• Title/Summary/Keyword: Chronic variable stress

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Chronic Administration of Monosodium Glutamate under Chronic Variable Stress Impaired Hypothalamic-Pituitary-Adrenal Axis Function in Rats

  • Seo, Hee-Jeong;Ham, Hyang-Do;Jin, Hyung-Yong;Lee, Woo-Hyung;Hwang, Hyun-Sub;Park, Soon-Ah;Kim, Yong-Sung;Choi, Suck-Chei;Lee, Seoul;Oh, Kyung-Jae;Kim, Byung-Sook;Park, Byung-Rim;Lee, Moon-Young
    • The Korean Journal of Physiology and Pharmacology
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    • v.14 no.4
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    • pp.213-221
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    • 2010
  • The hypothalamic-pituitary-adrenal (HPA) axis is the primary endocrine system to respond to stress. The HPA axis may be affected by increased level of corticotrophin-releasing factors under chronic stress and by chronic administration of monosodium glutamate (MSG). The purpose of this study was to investigate whether chronic MSG administration aggravates chronic variable stress (CVS)-induced behavioral and hormonal changes. Twenty-four adult male Sprague-Dawley rats, weighing 200~220 g, were divided into 4 groups as follows: water administration (CON), MSG (3 g/kg) administration (MSG), CVS, and CVS with MSG (3 g/kg) administration (CVS+MSG). In addition, for the purpose of comparing the effect on plasma corticosterone levels between chronic stress and daily care or acute stress, 2 groups were added at the end of the experiment; the 2 new groups were as follows: naive mice (n=7) and mice exposed to restraint stress for 2 h just before decapitation (A-Str, n=7). In an open field test performed after the experiment, the CVS+MSG group significant decrease in activity. The increase in relative adrenal weights in the CVS and CVS+MSG group was significantly greater than those in the CON and/or MSG groups. In spite of the increase in the relative adrenal weight, there was a significant decrease in the plasma corticosterone levels in the CVS+MSG group as compared to all other groups, except the naive group. These results suggest that impaired HPA axis function as well as the decrease in the behavioral activity in adult rats can be induced by chronic MSG administration under CVS rather than CVS alone.

The Effects of Gratitude Enhancement Program on Psycho-social and Physical Health of Chronic Schizophrenia (감사증진프로그램이 만성 조현병 환자의 심리사회적·신체적 건강에 미치는 효과)

  • Choo, Hyun-Sim;Kim, Joo Hyun
    • Journal of Korean Biological Nursing Science
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    • v.19 no.3
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    • pp.158-169
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    • 2017
  • Purpose: The purpose of this study was to identify the effects of the Gratitude Enhancement Program on self-esteem, interpersonal relationships, gratitude disposition, subjective happiness, stress index in patients with chronic schizophrenia. Methods: The research was designed for a nonequivalent control group before and after the test design. The subjects of this study were 29 patients in the experimental group and 28 patients in the control group. The Gratitude Enhancement Program was conducted three times a week for a total of nine sessions. Data were collected with questionnaires and measured with autonomic nervous system response (stress index) and was analyzed by t-test, chi-square test, Fisher's exact, and repeated measures ANOVA with the SPSS/WIN 23.0 program. Results: There are no significant differences in the homogeneity test of a dependent variable between groups. The experimental group showed significant higher scores of self-esteem, interpersonal relationships, gratitude disposition, and subjective happiness than the control group. There was no significant difference in the stress index between two groups. Conclusion: Based on the results of this study, this Gratitude Enhancement Program can be a good nursing intervention to improve self-esteem, interpersonal relationship, gratitude disposition, and subjective happiness for chronic schizophrenia patients.

Factors Influencing Functional Status in People with Chronic Lung Disease (만성폐질환 환자의 기능상태에 영향을 미치는 요인)

  • 오의금;김조자;이원희;김소선;권보은;장연수;이지연;김영진
    • Journal of Korean Academy of Nursing
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    • v.32 no.5
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    • pp.643-653
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    • 2002
  • The purpose of this study was to identify factors that influence the functional status of chronic lung disease patients. Method: A descriptive, correlational study design was used. The study was conducted at the outpatient respiratory clinic of the large university hospital in Korea. A convenience sample of 128 chronic lung patients (age = 64.2 yrs; 106 COPD, 17 bronchiectasis, 5 DILD) with mean FEV1 64.4 % predicted. Functional status was measured with SIP. Physical variables (FEV1% predicted, dyspnea, fatigue, pulmonary symptom distress), psychological variables (mood, stress), and situational variable (sleep quality) were examined. Dyspnea was measured by the BDI, fatigue was measured with the MFI. Mood was measured with the modified Korean version of POMS. Sleep quality was measured with the Pittsburgh Sleep Quality Index. Potential independent variables for the regression were age, gender, years since diagnosis, FEV1% predicted, dyspnea, fatigue, pulmonary symptom distress, stress, and sleep quality. Result: In general, functional status was relatively good. In regression analysis, functional status were significantly influenced by dyspnea, mood, age and fatigue. These variables explained 70 % of the variances in functional status. Conclusion: The results suggest that psychophysiologic symptom management should be a focus to enhance the functional status in this group.

Are Magnetic Resonance Imaging Findings of Ankle Instability Always Correlated with Operative and Physical Examination Findings? (외측 인대 손상의 자기공명영상 소견들이 수술 소견 및 신체검사와 항상 일치할까?)

  • Park, Hyun-woo
    • Journal of Korean Foot and Ankle Society
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    • v.25 no.1
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    • pp.1-5
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    • 2021
  • Physical examination and surgical findings and symptoms are often inconsistent with magnetic resonance imaging (MRI) findings when diagnosing chronic ankle lateral ligament instability, and confirmed surgical findings are used as the gold standard in most clinical studies. Anterior drawer testing is considered unreliable because normal findings are highly variable, and its accuracy ranges from 50% to 100%. Furthermore, radiographic stress imaging, such as in anterior drawer stress view, is performed under manual stress or using a stress device, and its findings also vary widely and confuse when interpreting stress views. The average accuracy of MRI findings is around 85% (range, 66%~91.7%), and thus, cannot be used as a primary indicator for surgery. For patients with suspected lateral ankle ligament instability, based on symptoms and physical examination findings, MRI may be useful for identifying lesions in ankle joints and for differentiating them from other conditions.

Factors Affecting Early Cancer Screening for Lung Cancer: Focusing on Lung Cancer Screening Subjects (폐암의 조기 암검진 여부에 미치는 요인: 폐암 검진 사업대상자를 중심으로)

  • Kim, Seok Hwan
    • The Journal of Korean Society for School & Community Health Education
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    • v.20 no.3
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    • pp.53-65
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    • 2019
  • Objectives: The purpose of this study is to examine the current status of cancer screening among subjects in the lung cancer screening cycle and to analyze the factors affecting the cancer screening of subjects in the lung cancer screening cycle. Methods: This study used the 'National Health and Nutrition Survey 7th Year (2017)' surveyed nationwide as the main data. The subjects are lung cancer screening projects, the dependent variable is early cancer screening, the independent variables are gender, age, marital status, household income level, education level, national health insurance type, private health insurance, The number of chronic diseases, general health examination, smoking status, drinking status, moderate intensity physical activity, stress perception rate, and weight control efforts were determined. Results: The results of this study showed that factors affecting early cancer screening of lung cancer screening subjects were gender, age, marital status, education level, national health insurance, smoking status, drinking status, moderate physical activity, and weight. Irrespective of the control effort, it was found that the private medical insurance, the number of chronic diseases, the medical examination, and the stress perception rate were affected. Conclusion: If the lung cancer screening subjects recognize the importance of early cancer screening themselves and create a social environment to increase their participation rate, lung cancer screening patients and their families will help them to live a healthy life.

Correlation with Psychosocial, Workplace Coping Skills, Pain, and Degree of Disability of Office Workers with Non-Specific Chronic Neck Pain

  • Ki-young Moon;Won-Jun Choi;Sangjun Son;Seyeon Jung;Sijin Lee;Doochul Shin
    • Physical Therapy Rehabilitation Science
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    • v.11 no.4
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    • pp.565-570
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    • 2022
  • Objective: The purpose of this study was to investigate the correlation between activity of daily living and social psychology and work mind of office workers with non-specific chronic neck pain (NSCNP). Design: Crossed-sectional study Methods: 86 patients with NSCNP were recruited for this study. Neck disability index (NDI) and Numerical pain rating scale (NPRS) were used to check the pain intensity and disability of patients with neck pain. To find out the occupational factors of the subjects, the Korean version of Latack Coping Scale was used. And,To find out the socio-psychological factors of the subjects, the Korean version of depression anxiety stress scale (DASS-21) was used. We performed correlation for each variable. Results: The correlation between NPRS and NDI and DASS-21 Scale were clear positive correlation (p<0.05). There was no statistical significance between the LATACK control group and the pain and disability index (p>0.05). A clear positive correlation was established between the avoidance group of LATACK and pain (p<0.01). Conclusions: Through this study, it is necessary to have time to manage depression, anxiety, and stress in the treatment of neck pain in office workers who spend a lot of time sitting. In addition, it is thought that there should be the ability to control oneself about one's duties in the workplace.

Correlations Among Body Weight, Life-Style and Health Status in Korean Adults (생활양식, 체중과 건강수준의 상관성분석)

  • 김영임
    • Journal of Korean Academy of Nursing
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    • v.21 no.2
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    • pp.195-203
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    • 1991
  • Correlations among body weight and sociodemographic factors, including life - style were tested as social determinants of health in a sample of 5,201 adults in Korea. The aim of this study was to determine the extent to which sociodemographic variables and life-style associated health behaviors explain body weight distribution. A second aim was to explain the relation of body weight and health status to stress the importance of body weight as an early risk indicator of health status. The canonical correlation between the weight distribution(underweight and overweight) and the independent variables was 0.29, 17% of the total variance was explained. Perceived health level represented the highest contribution(canonical coefficient 0.82) to body weight. Sociodemographic factors such as sex, economic status, and life-style factors such as smoking, exercise, regular meais and sleep showed comparatively high contributions to body weight. The relevance of body weight for health status including the rate of chronic disease and the rate of medical utilization was significant. Especially, underweight was clarified as being mere important than overweight to morbidity level and medical utilization. These findings suggest that perceived body weight is an important indicator of health status and is thus a valuable variable to be considered for nursing intervention and health education related to the promotion of health.

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Chronic Injuries and Types of Injuries Related to Adolescent Taekwondo Athletes (성장기 태권도 선수의 만성 통증과 손상 유형)

  • Kim, Ha-Kyung;Kim, Chang-Yoon;Shim, Hee-Jong;Park, Sung-Min;Bae, Byung-Jo
    • Journal of Korean Orthopaedic Sports Medicine
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    • v.8 no.1
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    • pp.46-50
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    • 2009
  • Purpose: This study was designed to analyze? the chronic pain of adolescent Taekwondo athletes, to research the understanding about chronic pain of coaches and athletes, to? reduce the development of chronic pain. Materials and Methods: From March. 2006 to June 2007, 210 athletics and 12 coaches of elementary, middle and high school in Kwang-ju city were surveyed. They was evaluated by physical examination, simple radiographs and MRI. Results: In 210 athletics, 162(77.1%) athletes had chronic pain. 19(11.7%) athletes had over three regions of pain, 74(45.7%) athletes had two regions of pain, 69(42.6%) athletes had one region of pain. In 274 cases of 164 athletes, the most common region was foot and ankle(145 cases, 52.9%), followed by hand(47 cases, 17.2%) and knee(38 cases,13.9%), hip(25 cases, 9.1%), and lumbar area(19 cases, 6.9%) The chronic pain was classified by injury type. Contusion of foot was 103 cases(most common), sprain of ankles was 40cases, Contusion of hands and wrists was 28 cases, and so on. The etiologies of injury that causes the chronic pain were match injury in training that is most common, intensive exercise and match injury in competition. Conclusion: The chronic pain was common in adolescent Taekwondo athletes. The ankle and foot were the most common region of chronic pain and the match injury was the most common injury, caused the chronic pain. Although athletes had considerable mental stress about chronic pain, the treatment of chronic pain and rest were insufficient. Therefore the variable effort to prevent injury and to treatment injury must be considered importantly.

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An Analysis on Health-Related Difference according to Socio-economic Class in Our Country

  • Lee, Kyung-Soo;Lim, Gyeong-Tae;Chung, Hee-Tae
    • Journal of Korean Clinical Health Science
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    • v.1 no.3
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    • pp.49-61
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    • 2013
  • Purpose. The purpose of this study is to analyze difference in quality of life related to health according to our country's social stratification. Methods. This study had analytical subjects as 7,992 adults(4,557 men, 3,435 women), who are included in a variable by social stratification among 15,691 people in the age group of 20~69 years old as examinees, based on the 4th Korea National Health and Nutrition Examination Survey. Results. This study obtained the following results. First, seeing the score of health-related life quality by social stratification, namely, the distribution of EQ-5D index, the new middle class(class II) was the highest(men with 0.966 point, women with 0.955 point). The agricultural self-employed class(class V) was indicated to be the lowest(men with 0.918 point, women with 0.866 point). In general, the more belonging to low social stratification led to having shown the lower aspect in EQ-5D index value. Second, as for the results of the hierarchical regression analysis, the factors of contributing to difference by social stratification in health-related quality of life were chronic disease, job stress, education, and income level in both men and women. The health behavior was grasped to be a factor of contributing only to women. Conclusions. To reduce difference in health-related quality of life according to social stratification in the future, the continuous investment is needed for supporting socially high-quality education and economic stability. The sphere of health will need to be given priority to the prevention of chronic disease and the development in effective management policy for the lower classes.

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Psychosocial Factors and Health Behaviors in Elderly People

  • Park, Mi-Kyoung
    • Korean Journal of Health Education and Promotion
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    • v.20 no.4
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    • pp.1-11
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    • 2003
  • The main purposes of this study were to investigate the content of health behaviors and to examine factors influencing the health behaviors of the elderly. Data regarding the health behavior of 126 people over 65 years of age living in community settings were used. All subjects were interviewed using a semi-structured questionnaire. The questionnaire consisted of sociodemographic variables, health behaviors, present chronic disease, subjective health status, a scale for worthy life, a scale for self-esteem, and a scale for loneliness. Health behaviors included 27questions on diet, exercise, stress-coping, smoking, drinking, a regular medical check-up, social activities, etc. The data analysis procedure included stepwise regression using health behavior as the dependent variable, and sociodemographics, illness, and psychosocial variables as independent variables. Stepwise regression revealed that factors such as feelings of worthy life($\beta$=-0.350, p<0.0001), communicating with otjers or the lack there of ($\beta$=0.183, p<0.05), and self-esteem($\beta$=0.196, p<0.05) were independently and significantly associated with health behaviors. For example, individuals who showed higher levels of worthy life and who had confiding relationships with others tended to practice more health behaviors. Subjects who had a higher level of self-esteem showed the same tendency. These results suggest the necessity of a intervention that considers psychosocial aspects should be included in care of the elderly so as to promote positive health behavior.