• Tuberculosis and Respiratory Diseases
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• 제81권3호
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• pp.167-174
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• 2018

Despite recent clinical guidelines, the optimal therapeutic strategy for the management of refractory chronic cough is still a challenge. The present systematic review was designed to assess the evidence for efficacy and safety of gabapentin in the treatment of chronic cough. A systematic search of PubMed, Embase, Cochrane Library databases, and publications cited in bibliographies was performed. Articles were searched by two reviewers with a priori criteria for study selection. Seven relevant articles were identified, including two randomized controlled trials, one prospective case-series designed with consecutive patients, one retrospective case series of consecutive patients, one retrospective case series with unknown consecutive status, and two case reports comprising six and two patients, respectively. Improvements were detected in cough-specific quality of life (Leicester Cough Questionnaire score) and cough severity (visual analogue scale score) following gabapentin treatment in randomized controlled trials. The results of prospective case-series showed that the rate of overall improvement of cough and sensory neuropathy with gabapentin was 68%. Gabapentin treatment of patients with chronic cough showed superior efficacy and a good safety record compared with placebo or standard medications. Additional randomized and controlled trials are needed.

• 가정∙방문간호학회지
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• 제19권1호
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• pp.74-82
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• 2012

Purpose: The aim of this study is to evaluate the effects of community based chronic disease management program for managing hypertension and diabetes mellitus. Method: The subjects of this study were 1,000 clients, who participated in a city community based chronic disease management program. The data were collected by a phone survey directly, and selected from DB of community based chronic disease management program, indirectly. The data were analyzed by the STATA program, using descriptive statistics, t-test, and Multiple regression analysis. Results: The mean score of knowledge of hypertension was 4.33 and diabetes mellitus was 2.52. The affecting factors of knowledge of hypertension were the clinic visiting point and blood sugar. However, the affecting factors of knowledge of diabetes mellitus was core lab point, diastolic blood pressure, and blood sugar. Conclusion: the results of this study showed that knowledge of hypertension increased with higher level of education, and younger ages, while knowledge of diabetes mellitus increased with higher level education, more core lab point, younger ages, and in males. Therefore, to control the chronic diseases more effectively in a community, it is important to develop a more systematic education and self- managing programs, using collaboration of health centers and local clinics.

• 지역사회간호학회지
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• 제19권2호
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• pp.226-233
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• 2008

Objectives: The purpose was to test the effect of an empowerment health management program on self-esteem and the quality of life for the elderly who live in cities. Methods: Forty-three elders were randomly assigned to either the experimental group that received the intervention to participate in one year's empowerment practice (one home visiting per week and phone counselling) (n=21) or to the control group that got home visiting only (n=22). The data was analyzed using ANCOVA. Results: There was no significant difference in the self-esteem score between the two groups after the intervention. But the quality of life score of the experimental group was significantly different from that of the control group after the intervention. Conclusions: The health management intervention using empowerment for the elderly living alone with chronic diseases in urban areas had positive effects on the quality of life. Therefore this intervention can be broadly applied to other elders living alone with chronic diseases in urban areas.

• Asian-Australasian Journal of Animal Sciences
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• 제5권3호
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• pp.411-418
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• 1992

Recently, onset of bacterial disease, especially infiltration of chronic respiratory diseases have been increasing at high rate. The main cause of these diseases are originated from inappropriate sanitary management and slow progress in introducing system and herd free system, which are the base of productivity improvement in bigger pig management, Methods for the prevention and removal of these diseases, are divided into four categories. The first category includes prevention and removal of infectious diseases by organizing strict animal quarantine, enforcing vaccination, and legal regulation and disposal at the time of outbreak. The second category includes improvement of production systems. This purpose can be achieved by discontinuing the open herd system, which brings on the invasion of foreign pathogens and replacing the system by the closed type of farm. To Continue eradication process step-wisely by performing the all-in all-out system at every pig pen or herd level is also effective for this purpose. The third category includes introduction of herd free system can be achieved by repopulating conventional pigs with SPF pigs. If these means are unrealizable from economic or technical viewpoint, medicated early weaning system is perfomed. This system consists of disinfection of pigsty at pre-postpartum stage, application of drugs to pregnant sows and newborn piglets in accordance with the medication program, and early weaning and rearing of newborn piglets in isolation. The fourth category is sanital leading by veterinarians, aimed to eliminating incentives for diseases through diagnoses. Their main activities include periodical monitoring and improvement leading on each responsible subject.

• KSBB Journal
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• 제29권1호
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• pp.36-41
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• 2014

Skin disease is one of the most common diseases and its incidence is increasing dramatically in modern society. Specially, many attempts have been made to treat chronic skin inflammation diseases, such as psoriasis and atopic dermatitis, but effective therapies for the immune cell-mediated skin diseases, including psoriasis and atopic dermatitis have not been developed. Until recently, several drug candidates which were claimed to be effective for skin diseases have been reported, but most of them are not used to treat chronic skin disease. Especially, Psoriasis is characterized by excessive growth and aberrant differentiation of keratinocytes, but is fully reversible with appropriate therapy. The trigger of the keratinocyte response is thought to be activation of the cellular immune system, with T cells and various immune-related cytokines. Formation of new blood vessels starts with early psoriatic changes and disappears with disease clearance. Several angiogenic mediators are up-regulated in psoriasis development. Contact- and mediator-dependent factors derived from keratinocytes, mast cells and immune cells may contribute to the strong blood vessel formation of psoriasis. New technologies and experimental models provide new insights into the role of angiogenesis in psoriasis pathogenesis. TMP and its derivatives themselves effectively inhibited in vitro cell migration, tube formation, and the expression of angiogenic factors. However, TMP and its derivatives induced side effects including hemolysis and local side effects. Therefore, in an attempt to reduce the toxicity and the undesirable side effects of TMP and derivatives, a liposomal formulation was prepared and tested for its effectiveness. TMP and derivatives liposomes retained the effectiveness of TMP in vitro while side effects were reduced. These results support the conclusion that TMP effectively inhibits in vitro angiogenesis, with the possibility that use as a psoriasis relief agent.

• 정신신체의학
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• 제7권2호
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• pp.252-255
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• 1999

최근 만성 통증 환자가 증가하고 있다. 특히 정신과 외래환자에서는 40% 이상이 통증으로 고통을 받고 있다. 그런데 한국인의 질병관과 질병에 대한 태도와 관련되어 나타나는 비정상 질병행동은 통증 환자에게 만성화 경향을 재촉하고 치료에 많은 어려움을 야기시키고 있다. 본 심포지움은 근관절계, 신경계질환, 만성 내과질환과 관련된 만성 통증을 어떻게 효율적으로 치료 할 것인가를 조명해 보고자 한다. 이로서 자문-조정 정신의학에서 만성 통증환자에 대한 효과적인 대처 요령을 습득하고자 한다.

• The Korean journal of internal medicine
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• 제39권1호
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• pp.7-24
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• 2024

Post-tuberculosis lung disease (PTLD) is emerging as a significant area of global interest. As the number of patients surviving tuberculosis (TB) increases, the subsequent long-term repercussions have drawn increased attention due to their profound clinical and socioeconomic impacts. A primary obstacle to its comprehensive study has been its marked heterogeneity. The disease presents a spectrum of clinical manifestations which encompass tracheobronchial stenosis, bronchiectasis, granulomas with fibrosis, cavitation with associated aspergillosis, chronic pleural diseases, and small airway diseases-all persistent consequences of PTLD. The spectrum of symptoms a patient may experience varies based on the severity of the initial infection and the efficacy of the treatment received. As a result, the long-term management of PTLD necessitates a detailed and specific approach, addressing each manifestation individually-a tailored strategy. In the immediate aftermath (0-12 months after anti-TB chemotherapy), there should be an emphasis on monitoring for relapse, tracheobronchial stenosis, and smoking cessation. Subsequent management should focus on addressing hemoptysis, managing infection including aspergillosis, and TB-associated chronic obstructive pulmonary disease or restrictive lung function. There remains a vast expanse of knowledge to be discovered in PTLD. This review emphasizes the pressing need for comprehensive, consolidated guidelines for management of patients with PTLD.

• 보건행정학회지
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• 제22권2호
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• pp.275-296
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• 2012

Graduate School of Public Health, Seoul National University The national health insurance system in Korea is characterized as relatively high out-of-pocket payments, which are the principal source of catastrophic health expenditure (CHE). The objectives of this study are to estimate the incidence of household CHE and to clarify the characteristics that affect the occurrence and recurrence of household CHE using the Seoul Welfare Panel Survey database for 2008 and 2010. Thresholds to estimate CHE were 10% and 20% of the total household income (T/X), and 25% and 40% of the income excluding food share (T/Y). Determinants of the occurrence and recurrence of CHE at the threshold of T/X=10% were analysed using multiple logistic regression models. Out of the 3,665 households that responded in 2008 survey, households with CHE were 12.07% (T/X${\geq}$10%), 5.34% (T/X${\geq}$20%), 6.84% (T/Y${\geq}$25%), and 4.44% (T/Y${\geq}$40%). Risk factors associated with household CHE included living with a spouse, non-Medicaid beneficiary, householder unemployment, low household income, the number of disabled members, poor subjective health, and the number of chronic diseases. A total of 41.78% of households with CHE in 2008 repeatedly experienced CHE in 2010. Risk factors of CHE recurrence included decreased household income and an increase in chronic diseases over the two time periods, the number of members with disability or chronic diseases, and the presence of cancer patients in 2008. Households with lower socioeconomic and health status had a higher financial burden on health care than do their counterpart households. There is a need to enhance society-wide financial protection from health spending among vulnerable citizens in Seoul, particularly, households with low income, disabled members or cancer patients.

• 디지털융복합연구
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• 제11권10호
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• pp.571-576
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• 2013

이 연구의 목적은 소방공무원의 직무관련성 질환에 대하여 조사하고 소방공무원의 건강관리와 질환 예방대책 마련에 필요한 기초자료를 제공하는 데 있다. 연구 방법은 1개 소방서에 근무하는 전체 소방공무원을 대상으로 구조화된 설문지를 이용하여 자기기입식 기록으로 설문을 받았다. 연구 결과 소방공무원의 37.7%가 만성질환을 가지고 있었고, 12.3%가 만성요통을 앓고 있었다. 증상 부위별로는 허리 41.5%, 어깨 33.0%, 목 23.6%순이었으며, 이로 인해 48.1%가 지난 한달 동안 신체적 아픔으로 집이나 직장 일로부터 지장을 받았다고 답하였다. 또한 54.1%에서 지난 1년 이내에 병원 치료를 받은 것으로 조사되었다. 이상의 결론 도출을 통하여 소방공무원의 특수건강 진단에 근골격계 질환과 관련된 프로그램의 추가, 근골격계 질환을 예방하기 위한 건강증진 프로그램의 개발, 직무 상 발생되는 급성장애에 대한 수시건강진단 체계의 도입 마련을 제언하고자 한다.

• 한국학교ㆍ지역보건교육학회지
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• 제14권3호
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• pp.15-26
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• 2013

Objectives: The purpose of this study was to evaluate self-reported symptoms of periodontal diseases. We performed a comprehensive analysis of periodontal health related factors. Methods: 581 volunteers representing a broad range of age from 20 to 65 were recruited from Seoul and Gyeonggi provinces. They participated in a self-administered survey of which the results were analyzed through the decision tree analysis using the data mining program. Results: 67% of the participants reported 'bad breath,' whereas 13.9% of participants reported 'toothache'. The decision analysis revealed that age was the most determining factor of adult periodontal health. Participants in 20s with a profound understanding of their periodontal health status exhibited a low vulnerability to periodontal diseases, whereas those lacking the awareness were more susceptible to the diseases. However, other participants in 30s and older showed a higher vulnerability to periodontal illness than those in 20s, whether or not they had suffered from chronic diseases. Conclusions: In order to effectively prevent periodontal diseases, an age-appropriate clinical approach will be necessary. For the younger age group it will be crucial to enhance the self-awareness of their current oral health status. On the other hand, those in 30s and older will need to pay a close attention to the prevention of chronic periodontal disease.