• Tuberculosis and Respiratory Diseases
• /
• 제66권3호
• /
• pp.211-215
• /
• 2009

폐색전증은 일반적으로 고령의 환자, 거동이 불가능한 경우, 만성 내과 질환, 외상이나 술 후 또는 혈액응고질환 등의 위험인자를 갖고 있는 환자에서 호발하는 질환으로 알려져 있다. 그러나, 최근 컴퓨터가 보편화되고 특히 젊은 연령층에서 컴퓨터 게임이 대중화 됨에 따라 이 또한 폐색전증의 위험인자가 될 수 있음을 이 증례를 통하여 보고하고자 한다. 36세 남자 환자가 가슴답답함과 호흡곤란증세로 급성심근경색 의증 하에 응급실로 전원되었다. 환자는 청색증과 저산소증을 보였으며, 흉부컴퓨터단층촬영상 양측 주 폐동맥에 혈전증이 관찰되었으며, 혈전용해술을 시행하여 성공적으로 치료하였다. 병력청취상 약 2주 전부터 하루에 12시간 이상 컴퓨터 게임을 하였으며, 이 외에 특별한 위험인자는 없었다. 현재 환자 상태는 양호하여 외래 추적관찰 중이며, 이 환자의 증례를 통하여 장시간의 컴퓨터 게임이 혈전용해술을 시행할 만큼 대량의 폐색전증을 발생할 수 있음을 알 수 있었고, 이에 대한 사회적인 인식 또한 필요할 것으로 사료된다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제17권5호
• /
• pp.2479-2483
• /
• 2016

Background: This study explored the knowledge and awareness about colorectal cancer (CRC) among undergraduate students of one of the leading universities in Saudi Arabia, along with the mode of information access. Materials and Methods: The present cross-sectional study was conducted at the King Abdulaziz University, Jeddah, Saudi Arabia, among students of different faculties. The study questionnaire, containing 28 items, was adapted from surveys identified in the relevant literature. The CRC awareness questionnaire consisted of an awareness section (early CRC signs and symptoms, and risk factors) and a knowledge section. The data were analyzed using the SPSS version 21.0. Results: A total of 525 undergraduate students participated in the study. The majority were females (63.0%) and approximately half (56.8%) were medical students. The majority of the students (82.3%) were aware of CRC, and 68% thought that CRC is a preventable disease. Regarding colorectal cancer screening tests, only one-third of students (33%) had actual knowledge, while the majority of the students (77.0%) thought that there are tests which help in early detection. Only 4% of the participants had a family history of CRC. The majority of the participants (84%) thought that CRC is a disease that can be cured. Almost 50-60% participants had good awareness level regarding risk factors, and signs and symptoms. Regarding knowledge, participant responses varied for family history (52%), age (59%), chronic infection of the colon (72%), obesity and lack of exercise (66%). More than one-third of the students had received information material regarding CRC from their curriculum followed by social media (20.4%), and nearly 40% from other sources such as TV, hospital and mass media. Female participants had significantly better awareness in a few questions regarding CRC awareness as compared to their male counterparts. There was a significant difference observed between medical and non-medical students (p<0.001) in overall score of awareness and knowledge about CRC while no significant difference found in gender-wise comparison. Conclusions: Knowledge and awareness of students about CRC were not up to the mark. Medical students and female students had better knowledge in a few areas, but the overall situation is dismal.

• Genomics & Informatics
• /
• 제11권4호
• /
• pp.211-217
• /
• 2013

Many biobanks were established as biorepositories for biomedical research, and a number of biobanks were founded in the 1990s. The main aim of the biobank is to store and to maintain biomaterials for studying chronic disease, identifying risk factors of specific diseases, and applying personalized drug therapies. This report provides a review of biobanks, including Korean biobanks and an analysis of sample volumes, regulations, policies, and ethical issues of the biobank. Until now, the top 6 countries according to the number of large-scale biobanks are the United Kingdom, United States, Sweden, France, the Netherlands, and Italy, and there is one major National Biobank of Korea (NBK) and 17 regional biobanks in Korea. Many countries have regulations and guidelines for the biobanks, and the importance of good management of biobanks is increasing. Meanwhile, according to a first survey of 456 biobank managers in the United States, biobankers are concerned with the underuse of the samples in their repositories, which need to be advertised for researchers. Korea Biobank Network (KBN) project phase II (2013-2015) was also planned for the promotion to use biospecimens in the KBN. The KBN is continuously introducing for researchers to use biospecimens in the biobank. An accreditation process can also be introduced for biobanks to harmonize collections and encourage use of biospecimens in the biobanks. KBN is preparing an on-line application system for the distribution of biospecimens and a biobank accreditation program and is trying to harmonize the biobanks.

• Yonsei Medical Journal
• /
• 제59권9호
• /
• pp.1079-1087
• /
• 2018

Purpose: Obstructive sleep apnea and chronic obstructive pulmonary disease are independent risk factors of cardiovascular disease (CVD), and their coexistence is known as overlap syndrome (OS). Endothelial dysfunction is the initial stage of CVD; however, underlying mechanisms linking OS and CVD are not well understood. The aim of this study was to explore whether OS can lead to more severe inflammation and endothelial apoptosis by promoting endothelial dysfunction, and to assess the intervention effects of antioxidant tempol. Materials and Methods: Male Wistar rats (n=66) were exposed to normal oxygen [normal control (NC) group], intermittent hypoxia (IH group), cigarette smoke (CH group), as well as cigarette smoke and IH (OS group). Tempol intervention was assessed in OS group treated with tempol (OST group) or NaCl (OSN group). After an 8-week challenge, lung tissues, serum, and fresh blood were harvested for analysis of endothelial markers and apoptosis. Results: The levels of intracellular adhesion molecule-1, vascular cellular adhesion molecule-1, and apoptosis in circulating epithelial cells were the highest in OS group and the lowest in NC group. These levels were all greater in IH group than in CH group, and were lower in OST group than in OS and OSN groups (all p<0.001). Conclusion: Synergistic effects of IH with cigarette smoke-induced emphysema produce a greater inflammatory status and endothelial apoptosis. OS-related inflammation and endothelial cell apoptosis may play important roles in promoting cardiovascular dysfunction, and antioxidant tempol could achieve a partial protective effect.

• 대한영상의학회지
• /
• 제83권5호
• /
• pp.1153-1159
• /
• 2022

긴머리확장증은 확장, 연장 및 구불구불한 형태의 대뇌동맥을 특징으로 하는 드문 질환이다. 주요 병리기전은 내탄력판의 파괴로 알려져 있으며, 위험요인으로 고령, 만성 고혈압, 그리고 대사성 질환 등이 있다. 긴머리확장증은 주로 후순환계의 척추뇌기저동맥을 침범하는 것으로 알려져 있으나, 전순환계, 특히 전대뇌동맥에 이환되는 경우도 있다. 긴머리확장증이 전순환계와 후순환계를 모두 침범한 사례는 아직 국내에 보고된 바가 없다. 이에 우리는 기저 질환이 없는 젊은 여자 환자에서 전순환계와 후순환계가 모두 이환된 매우 희귀한 형태의 긴머리확장증 사례를 현저한 영상 소견을 토대로 보고하고자 한다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권18호
• /
• pp.8391-8396
• /
• 2016

Thailand is becoming an aging society, this presenting as a serious problem situation especially regarding health. Chronic diseases found frequently in the elderly may be related to dietary intake and life style. Surin province has been reported as a risk area for liver fluke with a high incidence of cholangiocarcinma especially in the elderly. Therefore, this study aimed to determine the nutritional status and associated factors among elderly in Surin province, northeast of Thailand. A community-based cross-sectional study was conducted among 405 people aged 60 years and above, between September 2012 and July 2014. The participants were selected through a randomized systematic sampling method and completed a pre-designed questionnaire with general information, food recorded, weight, height, waist circumference, and behavior regarding to food consume related to liver fluke infection. The data were analyzed using descriptive statistics and Spearman's rank correlation coefficients. The majority of participants was female (63.5%), age between 60-70 years old (75.6%), with elementary school education (96.6%), living with their (78.9%), and having underlying diseases (38.3%). Carbohydrate (95.3%) was need to improve the consumption. The participants demonstrated under-nutrition (24.4%), over-nutrition (16.4%), and obesity (15.4%). Elderly had a waist circumference as the higher than normal level (34.0%). Gender, female, age 71-80 years old, elementary school and underlying diseases were significantly associated with poor nutritional status. The majority of them had a high knowledge (43.0%), moderate attitude (44.4%), and moderate practice (46.2%) regarding food consumption related to liver fluke infection. In conclusion, these findings data indicated that elderly age group often have an under- or over-nutritional status. Carbohydrate consumption needs to be improved. Some elderly show behavior regarding food consumption that is related to liver fluke infection hat needs to be improved, so that health education pertaining good nutrition is required.

• Journal of Nutrition and Health
• /
• 제46권6호
• /
• pp.521-530
• /
• 2013

Protein-energy malnutrition, PEM, and increased hs-CRP level are considered to be associated with increased risk of cardiovascular disease (CVD) in hemodialysis (HD) patients. This is commonly referred to as the vicious circle of malnutrition-inflammation-atherosclerosis cardiovascular disease (MIA syndrome) in chronic kidney disease (CKD). Low protein intake can decrease the serum level of albumin and increase inflammational markers; further, both low serum albumin and high hs-CRP are independent risk factors for all-cause mortality in HD patients. The aim of this study is comparing the serum levels of albumin and hs-CRP in HD patients according to the protein intake levels. The total number of subjects was 60 hemodialysis patients; they were grouped by dietary protein intake: low protein intake group (LPI, protein intake < 1.0 g/kg IBW, 11 men and 19 women) and adequate protein intake group (API, protein intake ${\geq}$ 1.0g/kg IBW, 12 men and 18 women). Blood biochemical parameters, nutrient intake, and dietary behaviors were compared between the LPI and API groups. The LPI group showed a significantly lower serum level of albumin and higher serum level of hs-CRP than the API group (p < 0.05). The LPI group showed a significantly lower intake of most nutrients than the API group (p < 0.05). Index of Nutritional Quality of most nutrients of the LPI and API groups were lower than 1.0. Dietary protein intake was positively correlated with the serum level of albumin (r = 0.306, p < 0.05) and negatively correlated with the serum level of hs-CRP (r = -0.435, p < 0.01). The serum level of hs-CRP was negatively correlated with that of albumin (r = -0.393, p < 0.01). According to these result, serum albumin and hs-CRP in HD patients were influenced by the protein intake levels. To prevent MIA syndrome, it is necessary to improve nutritional status, especially in protein and energy.

• 한국약용작물학회지
• /
• 제25권6호
• /
• pp.367-374
• /
• 2017

Background: An imbalance in energy intake and expenditure can cause obesity, which is a major risk factor for chronic diseases such as heart disease, type 2 diabetes, insulin resistance, cancers and hyperlipidemia. Methods and Results: In this study, we evaluated the anti-obesity effects of a water extract from the young leaves of barley sprout (BS) in 3T3-L1 cells and in high-fat diet (HFD)-induced obese mice (HF). Lipid accumulation measurement indicates that BS markedly inhibited adipogenesis by reducing lipid droplet production in a dose-dependent manner. Furthermore, the mRNA expression of adipogenic transcription factors peroxisome proliferator-activated receptor-${\gamma}$ and fatty acid synthetase, CCAAT/enhancer binding protein-${\alpha}$ and fatty acid binding protein 4 in 3T3-L1 cells was significantly inhibited by BS treatment. In an in vivo test, the BS-administered group of HFD-induced mice showed less body weight gain, and lower liver and epididymal white adipose tissue weights. The BS-treated mice showed decreased serum levels of leptin and lipids compared to untreated HFD mice and the levels of adiponectin and the HDL-cholesterol/total cholesterol ratio increased. These results indicate that BS inhibits body fat accumulation by reducing the mRNA expression of lipogenesis transcription factors and increasing serum adipokine concentration in in vitro and in vivo tests. Conclusions: BS reduced high fat diet-induced weight gain and had a positive effect on dyslipidemia.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• 제49권5호
• /
• pp.243-251
• /
• 2023

Objectives: Although a few studies have investigated the relationship between kidney and oral function (number of remaining teeth), their results remain inconclusive. Therefore, this study aimed to investigate the relationship between kidney function and oral health in community-dwelling healthy elderlies and examine the factors associated with kidney function. Materials and Methods: We used cross-sectional data from the Shimane prefecture cohort recruited by the Center for Community-Based Health Research and Education in 2019. We collected clinical data on dental status, background factors and kidney function (estimated glomerular filtration rate [eGFR], mL/min/1.73 m² and creatinine levels, mg/dL). Results: The study enrolled 481 participants, whose mean age was 66.7±7.4 years, and 223 (46.4%) participants were men. Multivariate analysis revealed significant correlations between eGFR (B=0.17, P=0.04), creatinine (B=-0.54, P<0.01), and the number of remaining teeth. The number of remaining teeth was associated with creatinine and eGFR, which are indicators of kidney function. Conclusion: This study suggests that preserving the teeth may prevent decline in kidney function. Dental professionals should provide instructions and professional care to reduce the risk of systemic diseases such as kidney dysfunction.

• 농촌의학ㆍ지역보건
• /
• 제30권3호
• /
• pp.279-292
• /
• 2005

본 연구는 2001년도 '국민건강 영양조사'에서 자료를 추출하여 농림어업인과 비농림어업인의 상병실태 및 건강행태를 비교 분석함으로써 건강 안전 연구, 사업 및 정책의 우선순위를 결정하는데 기초 자료를 제공하고자 수행되었다. 2001년도 '국민건강 영양조사' 원자료 분석은 30세 이상에 대하여 직업을 농림어업인군과 나머지 비농림어업인으로 나누어 비교분석하였다. 의사진단 만성질환 유병자율은 농림어업인 72.4%, 비농림어업인 49.8%로 나타났다. 그러나 유병자율을 연령대별로 비교해보면 농림어업인 대 비농림어업인의 비율은 30대 1.10배, 40대 1.30배, 50대 1.14배, 60대 1.08배, 70대 0.99배로 40대와 50대에서 두 그룹간의 차이가 크고 나머지 연령대에서는 큰 차이를 보이지 않았다. 의사진단 만성질병의 구조를 살펴보면 질환별로 농림어업인과 비농림어업인이 차이가 나는 것을 알 수 있는데 근골격계 질환의 경우 농림어업인이 61.50%, 비농림어업인이 25.13%로 나타나 농림어업인이 2.4배 이상 높았으며, 손상 중독은 농림어업인이 0.89%, 비농림어업인이 0.34%로 2.6배 이상 높은 것으로 나타났다. 농림어업인 중에서 근골격계질환 다음으로 많은 것은 순환기계 20.6%, 소화기계 19.9%, 내분비계 8.5%, 호흡기계 8.0% 순로 나타났다. 의사진단 만성질병을 세부질환별로 분류해보면 농림어업인에게 가장 문제가 되는 근골격계질환의 경우 관절염 > 요통 좌골통 > 신경통 류머티즘 > 디스크 > 관절증 > 골다공증의 순으로 나타났다. 평생 사고중독 경험율은 농림어업인의 경우 18.2%, 비농림어업인은 13.3%였으며, 사고중독 후유증 호소율은 농림어업인(8.1%)이 비농림어업인(3.7%) 보다 2배 이상 높게 나타났고, 농림어업인의 사고 유형의 분포는 골절 탈구 > 삐거나 인대늘어남 > 좌상, 발생원인은 교통운수사고 > 추락미끄러짐, 발생장소는 도로 > 논밭 > 주거 인접지역 순으로 나타났다. 건강하지 못하거나 매우 건강하지 못하게 느끼는 주관적 건강인식 비율은 농림어업인이 비농림어업인에 비해 거의 2배 가까이 건강을 나쁘게 인식하는 것으로 나타났으며, 흡연율과 운동미실천율이 농림어업인이 비농림어업인보다 높게 나타났다. 또한 스트레스 원인으로서 건강과 질병이라는 응답비율이 농림어업인이 비농림어업인에 비해 2.4배 많게 나타났다. 결론적으로 농림어업인은 비농림어업인에 비해 만성질병 유병률이 높게 나타났으며 그 중 근골격계질환이 가장 문제가 되고 있었다. 이는 농작업 특성상 작업자세가 불량하고 장시간 같은 자세로 일하는 시간이 길며 중량물 취급 등 근골격계 부담작업이 많기 때문으로 해석된다. 따라서 농림어업인의 건강증진사업은 일반적인 성인병 예방 중심의 사업이 아니라 농작업 특성을 반영하여 농림어업인에게 특화된 방향으로 전개되어야 할 것으로 생각한다. 이를 위해서는 농림어업인에게 주로 발생하는 질환 및 사고와 농작업과의 관련성을 심층분석하고 건강유해요인을 구명하는 연구가 지속적으로 수행되어야 하며 각각의 건강 유해요인별로 다양한 대책 마련이 필요하다고 하겠다.