• Journal of Oral Medicine and Pain
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• 제47권4호
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• pp.183-188
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• 2022

Purpose: The goal of this study was to investigate the causative factors related to the stress of temporomandibular disorders (TMDs) by evaluating salivary cortisol concentration in young adult TMD patients and control groups. Methods: Saliva was obtained from 32 young adult TMDs patients and 34 control patients without a history of TMDs who visited Chosun University Dental Hospital between June 1 and August 31, 2021. Enzyme-linked immunosorbent assay was conducted to measure the salivary cortisol concentration. Results: The salivary cortisol concentration in the TMD patient group and the control group differed significant significantly (p<0.05). The salivary cortisol concentration according to the duration of the clinical symptom of TMD differed significantly difference between the two groups in the male. The salivary cortisol concentration according to perceived stress level differed significantly in the mild and moderate groups (p<0.05). There was no significant difference in salivary cortisol concentration between the two groups related to bruxism or clenching (p>0.05). Conclusions: The salivary cortisol concentration in the TMD patient group and the control group showed statistical relevance, indicating that stress was a causative factor.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제33권4호
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• pp.359-362
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• 2011

Purpose: This study evaluated the clinical applications of implant placement and guided bone regeneration using a mineralized bone allograft and a barrier membrane derived from ox pericardium Methods: From January 2007 to June 2009, among the patients who received an implant at Chosun University Dental Hospital, patients were selected if they were treated with guided bone regeneration (GBR) with simultaneous implant placement or GBR prior to implant placement. The selected patients were sorted according to the materials and membranes used in GBR, and the implant survival rate was recorded by clinical examination and reviewing the medical records and the radiographs. Each study list was analyzed by SPSS (version 12.0, SPSS Inc., USA) software and the survival rate was verified by Chi-square tests. $P$ values less than 0.05% were deemed significant. Results: 278 implants were placed on a total of 101 patients and 8 implants resulted in failure. Three implants failed among 15 implants with only a mineralized bone allograft. No failure was shown among the 74 implants placed with mineralized bone allograft and a barrier membrane derived from ox pericardium. One group of 4 implant placements showed failure among the 102 implants placed with a mineralized bone allograft and another bone graft material. The group that had a barrier membrane derived from ox pericardium with a mineralized bone allograft or other bone materials showed no implant failure. Three failures were shown among the 21 implants placed with only bone graft and not using a membrane. The group with membranes other than a barrier membrane derived from ox pericardium showed 5 failures among 170 implants. Conclusion: The implant survival rate of the group with GBR using a mineralized bone allograft was 96.3%, which meant there was little difference compared to the groups of another bone graft materials (98.9%). The implant survival rate of the group without a membrane-was 85.7% and it showed a significant difference compared to the group using a barrier membrane derived from ox pericardium (100%) and the group using another membrane (97.1%).

• International Journal of Oral Biology
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• 제46권4호
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• pp.160-167
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• 2021

Nypa fruticans Wurmb (NFW) contains a large amount of phenolic acid and flavonoids, and is popular as a superfood in Myanmar. NFW has various biological activities, such as anti-inflammatory, anti-oxidant, and neuroprotective properties; however, the anti-cancer effect of NFW have not been reported. In this study, we investigated the anticancer activity of water extracts of NFW (WeNFW) and the underlying mechanism in human FaDu hypopharyngeal squamous carcinoma cells. The WeNFW inhibited FaDu cell growth in a dose-dependent manner without affecting normal cells (L929), as determined by an MTT assay and Live and Dead assay. In addition, the concentrations of WeNFW without cytotoxicity (0.025, 0.05, and 0.1 mg/mL) inhibited wound healing and colony formation. Furthermore, WeNFW significantly induced apoptosis through the proteolytic cleavage of caspase-3 and -9, poly (ADP-ribose) polymerase, and downregulation of Bcl-2 and upregulation of Bax in FaDu cells, as determined by DAPI staining, FACS analysis, and western blot analysis. Taken together, these results suggest that WeNFW exhibits potent anti-cancer effects by suppressing the growth of oral cancer cells, wound healing and colony formation activity. Via mitrochondrial-dependent apoptotic pathways in human FaDu hypopharyngeal squamous carcinoma cells. Therefore, WeNFW can provide a natural chemotherapeutic drug for oral cancer in humans.

• 대한치과교정학회지
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• 제31권2호통권85호
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• pp.283-300
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• 2001

본 연구는 부정교합 유형이나 지역 분포 및 시대적 변화 등을 파악하고 이해함으로써 환자의 적절한 의사소통을 위한 자료나 정보제공을 용이하게 하기 위해, 적절한 진단과 치료계획을 수립하는 데 도움을 주기 위해, 다가오는 21세기에 변모될 치의학을 준비하고 발전의 도약을 마련하기 위해, 향후 부정교합 치료의 방향성을 설정하기 위해 시행하였다. 이를 위해 1990년부터 1999년까지 10년간 조선대학교 부속치과병원 교정과에 내원하여 진단받은 부정교합 환자 중 진단용 모형과 진료기록부가 잘 보존된 3,070명을 대상으로 하여 부정교합의 양상과 내원환자의 분포 및 변화추세를 조사 연구한 결과 다음과 같은 결론을 얻었다. 1. 내원환자의 수는 매년 증가 추세에 있었으며, 남자가 43.5%, 여자가 56.5%로 여자가 남자보다 약 1.3배 더 많았다. 2. 연령별 분포에서 7세에서 12세 군의 내원율이 37.9%로 가장 높게 나타났으며 다음으로는 13세에서 18세 군이 32.0%, 19세에서 24세 군이 19.6%, 25세 이상 군이 7.1%, 0세에서 6세 군이 3.4%으로 가장 낮았다. 3. Hellman 치령별 분포에서 남녀 모두 영구치열의 완성기인 IVa가 54.9%로 가장 높게 나타났다. 4. 내원환자의 거주지 분포에서 광주시내 거주자가 내원환자의 71.0%로 10km이내가 56.3%, 20km이내가 14.7%였다. 5. 내원환자의 주소(chief complaint)별 분포에서 전치부 반대교합이 22.7%로 가장 높게 나타났으며, 하악전돌은 12.6%, 상악전치전돌은 12.2%를 보였다. 6. Angle씨 부정교합 분류별 분포에서 제I급 부정교합이 38.9%, 제 II급 1류 부정교합은 20.7%, 제 II급 2류 부정교합은2.0%, 제III급 부정교합은 38.4%였으며, 남자에서는 제III급 부정교합이, 여자에서는 제I급 부정교합의 비율이 가장 높게 나타났다. 7. 치아의 수직관계이상에 있어서 제II급 1류와 2류 부정교합에서는 과개교합이 24.3%와 56.7%로, 제III급 부정교합에서는 개교합이 21.4%로 가장 높게 나타났다. 8. 골격의 전후방적 부조화에 있어서 제II급 부정교합은 하악골 발육부전으로 인한 경우가 39.3%, 제III급 부정교합은 하악골 과다성장으로 인한 경우가 46.3%로 가장 높게 나타났다. 9. 교정치료시 발치유무에 따른 분포에 있어서 발치 치료는 33.1%, 비발치 치료는 66.9%를 차지하였고, 발치치료 중 38.6%가 상하악 좌우측 제1소구치를 발거하였다. 10. 악교정 수술환자는 매년 계속 증가 추세에 있었으며, 전체 환자의 7.9%가 악교정 수술을 받았다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제34권4호
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• pp.485-489
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• 2008

Basal cell nevus syndrome is a hereditary disease of an autosomal dominant trait with variable conditions such as basal cell carcinomas of the skin, deformity of rib, fusion of vertebrae, mental retardation, hypertelorism, and multiple odontogenic keratocysts. A 32 years old man with pus discharge from fistula on the vestibule of left upper 1st molar visited to Chosun University Dental Hospital. Radiographic evaluation revealed multiple maxillary and mandibular cysts that had multilocular radiolucency on left mandibular body area, thining of inferior border of left border of ramus and well defined unilocular radiolucency above right upper 1st and 2nd molar and from left upper 1st premolar to 2nd molar. In chest PA view, he had a forked rib in the left 4th rib and in skull PA view the calcification of falx cerebri was observed. There was not any skin lesion. After the preliminary evaluation, the patient was diagnosed with basal cell nevus syndrome and he underwent marsupialization for decreasing the size of cystic lesion and came to hospital for dressing 3days a week. As time goes by, the size of lesion decreased. So, one and half year after marsupialization, he underwent cyst enucleation and iliac bone graft for the mandibular lesion and buccal fat pad grafts for the maxillary lesions. After the surgery, the patient experienced normal healing without any complications and he is on long-term follow-up.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제23권2호
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• pp.185-190
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• 2001

We described three cases of immediate reimplantation of a frozen-thawed autogenous mandible composed of a mixture of iliac bone, marrow, and particulate hydroxyapatite in tumors of the mandible. Acceptable outcomes were obtained in three patients who underwent immediate autogenous mandibular graft reconstruction. The conditions leading to successful outcome of the procedure are also discussed. Reimplantation of frozen autogenous lesioned mandible was performed in three patients with mandibular tumors. Two reimplanted grafts survived without complications following surgery. One case had postoperative infection that resolved with appropriate antibiotic treatment. There were no recurrences of the primary lesions. Satisfactory facial contour after surgery was achieved. These results are most promising, and we believe that, with further refinement, this technique will offer a new and acceptable modality for facial reconstruction in patients with cancer.

• 대한치과보철학회지
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• 제55권3호
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• pp.258-263
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• 2017

목적: 이번 연구에서, 다양한 상황에서 골소실양을 평가하기 위하여 맞춤형 지대주를 사용한 환자에서 4년간의 후향적 방사선학적인 연구를 시행하였다. 대상 및 방법: 이번 연구의 대상은 CAD/CAM 맞춤형 지대주를 이용한 임플란트 고정성 보철물이다. 2011년 8월 1일부터 2012년 7월 31일 까지 조선대학교 치과병원 보철과에서 제작하여 고정성 보철물로 사용된 CAD/CAM 맞춤형 지대주와 상부 보철물들을 대상으로 하였으며, 고정성 보철물을 제작한 환자에 대하여 방사선학적 평가를 시행하여 보철물 장착 후 3개월, 6개월, 1년, 2년, 3년, 4년 단위로 총 4년 간의 후향적 연구를 시행하였다. 결과:연구 결과, CAD/CAM을 이용한 맞춤형 지대주는 기존 연구 결과에 비해 골소실 양이 적었다. 연결 고정된 그룹과 연결 고정되지 않은 그룹 간에 골소실 양(각각 0.27 mm, 0.5 mm)에 통계적으로 유의한 차이가 없었다. 또한 상악 전치부, 상악 구치부, 하악 전치부, 하악 구치부의 부위별 골소실양(각각 1.37 mm, 0.39 mm, 0.00 mm, 0.30 mm)에 통계적으로 유의한 차이가 있었다. 결론:CAD/CAM을 이용한 맞춤형 지대주는 연결 고정 여부에 따른 골소실 양에서 통계적으로 유의한 차이가 없었으며, 임플란트 식립 부위에 따른 골소실 양에서 통계적으로 유의한 차이가 있었다.

• 대한소아치과학회지
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• 제40권3호
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• pp.149-158
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• 2013

이 연구의 목적은 치과용 3차원 Come-beam CT 영상을 이용하여 정중과잉치의 형태와 매복 양상 및 연관된 합병증에 대해 평가하는 것이다. 2007년부터 2012년까지 정중과잉치를 주소로 조선대학교 치과병원 소아치과에 내원한 280명의 환아의 cone-beam CT 영상을 평가하였다. 매복된 정중과잉치는 여아보다 남아에서 더 빈번했고, 약 3.3 : 1의 비율을 보였으며 6~8세에서 가장 많이 관찰되었다. 환자당 정중과잉치의 개수는 1.38개였다. 대부분의 정중과잉치는 원추형(79.5%)이었으며, 역위방향(48.6%)으로 위치하고 있었다. 근원심적 위치로는 정중부(81.8%)가 가장 흔했고, 수직적으로는 치경부 근처(60.3%)에 가장 많이 분포하였으며, 순구개측 위치로는 구개측(73.8%)에 가장 많이 위치였다. 정중과잉치의 47.5%에서 합병증이 관찰되었고 인접치 변위와 맹출 지연이 가장 흔했다. 과잉치의 형태와 수직적 위치, 그리고 순구개측 위치가 합병증과 상관관계를 보였다. Cone-beam CT는 매복된 정중과잉치에 대한 3차원적 위치 정보와 정확한 영상을 제공하였다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제32권5호
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• pp.416-421
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• 2010

Purpose: The purpose of this study was to evaluate the incidence of intra- and postoperative complications of orthognathic surgery and their relevance. Materials and Methods: The clinical records and X-rays of 418 patients who underwent surgery at Chosun University Dental Hospital, Korea, over a 12-year period between 1998 and 2009 were examined. Results: The followings are some of the most common complications which happened during the oper-ations: Inadequate osteotomy in 25 cases, excessive bleeding in 11 cases, nerve injuries in 6 cases, soft tis-sue injuries in 8 cases, and tooth injury, and insertion of foreign bodies in 4 cases respectively. The most frequent complications which happened after surgery are shown below. Paraesthesia in 262 cases, dyspnea in 78 cases, pain in cervical region in 49 cases, open bite in 14 cases, plus 62 cases where other complications occurred. Despite the great variety of complications, severe life threatening complication frequency seems to be extremely low. Conclusion: Orthognathic surgery appears to be a relatively safe procedure but complications related to orthognathic surgery do still occur. Accurate evaluation and precise surgery are needed to minimize complications.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제33권6호
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• pp.525-528
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• 2011

A deep circumflex iliac artery (DCIA) flap is usually used for reconstruction in oral and maxillo-facial surgery department since introduced by O'Brien in 1975. Various flap designs are possible for osteomusculocutaneous, musculocutaneous, musculosseous and vascularized bone types. Iliac crest shape is similar to contour of mandible. Moreover, though a fibular flap has only 15~20 mm of cutting plane width, a DCIA flap contains much more bone amount, making this a similar reconstruction compare with normal mandible. A 68 year-old male with squamous cell carcinoma on the anterior floor of the mouth had an impression with T2N0Mx and the treatment procedure was DCIA reconstruction after wide resection and marginal mandibulectomy, with both supraomohyoid neck dissection. We present an experience of DCIA flap for reconstruction with a literature review.