과대학 예방의학교실) ;
  • 임현술 (동국대학교 의과대학 예방의학교실)
  • Received : 2016.08.25
  • Accepted : 2016.09.24
  • Published : 2016.09.30
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Abstract

Objectives: This study was performed in order to evaluate whether 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) could be detected among residents living near Camp Caroll in Waegwan and whether serum concentrations of dioxins, including 2,3,7,8-TCDD, and organochlorine pesticides (OCPs) are associated with length of residence. Methods: Study subjects totaled 113 (for dioxins) and 190 (for OCPs) adults who were selected from participants in a medical investigation. Serum concentrations of dioxins and OCPs were measured using HRGC/HRMS. Information on length of residence was obtained through questionnaires. Results: 2,3,7,8-TCDD was not detected in serum among all subjects. When length of residence was classified as a categorical variable, after adjusting for confounding variables, only residents living in Waegwan for 40 years or longer tended to have high total TEQ values and 2,3,4,7,8-PeCDF with marginal significances. There was no dose-response relation between length of residence and serum concentrations of these chemicals. In multiple regression models with continuous values of the length of residence, total TEQ value and 1,2,3,4,6,7,8-HpCDF were positively associated with length of residence. However, they explained about 3-5% of total variations of serum concentrations of these compounds, while age, consumption of fatty fish, body mass index, alcohol drinking, and cigarette smoking were main variables affecting serum concentrations of dioxins or OCPs. Conclusions: In the current study, high concentrations of certain compounds were mainly observed among persons who lived in Waegwan for at least for 40 years without a dose-response relation. Therefore, it seems difficult to conclude that length of residence meaningfully contributed to the current serum concentrations of dioxins or OCPs among residents in Waegwan. However, considering the half-life of 2,3,7,8-TCDD and indirect exposure routes, the limitations of the current study design should be considered in the interpretation of the study findings.

Keywords

References

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