• 대한불안의학회지
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• 제9권2호
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• pp.106-112
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• 2013

Objective : Several reports have found abnormal levels of androgen in post-traumatic stress disorder (PTSD) patients. This abnormality in androgen is hypothesized to due to chronic psychological stress effects on the hypothalamic-pituitary-gonadal (HPG) system. The present study was conducted to estimate serum testosterone levels in PTSD patients in comparison with normal subjects. Methods : Seventy-five male Korean veterans of the Vietnam War volunteered for the study, of which eleven were excluded because of incomplete psychological assessment. To measure basal serum testosterone, blood samples were collected between 8.00 and 9.30 a.m. The clinician administered PTSD scale (CAPS), the structured clinical interview for DSM-IV (SCID), Hamilton Anxiety Rating Scale (HAM-A), Hamilton Rating Scale for Depression (HAM-D), Mini International Neuropsychiatric Interview Plus (Korean version of MINI-Plus), CES-K (Korean version of combat exposure scale). Results : The serum testosterone level of PTSD patients ($5.4{\pm}2.5ng/mL$) was higher than that of a control group ($3.1{\pm}1.7ng/mL$, p<0.001). Testosterone levels were significantly correlated with CAPS (r=.38, p<.01), HAM-A (r=.35, p<.01) and HAM-D (r=.28, p<.01) in all subjects. Conclusion : The results of the present study suggest that chronic psychological stress affects the HPG system.

• Food Science and Biotechnology
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• 제17권4호
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• pp.713-717
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• 2008

In the present study, chronic effects of the hot water extracts of walnut seed (Juglans regia L.) (WSE) and Nelumbo nucifera seed (NSE) were investigated in mice exposed to 2 hr of restraint stress each day for 4 weeks. Corticosterone levels in serum were significantly increased in the vehicle-treated stressed group ($25\;{\mu}g/dL$) compared to that in the control group ($13\;{\mu}g/dL$). This stress induced gastric redness and lesions. However, treatment with WSE and/or NSE significantly protected the stomach from this lesion by 50-60% compared to that in the vehicletreated group. In the amygdala, the administration of WSE and/or NSE also reduced the immediate early gene (c-fos) expression by 70-90% vs. the vehicle-treated group. These suggest that WSE and/or NSE may reduce the appearance of symptoms induced by stress and these materials are useful as anti-stress foods, as natural products tend to be relatively safe compared to chemical products.

• The Korean Journal of Physiology and Pharmacology
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• 제22권5호
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• pp.567-575
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• 2018

Acute kidney injury (AKI), which is defined as a rapid decline of renal function, becomes common and recently recognized to be closely intertwined with chronic kidney diseases. Current treatment for AKI is largely supportive, and endoplasmic reticulum (ER) stress has emerged as a novel mediator of AKI. Since carbon monoxide attenuates ER stress, the objective of the present study aimed to determine the protective effect of carbon monoxide releasing molecule-2 (CORM2) on AKI associated with ER stress. Kidney injury was induced after LPS (15 mg/kg) treatment at 12 to 24 h in C57BL/6J mice. Pretreatment of CORM2 (30 mg/kg) effectively prevented LPS-induced oxidative stress and inflammation during AKI in mice. CORM2 treatment also effectively inhibited LPS-induced ER stress in AKI mice. In order to confirm effect of CO on the pathophysiological role of tubular epithelial cells in AKI, we used mProx24 cells. Pretreatment of CORM2 attenuated LPS-induced ER stress, oxidative stress, and inflammation in mProx24 cells. These data suggest that CO therapy may prevent ER stress-mediated AKI.

• 한국학교ㆍ지역보건교육학회지
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• 제19권2호
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• pp.43-52
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• 2018

Objects: In this study, we analyzed the correlation between stress and depression related to the quality of life of one elderly household, and analyzed the influence of stress and depression on the quality of life. In this study, I tried to make a plan for improving the quality of life for one elderly. Methods: In this study, the frequency and percentage according to the general characteristics of one elderly household were frequency analyzed. And the mean and standard deviation of stress, depression, quality of life were analyzed on average. And continuous analysis of stress, depression, quality of life, etc., conducted a technical analysis. Relationship to stress, depression, quality of life, correlation analysis was done. The effect of stress and depression on the quality of life was linear regression analysis. SPSS Version 23.0 was used for analysis. Result: Increased stress and increased depression in elderly single households was a static (+) correlation. And the results of the regression analysis showed that the higher the stress and depression of one elderly household, the lower the quality of life. Conclusion: For the improvement of the quality of life of one elderly household, the government should support stress and depression prevention programs according to sex, age, number of chronic diseases.

• 대한본초학회지
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• 제34권2호
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• pp.15-23
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• 2019

Objective : Reflux esophagitis (RE) is a disease that caused gastric acid reflux and inflammation due to unstable gastroesophageal sphincter, as increasing worldwide respectively. This study was conducted to evaluate the effect of Evodiae Fructus (EF) extract on chronic reflux esophagitis in rats. Methods : The EF was measured antioxidant activity, such as total polyphenol and total flavonoid contents, 1, 1-diphenyl-2-picrylhydrazyl (DPPH) and 2, 2'-azinobis-3-ethyl-enzothiazoline-6-sulfonic acid (ABTS) radical scavenging activity. Rats were divided into 3 groups; Nor (normal group), Con (chronic acid reflux esophagitis rats treatment with water), EF (chronic acid reflux esophagitis rat treatment with EF 200 mg/kg body weight group). A surgically-induced chronic acid reflux esophagitis (CARE) model was established in SD rats, and treated with water or EF 200 mg/kg body weight for 14 consecutive days. Results : Administration of EF to rats of induction of chronic acid reflux esophagitis was found to reduce esophagus tissues injury. Reactive oxygen species (ROS) and produces peroxynitrite ($ONOO^-$) levels of esophagus tissues were significantly decreased in EF compared to Con group. As results of esophagus protein analyses, EF effectively reduce inflammatory-related factors ($NF-{\kappa}Bp65$, $p-I{\kappa}B{\alpha}$, iNOS, $TNF-{\alpha}$, IL-6), and increase anti-oxidant enzyme (Nrf2, HO-1, SOD, catalase, GPx-1/2). Conclusions : These results suggest that EF administration comfirmed that decreased esophagus tissues injury, oxidantive stress, anti-inflammation effect, and increased anti-oxidant effect. Therefore, EF was the potential to be used as a natural therapeutic drug.

• 한국심리학회지 : 문화 및 사회문제
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• 제15권3호
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• pp.359-375
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• 2009

본 연구의 목적은 한국형 마음 챙김 명상에 기반한 스트레스 감소 프로그램이 근로자의 만성통증완화에 미치는 영향을 연구 하는데 있다. 이러한 목적을 달성하기 위하여 만성통증을 가진 근로자 20명을 대상으로 프로그램의 효과를 알아보기 위해 사전 검사, 사후 검사, 추수 검사에서 측정한 평균점수로 혼합변량분석(Mixed ANOVA)을 실시하였다. 분석된 자료는 심리적, 신체적, 신경 생리적 반응이었다. 아울러 프로그램 후 각 효과가 지속적으로 유지될 것인가를 추가 검증하고자 3개월 후에 사후검증도 실시하였다. 본 연구 결과, 프로그램 참여 집단의 신체적 증상과 신체화, 강박증, 대인예민성, 우울, 불안, 적대감, 공포불안, 정신증 등의 반응이 프로그램 참여 전에 비해 유의미하게 감소하였고, 또한 생리 및 신경생리지표 또한 프로그램 전에 비해 유의미한 변화가 나타났으며, 3개월 후까지 이러한 변화의 효과가 유지되었다. 본 연구의 결과로 보아 마음 챙김 명상에 기반한 스트레스 감소 프로그램은 통증환자의 심리적, 신체적, 신경생리적 통증완화에 유의미한 영향력을 미치는 것으로 밝혀졌다. 따라서 본 연구결과를 통해 만성통증환자의 임상적 프로그램 개발의 기초자료를 제공하고자 한다.

• 근관절건강학회지
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• 제6권1호
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• pp.85-99
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• 1999

Chronic disease such as rheumatoid arthritis is believed to induce a significant psychosocial stressors. The concept of illness intrusiveness-illness induced life style disruptions-was hypothesized to affect psychosocial status. And demographic, socioeconomic, disease and social characteristics were hypotehsized to affect illness intrusiveness. Hierarchial multiple regression analyses were used. As a result, among the demographic factors gender was identified as contributor to directly increase the psychosocial stress and education level was identified to affect the psychosocial stress through illness intrusiveness. Among socioeconomic factors, the burden about the cost of medical treatment was found to indirectly affect the psychosocial stress through the illness intrusiveness. Also income and job were found to affect directly the psychosocial status. Among the disease characteristics, only the pain level was identified to increase the psychosocial stress through the illness intrusiveness. Among the social characteristics, perceived social support is identified to increase the psychosocial stress through the illness intrusiveness. Based upon these results, some suggestions were made for minimizing illness intrusiveness in rheumatoid arthritis and future research.

• 대한족부족관절학회지
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• 제25권1호
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• pp.1-5
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• 2021

Physical examination and surgical findings and symptoms are often inconsistent with magnetic resonance imaging (MRI) findings when diagnosing chronic ankle lateral ligament instability, and confirmed surgical findings are used as the gold standard in most clinical studies. Anterior drawer testing is considered unreliable because normal findings are highly variable, and its accuracy ranges from 50% to 100%. Furthermore, radiographic stress imaging, such as in anterior drawer stress view, is performed under manual stress or using a stress device, and its findings also vary widely and confuse when interpreting stress views. The average accuracy of MRI findings is around 85% (range, 66%~91.7%), and thus, cannot be used as a primary indicator for surgery. For patients with suspected lateral ankle ligament instability, based on symptoms and physical examination findings, MRI may be useful for identifying lesions in ankle joints and for differentiating them from other conditions.

• 고신대학교 의과대학 학술지
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• 제33권2호
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• pp.135-140
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• 2018

Endometriosis is an estrogen-dependent chronic inflammatory condition that affects women in their reproductive period and is associated with pelvic pain and infertility. Oxidative stress (OS) occurs when reactive oxygen stress (ROS) and anti-oxidants are in imbalance. OS is a potential factor involved in the pathophysiology of endometriosis. Iron-induced ROS may trigger a chain of events resulting in the development and progression of endometriosis. Endogenous ROS are correlated with increased cellular proliferation and ERK1/2 activation in human endometriotic cells. An oxidative environment leads to stimulation of the ERK and PI3K/AKT/mTOR signaling pathways that facilitate endometriotic lesion progression through adhesion, angiogenesis, and proliferation. OS is also known to be involved in epigenetic mechanisms in endometriosis. We summarize the recent knowledge in our understanding of the role of oxidative stress in the pathogenesis of endometriosis.

• 한국임상수의학회지
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• 제35권2호
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• pp.57-59
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• 2018

A seven-month-old Hanwoo steer was presented immediately after transport with respiratory symptoms including a nasal discharge, depression, and anorexia. Though repeated treatments, bronchopneumonia had not been improved and had persisted for 10 months. Then, obstructive breath sound was heard. A cyst adjacent to the epiglottis could be observed with respiratory endoscopy. Consequently, chronic bronchopneumonia induced laryngeal cyst formation, resulting in obstructive dyspnea. And respiratory endoscopy may be useful for differentiating the causes of dyspnea in bovine clinical practice.