• 동의신경정신과학회지
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• 제14권1호
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• pp.27-44
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• 2003

Objective : The aim of this study was to assess protective effects of Whangryonhaedoktang on the chronic mild stress (CMS) animal model of depression. Method : Male Sprague-Dawley rats were used for this study. The subjects were divided into 3 groups (CMS-drug group: Whangryonhaedoktang was administered during CMS procedure, CMS-vehicle: water was administered during CMS procedure, normal control group: without CMS procedure). After 4 weeks of CMS procedure, Morris water maze (MWM) test and open field test were executed and tyrosine hydroxylase (TH) was measured in ventral tegmental area (VTA) and locus coeruleus (LC) of rat brain. Result : 1. CMS procedure induced defects of spatial learning in early period of MWM test. 2. CMS Whangryonhaedoktang group showed shorter escape latency in comparison with CMS control group in MWM test on the first day of the test. 3. CMS Whangryonhaedoktang group and CMS control group showed no significant difference of activities and emotional behaviors in comparison with normal control group in open field test. 4. CMS Whangryonhaedoktang group showed significant inhibition effects of TH expression in VTA and LC areas in comparison with CMS control group. Conclusion : These results suggest that Whangryonhaedoktang may have inhibition effects to early period defects of spatial learning and protective antidepressant effects in CMS model rats.

• 동의신경정신과학회지
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• 제13권2호
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• pp.121-147
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• 2002

This study was performed to evaluate the effects of Quibitang in the chronic mild stress(CMS) model of depression in rats. Chronic exposure to mild unpredictable stress was found to depress the consumption of sucrose solution in rats for 8 weeks. These CMS-treated rats were stratified into Quibitang gruop and saline group. And control rats were also stratified into Quibitang group and saline group. The change of the consumption of sucrose solution and the body weight were measured, and open field test, elevated startle response and plus maze test were performed, to investigate the anti-depression effect of Quibitang. The results were as follows: 1. The consumption of sucrose solution was significantly reversed in Quibitang-treated group at 9th, 11th, 12th week, but there was no significant change at 10th week 2. CMS schedule decreased body weight. CMS-treated groups showed decrease of body weight after 5 weeks. After 10 weeks, Quibitang group showed lower body weight than saline group in CMS-treated groups 3. In open field test, Quibitang group showed significant difference of locomotion, latency. 4. In elevated startIe test, Quibitang group showed no significant change of startle response. 5. In plus maze test, Quibitang group showed no significant change of plus maze-time and plus maze-error.

• 동의신경정신과학회지
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• 제15권2호
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• pp.53-70
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• 2004

Objective : This study was designed to assess the protective effects of Bambusae caulis and St. John's Wort on the animal model of depression, induced by chronic mild stress(CMS) Method : Male Wistar rats were used for this experiment. The subjects were divided into 4 groups ( 1. CMS-drugs: Bambusae caulis administered during CMS treatment, 2. CMS-drugs: St. John's Wort administered during CMS treatment, 3. CMS-vehicle: Water administered during CMS treatment, 4. normal control group without CMS treatment ). After 3 weeks of CMS treatment, they were executed open field test and weight, sucrose intake were measured. Result : 1. CMS Bambusae caulis group showed significant difference of locomotor activities and marginal difference of start latency in comparison with other groups in open field test. 2. There was no change of weights between CMS Bambusae caulis, St. John's Wort groups and CMS control group. 3. CMS St. John's Wort group showed upper level of sucrose intake than CMS Bambusae caulis group and CMS control group. Conclusion : These results suggest that Bambusae caulis may have protective antidepressant effects in CMS model rats. And these effects could be explained by the elevated locomotor activities in open field test.

• Journal of Veterinary Science
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• 제24권1호
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• pp.2.1-2.14
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• 2023

Background: Hypothermia is a crucial environmental factor that elevates the risk of cardiovascular disease, but the underlying effect is unclear. Objectives: This study examined the role of cold stress (CS) in cardiac injury and its underlying mechanisms. Methods: In this study, a chronic CS-induced myocardial injury model was used; mice were subjected to chronic CS (4℃) for three hours per day for three weeks. Results: CS could result in myocardial injury by inducing the levels of heat shock proteins 70 (HSP70), enhancing the generation of creatine phosphokinase-isoenzyme (CKMB) and malondialdehyde (MDA), increasing the contents of tumor necrosis factor-α (TNF-α), high mobility group box 1 (HMGB1) interleukin1b (IL-1β), IL-18, IL-6, and triggering the depletion of superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH). Multiple signaling pathways were activated by cold exposure, including pyroptosis-associated NOD-like receptor 3 (NLRP3)-regulated caspase-1-dependent/Gasdermin D (GSDMD), inflammation-related toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88)-mediated nuclear factor kappa B (NF-κB), and mitogen-activated protein kinase (MAPK), as well as oxidative stressinvolved thioredoxin-1/thioredoxin-interacting protein (Txnip) signaling pathways, which play a pivotal role in myocardial injury resulting from hypothermia. Conclusions: These findings provide new insights into the increased risk of cardiovascular disease at extremely low temperatures.

• Perspectives in Nursing Science
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• 제2권1호
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• pp.48-60
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• 2005

The relationship of psychological stress to human health is of interest to health care providers and researchers in the field of psychoneuroimmunology. The effect of stress on wound healing is a sub-component of study within the larger context, with relevance to both wounds that are acute and chronic in nature. Data from several studies that explore the influence of stress on events early in the trajectory of wound healing suggest that activation of both the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis are involved. There is consistent evidence that psychological stress is associated with dysregulation of immune and other responses to tissue injury that are required for healing and also to the final wound healing result. Current data pertinent to psychological stress and its wound healing consequences is reviewed and a biopsychosocial framework for future studies in this area is suggested and described.

• 대한불안의학회지
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• 제5권2호
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• pp.80-88
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• 2009

Disorder of Extreme Stress, Not Otherwise Specified (DESNOS) is the proposed diagnosis that meets the severe, complex, and prolonged psychological sequela of victims with chronic traumatization (e.g., family violence, incest, and childhood sexual or physical abuse). The hallmarks of DESNOS are a multiplicity of symptoms (e.g., somatization, dissociation, and depression), pathological changes in relationships, identity disturbances, and a propensity to experience repeated harm and injury at the hands of oneself and others. DESNOS can be directly assessed by Structured Interview of Disorder of Extreme Stress (SIDES) and Self- Report Inventory of Disorder of Extreme Stress (SIDES-SR). The treatment of DESNOS should be phaseoriented and involve movement back and forth among three basic stages : 1) stabilization ; 2) trauma processing ; 3) reintegration.

• Journal of Ginseng Research
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• 제35권1호
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• pp.111-123
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• 2011

To investigate the effects of repeated immobilization-stress challenge on the the hypothalamic-pituitary-adrenal axis, the genomic transcriptome in the adrenal cortex of immobilization-stressed mouse was analyzed by using a cDNA microarray. Mice were subjected to immobilization stress for 2 h per day for 5 consecutive d. With a 4.0-fold cutoff of arbitrary criteria, the expression levels of 168 out of 41,174 genes were significantly modulated in the adrenal cortex by stress when comparing the control and experimental groups. These genes were related to apoptosis, cell cycle, immune response, inflammatory responses, and signal transduction, and thus may be used as potential targets for the development of therapeutics for chronic stress or depression. Six significant genes among these were selected for real time polymerase chain reaction analysis to confirm the change of their expression levels. The gene for phospho 1 was also further investigated because its expression showed the greatest fold-change.

• 한국컴퓨터정보학회논문지
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• 제22권6호
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• pp.87-93
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• 2017

In this paper, we design a small low power single channel ECG(Electrocardiogram) system of Chest Belt type with fiber-type electrodes to measure emotional state change of game addict. HRV(Heart Rate Variability) is analyzed through heart rate signal measurement and the psychological stress state is judged by using it. And it verifies its effectiveness through prototype. First, we design HR measurement module through low power MCU(Micro Controller Unit) and implement prototype level measurement system. The results showed that the difference between the addiction group and the general group was confirmed and that the system was effective. The result of this study can be used for health management such as reduction of stress of the user through music and breathing that lowers the stress by detecting the stress state of the general person or the chronic ill person.

• 한국전문물리치료학회지
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• 제5권2호
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• pp.65-80
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• 1998

Parents of handicapped children are experiencing difficulties in their children's care, social isolation, change of life style and lirnited leisure time. Because the parents should take care of the children's daily life, they have lots of psychological and physical stress. Chronic stress of parents puts stress to the other family members and affects the development of children with handicap. The purpose of this study were to identify the level of stress in each of parents of children with motor problem, the characteristics of the children and general information related with the children, and to analyse the stress by reasons. Specially organized questionnaire were used for an investigation method. "Test of stress in mother who has children with chronic illness" by Kim Hee-soon were modified and used. The questionnaire answered by 43 mothers and 35 fathers were analyzed. Data analysis includes frequency analysis, Pearson correlation coefficients, paired-samples t-test and MANOV A by SPSSWIN. The results were as follows: 1) Degree of handicap was most moderate (46.5%), level of motor development was most pull to walk (34.9%), and combined handicap was 69.8%. 2) Sexual distribution represented that 51.2% male and 48.8% female. The cost of physical therapy was 69.8% in no more than 100,000 won. 3) The mean of age, for the mother was 32.8 years and 35.3 years. Level of motor development that mother and father expect was 88.4%, 83% walk alone. 4) Both mother and father experienced stress in other of Part II (changes in father was the illness status of the child and difficulty in taking care of child), Part III (prognosis of the child's condition), Part I (social-personal relationships and the responsibility of the care givers). In the total score of stress, mother's stress is indicated higher level than father's stress. 5) There was no correlationship between characteristics and stress of mother and father. 6) There was no statistically significant difference between characteristics and related general information of children with handicap and stress of mother and father. As a results, the mother of children with handicap are experiencing more stress than the father. Both of parents have the most difficulties in the changes in the illness status of the child and difficulty in taking care of child. This study can be used as resources of education, therapy and counselling for children with handicap and their parents. This study, also, can be used to encourage the quality of Iife for the children with handicapped and their family.

• 동의신경정신과학회지
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• 제19권3호
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• pp.299-307
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• 2008

In this study, we treated a patient with psychogenic chronic low back pain for 2 years with herbal medication treatment and psychotherapy. The case was a 17 years old female patient complained chronic low back pain for a long time. She received the spine operation, epidural injection, many kind of oriental medicine treatment about low back pain, but there was no improvement. We diagnosed her pain as a psychogenic pain disorder, and treated her with herbal medication for decrease her stress, and did a psychotherapy such as the progressive muscle relaxation, and counseled about trouble with her family. After treatment, her chronic low back pain was improved so much. We think that the herbal medication treatment and psychotherapy can be helpful to treat patients who have psychic and physical disorders.